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[Evolution of rheumatism in children during the past 30 years].

https://arctichealth.org/en/permalink/ahliterature231902
Source
Pediatriia. 1989;(4):13-7
Publication Type
Article
Date
1989
Author
N V Orlova
N S Kniazhetskaia
E V Soldatkin
Source
Pediatriia. 1989;(4):13-7
Date
1989
Language
Russian
Publication Type
Article
Keywords
Adolescent
Age Factors
Child
Child, Preschool
History, 20th Century
Humans
Rheumatic Fever - epidemiology - history
Rheumatic Heart Disease - epidemiology - history
Russia
Abstract
Based on the clinical, laboratory and instrumental studies made at the Cardiorheumatologic Department of the K.A. Rauchfuss City Child's Hospital in Leningrad the authors describe evolution shown by rheumatic fever in children over the recent 30 years. In their opinion, the cases of so-called classical rheumatic fever with moderate and maximal activity of the inflammatory process occurred more frequently over the recent years. In spite of this fact rheumatic fever in children is characterized today by the decreased number of relapses and by the reduced incidence of heart disease. Attention is drawn to the circumstance that over the recent years the pediatricians tend towards the underdiagnosis of rheumatic fever.
PubMed ID
2525248 View in PubMed
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[Somatic mutagenesis at T-cell receptor locus in inhabitants of radiation polluted regions as a result of the Chernobyl disaster].

https://arctichealth.org/en/permalink/ahliterature168174
Source
Radiats Biol Radioecol. 2006 May-Jun;46(3):307-14
Publication Type
Article
Author
I A Zamulaeva
S G Smirnova
N V Orlova
O A Vereshchagina
S Iu Chekin
I A Smirnova
L I Krikunova
V S Parshin
V K Ivanov
A S Saenko
Source
Radiats Biol Radioecol. 2006 May-Jun;46(3):307-14
Language
Russian
Publication Type
Article
Keywords
Chernobyl Nuclear Accident
Cytogenetic Analysis
Environmental Exposure
Environmental pollution
Female
Genes, T-Cell Receptor
Humans
Male
Mutagenesis
Mutation
Neoplasms - genetics
Radioactive Pollutants - toxicity
Russia
Abstract
In the period of 2001-2004, frequency of cells bearing mutations at T-cell receptor (TCR) locus was assessed in 553 inhabitants of radiation polluted regions of the Russian Federation and 154 unexposed control persons. The inhabitants were divided into three groups according to age at the moment of the Chernobyl disaster and 137Cs pollution density: 1) in utero, 37-555 kBq/m2; 2) 0-14 years old, 20-555 kBq/m2; 3) 18 and more years old, highest 137Cs density (185 more than 555 kBq/m2). The most intense changes of the TCR-mutant cell frequency were observed in the group of persons exposed to ionizing radiation in utero. The mean frequency of the mutant cells was higher in the first group than in age-matched control group by about 1.5-fold: 4.0 x 10(-4) vs 2.7 x 10(-4) accordingly (p
PubMed ID
16869162 View in PubMed
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[The association of TCR-mutant cells with DNA polymorphism in women residing in radiation polluted regions of the Russian Federation].

https://arctichealth.org/en/permalink/ahliterature148213
Source
Radiats Biol Radioecol. 2009 Jul-Aug;49(4):389-96
Publication Type
Article
Author
I A Zamulaeva
L E Sal'nikova
T I Ivanova
N V Orlova
S G Smirnova
N Sh Lapteva
A G Chumachenko
O B Belopol'skaia
L I Krikunova
I A Smirnova
A S Saenko
A V Rubanovich
Source
Radiats Biol Radioecol. 2009 Jul-Aug;49(4):389-96
Language
Russian
Publication Type
Article
Keywords
Cytochrome P-450 CYP1A1 - genetics
DNA - genetics
Environmental Exposure
Female
Flow Cytometry
Genital Diseases, Female - genetics - immunology
Genotype
Glutathione Transferase - genetics
Histocompatibility Antigens Class I - genetics
Humans
Lymphocyte Count
Lymphocytes - immunology
Membrane Proteins - genetics
Mutation
Polymorphism, Genetic
Radioactive Pollutants
Receptors, Antigen, T-Cell - genetics
Russia
Abstract
Using flow-cytometric method the frequency of lymphocytes beaming mutations at T-cell receptor (TCR) locus was assessed in women residing in radiation polluted regions of Bryansk and Tula Districts. Simultaneously genotyping of the 8 polymorph loci for genes involved in detoxication of xenobiotics and oestrogen metabolism was carried out. The increased TCR-mutant cell frequency was found to be characteristic of homozygotes of the low activity appropriated enzymes for 3 loci (HFE187, GSTM1 and MTHFR) at least. This tendency was statistically significant in case of deletion polymorphism of the GSTM1 gene: TCR-mutant cell frequency of the homozygous carriers of a deletion at the GSTM1 locus was (4.63 +/- 0.18) x 10(-4) while it was (4.05 +/- 0.15) x 10(-4) in other groups of persons. The greatest mutant cell frequency was observed in carriers of the minor allele 4889G of the locus CYP1A. More often the increased values of the TCR-mutant cells (outside range "3sigma") were determined in women with genotypes A/G or G/G of the locus CYP1A1 (25%) than in carries of the normal genotype A/A (1.6%) (OR = 20.6; p = 0.0002). The comparison of the groups of women with reproductive system diseases reveals significant elevation in the mean TCR-mutant cell frequency in inhabitants of the most radiation polluted region among others.
PubMed ID
19799358 View in PubMed
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