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Alcohol consumption and sudden coronary death in middle-aged Finnish men.

https://arctichealth.org/en/permalink/ahliterature235837
Source
Acta Med Scand. 1987;221(4):335-41
Publication Type
Article
Date
1987
Author
O. Suhonen
A. Aromaa
A. Reunanen
P. Knekt
Source
Acta Med Scand. 1987;221(4):335-41
Date
1987
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Alcohol Drinking
Coronary Disease - etiology - mortality
Death, Sudden - epidemiology - etiology
Finland
Humans
Male
Middle Aged
Prospective Studies
Risk
Sex Factors
Abstract
The association between consumption of alcoholic beverages (spirits, beer and wine) and coronary heart disease (CHD) mortality, especially the incidence of sudden coronary death (SCD), was investigated in a 5-year prospective population study comprising 4,532 men aged 40-64 years. The amount of alcohol used was estimated on the basis of answers to a self-filled structured questionnaire. The incidence of SCD was statistically significantly lower among abstainers than among alcohol consumers. The relative risk of SCD of alcohol consumers in comparison with abstainers was largest in the oldest age group and it became more apparent after a follow-up of a couple of years. Only the consumption of spirits was positively associated with the incidence of SCD. Among non-smokers the incidence of SCD was statistically significantly higher in consumers than in abstainers, a similar but not significant trend was observed among current smokers. The positive association between alcohol consumption and incidence of SCD was detected both in CHD-free men and in men with prior CHD. Consumption of alcoholic beverages, and in particular of spirits, is associated with an increased risk of SCD in Finnish men.
PubMed ID
3604749 View in PubMed
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Antioxidant vitamins in the diet: relationships with other personal characteristics in Finland.

https://arctichealth.org/en/permalink/ahliterature216830
Source
J Epidemiol Community Health. 1994 Dec;48(6):549-54
Publication Type
Article
Date
Dec-1994
Author
R. Järvinen
P. Knekt
R. Seppänen
A. Reunanen
M. Heliövaara
J. Maatela
A. Aromaa
Author Affiliation
Department of Clinical Nutrition, University of Kuopio, Finland.
Source
J Epidemiol Community Health. 1994 Dec;48(6):549-54
Date
Dec-1994
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Ascorbic Acid - administration & dosage
Carotenoids - administration & dosage
Confounding Factors (Epidemiology)
Cross-Sectional Studies
Diet Surveys
Employment
Female
Finland - epidemiology
Food Habits
Humans
Male
Marital status
Middle Aged
Rural Health
Sex Factors
Smoking
Urban health
Vitamin A - administration & dosage
Vitamin E - administration & dosage
Abstract
The study aimed to reveal associations between dietary antioxidant vitamins and other personal characteristics.
Population based, cross sectional survey.
Twenty seven rural, industrial, and semiurban communities in six different regions of Finland.
Subjects included 5304 men and 4750 women aged 15 years or older, who were interviewed about their dietary habits at the baseline study of the Finnish Mobile Clinic Health Examination Survey, 1967-72.
Intakes of carotenoids and vitamins A, E, and C were estimated from dietary history interviews covering the subjects' food consumption in the preceding year. In older age groups intakes of all the vitamins studied were low. Occupation had a profound effect on dietary antioxidant vitamins: intakes were highest in white collar workers and lowest in farmers; those classified as service workers, industrial workers, or housewives came in between. Current smoking was inversely associated with dietary carotenoids and vitamin C, especially in men. The vitamin intakes of ex-smokers were equal to or even slightly higher than those of never smokers. Married men had higher intakes of carotenoids and vitamin C than men living alone. Body mass index was not an important determinant of the intake of antioxidant vitamins.
The associations of dietary antioxidant vitamins with sociodemographic characteristics and smoking were strong enough to exert a confounding or modifying effect in studies on diet and diseases.
Notes
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Cites: Int J Epidemiol. 1993 Jun;22(3):520-78359970
Cites: Am J Clin Nutr. 1983 Feb;37(2):278-866823890
Cites: Duodecim. 1982;98(22):1666-736764189
Cites: Am J Clin Nutr. 1984 Oct;40(4):827-336486090
Cites: J Am Diet Assoc. 1985 Mar;85(3):313-243973320
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Cites: Br Med J (Clin Res Ed). 1986 Apr 12;292(6526):983-73083978
Cites: Scand J Soc Med. 1986;14(1):39-473704580
Cites: Nutr Cancer. 1987;10(1-2):53-653615217
Cites: Am J Epidemiol. 1988 Feb;127(2):283-963257350
Cites: Eur J Clin Nutr. 1988 Sep;42(9):797-8032846266
Cites: Prev Med. 1988 Nov;17(6):725-353244671
Cites: Int J Epidemiol. 1989 Jun;18(2):345-542788628
Cites: J Epidemiol Community Health. 1988 Dec;42(4):341-93256576
Cites: Am J Clin Nutr. 1990 Aug;52(2):361-72375302
Cites: Am J Public Health. 1990 Nov;80(11):1323-92240298
Cites: Br J Nutr. 1991 May;65(3):321-351878352
Cites: Eur J Clin Nutr. 1991 Sep;45(9):441-501959516
Cites: Prog Food Nutr Sci. 1991;15(4):183-2171784736
Cites: J Am Diet Assoc. 1992 Aug;92(8):969-771640041
Cites: Annu Rev Nutr. 1992;12:139-591503801
Cites: J Epidemiol Community Health. 1992 Aug;46(4):417-241431719
Cites: Nutr Cancer. 1992;17(3):297-3041437648
Cites: Ann N Y Acad Sci. 1992 Sep 30;669:249-58; discussion 258-91444030
Cites: Eur J Clin Nutr. 1993 Jan;47(1):31-418422871
Cites: Br J Nutr. 1993 Mar;69(2):315-328489991
Cites: Ann N Y Acad Sci. 1993 May 28;686:280-7; discussion 287-88512253
Cites: Ann N Y Acad Sci. 1993 May 28;686:335-45; discussion 345-68512259
Cites: J Am Diet Assoc. 1982 Dec;81(6):661-737142608
PubMed ID
7830008 View in PubMed
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Association of 25-hydroxyvitamin D with the incidence of knee and hip osteoarthritis: a 22-year follow-up study.

https://arctichealth.org/en/permalink/ahliterature129996
Source
Scand J Rheumatol. 2012 Mar;41(2):124-31
Publication Type
Article
Date
Mar-2012
Author
S. Konstari
M. Paananen
M. Heliövaara
P. Knekt
J. Marniemi
O. Impivaara
J. Arokoski
J. Karppinen
Author Affiliation
Department of Physical and Rehabilitation Medicine, Institute of Clinical Sciences, University of Oulu, Oulu, Finland. konstsan@mail.student.oulu.fi
Source
Scand J Rheumatol. 2012 Mar;41(2):124-31
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Adult
Comorbidity
Female
Finland - epidemiology
Health Surveys
Humans
Incidence
Male
Middle Aged
Osteoarthritis, Hip - blood - epidemiology
Osteoarthritis, Knee - blood - epidemiology
Reference Values
Seasons
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - blood - epidemiology
Abstract
In the light of conflicting results from previous studies on the role of vitamin D, we studied serum 25-hydroxyvitamin D [25(OH)D] with regard to its prediction of incident knee and hip osteoarthritis (OA).
The study population (n = 805) consisted of participants of a national health examination survey who had undergone baseline and follow-up clinical examinations at intervals of 20-23 years. Knee and hip OA were diagnosed on the basis of a standardized clinical examination by physicians with the same diagnostic criteria at baseline and follow-up. Information on covariates, including age, sex, season of blood draw, education, body mass index (BMI), physical workload, leisure time physical activity, smoking history, and previous injuries, was collected at baseline. Serum 25(OH)D concentrations were determined from baseline serum samples kept frozen at -20°C.
We found no significant association between serum 25(OH)D level and the risk of incident knee or hip OA. However, a statistically significant interaction between season of blood draw and serum 25(OH)D emerged when predicting the development of definite knee OA (p = 0.004). After adjusting for all the covariates, the relative odds (95% confidence interval) of developing definite knee OA per increment of 1 SD (20.7 ng/mL) in winter season 25(OH)D was 1.57 (1.10-2.27), whereas for summer season sera the corresponding rate was 0.53 (0.28-1.00).
The results do not support the hypothesis that a low level of serum 25(OH)D contributes to the development of OA. Instead, our study suggests that season is a potent effect modifier of 25(OH)D, which merits attention in future research.
PubMed ID
22043944 View in PubMed
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Association of overweight, trauma and workload with coxarthrosis. A health survey of 7,217 persons.

https://arctichealth.org/en/permalink/ahliterature220211
Source
Acta Orthop Scand. 1993 Oct;64(5):513-8
Publication Type
Article
Date
Oct-1993
Author
M. Heliövaara
M. Mäkelä
O. Impivaara
P. Knekt
A. Aromaa
K. Sievers
Author Affiliation
Social Insurance Institution, Helsinki, Finland.
Source
Acta Orthop Scand. 1993 Oct;64(5):513-8
Date
Oct-1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Body mass index
Body Weight
Cluster analysis
Cross-Sectional Studies
Female
Finland - epidemiology
Humans
Leg Injuries - complications
Male
Middle Aged
Odds Ratio
Osteoarthritis, Hip - epidemiology - etiology
Prevalence
Retrospective Studies
Risk factors
Stress, mechanical
Abstract
In a population sample health survey, body mass, previous trauma and physical stress were studied for associations with coxarthrosis. A sample of 8,000 persons representative of the Finnish population aged 30 or over was invited for examination, and 90 percent participated. On the basis of a standardized clinical examination, a physician diagnosed coxarthrosis in 6 percent of the women and 4 percent of the men. The prevalence rose with age. In persons with a past traumatic lower-limb injury, the odds ratio of unilateral coxarthrosis was 2.1 and of bilateral coxarthrosis 1.5, as adjusted for sex, age and other determinants using logistic regression. The sum index reflecting self-reported features of physical stress in present or previous occupations was directly proportional to the prevalence of coxarthrosis. Body mass index (kg/m2) was closely associated with bilateral coxarthrosis; the adjusted odds ratio (95 percent confidence intervals) for indices > 35, compared to those
PubMed ID
8237314 View in PubMed
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Association of radiological hand osteoarthritis with bone mineral mass: a population study.

https://arctichealth.org/en/permalink/ahliterature172174
Source
Rheumatology (Oxford). 2005 Dec;44(12):1549-54
Publication Type
Article
Date
Dec-2005
Author
M M Haara
J P A Arokoski
H. Kröger
A. Kärkkäinen
P. Manninen
P. Knekt
O. Impivaara
M. Heliövaara
Author Affiliation
Bone and Cartilage Research Unit (BCRU) and Department of General Practice and Public Health, University of Kuopio, Kuopio, Finland. mhaara@hytti.uku.fi
Source
Rheumatology (Oxford). 2005 Dec;44(12):1549-54
Date
Dec-2005
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Bone Density
Calcaneus - physiopathology - ultrasonography
Epidemiologic Methods
Female
Finland - epidemiology
Hand Joints - physiopathology - radiography
Humans
Male
Metacarpal Bones - physiopathology
Middle Aged
Osteoarthritis - complications - epidemiology - physiopathology - radiography
Osteoporosis - epidemiology - etiology - ultrasonography
Severity of Illness Index
Abstract
A number of previous studies have reported an inverse relationship between osteoarthritis and osteoporosis. However, the association has remained controversial because osteoarthritis in hand joints seems to associate differently from osteoarthritis in weight-bearing joints with bone mineral mass. We studied osteoarthritis in distal interphalangeal (DIP) joints and osteoarthritis in the base of the thumb (CMC-1) for their cross-sectional associations with metacarpal cortical bone mineral mass, and for their prediction of calcaneal broadband ultrasound attenuation.
A population sample of 8000 Finns aged 30 yr and over was invited to a comprehensive health examination in 1978-1980; 90% complied. Hand radiographs were taken from 3568 participants to diagnose osteoarthritis in various hand joints, and to determine two indicators of cortical bone mineral mass, the combined cortical thickness (CCT) and the metacarpal index (MCI). Calcaneal broadband ultrasound attenuation was measured 20 yr later in 340 of these participants with the Sahara sonometer.
In the cross-sectional setting, osteoarthritis in the DIP joints and osteoarthritis in the base of the thumb (CMC-1) were significantly associated with low CCT and low MCI. These associations were proportional to the radiological severity of osteoarthritis. In the follow-up setting, symmetrical DIP osteoarthritis adjusted for age, sex, body mass index, smoking, education, workload and MCI significantly predicted low values of broadband ultrasound attenuation.
Our results indicate a direct relation of both radiological DIP osteoarthritis and CMC-1 osteoarthritis with low cortical bone mineral mass, in proportion to the severity of osteoarthritis. The presence of symmetrical DIP osteoarthritis, a possible indicator of generalized osteoarthritis, suggests an increased risk of osteoporosis over time.
PubMed ID
16263784 View in PubMed
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Associations of tissue transglutaminase antibody seropositivity with coronary heart disease: Findings from a prospective cohort study.

https://arctichealth.org/en/permalink/ahliterature285628
Source
Nutr Metab Cardiovasc Dis. 2017 Sep;27(9):817-821
Publication Type
Article
Date
Sep-2017
Author
K. Heikkilä
H. Rissanen
M. Heliövaara
P. Knekt
M. Mäki
K. Kaukinen
Source
Nutr Metab Cardiovasc Dis. 2017 Sep;27(9):817-821
Date
Sep-2017
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Autoantibodies - blood
Biomarkers - blood
Celiac Disease - blood - diagnosis - epidemiology - immunology
Coronary Disease - blood - diagnosis - epidemiology - immunology
Female
Finland - epidemiology
GTP-Binding Proteins - immunology
Health Surveys
Humans
Incidence
Male
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
Risk factors
Serologic Tests
Transglutaminases - immunology
Abstract
Clinical experience and observational studies suggest that individuals with coeliac disease are at increased risk of coronary heart disease (CHD), but the precise mechanism for this is unclear. Laboratory studies suggest that it may relate to tissue transglutaminase antibodies (tTGAs). Our aim was to examine whether seropositivity for tTGA and endomysial antibodies (EMAs) are associated with incident CHD in humans.
We used data from Mini-Finland Health Survey, a prospective cohort study of Finnish men and women aged 35-80 at study baseline 1978-80. TTGA and EMA seropositivities were ascertained from baseline blood samples and incident CHD events were identified from national hospitalisation and death registers. Cox regression was used to examine the associations between antibody seropositivity and incident CHD. Of 6887 men and women, 562 were seropositive for tTGAs and 72 for EMAs. During a median follow-up of 26 years, 2367 individuals experienced a CHD event. We found no clear evidence for an association between tTGA positivity (hazard ratio, HR: 1.04, 95% confidence interval, CI: 0.83, 1.30) or EMA positivity (HR: 1.16, 95% CI: 0.77, 1.74) and incident CHD, once pre-existing CVD and known CHD risk factors had been adjusted for.
We found no clear evidence for an association of tTGA or EMA seropositivity with incident CHD outcomes, suggesting that tTG autoimmunity is unlikely to be the biological link between coeliac disease and CHD.
PubMed ID
28756971 View in PubMed
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Source
Int J Cancer. 1994 Feb 1;56(3):379-82
Publication Type
Article
Date
Feb-1-1994
Author
P. Knekt
A. Reunanen
H. Takkunen
A. Aromaa
M. Heliövaara
T. Hakulinen
Author Affiliation
Social Insurance Institution, Helsinki, Finland.
Source
Int J Cancer. 1994 Feb 1;56(3):379-82
Date
Feb-1-1994
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Colorectal Neoplasms - epidemiology
Female
Finland - epidemiology
Follow-Up Studies
Hematocrit
Hemoglobins - analysis
Humans
Iron - blood - metabolism
Lung Neoplasms - epidemiology
Male
Middle Aged
Neoplasms - epidemiology
Questionnaires
Risk factors
Sex Factors
Stomach Neoplasms - epidemiology
Time Factors
Transferrin - analysis - metabolism
Abstract
A high level of available tissue iron may increase the risk of cancer through its contribution to the production of free oxygen radicals. Serum iron, total iron-binding capacity (TIBC) and transferrin saturation levels were studied for their prediction of different cancers in a cohort of 41,276 men and women aged 20-74 years and initially free from cancer. During a mean follow-up of 14 years, 2,469 primary cancer cases were diagnosed. Excess risks of colorectal and lung cancers were found in subjects with transferrin saturation level exceeding 60%. The relative risks, adjusted for age, sex and smoking, were 3.04 for colorectal cancer and 1.51 for lung cancer, in comparison with subjects having lower levels. The risk of lung cancer was inversely related to serum TIBC, with a relative risk between the highest and lowest quartiles of 0.69 for men and 0.19 for women. For the risk of stomach cancer, we detected inverse relationships with serum iron and with transferrin saturation and a positive relationship with TIBC, but these associations weakened when the cancer cases occurring during the 5 first years of follow-up were excluded. High iron stores may increase the risk of colorectal cancer, whereas low iron stores may be an early sign of occult stomach cancer.
PubMed ID
8314326 View in PubMed
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Body iron stores, dietary iron intake and coronary heart disease mortality.

https://arctichealth.org/en/permalink/ahliterature214445
Source
J Intern Med. 1995 Sep;238(3):223-30
Publication Type
Article
Date
Sep-1995
Author
A. Reunanen
H. Takkunen
P. Knekt
R. Seppänen
A. Aromaa
Author Affiliation
Research and Development Centre, Social Insurance Institution, Helsinki, Finland.
Source
J Intern Med. 1995 Sep;238(3):223-30
Date
Sep-1995
Language
English
Publication Type
Article
Keywords
Coronary Disease - blood - chemically induced - mortality
Diet
Female
Finland - epidemiology
Follow-Up Studies
Hematologic Tests
Humans
Iron - administration & dosage - adverse effects - blood
Male
Middle Aged
Population Surveillance
Prospective Studies
Protein Binding
Risk factors
Abstract
To assess whether increased body iron stores and dietary iron intake are associated with an increased risk of coronary heart disease mortality.
A prospective population study with a mean mortality follow-up time of 14 years.
Participants attending a health screening examination carried out in several localities in Finland.
All 6086 men and 6102 women aged from 45 to 64 years at the baseline examination without known heart disease, who had had serum iron and total iron binding capacity (TIBC) assessed. In a random fifth of these people, dietary iron intake was assessed by a dietary history.
The study was observational without any interventions.
Mortality from coronary heart disease.
Altogether, 739 of the men and 245 of the women died from coronary heart disease. No relationship between TIBC and coronary mortality was observed in the men; in the women, an inverse although not significant association was found. Transferrin saturation was inversely but not significantly associated with coronary mortality in men; in women, the relationship was U-formed with a higher mortality at both the lower and higher ends of the distribution. Adjustment for other risk factors did not alter the results. No association was found with dietary iron intake and coronary mortality.
The results do not corroborate earlier findings that excess body iron stores and increased iron intake are associated with an elevated risk of coronary heart disease.
PubMed ID
7673851 View in PubMed
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CA 125 as a screening test for ovarian cancer.

https://arctichealth.org/en/permalink/ahliterature213328
Source
J Med Screen. 1996;3(1):40-2
Publication Type
Article
Date
1996
Author
M. Hakama
U H Stenman
P. Knekt
J. Järvisalo
T. Hakulinen
J. Maatela
A. Aromaa
Author Affiliation
Finnish Cancer Registry, Liisankatu 21, Helsinki, Finland.
Source
J Med Screen. 1996;3(1):40-2
Date
1996
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
CA-125 Antigen - blood
Case-Control Studies
False Positive Reactions
Female
Finland
Follow-Up Studies
Humans
Mass Screening - methods - statistics & numerical data
Middle Aged
Ovarian Neoplasms - diagnosis - epidemiology - prevention & control
Sensitivity and specificity
Tumor Markers, Biological - blood
Abstract
BACKGROUND - Screening for ovarian cancer is based on ultrasound, colour Doppler, and tumour markers. There is only limited evidence on their discriminatory performance and no evidence on their effectiveness in reducing mortality. OBJECTIVE - To investigate the discriminatory performance of CA 125 as a screening test for ovarian cancer. METHODS - A registry of 15 093 serum samples drawn in 1968-72 was linked to the cancer registry. During follow up between 1968 and 1980 24 ovarian cancers were identified. One or two matched case-control design nested within the sample bank was applied and the concentrations of CA 125 were assessed. RESULTS - Case-control differences (relative risk 4-0, 95% confidence interval 1.0 to 15.5 at 20 kU/1) were found. Detection rate of the CA 125 test was 21-33% and the true negative rate was 75-98% depending on the cut off level and interval between drawing of the blood sample and diagnosis of the cancer. CONCLUSION - CA 125 is not a valid screening test if used alone. Case-control differences of borderline significance were found in CA 125 before diagnosis of ovarian cancer, but they were not large enough to provide a sufficient detection rate.
PubMed ID
8861050 View in PubMed
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Circulating anti-Helicobacter pylori immunoglobulin A antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer.

https://arctichealth.org/en/permalink/ahliterature211464
Source
Am J Epidemiol. 1996 Jul 15;144(2):142-9
Publication Type
Article
Date
Jul-15-1996
Author
A. Aromaa
T U Kosunen
P. Knekt
J. Maatela
L. Teppo
O P Heinonen
M. Härkönen
M K Hakama
Author Affiliation
National Public Health Institute, Helsinki, Finland.
Source
Am J Epidemiol. 1996 Jul 15;144(2):142-9
Date
Jul-15-1996
Language
English
Publication Type
Article
Keywords
Aged
Antibodies, Bacterial - blood
Case-Control Studies
Female
Finland - epidemiology
Gastritis, Atrophic - microbiology
Helicobacter Infections - complications - enzymology - immunology
Helicobacter pylori - immunology
Humans
Immunoglobulin A - blood
Incidence
Male
Middle Aged
Odds Ratio
Pepsinogens - blood
Population Surveillance
Prospective Studies
Risk
Risk factors
Stomach Neoplasms - epidemiology - microbiology
Abstract
Helicobacter pylori infection has been suggested to be associated with an increased risk of gastric cancer, and low levels of serum pepsinogen I (PG I) have been linked to atrophic gastritis, which is a risk factor for gastric cancer. In Finland, 39,268 persons from 25 cohorts participated during 1968-1972 in a health examination survey and were followed for up to 13 years. A nested case-control study was performed on 84 stomach cancer patients identified from the Finnish Cancer Registry and 146 controls matched for age, sex, and municipality. Serum samples drawn at the baseline study were analyzed. An elevated level of serum anti-H. pylori immunoglobulin A (IgA) antibodies (a titer > or = 70) and a low serum PG I level ( or = 700), the odds ratio was only 1.50 (95% CI 0.70-3.22). When both high IgA and low PG I were present, the odds ratio was 5.96 (95% CI 2.02-17.57). The association of H. pylori infection with cancer became stronger with longer follow-up times, whereas that of low PG I was strongest at shorter follow-up times. Our findings support the hypothesis that H. pylori infection is a prevalent and potentially preventable cause of gastric cancer. They stress the value of IgA antibody determinations and provide new evidence for a pathogenesis leading from prolonged infection through atrophic gastritis to gastric cancer.
PubMed ID
8678045 View in PubMed
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113 records – page 1 of 12.