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Screening for insulin receptor gene DNA polymorphisms associated with glucose intolerance in a Scandinavian population.

https://arctichealth.org/en/permalink/ahliterature48670
Source
Diabetologia. 1991 Apr;34(4):265-70
Publication Type
Article
Date
Apr-1991
Author
M. Sten-Linder
S. Vilhelmsdotter
A. Wedell
I. Stern
T. Pollare
P. Arner
S. Efendic
R. Luft
H. Luthman
Author Affiliation
Department of Clinical Genetics, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
Source
Diabetologia. 1991 Apr;34(4):265-70
Date
Apr-1991
Language
English
Publication Type
Article
Keywords
Blood Glucose - metabolism
Body mass index
DNA - blood - genetics - isolation & purification
DNA Restriction Enzymes
Diabetes Mellitus, Type 2 - genetics - physiopathology
Female
Genotype
Glucose Tolerance Test
Humans
Insulin - blood
Leukocytes - physiology
Male
Middle Aged
Phenotype
Polymorphism, Restriction Fragment Length
Receptor, Insulin - genetics
Reference Values
Research Support, Non-U.S. Gov't
Sweden
Abstract
The significance of insulin receptor gene variants in the aetiology of Type 2 (non-insulin-dependent) diabetes mellitus has been investigated by analysis of restriction fragment length polymorphisms in a genetically homogeneous Swedish population. Seven polymorphisms were analysed, spanning functionally important regions of the insulin receptor locus. Four of these polymorphisms were mapped more accurately within the gene compared to previous studies. The genotype distribution was compared in 76 Type 2 diabetic patients and 84 healthy control subjects. No significant differences were found in the distribution of genotypes between diabetic and control subjects at the p less than 0.01 level. In order to study the possible association between quantitative measures of glucose metabolism and these DNA polymorphisms, the fasting glucose and insulin concentrations were compared in the different genotype groups of control subjects and mildly diabetic patients treated with diet. No differences in fasting glucose or insulin concentrations were found at the p less than 0.005 level of significance. In conclusion, no significant associations were found between insulin receptor gene DNA polymorphisms and glucose intolerance.
PubMed ID
1676686 View in PubMed
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