Skip header and navigation

Refine By

3 records – page 1 of 1.

Detecting chronic solvent encephalopathy in occupations at risk.

https://arctichealth.org/en/permalink/ahliterature124649
Source
Neurotoxicology. 2012 Aug;33(4):734-41
Publication Type
Article
Date
Aug-2012
Author
Heidi Furu
Markku Sainio
Hanna Kaisa Hyvärinen
Ritva Akila
Beatrice Bäck
Sanni Uuksulainen
Ari Kaukiainen
Author Affiliation
Finnish Institute of Occupational Health, Helsinki, Finland. heidi.furu@fimnet.fi
Source
Neurotoxicology. 2012 Aug;33(4):734-41
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Air Pollutants, Occupational - adverse effects
Attention - drug effects
Brain - drug effects - physiopathology
Chi-Square Distribution
Chronic Disease
Cognition - drug effects
Female
Finland
Health Surveys
Humans
Male
Mass Screening - methods
Memory - drug effects
Middle Aged
Neurologic Examination
Neuropsychological Tests
Neurotoxicity Syndromes - diagnosis - etiology - physiopathology - prevention & control - psychology
Occupational Diseases - chemically induced - diagnosis - physiopathology - psychology
Occupational Exposure - adverse effects - prevention & control
Occupational Health
Predictive value of tests
Prognosis
Questionnaires
Risk assessment
Risk factors
Severity of Illness Index
Solvents - adverse effects
Time Factors
Abstract
Chronic solvent encephalopathy (CSE) is under-reported worldwide due to difficulties in recognition and differences in national legislation. Although its occurrence in developed countries has declined, new cases continue to be detected. Our aim was to determine whether CSE can be detected in risk trades, using a stepwise screening procedure. Another aim was to evaluate if this method detects more cases than present occupational health service (OHS) practices do in Finland, a country with decreasing exposures, high OHS coverage and an annual rate of around forty cases of suspected CSE and seven cases of occupational CSE. The studied fields, based on the national occurrence of CSE, were industrial and construction painting, floor layering, the printing press industry, boat construction, reinforced plastic laminating and the metal industry. We obtained contact information from trade union registers and municipal OHS. A postal survey including the Euroquest (EQ) neurotoxic symptom questionnaire, Beck's Depression Inventory (BDI) and the Alcohol Use Disorders Identification Test-Consumption (Audit-C), and questions on exposure and medical conditions, was sent to 3,640 workers in the age range of 30-65 years in two Finnish provinces. The survey resulted in 1,730 responses (48%). This was followed by a clinical examination, with methods applicable to OHS, of subjects fulfilling the criteria: three or more EQ memory and concentration symptoms and sufficient exposure, a BDI score=18, an AUDIT-C score=8, and no evident medical condition explaining their symptoms. Of 338 respondents with memory and concentration symptoms, 129 subjects fulfilled all the criteria, of which 83 participated in clinical examinations. We found 38 CSE compatible cases. The study shows that more CSE compatible cases can be detected when the screening is directed towards the occupational fields at greatest risk. This stepwise method is more effective for finding CSE compatible cases than regular OHS activity. The number of cases was similar to the total annual occurrence, of new CSE-suspected cases, although the sample represented approximately 18% of the abundantly exposed workforce in Finland. Combining of exposure and medical differential diagnostics to neurotoxic symptom questionnaire, decreases the amount of cases needing clinical examinations. This two-step procedure can be carried out with methods suitable for OHS and other primary health care, both in industrialized and developed countries.
PubMed ID
22560996 View in PubMed
Less detail

Multimodal event-related potentials in occupational chronic solvent encephalopathy.

https://arctichealth.org/en/permalink/ahliterature126689
Source
Neurotoxicology. 2012 Aug;33(4):703-9
Publication Type
Article
Date
Aug-2012
Author
Petra Keski-Säntti
Kirsi Palmu
Miia Pitkonen
Sara Liljander
Juhani V Partanen
Ritva Akila
Markku Sainio
Anu Holm
Author Affiliation
Finnish Institute of Occupational Health, Department of Occupational Medicine, Brain and Work Research Centre, Topeliuksenkatu 41 a A, FI-00250, Helsinki, Finland. petra.keski-santti@hus.fi
Source
Neurotoxicology. 2012 Aug;33(4):703-9
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Acoustic Stimulation
Aged
Air Pollutants, Occupational - adverse effects
Analysis of Variance
Attention - drug effects
Auditory Perception - drug effects
Brain - drug effects - physiopathology
Case-Control Studies
Chronic Disease
Cognition - drug effects
Electroencephalography
Event-Related Potentials, P300 - drug effects
Female
Finland
Humans
Male
Middle Aged
Neuropsychological Tests
Neurotoxicity Syndromes - diagnosis - etiology - physiopathology - psychology
Occupational Diseases - chemically induced - diagnosis - physiopathology - psychology
Occupational Exposure - adverse effects
Occupational Health
Photic Stimulation
Predictive value of tests
Reaction Time - drug effects
Recognition (Psychology) - drug effects
Solvents - adverse effects
Time Factors
Visual Perception - drug effects
Abstract
The aim of this study was to test a multimodal event-related potential (ERP) paradigm in chronic solvent encephalopathy (CSE) to develop a sensitive method for the clinical diagnostics to CSE. The study comprised 11 CSE patients and 13 healthy controls. We used three tasks: an auditory odd-ball (AUD), a visual detection (VIS), and a recognition memory (MEM) task. The auditory and visual stimuli were presented in single- and dual-task conditions. The auditory P300 amplitude in single-task condition was smaller in the patient group than in the control group at the parietal (Pz) but not at the frontal midline electrode location. The auditory P300 response in the dual task condition AUD+VIS was unrecognizable in 8 of 11 patients and in 1 of 13 controls and in the AUD+MEM condition in 10 of 11 patients and in 4 of 13 controls. In the AUD+MEM condition, the auditory P300 amplitude at Pz was smaller in the patient group than in the control group. Reaction time for auditory stimuli in both dual conditions as well as for visual stimuli in AUD+VIS condition were in the patient group prolonged. The ERP results indicate that CSE patients present with slowed performance speed and difficulties in allocation of attention. Based on ERP results, the disturbance in brain activity in CSE seems to affect posterior aspects of the frontoparietal continuity. The multimodal paradigm seems promising as a tool for the clinical diagnostics of CSE.
PubMed ID
22366255 View in PubMed
Less detail

P300 of auditory event related potentials in occupational chronic solvent encephalopathy.

https://arctichealth.org/en/permalink/ahliterature161354
Source
Neurotoxicology. 2007 Nov;28(6):1230-6
Publication Type
Article
Date
Nov-2007
Author
Petra Keski-Säntti
Anu Holm
Ritva Akila
Katinka Tuisku
Tero Kovala
Markku Sainio
Author Affiliation
Helsinki University Central Hospital, Jorvi Hospital, Department of Neurology, Turuntie 150, FIN-02740, Espoo, Finland. petra.keski-santti@pp.inet.fi
Source
Neurotoxicology. 2007 Nov;28(6):1230-6
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - adverse effects
Attention - drug effects
Case-Control Studies
Central Nervous System Agents - adverse effects
Depressive Disorder, Major - physiopathology
Event-Related Potentials, P300 - drug effects
Evoked Potentials, Auditory - drug effects
Finland
Humans
Memory - drug effects
Middle Aged
Neuropsychological Tests
Neurotoxicity Syndromes - diagnosis - etiology - physiopathology - psychology
Occupational Diseases - chemically induced - diagnosis - physiopathology - psychology
Occupational Exposure
Predictive value of tests
Reaction Time - drug effects
Retrospective Studies
Solvents - adverse effects
Time Factors
Abstract
This retrospective study characterized the P300 component of the auditory event related potential (ERP) and assessed its diagnostic value in occupational chronic solvent encephalopathy (CSE). The P300 was recorded on 86 CSE patients by the classical oddball paradigm. In addition to the laboratory's reference values, we used an age and education matched control group that consisted of 104 blue-collar workers with no known occupational solvent exposure. The association of P300 values with solvent exposure indices, major depression, alcohol consumption, and neuropsychological parameters was studied. The P300 amplitude was lower in CSE patients (mean 7.5 microV; S.D. 3.6) compared to laboratory controls (mean 11.8 microV; S.D. 4.1; F(1,167)=24.4; p
PubMed ID
17869344 View in PubMed
Less detail