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18 records – page 1 of 2.

Changing attitudes in health promotion.

https://arctichealth.org/en/permalink/ahliterature237468
Source
Can Nurse. 1986 Feb;82(2):34-7
Publication Type
Article
Date
Feb-1986

Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

https://arctichealth.org/en/permalink/ahliterature257726
Source
JAMA. 2014 Oct 26;
Publication Type
Article
Date
Oct-26-2014
Author
J Gustav Smith
Kevin Luk
Christina-Alexandra Schulz
James C Engert
Ron Do
George Hindy
Gull Rukh
Line Dufresne
Peter Almgren
David S Owens
Tamara B Harris
Gina M Peloso
Kathleen F Kerr
Quenna Wong
Albert V Smith
Matthew J Budoff
Jerome I Rotter
L Adrienne Cupples
Stephen Rich
Sekar Kathiresan
Marju Orho-Melander
Vilmundur Gudnason
Christopher J O'Donnell
Wendy S Post
George Thanassoulis
Author Affiliation
Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden2Department of Heart Failure and Valvular Disease, Skåne University Hospital, Lund, Sweden3Department of Clinical Sciences, Lund University, Malmö, Sweden4Program in Medical and Pop.
Source
JAMA. 2014 Oct 26;
Date
Oct-26-2014
Language
English
Publication Type
Article
Abstract
Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.
To evaluate whether genetic data are consistent with an association between LDL-C, high-density lipoprotein cholesterol (HDL-C), or triglycerides (TG) and aortic valve disease.
Using a Mendelian randomization study design, we evaluated whether weighted genetic risk scores (GRSs), a measure of the genetic predisposition to elevations in plasma lipids, constructed using single-nucleotide polymorphisms identified in genome-wide association studies for plasma lipids, were associated with aortic valve disease. We included community-based cohorts participating in the CHARGE consortium (n?=?6942), including the Framingham Heart Study (cohort inception to last follow-up: 1971-2013; n?=?1295), Multi-Ethnic Study of Atherosclerosis (2000-2012; n?=?2527), Age Gene/Environment Study-Reykjavik (2000-2012; n?=?3120), and the Malmö Diet and Cancer Study (MDCS, 1991-2010; n?=?28?461).
Aortic valve calcium quantified by computed tomography in CHARGE and incident aortic stenosis in the MDCS.
The prevalence of aortic valve calcium across the 3 CHARGE cohorts was 32% (n?=?2245). In the MDCS, over a median follow-up time of 16.1 years, aortic stenosis developed in 17 per 1000 participants (n?=?473) and aortic valve replacement for aortic stenosis occurred in 7 per 1000 (n?=?205). Plasma LDL-C, but not HDL-C or TG, was significantly associated with incident aortic stenosis (hazard ratio [HR] per mmol/L, 1.28; 95% CI, 1.04-1.57; P?=?.02; aortic stenosis incidence: 1.3% and 2.4% in lowest and highest LDL-C quartiles, respectively). The LDL-C GRS, but not HDL-C or TG GRS, was significantly associated with presence of aortic valve calcium in CHARGE (odds ratio [OR] per GRS increment, 1.38; 95% CI, 1.09-1.74; P?=?.007) and with incident aortic stenosis in MDCS (HR per GRS increment, 2.78; 95% CI, 1.22-6.37; P?=?.02; aortic stenosis incidence: 1.9% and 2.6% in lowest and highest GRS quartiles, respectively). In sensitivity analyses excluding variants weakly associated with HDL-C or TG, the LDL-C GRS remained associated with aortic valve calcium (P?=?.03) and aortic stenosis (P?=?.009). In instrumental variable analysis, LDL-C was associated with an increase in the risk of incident aortic stenosis (HR per mmol/L, 1.51; 95% CI, 1.07-2.14; P?=?.02).
Genetic predisposition to elevated LDL-C was associated with presence of aortic valve calcium and incidence of aortic stenosis, providing evidence supportive of a causal association between LDL-C and aortic valve disease. Whether earlier intervention to reduce LDL-C could prevent aortic valve disease merits further investigation.
PubMed ID
25344734 View in PubMed
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Source
Can Nurse. 1977 Nov;73(11):44-5
Publication Type
Article
Date
Nov-1977
Author
S. Post
Source
Can Nurse. 1977 Nov;73(11):44-5
Date
Nov-1977
Language
English
Publication Type
Article
Keywords
Canada
Child
Child, Hospitalized
Humans
Pediatric Nursing
PubMed ID
922718 View in PubMed
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Genetic structure of West Greenland populations of lumpfish Cyclopterus lumpus.

https://arctichealth.org/en/permalink/ahliterature277137
Source
J Fish Biol. 2016 Oct 17;
Publication Type
Article
Date
Oct-17-2016
Author
E. Garcia-Mayoral
M. Olsen
R. Hedeholm
S. Post
E E Nielsen
D. Bekkevold
Source
J Fish Biol. 2016 Oct 17;
Date
Oct-17-2016
Language
English
Publication Type
Article
Abstract
In this study, 11 microsatellite markers were used to determine the structure of West Greenlandic lumpfish Cyclopterus lumpus populations across six spawning locations spanning >1500 km and compared with neighbouring populations in Canada and Iceland. To evaluate whether data allow for identification of origin of C. lumpus in Greenlandic waters, genetic assignment analysis was performed for 86 C. lumpus sampled on a feeding migration. Significant structuring with isolation by distance was observed in the West Greenland samples and two major subpopulations, north and south, were suggested. Based on FST values, closer relationships were observed between Greenland and Canada, than Greenland and Iceland. Surprisingly, the North Greenland population showed more similarities with Canadian samples, than did the geographically closer south-west Greenland population. Origin could be assigned for a high proportion of non-spawning fish and demonstrated a marked east-west spatial separation of fish of Greenlandic and Icelandic genotypes.
PubMed ID
27753091 View in PubMed
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Family-centered care for children: is it a reality?

https://arctichealth.org/en/permalink/ahliterature234596
Source
Hosp Trustee. 1987 Nov-Dec;11(6):15-7
Publication Type
Article
Author
S. Post
J. Powers
W. Baskerville
Source
Hosp Trustee. 1987 Nov-Dec;11(6):15-7
Language
English
Publication Type
Article
Keywords
Canada
Child
Child, Hospitalized
Family
Hospital Units
Humans
Questionnaires
PubMed ID
10284822 View in PubMed
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The role of the Canadian Institute of Child Health in promoting family-centered care.

https://arctichealth.org/en/permalink/ahliterature226676
Source
Child Health Care. 1990;19(4):209-12
Publication Type
Article
Date
1990
Author
D. Avard
S. Post
D. Drown
Author Affiliation
Canadian Institute of Child Health.
Source
Child Health Care. 1990;19(4):209-12
Date
1990
Language
English
Publication Type
Article
Keywords
Canada
Child
Child Health Services
Child, Hospitalized
Family
Health promotion
Humans
Obstetrics
Voluntary Health Agencies
PubMed ID
10107662 View in PubMed
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Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification.

https://arctichealth.org/en/permalink/ahliterature283391
Source
J Am Coll Cardiol. 2017 Jun 20;69(24):2941-2948
Publication Type
Article
Date
Jun-20-2017
Author
Mehdi Afshar
Kevin Luk
Ron Do
Line Dufresne
David S Owens
Tamara B Harris
Gina M Peloso
Kathleen F Kerr
Quenna Wong
Albert V Smith
Mathew J Budoff
Jerome I Rotter
L Adrienne Cupples
Stephen S Rich
James C Engert
Vilmundur Gudnason
Christopher J O'Donnell
Wendy S Post
George Thanassoulis
Source
J Am Coll Cardiol. 2017 Jun 20;69(24):2941-2948
Date
Jun-20-2017
Language
English
Publication Type
Article
Abstract
Mitral annular calcium (MAC), commonly identified by cardiac imaging, is associated with cardiovascular events and predisposes to the development of clinically important mitral valve regurgitation and mitral valve stenosis. However, its biological determinants remain largely unknown.
The authors sought to evaluate whether a genetic predisposition to elevations in plasma lipids is associated with the presence of MAC.
The authors used 3 separate Mendelian randomization techniques to evaluate the associations of lipid genetic risk scores (GRS) with MAC in 3 large patient cohorts: the Framingham Health Study, MESA (Multiethnic European Study of Atherosclerosis), and the AGE-RS (Age, Gene/Environment Susceptibility-Reykjavik Study). The authors provided cross-ethnicity replication in the MESA Hispanic-American participants.
MAC was present in 1,149 participants (20.4%). In pooled analyses across all 3 cohorts, a triglyceride GRS was significantly associated with the presence of MAC (odds ratio [OR] per triglyceride GRS unit: 1.73; 95% confidence interval [CI]: 1.24 to 2.41; p = 0.0013). Neither low- nor high-density lipoprotein cholesterol GRS was significantly associated with MAC. Results were consistent in cross-ethnicity analyses among the MESA Hispanic-Americans cohort (OR per triglyceride GRS unit: 2.04; 95% CI: 1.03 to 4.03; p = 0.04). In joint meta-analysis across all included cohorts, the triglyceride GRS was associated with MAC (OR per triglyceride GRS unit: 1.79; 95% CI: 1.32 to 2.41; p = 0.0001). The results were robust to several sensitivity analyses that limit both known and unknown forms of genetic pleiotropy.
Genetic predisposition to elevated triglyceride levels was associated with the presence of MAC, a risk factor for clinically significant mitral valve disease, suggesting a causal association. Whether reducing triglyceride levels can lower the incidence of clinically significant mitral valve disease requires further study.
PubMed ID
28619195 View in PubMed
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18 records – page 1 of 2.