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The effect of combined treatment with morphine sulphate and low-dose ketamine in a prehospital setting.

https://arctichealth.org/en/permalink/ahliterature147110
Source
Scand J Trauma Resusc Emerg Med. 2009;17:61
Publication Type
Article
Date
2009
Author
Patric Johansson
Poul Kongstad
Anders Johansson
Author Affiliation
Department of Falck Ambulance Ltd, Linnegatan 2, 281 25, Hässleholm, Sweden. patric73@tele2.se
Source
Scand J Trauma Resusc Emerg Med. 2009;17:61
Date
2009
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Analgesics - administration & dosage - pharmacology - therapeutic use
Analgesics, Opioid - administration & dosage - pharmacology - therapeutic use
Cohort Studies
Drug Therapy, Combination
Emergency medical services
Female
Humans
Ketamine - administration & dosage - pharmacology - therapeutic use
Male
Middle Aged
Morphine - administration & dosage - pharmacology - therapeutic use
Prospective Studies
Sweden
Abstract
Pain is a common condition among prehospital patients. The present study is designed to determine whether adding low-dose ketamine as additional analgesia improves the pain/nausea scores and hemodynamic parameters compared to morphine sulphate alone among patients with bone fractures.
Prospective, prehospital clinical cohort study. Twenty-seven patients were included with acute pain. Eleven patients received morphine sulphate 0.2 mg/kg (M-group) and 16 patients received morphine sulphate 0.1 mg/kg combined with 0.2 mg/kg ketamine (MK-group). Scores for pain, nausea, sedation (AVPU) and the haemodynamic parameters (systolic blood pressures (BP), heart rate (HR) and peripheral oxygen saturation (SpO2) were recorded at rescue scene before the start of analgesia and subsequently to admission at hospital.
Mean treatment time 46 +/- 17 minutes in the M-group and 56 +/- 11 minutes in the MK-group, respectively (ns). Mean doses of morphine sulphate in the M-group were 13.5 +/- 3.2 mg versus 7.0 +/- 1.5 mg in the MK-group. The mean additional doses of ketamine in the MK-group were 27.9 +/- 11.4 mg. There were significantly differences between the M- and the MK-group according to NRS scores for pain (5.4 +/- 1.9 versus 3.1 +/- 1.4) and BP (134 +/- 21 mmHg versus 167 +/- 32 mmHg) at admission at hospital, respectively (P
Notes
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PubMed ID
19943920 View in PubMed
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