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The 4154delA mutation carriers in the BRCA1 gene share a common ancestry.

https://arctichealth.org/en/permalink/ahliterature153810
Source
Fam Cancer. 2009;8(1):1-4
Publication Type
Article
Date
2009
Author
Silvija Ozolina
Olga Sinicka
Eriks Jankevics
Inna Inashkina
Jan Lubinski
Bohdan Gorski
Jacek Gronwald
Tatyana Nasedkina
Olga Fedorova
Ludmila Lyubchenko
Laima Tihomirova
Author Affiliation
Latvian Biomedical Research and Study Centre, Ratsupites str. 1, Riga, 1067, Latvia.
Source
Fam Cancer. 2009;8(1):1-4
Date
2009
Language
English
Publication Type
Article
Keywords
Breast Neoplasms - genetics
DNA Mutational Analysis
Female
Founder Effect
Genes, BRCA1
Genetic Predisposition to Disease
Haplotypes
Humans
Latvia
Male
Microsatellite Repeats
Mutation
Pedigree
Poland
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Polymorphism, Single-Stranded Conformational
Russia
Abstract
Uncertainty exists whether the 4154delA mutation of the BRCA1 gene detected in unrelated individuals from Latvia, Poland and Russia is a founder mutation with a common ancestral origin. To trace back this problem we analysed the mutation-associated haplotype of the BRCA1 intragenic SNPs as well as intragenic and nearby STR markers in mutation carriers from the aforementioned populations. The mutation-associated SNP alleles were found to be "T-A-A-A-A-G" for six intragenic SNPs of the BRCA1 gene (IVS8-58delT, 3232A/G, 3667A/G, IVS16-68A/G, IVS16-92A/G, IVS18+66G/A, respectively). The alleles 195, 154, 210 and 181 were found to be associated with the 4154delA mutation for STR markers D17S1325, D17S855, D17S1328 and D17S1320, correspondingly. Further analysis of markers in the 4154delA mutation carriers from all three populations allows us to assert that all analysed mutation carriers share a common ancestry.
PubMed ID
19067236 View in PubMed
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Crosslinguistic evidence for the diminutive advantage: gender agreement in Russian and Serbian children.

https://arctichealth.org/en/permalink/ahliterature164811
Source
J Child Lang. 2007 Feb;34(1):111-31
Publication Type
Article
Date
Feb-2007
Author
Nada Seva
Vera Kempe
Patricia J Brooks
Natalija Mironova
Angelina Pershukova
Olga Fedorova
Author Affiliation
University of Stirling, United Kingdom.
Source
J Child Lang. 2007 Feb;34(1):111-31
Date
Feb-2007
Language
English
Publication Type
Article
Keywords
Child Language
Child, Preschool
Cross-Cultural Comparison
Female
Humans
Language Development
Linguistics
Male
Russia
Sex Factors
Yugoslavia
Abstract
Our previous research showed that Russian children commit fewer gender-agreement errors with diminutive nouns than with their simplex counterparts. Experiment 1 replicates this finding with Russian children (N = 24, mean 3;7, range 2;10-4;6). Gender agreement was recorded from adjective usage as children described animal pictures given just their names, varying in derivational status (diminutive/ simplex), novelty, and gender. Experiment 2 extends the gender-agreement elicitation methodology developed for Russian to Serbian, a language with similar morphosyntactic structure but considerably fewer diminutives in child-directed speech. Serbian children (N = 22, mean age 3;8, range 3;0-4;1), exhibited an advantage for diminutive nouns of almost the same magnitude as the Russian children. The fact that the diminutive advantage was found in a language with a low frequency of diminutives in the input suggests that morphophonological homogeneity of word clusters and membership in dense neighbourhoods are important factors that contribute to the reduction of inflectional errors during language development.
PubMed ID
17340940 View in PubMed
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