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Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals.

https://arctichealth.org/en/permalink/ahliterature48571
Source
Nat Genet. 1992 Nov;2(3):212-5
Publication Type
Article
Date
Nov-1992
Author
S C Bain
J B Prins
C M Hearne
N R Rodrigues
B R Rowe
L E Pritchard
R J Ritchie
J R Hall
D E Undlien
K S Ronningen
Author Affiliation
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, UK.
Source
Nat Genet. 1992 Nov;2(3):212-5
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Base Sequence
Cell Line
Diabetes Mellitus, Type 1 - ethnology - genetics
Disease Susceptibility
Female
Great Britain
HLA-DR4 Antigen - analysis - genetics
Haplotypes - genetics
Humans
Insulin - genetics
Linkage (Genetics) - genetics
Lymphocytes - immunology
Male
Meiosis - genetics
Molecular Sequence Data
Norway
Parents
Research Support, Non-U.S. Gov't
Risk factors
Abstract
Type 1 or insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease of the insulin-producing pancreatic beta-cells which is determined by both genetic and environmental factors. The major histocompatibility complex and the insulin gene region (INS) on human chromosomes 6p and 11p, respectively, contain susceptibility genes. Using a mostly French data set, evidence for linkage of INS to IDDM was recently obtained but only in male meioses (suggesting involvement of maternal imprinting) and only in HLA-DR4-positive diabetics. In contrast, we find evidence for linkage in both male and female meioses and that the effect of the susceptibility gene(s) in the INS region is not dependent on the presence of HLA-DR4.
PubMed ID
1345171 View in PubMed
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