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Neuropathologic findings of dementia with lewy bodies (DLB) in a population-based Vantaa 85+ study.

https://arctichealth.org/en/permalink/ahliterature149537
Source
J Alzheimers Dis. 2009;18(3):677-89
Publication Type
Article
Date
2009
Author
Minna Oinas
Tuomo Polvikoski
Raimo Sulkava
Liisa Myllykangas
Kati Juva
Irma-Leena Notkola
Sari Rastas
Leena Niinistö
Hannu Kalimo
Anders Paetau
Author Affiliation
Department of Pathology, University of Helsinki, and Helsinki University Central Hospital, P.O. Box 21 (Haartmaninkatu 3), FI-00014 Helsinki, Finland. minna.oinas@helsinki.fi
Source
J Alzheimers Dis. 2009;18(3):677-89
Date
2009
Language
English
Publication Type
Article
Keywords
Aged, 80 and over
Brain - metabolism - pathology
Brain Stem - metabolism - pathology
Catchment Area (Health)
Female
Finland - epidemiology
Humans
Lewy Body Disease - epidemiology - metabolism - pathology
Limbic System - metabolism - pathology
Male
Neurofibrillary Tangles - metabolism - pathology
Population Surveillance - methods
alpha-Synuclein - metabolism
Abstract
The consortium on dementia with Lewy bodies has established consensus guidelines for the neuropathologic diagnosis of dementia with Lewy bodies (DLB) including the likelihood that the neuropathologic findings associate with the clinical syndrome. Nevertheless, clinico-pathological correlations remain controversial. We applied the consensus guidelines for determining Lewy-related pathology (LRP) and evaluated the clinical presentation in the prospective, population-based Vantaa 85+ study consisting of individuals at least 85 years of age. LRP was seen in 36% of 304 subjects and categorized as follows: 3% brainstem-predominant, 14% limbic, 15% diffuse neocortical type (4% could not be categorized). The likelihood that the neuropathology predicts the DLB clinical syndrome was low in 6%, intermediate in 13%, and high in 13% of all 304 subjects. In the latter two groups, 77% were demented, 35% had at least one extrapyramidal symptom, and 15% had visual hallucinations. Surprisingly, DLB clinical features associated better with high neurofibrillary stage than with diffuse neocortical LRP. Moreover, the neurofibrillary stage, substantia nigra neuron loss, and grade of Lewy neurites in hippocampal CA2-3 region, each showed a significant association with the extent of LRP. In conclusion, the neuropathologic DLB in this very elderly population was common, but the clinical symptoms tended to associate better with severe neurofibrillary pathology than with extensive LRP.
PubMed ID
19625740 View in PubMed
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Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study.

https://arctichealth.org/en/permalink/ahliterature157937
Source
Ann Med. 2008;40(3):232-9
Publication Type
Article
Date
2008
Author
Maarit Tanskanen
Terhi Peuralinna
Tuomo Polvikoski
Irma-Leena Notkola
Raimo Sulkava
John Hardy
Andrew Singleton
Sari Kiuru-Enari
Anders Paetau
Pentti J Tienari
Liisa Myllykangas
Author Affiliation
Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. maarit.tanskanen@helsinki.fi
Source
Ann Med. 2008;40(3):232-9
Date
2008
Language
English
Publication Type
Article
Keywords
Age Factors
Aged, 80 and over
Amyloidosis - epidemiology - genetics
Autopsy
Congo Red
Exons
Female
Finland - epidemiology
Gene Frequency
Haplotypes
Humans
Immunohistochemistry
Male
Myocardial Infarction - complications
Myocardium - pathology
Polymorphism, Genetic
Prealbumin - metabolism
Prevalence
Risk factors
alpha-Macroglobulins - genetics
tau Proteins - genetics
Abstract
Senile systemic amyloidosis (SSA) is characterized by deposition of wild-type transthyretin (TTR)-based amyloid in parenchymal organs in elderly individuals. Previously, no population-based studies have been performed on SSA.
Here we have studied the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over, as part of the population-based Vantaa 85+ Autopsy Study (n = 256). The diagnosis of SSA was based on histological examination of myocardial samples stained with Congo red and anti-TTR immunohistochemistry. The genotype frequencies of 20 polymorphisms in 9 genes in subjects with and without SSA were compared.
The prevalence of SSA was 25%. SSA was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2-macroglobulin (alpha2M), and the H2 haplotype of the tau gene (P-values 0.002, 0.004, 0.042, and 0.016).
This population-based study shows that SSA is very common in old individuals, affecting one-quarter of people aged over 85 years. Myocardial infarctions and variation in the genes for alpha2M and tau may be associated with SSA.
PubMed ID
18382889 View in PubMed
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Spouse caregivers' perceptions of influence of dementia on marriage.

https://arctichealth.org/en/permalink/ahliterature189510
Source
Int Psychogeriatr. 2002 Mar;14(1):47-58
Publication Type
Article
Date
Mar-2002
Author
Ulla Eloniemi-Sulkava
Irma-Leena Notkola
Kaija Hämäläinen
Terhi Rahkonen
Petteri Viramo
Maija Hentinen
Sirkka-Liisa Kivelä
Raimo Sulkava
Author Affiliation
Department of Public Health and General Practice, University of Kuopio, Finland. ulla.eloniemi@uku.fi
Source
Int Psychogeriatr. 2002 Mar;14(1):47-58
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Aged
Aged, 80 and over
Attitude to Health
Caregivers - psychology
Cost of Illness
Dementia - psychology
Family Relations
Female
Finland
Happiness
Humans
Longitudinal Studies
Male
Marriage - psychology
Personal Satisfaction
Questionnaires
Sexual Behavior - psychology
Spouses - psychology
Stress, Psychological
Abstract
To investigate what kind of changes spouse caregivers of demented patients experience after the onset of dementia (a) in the general atmosphere, happiness, and relations of marriage and (b) in the sexual side of marriage.
Semistructured telephone interviews of spouse caregivers of demented patients.
Community-living demented patients and their spouse caregivers in eastern Finland.
The spouse caregivers of 42 demented patients recruited from a previous intervention study.
The questionnaire covered different areas of marriage from the time before and after the onset of dementia.
A statistically significant decline had occurred in extent of happiness (p = .012), in equal relations (p = .001), and in patients' expressions of sexual needs (p
PubMed ID
12094907 View in PubMed
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