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Increased levels of intercellular adhesion molecules and vascular cell adhesion molecules in pre-eclampsia.

https://arctichealth.org/en/permalink/ahliterature64342
Source
Br J Obstet Gynaecol. 1997 Apr;104(4):466-70
Publication Type
Article
Date
Apr-1997
Author
S. Djurovic
R. Schjetlein
F. Wisløff
G. Haugen
K. Berg
Author Affiliation
University of Oslo and Department of Medical Genetics, Ullevål University Hospital, Norway.
Source
Br J Obstet Gynaecol. 1997 Apr;104(4):466-70
Date
Apr-1997
Language
English
Publication Type
Article
Keywords
Adult
Analysis of Variance
Enzyme-Linked Immunosorbent Assay
Female
Fetal Growth Retardation - diagnosis - metabolism
Forecasting
Humans
Intercellular Adhesion Molecule-1 - blood - metabolism
Pre-Eclampsia - metabolism
Pregnancy
Prenatal Diagnosis - methods
Prospective Studies
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Vascular Cell Adhesion Molecule-1 - blood - metabolism
Abstract
OBJECTIVE: To investigate the correlation between soluble forms of the intercellular adhesion molecule (sICAM-1) and vascular cell adhesion molecule (sVCAM-1) and the severity of pre-eclampsia or its possible consequences for fetal growth. DESIGN: Prospective observational study. SETTING: Institute of Medical Genetics, University of Oslo, Department of Medical Genetics and Haematological Research Laboratory, Ullevål University Hospital; and the Department of Obstetrics and Gynaecology, The National Hospital, Oslo, Norway. PARTICIPANTS: Seventy-six women with normotensive pregnancies and 157 women with pre-eclampsia divided into three subgroups: mild, severe and pre-eclampsia with fetal growth retardation. METHODS: ELISA-measurements of plasma sICAM-1 and sVCAM-1 were performed in a group of healthy pregnant normotensive women and three groups of women with varying degrees of pre-eclampsia. RESULTS: sICAM-1 concentrations were higher in the pre-eclampsia group compared with the control group, but this difference was not statistically significant. Plasma concentrations of sVCAM-1 were significantly greater (P
PubMed ID
9141584 View in PubMed
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Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.

https://arctichealth.org/en/permalink/ahliterature154634
Source
Mol Psychiatry. 2010 May;15(5):463-72
Publication Type
Article
Date
May-2010
Author
S. Le Hellard
T W Mühleisen
S. Djurovic
J. Fernø
Z. Ouriaghi
M. Mattheisen
C. Vasilescu
M B Raeder
T. Hansen
J. Strohmaier
A. Georgi
F F Brockschmidt
I. Melle
I. Nenadic
H. Sauer
M. Rietschel
M M Nöthen
T. Werge
O A Andreassen
S. Cichon
V M Steen
Author Affiliation
Department of Clinical Medicine, Bergen Mental Health Research Center, University of Bergen, Bergen, Norway. stephanie.le.hellard@helse-bergen.no
Source
Mol Psychiatry. 2010 May;15(5):463-72
Date
May-2010
Language
English
Publication Type
Article
Keywords
Adult
Antipsychotic Agents - therapeutic use
Case-Control Studies
Chromosomes, Human, Pair 17 - genetics
Chromosomes, Human, Pair 22 - genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Germany
Humans
Lipogenesis - drug effects - genetics
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide - genetics
Scandinavia
Schizophrenia - drug therapy - genetics
Sterol Regulatory Element Binding Protein 1 - genetics
Sterol Regulatory Element Binding Protein 2 - genetics
Abstract
Several studies have reported structural brain abnormalities, decreased myelination and oligodendrocyte dysfunction in schizophrenia. In the central nervous system, glia-derived de novo synthesized cholesterol is essential for both myelination and synaptogenesis. Previously, we demonstrated in glial cell lines that antipsychotic drugs induce the expression of genes involved in cholesterol and fatty acids biosynthesis through activation of the sterol regulatory element binding protein (SREBP) transcription factors, encoded by the sterol regulatory element binding transcription factor 1 (SREBF1) and sterol regulatory element binding transcription factor 2 (SREBF2) genes. Considering the importance of these factors in the lipid biosynthesis and their possible involvement in antipsychotic drug effects, we hypothesized that genetic variants of SREBF1 and/or SREBF2 could affect schizophrenia susceptibility. We therefore conducted a HapMap-based association study in a large German sample, and identified association between schizophrenia and five markers in SREBF1 and five markers in SREBF2. Follow-up studies in two independent samples of Danish and Norwegian origin (part of the Scandinavian collaboration of psychiatric etiology study, SCOPE) replicated the association for the five SREBF1 markers and for two markers in SREBF2. A combined analysis of all samples resulted in highly significant genotypic P-values of 9 x 10(-4) for SREBF1 (rs11868035, odd ration (OR)=1.26, 95% confidence interval (CI) (1.09-1.45)) and 4 x 10(-5) for SREBF2 (rs1057217, OR=1.39, 95% CI (1.19-1.63)). This finding strengthens the hypothesis that SREBP-controlled cholesterol biosynthesis is involved in the etiology of schizophrenia.
PubMed ID
18936756 View in PubMed
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Whole blood folate, homocysteine in serum, and risk of first acute myocardial infarction.

https://arctichealth.org/en/permalink/ahliterature10578
Source
Atherosclerosis. 1999 Dec;147(2):317-26
Publication Type
Article
Date
Dec-1999
Author
B. Christensen
S. Landaas
I. Stensvold
S. Djurovic
L. Retterstøl
J. Ringstad
K. Berg
D S Thelle
Author Affiliation
Department of Medical Genetics, Ullevâl University Hospital, N-0407, Oslo, Norway.
Source
Atherosclerosis. 1999 Dec;147(2):317-26
Date
Dec-1999
Language
English
Publication Type
Article
Keywords
Age Distribution
Age of Onset
Aged
Case-Control Studies
Comparative Study
Confidence Intervals
Female
Health Surveys
Homocysteine - blood
Humans
Incidence
Male
Mass Screening - methods
Middle Aged
Myocardial Infarction - blood - diagnosis - epidemiology
Norway - epidemiology
Odds Ratio
Pteroylpolyglutamic Acids - blood
Reference Values
Research Support, Non-U.S. Gov't
Risk assessment
Risk factors
Sex Distribution
Abstract
High level of total homocysteine (tHcy) is a risk factor for coronary artery disease (CAD), but the mechanism is not known. The serum concentration of tHcy, total cholesterol, high density lipoprotein cholesterol (HDL-C), and apolipoprotein A-I (apo A-I) and the concentration of folate in whole blood were measured in 107 patients with first acute myocardial infarction (MI) and 103 controls. The level of whole blood folate was lower and that of tHcy higher in cases than in controls. An increase of 50 nmol/l whole blood folate was associated with an OR for MI of 0.75, and an increase of 5 micromol/l tHcy with an OR for MI of 1.57. Correlations were observed between the levels of whole blood folate and tHcy and between whole blood folate and alcohol intake, and in MI cases, between tHcy, HDL-C, and apo A-I as well as between HDL-C and alcohol intake. The number of cigarette smokers was higher among cases than controls. In smokers, the level of tHcy was higher and that of whole blood folate lower than in non-smokers. After adjustment for smoking, the whole blood folate and tHcy-associated risks of MI became non-significant. We conclude that smoking may affect folate status and tHcy level adversely. The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.
Notes
Comment In: Atherosclerosis. 2000 Jun;150(2):441-210917871
PubMed ID
10559518 View in PubMed
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