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1913 men study - a longitudinal study of the development of stroke in a population.

https://arctichealth.org/en/permalink/ahliterature250389
Source
Scand J Soc Med Suppl. 1977;14:122-7
Publication Type
Article
Date
1977
Author
R. Adolfsson
K. Svärdsudd
G. Tibblin
Source
Scand J Soc Med Suppl. 1977;14:122-7
Date
1977
Language
English
Publication Type
Article
Keywords
Adult
Aged
Blood pressure
Blood Sedimentation
Cerebrovascular Disorders - epidemiology - etiology
Cholesterol - blood
Finland
Humans
Longitudinal Studies
Male
Middle Aged
Regression Analysis
Risk
Smoking
Abstract
Risk factors for the development of stroke was studied in a prospective long-term investigation of 855 male in a random population sampled of the same age. After 13 years of follow-up 25 participants had suffered from stroke, which gives an incidence of 19/10,000 annually. At the 1963 year investigation several parametras were studied. The stroke-prone person had higher values of systolic and diastolic blood pressure and had a significant greater total heart volume. Blood parametras as the fasting of serum cholesterole, triglyceride and erytrocyte sedimentation rate were significantly elevated in those who developed stroke. They also tended to consume more coffee and showed a higher tobacco consumption. By applying the multiple regression model it was disclosed that the most predective risk-variables were diastolic blood pressure, erytrocyte sedimentation rate and smoking habits.
PubMed ID
298994 View in PubMed
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Anticipation in Swedish families with bipolar affective disorder.

https://arctichealth.org/en/permalink/ahliterature217460
Source
J Med Genet. 1994 Sep;31(9):686-9
Publication Type
Article
Date
Sep-1994
Author
P O Nylander
C. Engström
J. Chotai
J. Wahlström
R. Adolfsson
Author Affiliation
Department of Psychiatry, University of Umeå, Sweden.
Source
J Med Genet. 1994 Sep;31(9):686-9
Date
Sep-1994
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Bipolar Disorder - genetics
Female
Humans
Male
Middle Aged
Pedigree
Regression Analysis
Sweden
Abstract
Anticipation describes an inheritance pattern within a pedigree with an increase in disease severity or decrease in age at onset or both in successive generations. The phenomenon of anticipation has recently been shown to be correlated with the expansion of trinucleotide repeat sequences in different disorders. We have studied differences of age at onset and disease severity between two generations in 14 families with unilinear inheritance of bipolar affective disorder (BPAD). There was a significant difference in age at onset (p
Notes
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PubMed ID
7815436 View in PubMed
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Anticipation in Swedish families with schizophrenia.

https://arctichealth.org/en/permalink/ahliterature216152
Source
Psychiatr Genet. 1995;5(4):181-6
Publication Type
Article
Date
1995
Author
J. Chotai
C. Engström
B. Ekholm
M L son Berg
R. Adolfsson
P O Nylander
Author Affiliation
Department of Psychiatry, University of Umeå, Sweden.
Source
Psychiatr Genet. 1995;5(4):181-6
Date
1995
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
Fathers
Female
Humans
Interviews as Topic
Male
Medical Records
Middle Aged
Mothers
Nuclear Family
Repetitive Sequences, Nucleic Acid
Schizophrenia - genetics
Sweden
Abstract
Nineteen parent-offspring pairs obtained from 14 two-generation families with available medical records and diagnosis of schizophrenia were studied to compare the ages of onset of the parent generation with those of the offspring generation. The mean age of onset for the parent generation was 37.3 +/- 6.0 years and for the offspring generation was 20.8 +/- 4.4. The mean difference was thus 16.5 +/- 6.2, suggesting the occurrence of anticipation in schizophrenia (p
PubMed ID
8750361 View in PubMed
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Anticipation in unipolar affective disorder.

https://arctichealth.org/en/permalink/ahliterature35126
Source
J Affect Disord. 1995 Oct 9;35(1-2):31-40
Publication Type
Article
Date
Oct-9-1995
Author
C. Engström
A S Thornlund
E L Johansson
M. Långström
J. Chotai
R. Adolfsson
P O Nylander
Author Affiliation
Department of Psychiatry, University of Umeå, Sweden.
Source
J Affect Disord. 1995 Oct 9;35(1-2):31-40
Date
Oct-9-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Child
Child of Impaired Parents - psychology
Cohort Studies
Depressive Disorder - diagnosis - genetics - mortality - psychology
Disease-Free Survival
Female
Humans
Life tables
Male
Middle Aged
Phenotype
Proportional Hazards Models
Research Support, Non-U.S. Gov't
Risk factors
Suicide - statistics & numerical data
Sweden
Trinucleotide Repeats
Abstract
Anticipation describes an inheritance pattern within a pedigree with an increase in disease severity and/or decrease in age at onset in successive generations. The phenomenon of anticipation has recently been shown to be correlated with the expansion of trinucleotide repeat sequences in a neuromuscular disease, various neurodegenerative disorders and mental retardation. We have studied parent-offspring differences in age at onset and disease severity in 31 pairs with unilineal inheritance of unipolar affective disorder (UPAD). Life-table analyses showed a significant decrease in survival to 1st episode of major depression in the offspring generation compared with the parental generation (P = 0.0007). There was also a significant difference in age at onset (P
PubMed ID
8557885 View in PubMed
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[A special psychogeriatric admission unit gives better care].

https://arctichealth.org/en/permalink/ahliterature238229
Source
Lakartidningen. 1985 Oct 2;82(40):3388-91
Publication Type
Article
Date
Oct-2-1985
Author
R. Adolfsson
L. Berglund
P O Sandman
Source
Lakartidningen. 1985 Oct 2;82(40):3388-91
Date
Oct-2-1985
Language
Swedish
Publication Type
Article
Keywords
Aged
Dementia - therapy
Geriatric Psychiatry
Humans
Patient Admission
Sweden
PubMed ID
4058122 View in PubMed
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Assignment of the locus for PLO-SL, a frontal-lobe dementia with bone cysts, to 19q13.

https://arctichealth.org/en/permalink/ahliterature205997
Source
Am J Hum Genet. 1998 Feb;62(2):362-72
Publication Type
Article
Date
Feb-1998
Author
P. Pekkarinen
I. Hovatta
P. Hakola
O. Järvi
M. Kestilä
U. Lenkkeri
R. Adolfsson
G. Holmgren
P O Nylander
L. Tranebjaerg
J D Terwilliger
J. Lönnqvist
L. Peltonen
Author Affiliation
Department of Human Molecular Genetics, Institute of Biomedicine, University of Helsinki, Helsinki, Finland.
Source
Am J Hum Genet. 1998 Feb;62(2):362-72
Date
Feb-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Amyloid beta-Protein Precursor - genetics
Bone Cysts - epidemiology - genetics - mortality
Chromosome Mapping
Chromosomes, Human, Pair 19
Dementia - epidemiology - genetics - mortality
Family
Female
Finland - epidemiology
Frontal Lobe
Genes, Recessive
Genetic Linkage
Genetic markers
Humans
Male
Middle Aged
Nerve Tissue Proteins - genetics
Pedigree
Polymorphism, Single-Stranded Conformational
Prevalence
Abstract
PLO-SL (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy) is a recessively inherited disorder characterized by systemic bone cysts and progressive presenile frontal-lobe dementia, resulting in death at
Notes
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PubMed ID
9463329 View in PubMed
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Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.

https://arctichealth.org/en/permalink/ahliterature174580
Source
Neurobiol Aging. 2005 Aug-Sep;26(8):1145-51
Publication Type
Article
Author
R. Rademakers
K. Sleegers
J. Theuns
M. Van den Broeck
S. Bel Kacem
L-G Nilsson
R. Adolfsson
C M van Duijn
C. Van Broeckhoven
M. Cruts
Author Affiliation
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB8), University of Antwerp, Belgium.
Source
Neurobiol Aging. 2005 Aug-Sep;26(8):1145-51
Language
English
Publication Type
Article
Keywords
Aged
Alzheimer Disease - enzymology - genetics
Cyclin-Dependent Kinase 5
Cyclin-Dependent Kinases - genetics
DNA Mutational Analysis
Exons - genetics
Female
Gene Frequency - genetics
Genetic Testing
Genetic Variation - genetics
Genotype
Haplotypes
Humans
Introns - genetics
Male
Middle Aged
Mutation - genetics
Nerve Tissue Proteins - genetics
Netherlands
Sweden
Abstract
Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases. By extensive genetic analysis of the genes encoding CDK5 (CDK5), p35 (CDK5R1) and p39 (CDK5R2), we excluded causal mutations in 70 familial early-onset AD patients. We performed an association study with five informative SNPs in CDK5 in two independent samples of early-onset AD patients and matched control individuals from The Netherlands and northern Sweden. Association was observed with g.149800G>C in intron 5 of CDK5, and a two times increased risk was observed in both patient samples for carriers of the C-allele. Our data are indicative for a role of the CDK5 molecular complex in the genetic etiology of early-onset AD, and suggest that a yet unknown functional variant in CDK5 or in a nearby gene might lead to increased susceptibility for early-onset AD.
PubMed ID
15917097 View in PubMed
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Care for demented patients in different living conditions. Effects on cognitive function, ADL-capacity and behaviour.

https://arctichealth.org/en/permalink/ahliterature73012
Source
Scand J Prim Health Care. 1995 Sep;13(3):205-10
Publication Type
Article
Date
Sep-1995
Author
A. Wimo
R. Adolfsson
P O Sandman
Author Affiliation
Research Unit of Primary Health Care, Sundsvall, Sweden.
Source
Scand J Prim Health Care. 1995 Sep;13(3):205-10
Date
Sep-1995
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Aged
Cognition
Dementia - nursing - physiopathology - psychology
Female
Geriatric Assessment
Group Homes - organization & administration
Health status
Humans
Male
Prospective Studies
Sweden
Abstract
OBJECTIVE--To assess if and how demented patients' living conditions affect their level of functioning. DESIGN--A prospective concurrent control-study. SETTING--Sundsvall, an industrial community in the middle of Sweden. PARTICIPANTS--Forty-six demented patients in group-living (GL-group) and 62 controls (C-group). MAIN OUTCOME MEASURE--Cognitive function, ADL-capacity and behaviour were measured every third month during one year. RESULTS--Both groups deteriorated, but the decline was significantly slower in the GL-group regarding some ADL-functions, e.g. dressing and motor functions, whereas some behavioural disturbances were significantly more frequent in the GL-group. No differences were observed regarding the level of cognitive function. CONCLUSION--The living condition has small effects on cognitive function and ADL-capacity. The behavioural disturbances observed in GL should be the focus of future research.
PubMed ID
7481173 View in PubMed
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A comparison of multiplex and simplex families with Alzheimer's disease/senile dementia of Alzheimer type within a well defined population.

https://arctichealth.org/en/permalink/ahliterature219097
Source
J Neural Transm Park Dis Dement Sect. 1994;7(1):61-72
Publication Type
Article
Date
1994
Author
I. Alafuzoff
E. Almqvist
R. Adolfsson
S. Lake
W. Wallace
D A Greenberg
B. Winblad
Author Affiliation
Department of Pathology, Alzheimer's Disease Research Centre, Department of Geriatric Medicine, Karolinska Institute, Huddinge University Hospital, Sweden.
Source
J Neural Transm Park Dis Dement Sect. 1994;7(1):61-72
Date
1994
Language
English
Publication Type
Article
Keywords
Age of Onset
Aged
Alzheimer Disease - epidemiology - genetics
Dementia - epidemiology - genetics
Family
Female
Humans
Male
Middle Aged
Prevalence
Abstract
A study was made on 150 clinically demented patients presenting at autopsy at Umeå University Hospital in Sweden. In 90 of the cases dementia was considered to be primary in nature and of these forty six per cent (41 cases), fulfilled both the clinical and histopathological criteria for the diagnosis of Alzheimer's disease/Senile dementia of Alzheimer type (AD/SDAT). The families of these 41 AD/SDAT cases were then studied, and a family history obtained through interviews with multiple family informants and from civil and medical records. Additional diseased family members suffering from progressive dementia (multiplex families) were observed in 12 probands out of 41 (29%). Multiplex families exhibited similar clinical and histopathological characteristics as simplex families containing a single affected individual. The secondary cases in the multiplex families exhibited similar demographic and clinical characteristics as the probands. 39% of the multiplex and 14% of the simplex cases had an early age of onset of the disease, that was under 65 years. The overall prevalence of progressive dementia disorders in the 41 families was 5.9%. The prevalence of a progressive dementia disorder was 11% in the multiplex families (14% for the early onset cases) and 3.5% in the simplex families (2% for the early onset cases). The prevalence of progressive dementia disorder for family members who had passed the mean age of the onset of the disease for their family, was 45% for multiplex and 18% for simplex families. Furthermore the incidence rate for dementia was significantly higher (p
PubMed ID
8579770 View in PubMed
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Dementia day care and its effects on symptoms and institutionalization--a controlled Swedish study.

https://arctichealth.org/en/permalink/ahliterature220963
Source
Scand J Prim Health Care. 1993 Jun;11(2):117-23
Publication Type
Article
Date
Jun-1993
Author
A. Wimo
B. Mattsson
R. Adolfsson
T. Eriksson
A. Nelvig
Author Affiliation
Primary Health Care Research Unit, Sundsvall, Sweden.
Source
Scand J Prim Health Care. 1993 Jun;11(2):117-23
Date
Jun-1993
Language
English
Publication Type
Article
Keywords
Activities of Daily Living - psychology
Aged
Alzheimer Disease - psychology - therapy
Caregivers - psychology
Day Care - utilization
Dementia - psychology - therapy
Female
Geriatric Assessment
Homes for the Aged - utilization
Humans
Institutionalization - trends
Male
Mental Status Schedule
Neuropsychological Tests
Sweden
Abstract
To examine the effects of Day Care (DC) on demented patients.
A prospective non-randomized concurrent-control study.
55 demented patients in DC and 44 controls.
Sundsvall, an industrial community in northern Sweden.
Cognition, ADL-functions, behaviour and institutionalization.
Measurements of cognition, ADL-functions, and behaviour showed no or only small differences between the groups. After one year, 24% of the patients in the DC-group were institutionalized, compared with 44% of the controls. In the control group, the exhaustion of spouse and supervision need were highly correlated to institutionalization (p
PubMed ID
8356361 View in PubMed
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28 records – page 1 of 3.