Results of treatment of 298 patients with colon cancer in the absence of distant metastases were analyzed. The long-term follow-up results were obtained after up to 20 years; 10 years follow-up results were obtained in 95% of the operated patients. The survival rate was significantly dependant on the stage of the disease, i.e., on the presence of regional lymph nodes invasion. Authors conclude, that possibilities of surgical treatment in further improvement of survival rates are to certain limited and exhausted. Therefore, further workout of perioperative combined chemo- and radiotherapy of patients with colon cancer is expected to improve the results.