Skip header and navigation

Refine By

1 records – page 1 of 1.

Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.
Arch Intern Med. 2010 Nov 8;170(20):1850-5
Publication Type
Haiqing Shen
Coleen M Damcott
Evadnie Rampersaud
Toni I Pollin
Richard B Horenstein
Patrick F McArdle
Patricia A Peyser
Lawrence F Bielak
Wendy S Post
Yen-Pei C Chang
Kathleen A Ryan
Michael Miller
John A Rumberger
Patrick F Sheedy
John Shelton
Jeffrey R O'Connell
Alan R Shuldiner
Braxton D Mitchell
Author Affiliation
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Arch Intern Med. 2010 Nov 8;170(20):1850-5
Publication Type
Aged, 80 and over
Apolipoprotein B-100 - blood - genetics
Calcinosis - blood - ethnology - genetics
Cholesterol, LDL - blood
Coronary Artery Disease - blood - ethnology - genetics
DNA - genetics
Denmark - ethnology
Genome-Wide Association Study
Middle Aged
Pennsylvania - epidemiology
Polymorphism, Single Nucleotide
Retrospective Studies
Risk factors
Young Adult
Elevated low-density lipoprotein cholesterol (LDL-C) levels are a major cardiovascular disease risk factor. Genetic factors are an important determinant of LDL-C levels.
To identify single nucleotide polymorphisms associated with LDL-C and subclinical coronary atherosclerosis, we performed a genome-wide association study of LDL-C in 841 asymptomatic Amish individuals aged 20 to 80 years, with replication in a second sample of 663 Amish individuals. We also performed scanning for coronary artery calcification (CAC) in 1018 of these individuals.
From the initial genome-wide association study, a cluster of single nucleotide polymorphisms in the region of the apolipoprotein B-100 gene (APOB) was strongly associated with LDL-C levels (P
Cites: Circulation. 1996 Nov 1;94(9):2159-708901667
Cites: Am J Epidemiol. 2004 Sep 1;160(5):407-2015321837
Cites: J Lipid Res. 1997 Jul;38(7):1361-739254062
Cites: J Clin Invest. 1998 Mar 1;101(5):1084-939486979
Cites: N Engl J Med. 1998 May 28;338(22):1577-849603795
Cites: J Am Coll Cardiol. 2005 Jul 5;46(1):158-6515992651
Cites: J Am Soc Nephrol. 2005 Nov;16 Suppl 2:S115-916251246
Cites: Hum Mol Genet. 2006 Aug 15;15(16):2468-7816835261
Cites: Circulation. 2007 Feb 13;115(6):717-2417261661
Cites: Genet Epidemiol. 2000;19 Suppl 1:S36-4211055368
Cites: J Biol Chem. 2001 Mar 23;276(12):9214-811115503
Cites: Twin Res. 2002 Apr;5(2):87-9711931686
Cites: Atherosclerosis. 2007 Mar;191(1):40-716730014
Cites: J Am Coll Cardiol. 2007 May 22;49(20):2013-2017512357
Cites: Am Heart J. 2008 May;155(5):823-818440328
Cites: Atherosclerosis. 2009 Jan;202(1):289-9518452924
Cites: Bioinformatics. 2003 Jan;19(1):149-5012499305
Cites: Arterioscler Thromb Vasc Biol. 1997 Apr;17(4):741-79108789
Cites: Clin Chem. 1972 Jun;18(6):499-5024337382
Cites: Science. 1986 Apr 4;232(4746):34-473513311
Cites: Proc Natl Acad Sci U S A. 1989 Jan;86(2):587-912563166
Cites: J Am Coll Cardiol. 1990 Mar 15;15(4):827-322407762
Cites: J Lipid Res. 1994 Apr;35(4):574-838006512
Comment In: Arch Intern Med. 2011 Jun 13;171(11):1039-40; author reply 104021670376
PubMed ID
21059979 View in PubMed
Less detail