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Balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension.

https://arctichealth.org/en/permalink/ahliterature108764
Source
Heart. 2013 Oct;99(19):1415-20
Publication Type
Article
Date
Oct-2013
Author
Arne K Andreassen
Asgrimur Ragnarsson
Einar Gude
Odd Geiran
Rune Andersen
Author Affiliation
Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway. aandreas@ous-hf.no
Source
Heart. 2013 Oct;99(19):1415-20
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Aged
Angioplasty, Balloon - adverse effects - mortality
Arterial Pressure
Biological Markers - blood
Cardiac Catheterization
Cardiac output
Chronic Disease
Endarterectomy
Exercise Test
Exercise Tolerance
Female
Humans
Hypertension, Pulmonary - blood - diagnosis - mortality - physiopathology - surgery - therapy
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Norway
Peptide Fragments - blood
Predictive value of tests
Prospective Studies
Pulmonary Embolism - blood - diagnosis - mortality - physiopathology - surgery - therapy
Recovery of Function
Time Factors
Treatment Outcome
Troponin T - blood
Ventricular Function, Right
Abstract
To examine the effect of balloon pulmonary angioplasty (BPA) on chronic thromboembolic pulmonary hypertension (CTEPH) in patients with inoperable disease or persistent pulmonary hypertension after pulmonary endarterectomy.
Observational cohort study.
Referred patients with inoperable or persistent CTEPH.
Twenty consecutive CTEPH patients (10 females), aged 60±10 years.
Right heart catheterisation, functional capacity (cardiopulmonary exercise testing (CPET) and NYHA class) and blood sampled biomarkers N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin T examined at the time of diagnosis and repeated in all patients 3 months after the last BPA.
Seventy-three catheterisations were performed with 18.6±6.1 BPAs per patient on segmental and subsegmental arteries. Two deaths occurred following the first BPA, with an overall 10% periprocedural death rate. Reperfusion oedema complicated seven procedures. Comparisons before and after BPA showed significant haemodynamic improvements, including decreased mean pulmonary artery pressure (mPAP) (45±11 mm Hg vs 33±10 mm Hg; p
PubMed ID
23846611 View in PubMed
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