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Affect regulation and psychopathology in women with borderline personality disorder.

https://arctichealth.org/en/permalink/ahliterature118764
Source
Dan Med J. 2012 Nov;59(11):A4521
Publication Type
Article
Date
Nov-2012
Author
Rune Andersen
Nina Timmerby
Erik Simonsen
Author Affiliation
Psykiatrisk Forskningsenhed, Region Sjælland, Roskilde, Denmark. runan@regionsjaelland.dk
Source
Dan Med J. 2012 Nov;59(11):A4521
Date
Nov-2012
Language
English
Publication Type
Article
Keywords
Adult
Affect
Affective Symptoms - etiology
Aggression - psychology
Borderline Personality Disorder - complications - diagnosis - psychology
Denmark
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Impulsive Behavior - etiology
Interpersonal Relations
Middle Aged
Personality Inventory - standards - statistics & numerical data
Psychiatric Status Rating Scales
Psychometrics
Psychopathology
Self Report
Self-Injurious Behavior - etiology
Translating
Abstract
Dysfunction in affect regulation is a prominent feature that grossly impairs behavioural and interpersonal domains of experience and underlies a great deal of the psychopathology in borderline personality disorder (BPD). However, no study has yet been published that evaluates the psychometric properties of the translated Danish version of self-report measures sensitive to the different aspects and dimensions of dysfunction in affect regulation prevalent in BPD.
This study comprised a group of women diagnosed with BPD (n = 29) and a comparison group of healthy subjects (n = 29) who reported psychopathology and levels of affective instability, aggression, impulsivity and alexithymia by self-report measures.
Our results demonstrated that women with BPD have significant psychopathology and report significantly higher levels of dysfunction in separate components of affect regulation by self-report measures than the comparison group of healthy subjects. Our results also provided partial support for the psychometric appropriateness and clinical relevance of the translated Danish version of affect regulation measures.
The normative reference range indicated by our results makes the measures useful as a practical assessment tool.
not relevant.
PubMed ID
23171744 View in PubMed
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Balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension.

https://arctichealth.org/en/permalink/ahliterature108764
Source
Heart. 2013 Oct;99(19):1415-20
Publication Type
Article
Date
Oct-2013
Author
Arne K Andreassen
Asgrimur Ragnarsson
Einar Gude
Odd Geiran
Rune Andersen
Author Affiliation
Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway. aandreas@ous-hf.no
Source
Heart. 2013 Oct;99(19):1415-20
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Aged
Angioplasty, Balloon - adverse effects - mortality
Arterial Pressure
Biological Markers - blood
Cardiac Catheterization
Cardiac output
Chronic Disease
Endarterectomy
Exercise Test
Exercise Tolerance
Female
Humans
Hypertension, Pulmonary - blood - diagnosis - mortality - physiopathology - surgery - therapy
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Norway
Peptide Fragments - blood
Predictive value of tests
Prospective Studies
Pulmonary Embolism - blood - diagnosis - mortality - physiopathology - surgery - therapy
Recovery of Function
Time Factors
Treatment Outcome
Troponin T - blood
Ventricular Function, Right
Abstract
To examine the effect of balloon pulmonary angioplasty (BPA) on chronic thromboembolic pulmonary hypertension (CTEPH) in patients with inoperable disease or persistent pulmonary hypertension after pulmonary endarterectomy.
Observational cohort study.
Referred patients with inoperable or persistent CTEPH.
Twenty consecutive CTEPH patients (10 females), aged 60±10 years.
Right heart catheterisation, functional capacity (cardiopulmonary exercise testing (CPET) and NYHA class) and blood sampled biomarkers N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin T examined at the time of diagnosis and repeated in all patients 3 months after the last BPA.
Seventy-three catheterisations were performed with 18.6±6.1 BPAs per patient on segmental and subsegmental arteries. Two deaths occurred following the first BPA, with an overall 10% periprocedural death rate. Reperfusion oedema complicated seven procedures. Comparisons before and after BPA showed significant haemodynamic improvements, including decreased mean pulmonary artery pressure (mPAP) (45±11 mm Hg vs 33±10 mm Hg; p
PubMed ID
23846611 View in PubMed
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Lipopolysaccharide heterogeneity and escape mechanisms of Neisseria meningitidis: possible consequences for vaccine development.

https://arctichealth.org/en/permalink/ahliterature207646
Source
Microb Pathog. 1997 Sep;23(3):139-55
Publication Type
Article
Date
Sep-1997
Author
S. Rune Andersen
J. Kolberg
E A Høiby
E. Namork
D A Caugant
L. Oddvar Frøholm
E. Jantzen
G. Bjune
Author Affiliation
Department of Vaccinology, National Institute of Public Health, P.O. Box 4404 Torshov, Oslo, N-0403, Norway.
Source
Microb Pathog. 1997 Sep;23(3):139-55
Date
Sep-1997
Language
English
Publication Type
Article
Keywords
Animals
Antibodies, Bacterial
Antibodies, Monoclonal
Bacterial Vaccines - chemistry
Carbohydrate Sequence
Epitopes - chemistry
Humans
Lipopolysaccharides - chemistry - immunology
Meningitis, Meningococcal - epidemiology - microbiology - prevention & control
Mice
Molecular Epidemiology
Molecular Sequence Data
Molecular Structure
Neisseria meningitidis - immunology - isolation & purification
Norway - epidemiology
Abstract
We wanted to compare the potential protective capacity of antibodies to meningococcal lipopolysaccharides (LPS). The frequency of occurrence and degree of expression of the epitopes recognized by murine monoclonal antibodies (MAbs) to immunotypes L3,7,9 (9-2-L379) and L8 (2-1-L8) and to the LPS inner core (216-Lc and 217-Lc), were determined among 77 consecutive Norwegian meningococcal patient isolates from 1995. The immunotype L3,7,9 was strongly expressed by 95% of the isolates, whereas L8 was weakly to moderately expressed by 9%. The inner core epitopes, were widely distributed among the serogroup B organisms, but were proved weakly expressed. The bactericidal activity of the four MAbs to various selected strains, was found to correlate positively with the quantity of the LPS epitopes recognized by these four MAbs in the bacteria. When tested in the serum bactericidal assay (SBA), often a few percent of the colonies of the inocula survived high concentrations of the MAbs. The results indicate that escape from the bactericidal action could be achieved through: (i) selection of variants not expressing the LPS-epitope of the actual MAb, (ii) a relative reduction in the density of the LPS-epitope achieved by dilution with another LPS structure or (iii) other factors, not yet understood. In conclusion, antibodies to the L3,7,9 epitope seem to be of importance for protection, whereas antibodies to the epitopes of the LPS inner core or immunotype L8, are not likely to offer protection alone. However, in order to prevent escape through alteration of the LPS pattern of the microbes, various LPS structures should probably be present in the OMV vaccine.
PubMed ID
9281472 View in PubMed
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