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Association between levels of persistent organic pollutants in adipose tissue and cryptorchidism in early childhood: a case-control study.

https://arctichealth.org/en/permalink/ahliterature272722
Source
Environ Health. 2015;14:78
Publication Type
Article
Date
2015
Author
Jaakko J Koskenniemi
Helena E Virtanen
Hannu Kiviranta
Ida N Damgaard
Jaakko Matomäki
Jørgen M Thorup
Timo Hurme
Niels E Skakkebaek
Katharina M Main
Jorma Toppari
Source
Environ Health. 2015;14:78
Date
2015
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Benzofurans - toxicity
Case-Control Studies
Child
Child, Preschool
Cross-Sectional Studies
Cryptorchidism - chemically induced - epidemiology
Denmark - epidemiology
Dioxins - toxicity
Environmental Pollutants - toxicity
Female
Finland - epidemiology
Halogenated Diphenyl Ethers - toxicity
Humans
Incidence
Infant
Infant, Newborn
Male
Polychlorinated Biphenyls - toxicity
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - epidemiology
Abstract
Congenital cryptorchidism, i.e. failure of the testicular descent to the bottom of the scrotum, is a common birth defect. The evidence from epidemiological, wildlife, and animal studies suggests that exposure to mixtures of endocrine disrupting chemicals during fetal development may play a role in its pathogenesis. We aimed to assess the association between cryptorchidism and prenatal exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), and polybrominated diphenyl ethers (PBDEs).
We conducted a case-control study consisting of 44 cryptorchid cases, and 38 controls operated for inguinal hernia, umbilical hernia, or hydrocele at the Turku University Hospital or Rigshospitalet, Copenhagen in 2002-2006. During the operation a subcutaneous adipose tissue biopsy was taken. Samples were analysed for 37 PCBs, 17 PCDD/Fs and 14 PBDEs by gas chromatography-high-resolution mass spectrometry. Chemical concentrations were adjusted for postnatal variation introduced by differences in duration of breastfeeding, age at the operation, and country of origin with a multiple linear regression. Association between adjusted and unadjusted chemical concentrations and the risk of cryptorchidism were analysed with logistic regression to get an estimate for odds ratio (OR) of cryptorchidism per multiplication of chemical concentrations with ca. 2.71 (Napier's constant).
Total-TEq i.e. the WHO-recommended 2,3,7,8-TCDD equivalent quantity of 17 dioxins and 12 dioxin-like PCBs and sum of PCDD/Fs were positively associated with cryptorchidism [OR 3.21 (95% CI 1.29-9.09), OR 3.69 (95% CI 1.45-10.9), respectively], when adjusting for country of origin, the duration the child was breastfed, and age at operation. The association between the sum of PCBs and cryptorchidism was close to significant [OR 1.92 (95% CI 0.98-4.01)], whereas the association between the sum of PBDEs and cryptorchidism was not [OR 0.86 (95% CI 0.47-1.54)]. There were no associations between unadjusted chemical concentrations and the risk of cryptorchidism.
Prenatal exposure to PCDD/Fs and PCDD/F-like PCBs may be associated with increased risk for cryptorchidism. Our finding does not exclude the possibility of an association between the exposure to PBDEs and cryptorchidism.
Notes
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PubMed ID
26403566 View in PubMed
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Association between organic dietary choice during pregnancy and hypospadias in offspring: a study of mothers of 306 boys operated on for hypospadias.

https://arctichealth.org/en/permalink/ahliterature120122
Source
J Urol. 2013 Mar;189(3):1077-82
Publication Type
Article
Date
Mar-2013
Author
Jeppe Schultz Christensen
Camilla Asklund
Niels E Skakkebæk
Niels Jørgensen
Helle Raun Andersen
Troels Munch Jørgensen
Lars Henning Olsen
Anette Pernille Høyer
Jan Moesgaard
Jørgen Thorup
Tina Kold Jensen
Author Affiliation
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
Source
J Urol. 2013 Mar;189(3):1077-82
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Denmark - epidemiology
Diet - adverse effects
Female
Humans
Hypospadias - epidemiology - etiology - surgery
Incidence
Infant, Newborn
Life Style
Male
Maternal Exposure - adverse effects
Odds Ratio
Pregnancy
Questionnaires
Risk factors
Urologic Surgical Procedures, Male - methods
Abstract
The etiology of hypospadias is poorly understood. Exposure to pesticides has been considered a risk factor, although findings are inconsistent. Diet constitutes a significant exposure route for pesticides, and pesticide residues are more frequently reported in conventional than organic food products. We examined the association between organic dietary choice during pregnancy and presence of hypospadias in the offspring.
Mothers of 306 boys operated on for hypospadias were frequency matched for geography and child birth year to 306 mothers of healthy boys in a case-control study. Telephone interviews were conducted regarding demographic and lifestyle factors, including intake and organic choice of selected food items (milk, dairy products, egg, fruit, vegetables and meat). Logistic regression models were constructed for dietary variables, and odds ratios were calculated controlling for maternal age, body mass index and alcohol consumption.
Overall organic choice of food items during pregnancy was not associated with hypospadias in the offspring. However, frequent current consumption of high fat dairy products (milk, butter) while rarely or never choosing the organic alternative to these products during pregnancy was associated with increased odds of hypospadias (adjusted OR 2.18, 95% CI 1.09-4.36).
This large case-control study of boys operated on for hypospadias suggests an association between hypospadias in the offspring and the mother not choosing the organic alternative, and having a high current intake of nonorganic butter and cheese. This finding could be due to chemical contamination of high fat dairy products. However, general lifestyle and health behavior related to choosing organic alternatives may also explain the finding.
Notes
Comment In: J Urol. 2013 Mar;189(3):798-923246851
PubMed ID
23036983 View in PubMed
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Association Between Use of Marijuana and Male Reproductive Hormones and Semen Quality: A Study Among 1,215 Healthy Young Men.

https://arctichealth.org/en/permalink/ahliterature268197
Source
Am J Epidemiol. 2015 Sep 15;182(6):473-81
Publication Type
Article
Date
Sep-15-2015
Author
Tina Djernis Gundersen
Niels Jørgensen
Anna-Maria Andersson
Anne Kirstine Bang
Loa Nordkap
Niels E Skakkebæk
Lærke Priskorn
Anders Juul
Tina Kold Jensen
Source
Am J Epidemiol. 2015 Sep 15;182(6):473-81
Date
Sep-15-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Cross-Sectional Studies
Denmark - epidemiology
Follow-Up Studies
Healthy Volunteers
Humans
Incidence
Male
Marijuana Abuse - blood - epidemiology
Reproductive health
Retrospective Studies
Semen Analysis - methods
Sperm Count
Testosterone - blood
Young Adult
Abstract
A total of 1,215 young Danish men aged 18-28 years were recruited between 2008 and 2012 when they attended a compulsory medical examination to determine their fitness for military service. The participants delivered a semen sample, had a blood sample drawn, and underwent a physical examination. They responded to questionnaires including information on marijuana and recreational drug use during the past 3 months (no use, use once per week or less, or use more than once per week). A total of 45% had smoked marijuana within the last 3 months. Regular marijuana smoking more than once per week was associated with a 28% (95% confidence interval (CI): -48, -1) lower sperm concentration and a 29% (95% CI: -46, -1) lower total sperm count after adjustment for confounders. The combined use of marijuana more than once per week and other recreational drugs reduced the sperm concentration by 52% (95% CI: -68, -27) and total sperm count by 55% (95% CI: -71, -31). Marijuana smokers had higher levels of testosterone within the same range as cigarette smokers. Our findings are of public interest as marijuana use is common and may be contributing to recent reports of poor semen quality.
Notes
Comment In: Am J Epidemiol. 2015 Sep 15;182(6):482-426283091
PubMed ID
26283092 View in PubMed
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Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries.

https://arctichealth.org/en/permalink/ahliterature63426
Source
Am J Epidemiol. 2004 Jan 1;159(1):49-58
Publication Type
Article
Date
Jan-1-2004
Author
Tina Kold Jensen
Niels Jørgensen
Margus Punab
Trine B Haugen
Jyrki Suominen
Birute Zilaitiene
Antero Horte
Anne-Grethe Andersen
Elisabeth Carlsen
Øystein Magnus
Valentinas Matulevicius
Ingrid Nermoen
Matti Vierula
Niels Keiding
Jorma Toppari
Niels E Skakkebaek
Author Affiliation
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. tkjensen@health.sdu.dk
Source
Am J Epidemiol. 2004 Jan 1;159(1):49-58
Date
Jan-1-2004
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Cross-Sectional Studies
Europe - epidemiology
Female
Genital Diseases, Male - epidemiology - etiology - pathology
Humans
Male
Military Personnel
Pregnancy
Prenatal Exposure Delayed Effects
Questionnaires
Research Support, Non-U.S. Gov't
Semen - physiology
Smoking - adverse effects
Sperm Count
Testis - pathology
Abstract
Between 1996 and 1999, the authors invited all young men from five European countries who were undergoing compulsory medical examination for possible military service to participate in a study on male reproductive health. The participation rate was 19% in two cities in Denmark (n = 889), 17% in Oslo, Norway (n = 221), 13% in Turku, Finland (n = 313), 14% in Kaunas, Lithuania (n = 157), and 19% in Tartu, Estonia (n = 190). Each man provided a semen sample, was examined by a physician, and, in collaboration with his mother, completed a questionnaire about general and reproductive health, current smoking habits, and exposure to smoking in utero. After adjustment for confounding factors, men exposed to smoking in utero had a reduction in sperm concentration of 20.1% (95% confidence interval (CI): 6.8, 33.5) and a reduction in total sperm count of 24.5% (95% CI: 9.5, 39.5) in comparison with unexposed men. Percentages of motile and morphologically normal sperm cells were 1.85 (95% CI: 0.46, 3.23) and 0.64 (95% CI: -0.02, 1.30) percentage points lower, respectively, among men exposed in utero, and exposed men had a 1.15-ml (95% CI: 0.66, 1.64) smaller testis size. The associations were present when data from the study centers were analyzed separately (though not in Lithuania, where only 1% of mothers smoked during pregnancy), although the strength of the association varied. Maternal smoking may have long-term implications for the reproductive health of the offspring. This is another good reason to advise pregnant women to avoid smoking.
PubMed ID
14693659 View in PubMed
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Association of placenta organotin concentrations with congenital cryptorchidism and reproductive hormone levels in 280 newborn boys from Denmark and Finland.

https://arctichealth.org/en/permalink/ahliterature115317
Source
Hum Reprod. 2013 Jun;28(6):1647-60
Publication Type
Article
Date
Jun-2013
Author
Panu Rantakokko
Katharina M Main
Christine Wohlfart-Veje
Hannu Kiviranta
Riikka Airaksinen
Terttu Vartiainen
Niels E Skakkebæk
Jorma Toppari
Helena E Virtanen
Author Affiliation
National Institute for Health and Welfare, Department of Environmental Health, Chemical Exposure Unit, Neulaniementie 4, FI-70210 Kuopio, Finland. panu.rantakokko@thl.fi
Source
Hum Reprod. 2013 Jun;28(6):1647-60
Date
Jun-2013
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
Cryptorchidism - etiology
Denmark
Endocrine Disruptors - metabolism
Female
Finland
Follicle Stimulating Hormone - blood
Gas Chromatography-Mass Spectrometry
Gonadotropins, Pituitary - blood
Humans
Infant, Newborn
Logistic Models
Luteinizing Hormone - blood
Male
Organotin Compounds - metabolism
Placenta - metabolism
Pregnancy
Prenatal Exposure Delayed Effects
Risk factors
Sex Hormone-Binding Globulin - metabolism
Trialkyltin Compounds - metabolism
Abstract
Is the placental burden of organotin compounds (OTCs) associated with congenital cryptorchidism in infant offspring from Finland and Denmark?
Increasing concentrations of OTCs had a negative association with cryptorchidism in Finland, whereas a positive association was found in Denmark.
The rapid increase in the prevalence of cryptorchidism suggests that environmental factors, such as endocrine disruptors, may be involved. OTCs are endocrine disruptors at very low concentrations due to activation of the retinoid X receptor (RXR).
Between the years 1997 and 2001, placentas from mothers of cryptorchid boys and from healthy controls were collected from Denmark (39 cases, 129 controls) and Finland (56 cases, 56 controls). In Denmark 33 and 6 boys, and in Finland 22 and 34 boys had mild or severe cryptorchidism, respectively. The association between concentrations of four OTCs [monobutyltin (MBT), dibutyltin (DBT), tributyltin (TBT) and triphenyltin (TPhT)] and case-control status was estimated.
In both countries, placenta samples were selected from larger cohorts. In Finland placenta samples were collected from boys with cryptorchidism at birth and matched controls (nested case-control design). Matching criteria were parity, maternal smoking (yes/no), diabetes (yes/no), gestational age (±7 days) and date of birth (±14 days). Numbers of controls per case was 1. In Denmark, all available placentas from cryptorchid boys were chosen and control placentas were selected randomly from the total Danish cohort (case-cohort design). The average number of controls per case was 3.3. OTCs in placenta samples were analysed with liquid extraction, ethylation and gas chromatography-mass spectrometry determination and coded by country-specific tertiles.
Generally, the concentrations of OTCs were very low. For most analytes, a large proportion of samples (29-96% depending on the country and case-control status) had OTC concentrations below the limit of quantification (LOQ). As an exception, the concentration of TBT was >LOQ in 99% of Finnish placentas. The mean concentrations of DBT and TBT were 1.5 and 7 times higher in Finland than in Denmark, respectively. For DBT in Danish placentas, the odds ratio (OR) for cryptorchidism in the second tertile (0.10-0.14 ng/g) when compared with the first tertile (
PubMed ID
23520400 View in PubMed
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Association of placenta organotin concentrations with growth and ponderal index in 110 newborn boys from Finland during the first 18 months of life: a cohort study.

https://arctichealth.org/en/permalink/ahliterature257106
Source
Environ Health. 2014;13(1):45
Publication Type
Article
Date
2014
Author
Panu Rantakokko
Katharina M Main
Christine Wohlfart-Veje
Hannu Kiviranta
Riikka Airaksinen
Terttu Vartiainen
Niels E Skakkebæk
Jorma Toppari
Helena E Virtanen
Author Affiliation
National Institute for Health and Welfare, Department of Environmental Health, Toxicology and Chemical Exposure Unit, Neulaniementie 4, FI-70210 Kuopio, Finland. panu.rantakokko@thl.fi.
Source
Environ Health. 2014;13(1):45
Date
2014
Language
English
Publication Type
Article
Keywords
Adult
Child Development
Cohort Studies
Cryptorchidism - epidemiology
Environmental Pollutants - analysis
Female
Finland - epidemiology
Humans
Infant, Newborn
Male
Organotin Compounds - analysis
Placenta - chemistry
Pregnancy
Weight Gain
Young Adult
Abstract
Humans are exposed to tributyltin (TBT), previously used as an antifouling paint in ships, mainly through fish consumption. As TBT is a known obesogen, we studied the association of placenta TBT and other organotin compounds (OTCs) with ponderal index (PI) and growth during the first 18 months of life in boys.
In a prospective Finnish study, 110 placenta samples were collected from mothers of boys born in 1997-1999 with (n?=?55) and without (n?=?55) cryptorchidism. To account for the original study design, linear regression, weighted for sampling fractions of boys with (121/55) and without (5677/55) cryptorchidism from the total cohort, was used to study the association between placenta OTCs and children's weight, length, growth rates and PI up to 18 months of age.
Placenta TBT concentrations were above the limit of quantification (LOQ) in 99% of the samples. However, monobutyltin (MBT), dibutyltin (DBT) and triphenyltin (TPhT) concentrations were below LOQ in 90%, 35% and 57% of samples, respectively. Placenta TBT was positively associated (p?=?0.024) with weight gain during the first three months of life, but no other significant associations were observed for weight or length gain. Also, no significant associations between placenta OTC concentrations and child length, weight or PI at any time point were found.
We observed a trend towards higher weight gain from birth to 3 months of age with increasing placenta TBT concentration. These results should be interpreted with caution because obesogenic effects in animal experiments were seen after in-utero TBT exposures to doses that were orders of magnitude higher. Also the number of study subjects included in this study was limited.
Notes
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PubMed ID
24899383 View in PubMed
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Caffeine intake and semen quality in a population of 2,554 young Danish men.

https://arctichealth.org/en/permalink/ahliterature144645
Source
Am J Epidemiol. 2010 Apr 15;171(8):883-91
Publication Type
Article
Date
Apr-15-2010
Author
Tina Kold Jensen
Shanna H Swan
Niels E Skakkebaek
Sanne Rasmussen
Niels Jørgensen
Author Affiliation
University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. tkjensen@health.sdu.dk
Source
Am J Epidemiol. 2010 Apr 15;171(8):883-91
Date
Apr-15-2010
Language
English
Publication Type
Article
Keywords
Analysis of Variance
Caffeine - adverse effects
Chi-Square Distribution
Cross-Sectional Studies
Denmark
Drinking Behavior
Food Habits
Humans
Life Style
Male
Men
Military Personnel - statistics & numerical data
Questionnaires
Regression Analysis
Semen
Semen Analysis
Sperm Count
Sperm Motility
Statistics, nonparametric
Abstract
The authors examined the association between semen quality and caffeine intake among 2,554 young Danish men recruited when they were examined to determine their fitness for military service in 2001-2005. The men delivered a semen sample and answered a questionnaire including information about caffeine intake from various sources, from which total caffeine intake was calculated. Moderate caffeine and cola intakes (101-800 mg/day and 14 0.5-L bottles/week) and/or caffeine (>800 mg/day) intake was associated with reduced sperm concentration and total sperm count, although only significant for cola. High-intake cola drinkers had an adjusted sperm concentration and total sperm count of 40 mill/mL (95% confidence interval (CI): 32, 51) and 121 mill (95% CI: 92, 160), respectively, compared with 56 mill/mL (95% CI: 50, 64) and 181 mill (95% CI: 156, 210) in non-cola-drinkers, which could not be attributed to the caffeine they consumed because it was
Notes
Comment In: Am J Epidemiol. 2010 Jun 15;171(12):132420507902
PubMed ID
20338976 View in PubMed
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CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men.

https://arctichealth.org/en/permalink/ahliterature191829
Source
Lancet. 2002 Jan 5;359(9300):44-6
Publication Type
Article
Date
Jan-5-2002
Author
Ewa Rajpert-De Meyts
Henrik Leffers
Jørgen H Petersen
Anne Grethe Andersen
Elisabeth Carlsen
Niels Jørgensen
Niels E Skakkebaek
Source
Lancet. 2002 Jan 5;359(9300):44-6
Date
Jan-5-2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Case-Control Studies
Denmark
Humans
Infertility, Male - genetics
Male
Receptors, Androgen - blood - genetics
Risk factors
Sperm Count
Trinucleotide Repeats - genetics
Abstract
Several reports implicated a relation between the trinucleotide (CAG) repeat length in the androgen-receptor gene and male infertility, whereas others failed to find an association. We investigated the CAG repeat length in relation to sperm production and reproductive hormones in 119 infertile men and 110 men with proven fertility. We found no difference in the distribution of CAG repeat lengths between the groups and no association with reproductive parameters. This finding suggests that, within the normal range of 14-33 repeats, there is no biological link between the CAG repeat length and fertility. This lack of association was comfirmed by an analysis of the data from all previously published European studies (in total 674 infertile men and 660 controls).
PubMed ID
11809188 View in PubMed
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Circannual rhythm in the incidence of cryptorchidism in Finland.

https://arctichealth.org/en/permalink/ahliterature176412
Source
Int J Androl. 2005 Feb;28(1):53-7
Publication Type
Article
Date
Feb-2005
Author
Marko Kaleva
Helena E Virtanen
Anne-Maarit Haavisto
Katharina M Main
Mikko Reunanen
Niels E Skakkebaek
Jorma Toppari
Author Affiliation
Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland. marko.kaleva@utu.fi
Source
Int J Androl. 2005 Feb;28(1):53-7
Date
Feb-2005
Language
English
Publication Type
Article
Keywords
Circadian Rhythm
Cryptorchidism - epidemiology
Finland - epidemiology
Humans
Incidence
Male
Abstract
Conflicting data on circannual variation in birth rates of urogenital malformations have been reported previously. To assess risk factors of cryptorchidism we studied the seasonal variation of cryptorchidism in Finland. We performed a prospective cryptorchidism study in Turku, Finland, from 1997 to 2001 to evaluate the incidence of cryptorchidism. Clinical examinations were performed at birth and at 3 months. Of 9511 liveborn boys (1471 preterm boys) 216 (53 preterm boys) were cryptorchid at birth and 106 (19 preterm boys) at 3 months. The incidence of cryptorchidism was significantly higher in spring (February-April) (3.0%) than in summer (May-July) (1.7%) (OR 1.79; 95% CI: 1.23-2.63). This seasonal difference was observed both among preterm and term boys. We conclude that a circannual fluctuation in the incidence of cryptorchidism exists, which indicates an influence by environmental factors. The underlying reason for cyclicity affects similarly both preterm and term boys.
PubMed ID
15679622 View in PubMed
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Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience.

https://arctichealth.org/en/permalink/ahliterature136618
Source
Acta Paediatr. 2011 Jun;100(6):793-806
Publication Type
Article
Date
Jun-2011
Author
Lise Aksglaede
Niels E Skakkebaek
Kristian Almstrup
Anders Juul
Author Affiliation
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. lise.aksglaede@rh.regionh.dk
Source
Acta Paediatr. 2011 Jun;100(6):793-806
Date
Jun-2011
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Denmark
Follow-Up Studies
Humans
Infant
Klinefelter Syndrome - blood - complications - diagnosis - genetics
Male
Middle Aged
Mosaicism
Phenotype
Retrospective Studies
Testis - pathology
Young Adult
Abstract
Klinefelter syndrome (KS) is the most frequent sex chromosome disorder in males, but the phenotype varies greatly and is therefore highly under-diagnosed. We aimed at describing the phenotypic characteristics throughout life from clinical follow-up of our large cohort of patients with KS.
A retrospective observational study of 166 males with nonmosaic 47,XXY KS aged 0.3-80.3 years. Data on phenotype, growth, body composition, bone mineral density, sex hormones, lipids, glycosylated haemoglobin (HbA1C) and prostate-specific antigen were recorded. In addition, histological examination of testicular biopsies from 29 patients was performed.
Patients with Klinefelter were taller already in childhood. All patients had smaller testicular volume and elevated luteinizing hormone (LH) and follicle-stimulating hormone levels in adulthood. Cryptorchidism was reported in 14%, gynaecomastia in 44%, and 36% required speech therapy or educational support. The abnormal biochemical parameters became evident after onset of puberty and correlated with histological findings of a gradual deterioration of seminiferous tubules and massive Leydig cell hyperplasia in adults.
Our patients presented with a wide spectrum of the classical Klinefelter symptoms. In adulthood, two features were consistently present in every patient: small testes and high LH/testosterone ratio, often despite normal testosterone levels. Such biochemical parameters combined with small testes should lead to a suspicion of KS.
PubMed ID
21362037 View in PubMed
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