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A 3-year follow-up of sun behavior in patients with cutaneous malignant melanoma.

https://arctichealth.org/en/permalink/ahliterature106960
Source
JAMA Dermatol. 2014 Feb;150(2):163-8
Publication Type
Article
Date
Feb-2014
Author
Luise Winkel Idorn
Pameli Datta
Jakob Heydenreich
Peter Alshede Philipsen
Hans Christian Wulf
Author Affiliation
Dermatological Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Source
JAMA Dermatol. 2014 Feb;150(2):163-8
Date
Feb-2014
Language
English
Publication Type
Article
Keywords
Adult
Case-Control Studies
Denmark
Female
Follow-Up Studies
Health Behavior
Humans
Male
Melanoma - etiology - pathology
Middle Aged
Prospective Studies
Risk factors
Skin Neoplasms - etiology - pathology
Sunlight - adverse effects
Time Factors
Ultraviolet Rays - adverse effects
Abstract
IMPORTANCE UV radiation (UVR) exposure is the primary environmental risk factor for developing cutaneous malignant melanoma (CMM). OBJECTIVE To measure changes in sun behavior from the first until the third summer after the diagnosis of CMM using matched controls as a reference. DESIGN, SETTING, AND PARTICIPANTS Three-year follow-up, observational, case-control study performed from May 7 to September 22, 2009, April 17 to September 15, 2010, and May 6 to July 31, 2011, at a university hospital in Denmark of 21 patients with CMM and 21 controls matched to patients by sex, age, occupation, and constitutive skin type participated in the study. Exposure to UVR was assessed the first and second summers (n=20) and the first and third summers (n=22) after diagnosis. Data from 40 participants were analyzed. MAIN OUTCOMES AND MEASURES Exposure to UVR was assessed by personal electronic UVR dosimeters that measured time-related UVR in standard erythema dose (SED) and corresponding sun diaries (mean, 74 days per participant each participation year). RESULTS Patients' daily UVR dose and UVR dose in connection with various behaviors increased during follow-up (quantified as an increase in daily UVR dose each year; all days: mean, 0.3 SED; 95% CI, 0.05-0.5 SED; days with body exposure: mean, 0.6 SED; 95% CI, 0.07-1.2 SED; holidays: mean, 1.2 SED; 95% CI, 0.3-2.1 SED; days abroad: 1.9 SED; 95% CI, 0.4-3.4 SED; and holidays with body exposure: mean, 2.3 SED; 95% CI, 1.1-3.4 SED). After the second year of follow-up, patients' UVR dose was higher than that of controls, who maintained a stable UVR dose. No difference was found between groups in the number of days with body exposure or the number of days using sunscreen in the second and third years of follow-up. CONCLUSIONS AND RELEVANCE Our findings suggest that patients with CMM do not maintain a cautious sun behavior in connection with an increase in UVR exposure, especially on days with body exposure, when abroad, and on holidays.
PubMed ID
24080851 View in PubMed
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Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations.

https://arctichealth.org/en/permalink/ahliterature167185
Source
J Neuroimmunol. 2006 Nov;180(1-2):193-8
Publication Type
Article
Date
Nov-2006
Author
Frida Lundmark
Hanne F Harbo
Elisabeth G Celius
Janna Saarela
Pameli Datta
Annette Oturai
Cecilia M Lindgren
Thomas Masterman
Hugh Salter
Jan Hillert
Author Affiliation
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden. frida.lundmark@ki.se
Source
J Neuroimmunol. 2006 Nov;180(1-2):193-8
Date
Nov-2006
Language
English
Publication Type
Article
Keywords
Adult
Antigens, CD - genetics - immunology
Antigens, CD4 - genetics - immunology
Biological Markers - metabolism
Case-Control Studies
Cohort Studies
DNA Mutational Analysis
Denmark - epidemiology
European Continental Ancestry Group - genetics
Female
Finland - epidemiology
Gene Frequency - genetics
Genetic Markers - genetics - immunology
Genetic Predisposition to Disease - genetics
Genetic Testing
Humans
Linkage Disequilibrium
Male
Middle Aged
Multiple Sclerosis - epidemiology - genetics - immunology
Norway - epidemiology
Polymorphism, Single Nucleotide - genetics
Predictive value of tests
Sweden - epidemiology
Abstract
We have investigated the genetic involvement of the CD4 and the LAG3 genes, two appealing candidates for MS due to their suggested role in MS pathology. We genotyped a Swedish case-control material consisting of 920 MS patients and 778 controls in an initial study of CD4, three SNPs showed a significant association with MS. An independent material consisting of 1720 Nordic MS patients and 1416 controls were used for confirmation of associated markers in CD4 and to do a confirmative study of the LAG3 gene from previous findings. The result, including a total of 2640 MS patients and 2194 controls shows no significant association with CD4 and LAG3 and MS. We conclude that these genes are of minor importance in regard of genetic predisposition to the MS.
PubMed ID
17020785 View in PubMed
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Concordance for disease course and age of onset in Scandinavian multiple sclerosis coaffected sib pairs.

https://arctichealth.org/en/permalink/ahliterature181674
Source
Mult Scler. 2004 Feb;10(1):5-8
Publication Type
Article
Date
Feb-2004
Author
Annette Bang Oturai
Lars P Ryder
Sten Fredrikson
Kjell-Morten Myhr
Elisabeth G Celius
Hanne Flinstad Harbo
Oluf Andersen
Eva Akesson
Jan Hillert
Hans O Madsen
Harald Nyland
Anne Spurkland
Pameli Datta
Arne Svejgaard
Per S Sorensen
Author Affiliation
Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. annette@oturai.net
Source
Mult Scler. 2004 Feb;10(1):5-8
Date
Feb-2004
Language
English
Publication Type
Article
Keywords
Age of Onset
Female
Genetic Predisposition to Disease
HLA-DR2 Antigen - genetics
Heterozygote
Humans
Male
Middle Aged
Multiple Sclerosis - epidemiology - genetics - immunology
Scandinavia - epidemiology
Siblings
Abstract
Investigation of coaffected sib pairs is one method to determine the genetic influence on the clinical presentation of many complex diseases, such as multiple sclerosis (MS). Investigation of the clinical concordance in coaffected sib pairs may be a prerequisite to identify genes that modify the clinical outcome. The aim of this study was to investigate a possible genetic influence on selected demographic and clinical variables among familial Scandinavian MS cases.
We identified 136 Caucasian Scandinavian families with MS coaffected sib pairs from Denmark, Norway and Sweden. Cohen's kappa coefficient and the intraclass correlation coefficient were used to assess concordances in sib pairs. Furthermore, clinical features and HLA-DR2 carrier status were compared among the probands of sib pairs.
We found significant concordance of the disease course (kappa = 0.28, P
PubMed ID
14760946 View in PubMed
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Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients.

https://arctichealth.org/en/permalink/ahliterature183153
Source
J Neuroimmunol. 2003 Oct;143(1-2):101-6
Publication Type
Article
Date
Oct-2003
Author
Hanne F Harbo
Pameli Datta
Annette Oturai
Lars P Ryder
Stephen Sawcer
Efrosini Setakis
Eva Akesson
Elisabeth G Celius
Helena Modin
Magnhild Sandberg-Wollheim
Kjell-Morten Myhr
Oluf Andersen
Jan Hillert
Per Soelberg Sorensen
Arne Svejgaard
Alastair Compston
Frode Vartdal
Anne Spurkland
Author Affiliation
Institute of Immunology, Rikshospitalet University Hospital, 0027 Oslo, Norway. h.f.harbo@labmed.uio.no
Source
J Neuroimmunol. 2003 Oct;143(1-2):101-6
Date
Oct-2003
Language
English
Publication Type
Article
Keywords
Alleles
Chromosomes, Human, Pair 6 - genetics
Female
Genetic Predisposition to Disease
Genetic Testing - methods - statistics & numerical data
Genome, Human
Genotype
Histocompatibility testing
Humans
Linkage Disequilibrium - genetics
Male
Microsatellite Repeats
Multiple Sclerosis - epidemiology - genetics
Scandinavia - epidemiology
Abstract
We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens.
PubMed ID
14575924 View in PubMed
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