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P300 of auditory event related potentials in occupational chronic solvent encephalopathy.

https://arctichealth.org/en/permalink/ahliterature161354
Source
Neurotoxicology. 2007 Nov;28(6):1230-6
Publication Type
Article
Date
Nov-2007
Author
Petra Keski-Säntti
Anu Holm
Ritva Akila
Katinka Tuisku
Tero Kovala
Markku Sainio
Author Affiliation
Helsinki University Central Hospital, Jorvi Hospital, Department of Neurology, Turuntie 150, FIN-02740, Espoo, Finland. petra.keski-santti@pp.inet.fi
Source
Neurotoxicology. 2007 Nov;28(6):1230-6
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - adverse effects
Attention - drug effects
Case-Control Studies
Central Nervous System Agents - adverse effects
Depressive Disorder, Major - physiopathology
Event-Related Potentials, P300 - drug effects
Evoked Potentials, Auditory - drug effects
Finland
Humans
Memory - drug effects
Middle Aged
Neuropsychological Tests
Neurotoxicity Syndromes - diagnosis - etiology - physiopathology - psychology
Occupational Diseases - chemically induced - diagnosis - physiopathology - psychology
Occupational Exposure
Predictive value of tests
Reaction Time - drug effects
Retrospective Studies
Solvents - adverse effects
Time Factors
Abstract
This retrospective study characterized the P300 component of the auditory event related potential (ERP) and assessed its diagnostic value in occupational chronic solvent encephalopathy (CSE). The P300 was recorded on 86 CSE patients by the classical oddball paradigm. In addition to the laboratory's reference values, we used an age and education matched control group that consisted of 104 blue-collar workers with no known occupational solvent exposure. The association of P300 values with solvent exposure indices, major depression, alcohol consumption, and neuropsychological parameters was studied. The P300 amplitude was lower in CSE patients (mean 7.5 microV; S.D. 3.6) compared to laboratory controls (mean 11.8 microV; S.D. 4.1; F(1,167)=24.4; p
PubMed ID
17869344 View in PubMed
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