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Genetic influences on resting electrocardiographic variables in older women: a twin study.

https://arctichealth.org/en/permalink/ahliterature153101
Source
Ann Noninvasive Electrocardiol. 2009 Jan;14(1):57-64
Publication Type
Article
Date
Jan-2009
Author
Sara Mutikainen
Alfredo Ortega-Alonso
Markku Alén
Jaakko Kaprio
Jouko Karjalainen
Taina Rantanen
Urho M Kujala
Author Affiliation
Department of Health Sciences, University of Jyväskylä, Finland. sara.mutikainen@gmail.com
Source
Ann Noninvasive Electrocardiol. 2009 Jan;14(1):57-64
Date
Jan-2009
Language
English
Publication Type
Article
Keywords
Aged
Aging - genetics
Cohort Studies
Confidence Intervals
Electrocardiography
Female
Finland
Genetic Predisposition to Disease
Heart rate - genetics
Humans
Middle Aged
Reference Values
Rest
Twins
Twins, Dizygotic
Twins, Monozygotic
Abstract
Previous studies in young and middle-aged men and women have shown that resting electrocardiographic (ECG) variables are influenced by genetic factors. However, the extent to which resting ECG variables are influenced by genetic factors in older women is unknown. Thus, the aim of this study was to estimate the relative contribution of genetic and environmental influences to individual differences in resting ECG variables among older female twins without overt cardiac diseases.
Resting ECG recordings were obtained from 186 monozygotic and 203 dizygotic twin individuals, aged 63-76 years. Quantitative genetic modeling was used to decompose the phenotypic variance in each resting ECG variable into additive genetic, dominance genetic, shared environmental, and unique environmental influences.
The results showed that individual differences in the majority of the resting ECG variables were moderately to highly explained by additive genetic influences, ranging from 32% for T axis to 72% for TV(5). The results also suggested dominance genetic influences on QRS duration, TV(1), and Sokolow-Lyon voltage (36%, 53%, and 57%, respectively). Unique environmental influences were important for each resting ECG variable, whereas shared environmental influences were detected only for QT interval and QTc.
In older women without overt cardiac diseases, genetic influences explain a moderate to high proportion of individual differences in the majority of the resting ECG variables. Genetic influences are especially strong for T-wave amplitudes, left ventricular mass, and hypertrophy indices, whereas other variables, including heart rate, intervals, and axes, are more affected by environmental influences.
PubMed ID
19149794 View in PubMed
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Objectively measured physical activity in Finnish employees: a cross-sectional study.

https://arctichealth.org/en/permalink/ahliterature265559
Source
BMJ Open. 2014;4(12):e005927
Publication Type
Article
Date
2014
Author
Sara Mutikainen
Elina Helander
Julia Pietilä
Ilkka Korhonen
Urho M Kujala
Source
BMJ Open. 2014;4(12):e005927
Date
2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Body mass index
Cross-Sectional Studies
Employment
Exercise - physiology
Female
Finland
Health promotion
Heart rate
Humans
Male
Middle Aged
Obesity - prevention & control - therapy
Occupational Health
Oxygen consumption
Physical Exertion - physiology
Recreation
Reference Values
Self Report
Sex Factors
Work
Young Adult
Abstract
To objectively measure the amount of intensity-specific physical activity by gender and age with respect to body mass index (BMI) during workdays and days off among Finnish employees.
A cross-sectional study.
Primary care occupational healthcare units.
A sample of 9554 Finnish employees (4221 men and 5333 women; age range 18-65 years; BMI range 18.5-40 kg/m(2)) who participated in health assessments related to occupational health promotion.
The amount of moderate-to-vigorous (MVPA) and vigorous (VPA) physical activity (=3 and =6 metabolic equivalents, respectively) was assessed by estimating the minute-to-minute oxygen consumption from the recorded beat-to-beat R-R interval data. The estimation method used heart rate, respiration rate and on/off response information from R-R interval data calibrated by age, gender, height, weight and self-reported physical activity class. The proportion of participants fulfilling the aerobic physical activity recommendation of =150 min/week was calculated on the basis of =10 min bouts, by multiplying the VPA minutes by 2.
Both MVPA and VPA were higher among men and during days off, and decreased with increasing age and BMI (p
Notes
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PubMed ID
25500160 View in PubMed
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Physical Activity: Absolute Intensity versus Relative-to-Fitness-Level Volumes.

https://arctichealth.org/en/permalink/ahliterature286726
Source
Med Sci Sports Exerc. 2017 Mar;49(3):474-481
Publication Type
Article
Date
Mar-2017
Author
Urho M Kujala
Julia Pietilä
Tero Myllymäki
Sara Mutikainen
Tiina Föhr
Ilkka Korhonen
Elina Helander
Source
Med Sci Sports Exerc. 2017 Mar;49(3):474-481
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Body mass index
Cross-Sectional Studies
Electrocardiography, Ambulatory
Exercise - physiology
Female
Finland
Heart Rate - physiology
Humans
Male
Middle Aged
Obesity - physiopathology
Overweight - physiopathology
Oxygen Consumption - physiology
Physical Fitness - physiology
Respiratory Rate - physiology
Sex Factors
Young Adult
Abstract
This study aimed to investigate in a real-life setting how moderate- and vigorous-intensity physical activity (PA) volumes differ according to absolute intensity recommendation and relative to individual fitness level by sex, age, and body mass index.
A total of 23,224 Finnish employees (10,201 men and 13,023 women; ages 18-65 yr; body mass index = 18.5-40.0 kg·m) participated in heart rate recording for 2+ d. We used heart rate and its variability, respiration rate, and on/off response information from R-R interval data calibrated by participant characteristics to objectively determine daily PA volume, as follows: daily minutes of absolute moderate (3-
PubMed ID
27875497 View in PubMed
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