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Absence of indigenous specific West Nile virus antibodies in Tyrolean blood donors.

https://arctichealth.org/en/permalink/ahliterature134646
Source
Eur J Clin Microbiol Infect Dis. 2012 Jan;31(1):77-81
Publication Type
Article
Date
Jan-2012
Author
S T Sonnleitner
J. Simeoni
E. Schmutzhard
M. Niedrig
F. Ploner
H. Schennach
M P Dierich
G. Walder
Author Affiliation
Hygiene and Medical Microbiology, Medical University Innsbruck, Fritz Pregl Straße 1-3/III, Innsbruck, Austria. sissyson@gmx.at
Source
Eur J Clin Microbiol Infect Dis. 2012 Jan;31(1):77-81
Date
Jan-2012
Language
English
Publication Type
Article
Keywords
Adult
Antibodies, Viral - blood
Blood Donors
Child, Preschool
Encephalitis Viruses, Tick-Borne - immunology
Enzyme-Linked Immunosorbent Assay
Europe
False Positive Reactions
Female
Humans
Italy
Male
Middle Aged
Neutralization Tests
West Nile Fever - diagnosis - epidemiology - virology
West Nile virus - immunology
Abstract
In the last several years, West Nile virus (WNV) was proven to be present especially in the neighboring countries of Austria, such as Italy, Hungary, and the Czech Republic, as well as in eastern parts of Austria, where it was detected in migratory and domestic birds. In summer 2010, infections with WNV were reported from Romania and northern Greece with about 150 diseased and increasingly fatal cases. We tested the sera of 1,607 blood donors from North Tyrol (Austria) and South Tyrol (Italy) for antibodies against WNV by using IgG enzyme-linked immunosorbent assay (ELISA). Initial results of the ELISA tests showed seroprevalence rates of 46.2% in North Tyrol and 0.5% in South Tyrol, which turned out to be false-positive cross-reactions with antibodies against tick-borne encephalitis virus (TBEV) by adjacent neutralization assays. These results indicate that seropositivity against WNV requires confirmation by neutralization assays, as cross-reactivity with TBEV is frequent and because, currently, WNV is not endemic in the study area.
PubMed ID
21556676 View in PubMed
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