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6 records – page 1 of 1.

[Deliberations on the future organization of diagnostic and treatment control of hyperlipidemia. Experiences from the county of Funen]

https://arctichealth.org/en/permalink/ahliterature38197
Source
Ugeskr Laeger. 1989 Feb 20;151(8):483-7
Publication Type
Article
Date
Feb-20-1989

External quality assurance model for improvement of specificity and accuracy of serum hormone determinations in the Nordic countries.

https://arctichealth.org/en/permalink/ahliterature103877
Source
Ups J Med Sci. 1990;95(3):257-8
Publication Type
Article
Date
1990
Author
A. Ruokonen
P. Hyltoft-Petersen
O. Blaabjerg
Author Affiliation
Department of Clinical Chemistry, Oulun Yliopisto, Finland.
Source
Ups J Med Sci. 1990;95(3):257-8
Date
1990
Language
English
Publication Type
Article
Keywords
Chemistry, Clinical - standards
Hormones - blood
Humans
Quality Control
Reproducibility of Results
Scandinavia
Sensitivity and specificity
PubMed ID
2100403 View in PubMed
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[Hyperlipidemia in patients under 60 years of age admitted for suspected myocardial infarction]

https://arctichealth.org/en/permalink/ahliterature55430
Source
Ugeskr Laeger. 1989 Feb 20;151(8):489-91
Publication Type
Article
Date
Feb-20-1989

Screening for haemochromatosis: prevalence among Danish blood donors.

https://arctichealth.org/en/permalink/ahliterature48646
Source
J Intern Med. 1991 Sep;230(3):265-70
Publication Type
Article
Date
Sep-1991
Author
P. Wiggers
J. Dalhøj
H. Kiaer
H. Ring-Larsen
P H Petersen
O. Blaabjerg
M. Hørder
Author Affiliation
Department of Blood Banking and Clinical Immunology, Odense University Hospital, Denmark.
Source
J Intern Med. 1991 Sep;230(3):265-70
Date
Sep-1991
Language
English
Publication Type
Article
Keywords
Adult
Biopsy
Blood Donors
Denmark - epidemiology
Female
Ferritin - blood
Hemochromatosis - diagnosis - epidemiology - genetics
Histocompatibility testing
Humans
Iron - blood
Liver - pathology
Male
Mass Screening - methods
Middle Aged
Prevalence
Transferrin - metabolism
Abstract
Hereditary haemochromatosis is an autosomal recessive disease that is genetically expressed by excessive accumulation of iron in the tissues, resulting in cirrhosis, diabetes mellitus, cardiomyopathy and hypogonadism. As the disease may be diagnosed before the appearance of symptoms, and prevented by repeated phlebotomies, there are strong implications for adoption of a screening procedure. Determinations of transferrin saturation (TS) and serum ferritin concentration (SF) were used to screen 4302 blood donors, who were selected for follow-up studies if they fulfilled any of the following three criteria: (i) TS greater than or equal to 0.7; (ii) TS greater than or equal to 0.5 together with SF greater than or equal to 150 micrograms l-1; (iii) SF greater than or equal to 300 micrograms l-1. A total of 58 subjects who fulfilled at least one of these criteria were reinvestigated, after which 18 individuals still fulfilled at least one criterion. Fifteen subjects having SF greater than or equal to 300 micrograms l-1 were offered liver biopsy and thirteen of these accepted. In one individual, no stainable iron was detected, and two subjects did not fulfil the previously established diagnostic criteria for the diagnosis of hereditary haemochromatosis. Ten subjects who had a high TS and liver iron grade 2-4 according to Bassett were classified accordingly as homozygotes. On the basis of these results, the prevalence of haemochromatosis in Denmark was estimated to be 0.0037-0.0046.
PubMed ID
1895049 View in PubMed
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Serum lactate dehydrogenase isoenzyme 1 and prediction of death in patients with metastatic testicular germ cell tumors.

https://arctichealth.org/en/permalink/ahliterature19932
Source
Clin Chem Lab Med. 2001 Jan;39(1):38-44
Publication Type
Article
Date
Jan-2001
Author
F E von Eyben
O. Blaabjerg
P. Hyltoft-Petersen
E L Madsen
R. Amato
F. Liu
H. Fritsche
Author Affiliation
The Department of Clinical Chemistry, Odense University Hospital, Denmark. feve@post5.tele.dk
Source
Clin Chem Lab Med. 2001 Jan;39(1):38-44
Date
Jan-2001
Language
English
Publication Type
Article
Keywords
Chorionic Gonadotropin - blood
Humans
Isoenzymes - blood
L-Lactate Dehydrogenase - blood - chemistry
Male
Neoplasm Metastasis
Neoplasms, Germ Cell and Embryonal - blood - enzymology - mortality
Predictive value of tests
ROC Curve
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Testicular Neoplasms - blood - enzymology - mortality
Time Factors
Tumor Markers, Biological
alpha-Fetoproteins - metabolism
Abstract
The International Germ Cell Cancer Collaborative Group study of patients with metastatic testicular germ cell tumors showed that catalytic concentration of serum lactate dehydrogenase (S-LD), serum alpha-fetoprotein concentration (S-AFP), and serum human chorionic gonadotropin concentration (S-hCG) predicted death from tumor. The recent international TNM classification (T primary tumor, N lymph node metastasis, M distant metastasis) is based on these results. The aim of our study was to evaluate whether catalytic concentration of S-LD isoenzyme 1 (S-LD-1) was a better predictor than the criteria used for the international classification. In an evaluation series of 44 patients from Odense University Hospital, Denmark, a raised S-LD-1 (>1.0 x upper limit of reference values) had a predictive value for death from tumor in 5-years observation of 46%. The predictive value was 46% for S-LD, 25% for S-AFP, and 40% for S-hCG. A normal SLD-1 had a predictive value for survival over 5-years observation of 100%. It was 81% for S-LD, 75% for SAFP, and 77% for S-hCG. The fraction of the patients who died of tumor and had a raised tumor marker value was 100% for S-LD-1, 46% for S-LD, 9% for S-AFP, and 18% for S-hCG. The fraction of patients with a normal serum tumor marker value among those who survived was 61% for S-LD-1, 81% for S-LD, 94% for SAFP, and 94% for S-hCG. A validation series of 37 patients treated at the University of Texas MD Anderson Cancer Center showed similar findings. Combining the patients in the two series, a raised value of SLD-1 classified more patients into a subgroup with an impaired survival (53%) than S-LD (35%), S-AFP (6%), or S-hCG (11%), and the high risk subgroups based on the international classification (40%). The findings have implications for the staging and treatment of patients with metastatic testicular germ cell tumors.
PubMed ID
11256799 View in PubMed
Less detail

Serum lactate dehydrogenase isoenzyme 1 and relapse in patients with nonseminomatous testicular germ cell tumors clinical stage I.

https://arctichealth.org/en/permalink/ahliterature19617
Source
Acta Oncol. 2001;40(4):536-40
Publication Type
Article
Date
2001
Author
F E von Eyben
E L Madsen
O. Blaabjerg
P H Petersen
H. von der Maase
G K Jacobsen
M. Rørth
Author Affiliation
Department of Clinical Chemistry, Odense University Hospital, Denmark. feve@post5.tele.dk
Source
Acta Oncol. 2001;40(4):536-40
Date
2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Carcinoma, Embryonal - enzymology - pathology
Combined Modality Therapy
Denmark - epidemiology
Disease-Free Survival
Endodermal Sinus Tumor - enzymology - pathology
Follow-Up Studies
Humans
Isoenzymes - blood
L-Lactate Dehydrogenase - blood
Life tables
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Proteins - blood
Neoplasm Recurrence, Local - epidemiology
Neoplasm Staging
Orchiectomy
Radiotherapy, Adjuvant
Teratoma - enzymology - pathology
Testicular Neoplasms - enzymology - pathology
Treatment Outcome
Tumor Markers, Biological - blood
Abstract
Serum lactate dehydrogenase isoenzyme 1 catalytic concentration (S-LD-1) was measured at the time of orchiectomy in 104 patients with nonseminomatous testicular germ cell tumors (NSTGCT) clinical stage I who participated in a randomized study comparing surveillance after orchiectomy (group I) and radiotherapy (group II). For 68 patients, S-LD-1 was measured in a serum sample before or on the day of the orchiectomy. Twenty-seven patients (40%) had elevated S-LD-1; median 102 U/L (range 41-335). For the remaining 36 patients. S-LD-1 was measured in a serum sample after orchiectomy: 8 of these patients (22%) had elevated S-LD-1. S-LD-1 was normalized shortly after surgery in most patients with a preorchiectomy elevated S-LD-1. Fifteen of the 68 patients relapsed: 9 out of 27 with an elevated S-LD-1 and 6 out of 41 patients with normal S-LD-1 (p = 0.13, Fisher's exact test). In group 1, those with a preoperatively elevated S-LD-1 had a lower 8-years' relapse-free survival than those with a normal S-LD-1 (40% vs. 80%, p = 0.003, log-rank test). The role of S-LD-1 in the staging, prognostication and monitoring of patients with NSGCT clinical stage I should be further explored in a large, prospective study.
PubMed ID
11504315 View in PubMed
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6 records – page 1 of 1.