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Apolipoprotein(a), fibrinopeptide A and carotid atherosclerosis in middle-aged men.

https://arctichealth.org/en/permalink/ahliterature217223
Source
Thromb Haemost. 1994 Oct;72(4):563-6
Publication Type
Article
Date
Oct-1994
Author
T. Rankinen
S. Väisänen
M. Mercuri
R. Rauramaa
Author Affiliation
Kuopio Research Institute of Exercise Medicine, Finland.
Source
Thromb Haemost. 1994 Oct;72(4):563-6
Date
Oct-1994
Language
English
Publication Type
Article
Keywords
Anthropometry
Apolipoproteins - analysis
Apoprotein(a)
Arteriosclerosis - blood - epidemiology
Blood pressure
Carotid Arteries - anatomy & histology
Carotid Artery Diseases - blood - epidemiology
Carotid Artery, Common - anatomy & histology
Carotid Stenosis - epidemiology
Cohort Studies
Diet
Fibrinopeptide A - analysis
Finland - epidemiology
Humans
Lipids - blood
Lipoprotein(a)
Male
Middle Aged
Muscle, Smooth, Vascular - ultrastructure
Risk factors
Smoking
Abstract
The association between apolipoprotein(a) [apo(a)], fibrinogen, fibrinopeptide A (FPA) and carotid intima-media thickness (IMT) was analyzed in Eastern Finnish men aged 50 to 60 years. Apo(a) correlated directly with carotid bifurcation (r = 0.26, p = 0.001), but not with common carotid IMT. Men in the lowest quartile of apo(a) had thinner (p = 0.013) IMT in bifurcation [1.59 mm (95% CI 1.49; 1.68)] compared to the men in the highest [1.91 mm (95% CI 1.73; 2.09)] apo(a) quartile. The difference remained (p = 0.038) after adjusting for confounders. Plasma fibrinogen was not related to carotid IMT, whereas FPA correlated with common carotid (r = 0.21, p = 0.016) and carotid bifurcation (r = 0.21, p = 0.018) IMT. These associations abolished after adjusting for the confounders. The data suggest that apo(a) associate with carotid atherosclerosis independent of other risk factors for ischemic cardiovascular diseases.
Notes
Comment In: Thromb Haemost. 1995 Aug;74(2):799-8008585028
PubMed ID
7878633 View in PubMed
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Association of risk factors and body iron status to carotid atherosclerosis in middle-aged eastern Finnish men.

https://arctichealth.org/en/permalink/ahliterature217619
Source
Eur Heart J. 1994 Aug;15(8):1020-7
Publication Type
Article
Date
Aug-1994
Author
R. Rauramaa
S. Väisänen
M. Mercuri
T. Rankinen
I. Penttila
M G Bond
Author Affiliation
Kuopio Research Institute of Exercise Medicine, Finland.
Source
Eur Heart J. 1994 Aug;15(8):1020-7
Date
Aug-1994
Language
English
Publication Type
Article
Keywords
Carotid Stenosis - blood - epidemiology - ultrasonography
Cohort Studies
Coronary Artery Disease - blood - epidemiology - ultrasonography
Cross-Cultural Comparison
Cross-Sectional Studies
Exercise Test
Ferritins - blood
Finland - epidemiology
Humans
Intracranial Arteriosclerosis - blood - epidemiology - ultrasonography
Iron - blood
Life Style
Male
Middle Aged
Myocardial Infarction - blood - epidemiology - ultrasonography
Risk factors
Tunica Intima - ultrasonography
Tunica Media - ultrasonography
Abstract
High body iron stores have been proposed as a risk factor for advanced atherosclerosis. We investigated the prevalence of early atherosclerotic changes, and their relation to conventional CHD risk factors and body iron status. A cross-sectional study was carried out in 206 men aged 50 to 60 years (6% random population sample). Intima-media thickness (IMT) of the carotid artery was evaluated with high-resolution B-mode ultrasonography. Statistical analyses were performed separately for men with and without cardiovascular disease (CVD). Among all the study participants, 6.6% had IMT > 1.3 mm in the common carotid artery, whereas 53.8% had IMT > 1.5 mm in the carotid bifurcation. Respective values were 4.8% and 46.8% for those without CVD, and 8.5% and 62.2% for those with CVD. Mean IMT in the carotid bifurcation, the predilection site for atherosclerosis, was 1.85 mm (95% CI 1.72; 1.98) in the men with CVD, as compared to 1.65 mm (95% CI 1.56; 1.73) in the men free of CVD. Serum LDL cholesterol (beta = 0.26), saturated fat intake (beta = 0.20), blood haemoglobin (beta = -0.29), systolic blood pressure (beta = 0.21) and smoking (beta = 0.19), jointly explained 23% of the variance in the carotid bifurcation IMT in the men without CVD. Neither serum ferritin, transferrin nor dietary iron levels were associated with carotid bifurcation atherosclerosis. On the other hand, in the men with CVD, age (beta = 0.34) and physical activity (beta = -0.25) jointly explained 16.5% of the IMT variance in the carotid bifurcation.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
7988592 View in PubMed
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Coeliac disease in children and adolescents with type 1 diabetes: a study of growth, glycaemic control, and experiences of families.

https://arctichealth.org/en/permalink/ahliterature190119
Source
Acta Paediatr. 2002;91(3):297-302
Publication Type
Article
Date
2002
Author
T. Saukkonen
S. Väisänen
H K Akerblom
E. Savilahti
Author Affiliation
Hospital for Children and Adolescents, University of Helsinki, Finland. tts20@cam.ac.uk
Source
Acta Paediatr. 2002;91(3):297-302
Date
2002
Language
English
Publication Type
Article
Keywords
Adolescent
Age Distribution
Blood Glucose - analysis
Celiac Disease - diagnosis - epidemiology
Child
Child Development - physiology
Child, Preschool
Comorbidity
Diabetes Mellitus, Type 1 - diagnosis - epidemiology
Female
Finland - epidemiology
Follow-Up Studies
Humans
Infant
Male
Mass Screening
Prevalence
Probability
Quality of Life
Retrospective Studies
Risk factors
Sex Distribution
Abstract
The aim of this study was to evaluate whether coeliac disease affects growth, glycaemic control, and general well-being of children and adolescents with type I diabetes. Eighteen subjects were found to have coeliac disease by a screening program. Gastrointestinal symptoms, changes in growth and the levels of glycated haemoglobin (GHbA1) were analysed, as well as subjective well-being before and after diagnosis of coeliac disease. Overt gastrointestinal symptoms and deterioration of growth prior to disclosure of coeliac disease were seen only in one patient who had both of these conditions. Retrospectively, most subjects reported mild gastrointestinal complaints, which resolved on a gluten-free diet. Introduction of a gluten-free diet did not have any positive effect on glycaemic control, but was associated with an increase in weight-for-height (from 4.3+/-18.1 to 8.2+/-15.4% deviation from population median, p = 0.02). This increase in weight-for-height was inversely correlated with changes in GHbA1 (r = -0.574, p = 0.02).
Coeliac disease is rarely associated with signs of malabsorption in children and adolescents with type I diabetes. Introduction of a gluten-free diet may be associated with excess weight gain. We recommend intensified follow-up for these subjects.
PubMed ID
12022302 View in PubMed
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Evaluation of occupational health service in the wood processing industry--determination of employee satisfaction.

https://arctichealth.org/en/permalink/ahliterature72770
Source
Occup Med (Lond). 1997 Feb;47(2):95-100
Publication Type
Article
Date
Feb-1997
Author
V. Kujala
S. Väisänen
Author Affiliation
University of Oulu, Department of Public Health Science and General Practice, Finland.
Source
Occup Med (Lond). 1997 Feb;47(2):95-100
Date
Feb-1997
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Consumer Satisfaction
Female
Finland
Health Education - standards
Humans
Industry
Male
Middle Aged
Occupational Health Nursing - standards
Occupational Health Services - standards
Wood
Abstract
In order to define priorities for improvement of the occupational health service (OHS) in one primary health care unit, employees' satisfaction was evaluated with a postal questionnaire. The questionnaire covered items on service reservation, personal health education received, quality of the OHS, and use of the OHS within six months by the employees. This evaluation was one step of the quality system that was planned in accordance with the ISO 9004-2 standard for continuous quality improvement of OHS. The study population was all of 1,050 employees working for five employers; 546 (52%) employees responded to the inquiry. However, only 377 of them had made use of the OHS within the last six months before the inquiry. The mean age of the responders was 42 years (SD = 9 years) and 76% of the respondents were men. The percentages of employees with a high degree of satisfaction with the quality of the OHS and personal health education in the OHS were 76% and 69%, respectively. However, concerning the quality of the OHS, the proportion of highly satisfied employees was 27% higher (95% CI = 19-35%) among those who had used OHS within six months compared to the others. Furthermore, when the oldest (> 48 years) and the youngest (
PubMed ID
9156479 View in PubMed
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Factor VII coagulant activity in relation to serum lipoproteins and dietary fat in middle-aged men.

https://arctichealth.org/en/permalink/ahliterature215748
Source
Thromb Haemost. 1995 Mar;73(3):435-8
Publication Type
Article
Date
Mar-1995
Author
S. Väisänen
T. Rankinen
I. Penttilä
R. Rauramaa
Author Affiliation
Kuopio Research Institute of Exercise Medicine, Finland.
Source
Thromb Haemost. 1995 Mar;73(3):435-8
Date
Mar-1995
Language
English
Publication Type
Article
Keywords
Antigens - analysis
Apolipoprotein A-II - blood
Apolipoproteins B - blood
Body mass index
Cardiovascular Diseases - blood - epidemiology
Cholesterol - blood
Cohort Studies
Dietary Fats
Factor VII - analysis
Finland - epidemiology
Food Habits
Humans
Lipoproteins - blood
Male
Middle Aged
Multivariate Analysis
Risk factors
Smoking - blood
Triglycerides - blood
Abstract
The associations of serum lipoproteins and habitual diet to factor VII coagulant activity (FVIIc) were analysed in 119 middle-aged men. FVIIc was measured by one-stage clotting assay, cholesterol and triglycerides enzymatically, serum apolipoproteins (apo) immunoturbidimetrically and habitual diet using four-day food records. ApoB, cholesterol, triglycerides, apoA-II, LDL cholesterol and dietary fat correlated directly to FVIIc (p 38 E%), in the middle tertile FVIIc increased gradually from low to high fat intake, whereas in the highest apoB tertile FVIIc was not related to dietary fat (p = 0.038 for age-adjusted interaction). The present data demonstrate a direct relation between apoB and FVIIc in middle-aged men. Low fat diet seem to associate to decreased FVIIc especially in subjects in the lower end of the apoB distribution.
PubMed ID
7667825 View in PubMed
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Positive and negative life changes and LDL cholesterol.

https://arctichealth.org/en/permalink/ahliterature202120
Source
J Biosoc Sci. 1999 Apr;31(2):269-77
Publication Type
Article
Date
Apr-1999
Author
A. Helminen
T. Rankinen
P. Halonen
S. Väisänen
R. Rauramaa
Author Affiliation
Kuopio Research Institute of Exercise Medicine, University of Kuopio, Finland.
Source
J Biosoc Sci. 1999 Apr;31(2):269-77
Date
Apr-1999
Language
English
Publication Type
Article
Keywords
Cholesterol, LDL - blood
Finland - epidemiology
Follow-Up Studies
Humans
Hypercholesterolemia - epidemiology - psychology
Life Change Events
Logistic Models
Male
Middle Aged
Odds Ratio
Stress, Psychological - physiopathology
Abstract
Epidemiological studies have revealed that stressful changes in social environment increase the risk of cardiovascular mortality. In this study, the influence of major negative and positive life changes on serum cholesterol was examined in middle-aged men to determine a possible biochemical link between life changes and cardiovascular mortality. The results showed no influence of negative life changes on serum cholesterols. However, positive life changes significantly predicted a reduction in total and LDL (low-density lipoprotein) cholesterol levels after adjustment for the baseline cardiovascular health status, baseline cholesterol level, diet, body mass index, waist-to-hip ratio and cardiorespiratory fitness. The odds ratio for lowering LDL cholesterol was 5.2 in the men reporting positive events compared with those reporting none. The findings suggest a predictive value of positive life changes for atherogenic lipid profile in middle-aged men.
PubMed ID
10333656 View in PubMed
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Prevalence and change of cardiovascular risk factors among men born 1900-19: the Finnish cohorts of the Seven Countries Study.

https://arctichealth.org/en/permalink/ahliterature220437
Source
Age Ageing. 1993 Sep;22(5):365-76
Publication Type
Article
Date
Sep-1993
Author
A. Nissinen
M. Tervahauta
J. Pekkanen
P. Kivinen
J. Stengård
E. Kaarsalo
S L Kivelä
S. Väisänen
J T Salonen
J. Tuomilehto
Author Affiliation
Department of Community Health and General Practice, University of Kuopio, Finland.
Source
Age Ageing. 1993 Sep;22(5):365-76
Date
Sep-1993
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Cohort Studies
Coronary Disease - epidemiology - etiology - mortality - prevention & control
Cross-Sectional Studies
Finland - epidemiology
Follow-Up Studies
Geriatric Assessment
Humans
Incidence
Male
Risk factors
Rural Population - statistics & numerical data
Survival Rate
Abstract
In a 30-year follow-up survey of the Finnish cohorts of the Seven Countries Study in 1989, 470 men aged 70-89 years were examined in two rural areas of Finland, in the East and in the West. Life-style-related coronary heart disease risk factors were at high levels in both groups, but the difference between areas found in the same cohort in middle age had mostly disappeared or partially reversed. Mean levels of systolic/diastolic blood pressure, body mass index, fasting blood glucose, blood glucose after 2-hour oral glucose tolerance test, and plasma fibrinogen were higher in the West than in the East (p
PubMed ID
8237628 View in PubMed
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Relationship between lipid peroxidation and plasma fibrinogen in middle-aged men.

https://arctichealth.org/en/permalink/ahliterature197371
Source
Thromb Res. 2000 Sep 1;99(5):453-9
Publication Type
Article
Date
Sep-1-2000
Author
T. Rankinen
E. Hietanen
S. Väisänen
M. Lehtiö
I. Penttilä
C. Bouchard
R. Rauramaa
Author Affiliation
Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland. Rankint@pbrc.edu
Source
Thromb Res. 2000 Sep 1;99(5):453-9
Date
Sep-1-2000
Language
English
Publication Type
Article
Keywords
Arteriosclerosis - blood - etiology
Blood Gas Analysis
Body mass index
Cohort Studies
Fibrinogen - metabolism
Finland - epidemiology
Humans
Leukocyte Count
Lipid Peroxidation - physiology
Male
Malondialdehyde - blood
Middle Aged
Regression Analysis
Risk factors
Smoking
Abstract
The relationship between lipid peroxidation (plasma malondialdehyde [MDA] concentration) and plasma fibrinogen level was analyzed in 144 men, aged 53-62 years. MDA was measured colorimetrically and fibrinogen with the thrombin method. Mean plasma MDA concentration was 12.6 (SD 1.2) micromol/L, plasma fibrinogen level 2.91 (0.47) g/L, and body mass index 27.1 (3.5) kg/m(2). Prevalence of smoking was 17%. MDA correlated moderately with fibrinogen. Both MDA and fibrinogen correlated positively with waist hip ratio (WHR) and blood leukocyte count, but inversely with VO(2)max. Both MDA and fibrinogen levels were higher in smokers than in non-smokers (p
PubMed ID
10973673 View in PubMed
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Social network in relation to plasma fibrinogen.

https://arctichealth.org/en/permalink/ahliterature208744
Source
J Biosoc Sci. 1997 Apr;29(2):129-39
Publication Type
Article
Date
Apr-1997
Author
A. Helminen
T. Rankinen
S. Väisänen
R. Rauramaa
Author Affiliation
Kuopio Research Institute of Exercise Medicine, Department of Physiology, University of Kuopio, Finland.
Source
J Biosoc Sci. 1997 Apr;29(2):129-39
Date
Apr-1997
Language
English
Publication Type
Article
Keywords
Cardiovascular Diseases - blood - etiology
Fibrinogen - metabolism
Finland
Health status
Humans
Male
Middle Aged
Questionnaires
Risk factors
Sampling Studies
Smoking - adverse effects
Social Support
Abstract
Consistent findings about the inverse association of social network level with coronary heart disease mortality and morbidity suggest the importance of investigating biological pathways of association. Differences in plasma fibrinogen level were investigated among middle-aged men with weak and strong structural and functional social network ties. Men with low scores in the adequacy of social participation variable (structural) had higher mean values of plasma fibrinogen than those with high scores. The difference remained after adjustment for age, smoking and cardiovascular health status and after possible modifying factors were taken into account, but did not remain significant after allowing for physical fitness. Men with high scores in overall support (functional) had higher plasma fibrinogen levels compared to the men with low scores. This difference persisted after age and cardiovascular health status were taken into account but was explained by smoking. The data suggest that smoking and cardiorespiratory fitness are important mediating or modifying factors between structural and functional aspects of social network ties and plasma fibrinogen.
PubMed ID
9881125 View in PubMed
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Variation in plasma fibrinogen over one year: relationships with genetic polymorphisms and non-genetic factors.

https://arctichealth.org/en/permalink/ahliterature208556
Source
Thromb Haemost. 1997 May;77(5):884-9
Publication Type
Article
Date
May-1997
Author
S. Väisänen
R. Rauramaa
I. Penttilä
T. Rankinen
J. Gagnon
L. Pérusse
M. Chagnon
C. Bouchard
Author Affiliation
Kuopio Research Institute of Exercise Medicine, University of Kuopio, Finland.
Source
Thromb Haemost. 1997 May;77(5):884-9
Date
May-1997
Language
English
Publication Type
Article
Keywords
Biological Markers
Body constitution
Cholesterol, HDL - blood
Cohort Studies
Coronary Disease - epidemiology
Deoxyribonuclease HindIII
Deoxyribonucleases, Type II Site-Specific
Energy Metabolism
Fibrinogen - analysis - genetics - metabolism
Finland
Humans
Leukocyte Count
Longitudinal Studies
Male
Middle Aged
Oxygen consumption
Polymorphism, Restriction Fragment Length
Random Allocation
Risk factors
Time Factors
Abstract
We analyzed plasma fibrinogen level in relation to genetic polymorphisms in the alpha- and beta-fibrinogen gene loci. Furthermore, the association of other CVD risk markers with fibrinogen was studied twice, with a time interval of one year in 50 to 60 year old men (n = 183). DNA polymorphisms were detected by PCR and digestion with Taq I (alpha-fibrinogen), Hind III and Bcl I (beta-fibrinogen) restriction enzymes. The correlation coefficient between fibrinogen measurements was 0.48 (p
PubMed ID
9184397 View in PubMed
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10 records – page 1 of 1.