Skip header and navigation

Refine By

4 records – page 1 of 1.

Ambulatory cardiac arrhythmias in relation to mild hypokalaemia and prognosis in community dwelling middle-aged and elderly subjects.

https://arctichealth.org/en/permalink/ahliterature281049
Source
Europace. 2016 Apr;18(4):585-91
Publication Type
Article
Date
Apr-2016
Author
Nick Mattsson
Golnaz Sadjadieh
Preman Kumarathurai
Olav Wendelboe Nielsen
Lars Køber
Ahmad Sajadieh
Source
Europace. 2016 Apr;18(4):585-91
Date
Apr-2016
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Atrial Premature Complexes - etiology - mortality - physiopathology
Biomarkers - blood
Denmark
Disease-Free Survival
Diuretics - therapeutic use
Electrocardiography, Ambulatory
Female
Humans
Hypokalemia - blood - complications - diagnosis - drug therapy - mortality
Independent living
Kaplan-Meier Estimate
Linear Models
Logistic Models
Male
Middle Aged
Multivariate Analysis
Potassium - blood
Predictive value of tests
Proportional Hazards Models
Risk factors
Severity of Illness Index
Tachycardia, Supraventricular - etiology - mortality - physiopathology
Time Factors
Ventricular Premature Complexes - diagnosis - etiology - mortality - physiopathology
Abstract
Severe hypokalaemia can aggravate arrhythmia tendency and prognosis, but less is known about risk of mild hypokalaemia, which is a frequent finding. We examined the associations between mild hypokalaemia and ambulatory cardiac arrhythmias and their prognosis.
Subjects from the cohort of the 'Copenhagen Holter Study' (n = 671), with no history of manifest cardiovascular (CV) disease or stroke, were studied. All had laboratory tests and 48-h ambulatory electrocardiogram (ECG) recording. The median follow-up was 6.3 years. p-Potassium was inversely associated with frequency of premature ventricular complexes (PVCs) especially in combination with diuretic treatment (r = -0.22, P = 0.015). Hypokalaemia was not associated with supraventricular arrhythmias. Subjects at lowest quintile of p-potassium (mean 3.42, range 2.7-3.6 mmol/L) were defined as hypokalaemic. Cardiovascular mortality was higher in the hypokalaemic group (hazard ratio and 95% confidence intervals: 2.62 (1.11-6.18) after relevant adjustments). Hypokalaemia in combination with excessive PVC worsened the prognosis synergistically; event rates: 83 per 1000 patient-year in subjects with both abnormalities, 10 and 15 per 1000 patient-year in those with one abnormality, and 3 per 1000 patient-year in subjects with no abnormality. One variable combining hypokalaemia with excessive supraventricular arrhythmias gave similar results in univariate analysis, but not after multivariate adjustments.
In middle-aged and elderly subjects with no manifest heart disease, mild hypokalaemia is associated with increased rate of ventricular but not supraventricular arrhythmias. Hypokalaemia interacts synergistically with increased ventricular ectopy to increase the risk of adverse events.
PubMed ID
26293625 View in PubMed
Less detail

Improvement of clinical quality indicators through reorganization of the acute care by establishing an emergency department-a register study based on data from national indicators.

https://arctichealth.org/en/permalink/ahliterature269333
Source
Scand J Trauma Resusc Emerg Med. 2014;22:60
Publication Type
Article
Date
2014
Author
Maria Søe Mattsson
Nick Mattsson
Hanne B Jørsboe
Source
Scand J Trauma Resusc Emerg Med. 2014;22:60
Date
2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Critical Care - standards - trends
Critical Illness - therapy
Denmark
Emergencies
Emergency Service, Hospital - organization & administration
Female
Humans
Male
Middle Aged
Quality Improvement
Quality Indicators, Health Care - standards
Registries
Retrospective Studies
Abstract
The Emergency Departments (EDs) reorganization process in Denmark began in 2007 and includes creating a single entrance for all emergency patients, establishing triage, having a specialist in the front and introducing the use of electronic overview boards and electronic patient files. The aim of this study was to investigate the quality of acute care in a re-organized ED based on national indicator project data in a pre and post reorganizational setting.
Quasi experimental design was used to examine the effect of the health care quality in relation to the reorganization of an ED. Patients admitted at Nykøbing Falster Hospital in 2008 or 2012 were included in the study and data reports from the national databases (RKKP) regarding stroke, COPD, heart failure, bleeding and perforated ulcer or hip fracture were analysed. Holbæk Hospital works as a control hospital. Chi-square test was used for analysing significant differences from pre-and post intervention and Z-test to compare the experimental groups to the control group (HOL). P?
Notes
Cites: Scand J Trauma Resusc Emerg Med. 2013;21:7624180367
Cites: Am J Emerg Med. 2006 Nov;24(7):818-2117098104
Cites: QJM. 2008 Jul;101(7):529-3318417499
Cites: Emerg Med J. 2008 Dec;25(12):815-919033498
Cites: Ann Emerg Med. 2010 Feb;55(2):142-160.e119556030
Cites: Emerg Med J. 2010 Feb;27(2):86-9220156855
Cites: Scand J Trauma Resusc Emerg Med. 2013;21:6223938117
Cites: Scand J Trauma Resusc Emerg Med. 2011;19:4221718476
Cites: Scand J Trauma Resusc Emerg Med. 2011;19:4321771339
Cites: Ugeskr Laeger. 2011 Oct 3;173(40):2490-321975184
Cites: Scand J Trauma Resusc Emerg Med. 2012;20:2922490233
Cites: Acad Emerg Med. 2013 Jun;20(6):554-6123758301
Cites: Am J Emerg Med. 2013 Jul;31(7):1042-623706579
Cites: BMC Emerg Med. 2010;10:1220525299
PubMed ID
25370418 View in PubMed
Less detail

Mild Hypokalemia and Supraventricular Ectopy Increases the Risk of Stroke in Community-Dwelling Subjects.

https://arctichealth.org/en/permalink/ahliterature283189
Source
Stroke. 2017 Mar;48(3):537-543
Publication Type
Article
Date
Mar-2017
Author
Nick Mattsson
Preman Kumarathurai
Bjørn Strøier Larsen
Olav Wendelboe Nielsen
Ahmad Sajadieh
Source
Stroke. 2017 Mar;48(3):537-543
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Aged
Atrial Premature Complexes - complications - epidemiology
Denmark - epidemiology
Electrocardiography, Ambulatory
Female
Humans
Hypokalemia - complications - epidemiology
Incidence
Independent living
Male
Middle Aged
Risk
Stroke - epidemiology - etiology
Abstract
Stroke is independently associated with the common conditions of hypokalemia and supraventricular ectopy, and we hypothesize that the combination of excessive supraventricular ectopic activity and hypokalemia has a synergistic impact on the prognosis in terms of stroke in the general population.
Subjects (55-75 years old) from the Copenhagen Holter Study cohort (N=671) with no history of atrial fibrillation or stroke were studied-including baseline values of potassium and ambulatory 48-hour Holter monitoring. Excessive supraventricular ectopic activity is defined as =30 premature atrial complexes per hour or any episodes of runs of =20. Hypokalemia was defined as plasma-potassium =3.6 mmol/L. The primary end point was ischemic stroke. Cox models were used.
Hypokalemia was mild (mean, 3.4 mmol/L; range, 2.7-3.6). Hypokalemic subjects were older (67.0±6.94 versus 64.0±6.66 years; P
PubMed ID
28174323 View in PubMed
Less detail

Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmö Preventive Project Cohort.

https://arctichealth.org/en/permalink/ahliterature286660
Source
Stroke. 2017 Nov;48(11):2973-2978
Publication Type
Article
Date
Nov-2017
Author
Linda S Johnson
Nick Mattsson
Ahmad Sajadieh
Per Wollmer
Martin Söderholm
Source
Stroke. 2017 Nov;48(11):2973-2978
Date
Nov-2017
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Brain Ischemia - blood - mortality
Female
Follow-Up Studies
Humans
Male
Middle Aged
Potassium - blood
Risk factors
Stroke - blood - mortality
Sweden - epidemiology
Abstract
Low serum potassium is associated with stroke in populations with cardiovascular disease, hypertension, and diabetes mellitus but has not been studied in a mainly healthy population. We aimed to study the relation between serum potassium and incident stroke and mortality in the Malmö Preventive Project, a large cohort with screening in early mid-life and follow-up >25 years.
Serum potassium measurements and covariates were available in 21?353 individuals (79% men, mean age 44 years). Mean follow-up time was 26.9 years for stroke analyses and 29.3 years for mortality analyses. There were 2061 incident stroke events and 8709 deaths. Cox regression analyses adjusted for multiple stroke risk factors (age, sex, height, weight, systolic blood pressure, fasting blood glucose, serum sodium, current smoking, prevalent diabetes mellitus, prevalent coronary artery disease, and treatment for hypertension) were fitted.
There was an independent, linear association between serum potassium, per mmol/L increase, and both stroke (hazard ratio, 1.33; 95% confidence interval, 1.17-1.52; P
PubMed ID
28974633 View in PubMed
Less detail