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Biopsy and histopathologic diagnosis of oral premalignant and malignant lesions.

https://arctichealth.org/en/permalink/ahliterature157899
Source
J Can Dent Assoc. 2008 Apr;74(3):283-8
Publication Type
Article
Date
Apr-2008
Author
Catherine F Poh
Samson Ng
Kenneth W Berean
P Michele Williams
Miriam P Rosin
Lewei Zhang
Author Affiliation
University of British Columbia, and BC Oral Cancer Prevention Program, BC Cancer Agency/Cancer Research Centre, Vancouver, British Columbia.
Source
J Can Dent Assoc. 2008 Apr;74(3):283-8
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
Biopsy - methods
British Columbia
Carcinoma, Squamous Cell - pathology
Epithelium - pathology
Humans
Mouth Neoplasms - pathology
Precancerous Conditions - pathology
Preventive Health Services - organization & administration
Abstract
Accurate diagnosis of premalignant or malignant oral lesions depends on the quality of the biopsy, adequate clinical information and correct interpretation of the biopsy results. The purpose of this paper is to review the procedures for obtaining appropriate biopsy samples, and the criteria for diagnosing and grading dysplasias. The World Health Organization's description of the architectural and cytologic epithelial changes that characterize dysplasia is detailed, and guidelines for following up patients with premalignant and malignant lesions are provided. The benefits of using the centralized services and expertise of the British Columbia Oral Biopsy Service are also reviewed.
PubMed ID
18387269 View in PubMed
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Canadian Optically-guided approach for Oral Lesions Surgical (COOLS) trial: study protocol for a randomized controlled trial.

https://arctichealth.org/en/permalink/ahliterature130191
Source
BMC Cancer. 2011;11:462
Publication Type
Article
Date
2011
Author
Catherine F Poh
J Scott Durham
Penelope M Brasher
Donald W Anderson
Kenneth W Berean
Calum E MacAulay
J Jack Lee
Miriam P Rosin
Author Affiliation
Department of Oral Biological and Medical Science, The University of British Columbia, Wesbrook Mall, Vancouver, Canada. cpoh@interchange.ubc.ca
Source
BMC Cancer. 2011;11:462
Date
2011
Language
English
Publication Type
Article
Keywords
Canada
Carcinoma in Situ - surgery
Carcinoma, Squamous Cell - surgery
Cost-Benefit Analysis
Double-Blind Method
Fluorescence
Head and Neck Neoplasms - surgery
Humans
Mouth Neoplasms - surgery
Neoplasm Recurrence, Local
Quality-Adjusted Life Years
Surgery, Computer-Assisted - economics - methods
Abstract
Oral cancer is a major health problem worldwide. The 5-year survival rate ranges from 30-60%, and has remained unchanged in the past few decades. This is mainly due to late diagnosis and high recurrence of the disease. Of the patients who receive treatment, up to one third suffer from a recurrence or a second primary tumor. It is apparent that one major cause of disease recurrence is clinically unrecognized field changes which extend beyond the visible tumor boundary. We have previously developed an approach using fluorescence visualization (FV) technology to improve the recognition of the field at risk surrounding a visible oral cancer that needs to be removed and preliminary results have shown a significant reduction in recurrence rates.
This paper describes the study design of a randomized, multi-centre, double blind, controlled surgical trial, the COOLS trial. Nine institutions across Canada will recruit a total of 400 patients with oral severe dysplasia or carcinoma in situ (N = 160) and invasive squamous cell carcinoma (N = 240). Patients will be stratified by participating institution and histology grade and randomized equally into FV-guided surgery (experimental arm) or white light-guided surgery (control arm). The primary endpoint is a composite of recurrence at or 1 cm within the previous surgery site with 1) the same or higher grade histology compared to the initial diagnosis (i.e., the diagnosis used for randomization); or 2) further treatment due to the presence of severe dysplasia or higher degree of change at follow-up. This is the first randomized, multi-centre trial to validate the effectiveness of the FV-guided surgery.
In this paper we described the strategies, novelty, and challenges of this unique trial involving a surgical approach guided by the FV technology. The success of the trial requires training, coordination, and quality assurance across multiple sites within Canada. The COOLS trial, an example of translational research, may result in reduced recurrence rates following surgical treatment of early-stage oral cancer with significant impacts on survival, morbidity, patients' quality of life and the cost to the health care system.
Clinicaltrials.gov NCT01039298.
Notes
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PubMed ID
22026481 View in PubMed
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Evaluation of a suspicious oral mucosal lesion.

https://arctichealth.org/en/permalink/ahliterature157900
Source
J Can Dent Assoc. 2008 Apr;74(3):275-80
Publication Type
Article
Date
Apr-2008
Author
P Michele Williams
Catherine F Poh
Allan J Hovan
Samson Ng
Miriam P Rosin
Author Affiliation
University of British Columbia and Department of Oral Oncology, BC Cancer Agency/Cancer Research Centre, Vancouver, British Columbia.
Source
J Can Dent Assoc. 2008 Apr;74(3):275-80
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
Alcohol Drinking
Biopsy
British Columbia
Coloring Agents - diagnostic use
Diagnosis, Differential
Fluorescence
Humans
Medical History Taking
Mouth Mucosa - pathology
Mouth Neoplasms - diagnosis - pathology
Physical Examination
Precancerous Conditions - diagnosis - pathology
Preventive Health Services
Smoking
Tolonium Chloride - diagnostic use
Abstract
Dentists who encounter a change in the oral mucosa of a patient must decide whether the abnormality requires further investigation. In this paper, we describe a systematic approach to the assessment of oral mucosal conditions that are thought likely to be premalignant or an early cancer. These steps, which include a comprehensive history, step-by-step clinical examination (including use of adjunctive visual tools), diagnostic testing and formulation of diagnosis, are routinely used in clinics affiliated with the British Columbia Oral Cancer Prevention Program (BC OCPP) and are recommended for consideration by dentists for use in daily practice.
PubMed ID
18387268 View in PubMed
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Gender- and ethnicity-specific survival trends of oral cavity and oropharyngeal cancers in British Columbia.

https://arctichealth.org/en/permalink/ahliterature119970
Source
Cancer Causes Control. 2012 Dec;23(12):1899-909
Publication Type
Article
Date
Dec-2012
Author
Ajit Auluck
Greg Hislop
Chris Bajdik
John Hay
Joan L Bottorff
Lewei Zhang
Miriam P Rosin
Author Affiliation
Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
Source
Cancer Causes Control. 2012 Dec;23(12):1899-909
Date
Dec-2012
Language
English
Publication Type
Article
Keywords
British Columbia - epidemiology
Female
Humans
Incidence
Male
Mouth Neoplasms - epidemiology - ethnology - mortality
Oropharyngeal Neoplasms - epidemiology - ethnology - mortality
Sex Factors
Survival Rate
Abstract
A shift in etiology of oral cancers has been associated with a rise in incidence for oropharyngeal cancers (OPC) and decrease for oral cavity cancers (OCC); however, there is limited information about population-based survival trends. We report epidemiological transitions in survival for both OPC and OCC from a population-based cancer registry, focusing upon gender and ethnic differences.
All primary oral cancers diagnosed between 1980 and 2005 were identified from the British Columbia Cancer Registry and regrouped into OPC and OCC by topographical subsites, time periods (1980-1993 and 1994-2005), stage at diagnosis, and ethnicity. Cases were then followed up to December 2009. Using gender-based analysis, actuarial life tables were used to calculate survival rates, which were compared using Kaplan-Meier curves and log-rank tests.
For OPC, survival improved, significant for tonsil and base of tongue in men and marginally significant at base of tongue in women. This improvement occurred in spite of an increase in late-stage diagnosis for OPC in both genders. Interestingly, there was no difference in survival for early- and late-stage disease for OPC in men. For OCC, there was a decrease in survival for floor of mouth cancers in both genders although significant in women only. South Asians had the poorest survival for OCC in both genders.
Survival for OPC improved, more dramatically in men than women, in spite of late-stage diagnosis and increasing nodal involvement. Given the poor survival rates and need for early detection, targeted OCC screening programs are required for South Asians.
PubMed ID
23053792 View in PubMed
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Heads up! - a call for dentists to screen for oral cancer.

https://arctichealth.org/en/permalink/ahliterature168831
Source
J Can Dent Assoc. 2006 Jun;72(5):413-6
Publication Type
Article
Date
Jun-2006
Author
Catherine F Poh
P Michele Williams
Lewei Zhang
Miriam P Rosin
Author Affiliation
University of British Columbia,2199 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z3.
Source
J Can Dent Assoc. 2006 Jun;72(5):413-6
Date
Jun-2006
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Dentists
Early Diagnosis
Humans
Mass Screening
Middle Aged
Mouth Neoplasms - diagnosis - mortality
Professional Role
Survival Rate
PubMed ID
16772064 View in PubMed
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A magic wand for the community dental office? Observations from the British Columbia Oral Cancer Prevention Program.

https://arctichealth.org/en/permalink/ahliterature161366
Source
J Can Dent Assoc. 2007 Sep;73(7):607-9
Publication Type
Article
Date
Sep-2007
Author
Denise M Laronde
Catherine F Poh
P Michele Williams
T Greg Hislop
Lewei Zhang
Calum MacAulay
Miriam P Rosin
Author Affiliation
BC Oral Cancer Prevention Program, BC Cancer Control Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z 1L3. Miriam_Rosin@shaw.ca
Source
J Can Dent Assoc. 2007 Sep;73(7):607-9
Date
Sep-2007
Language
English
Publication Type
Article
Keywords
British Columbia
Community Dentistry
Fluorescence
Humans
Light - diagnostic use
Mass Screening - instrumentation
Mouth Neoplasms - prevention & control
PubMed ID
17868508 View in PubMed
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New hope for an oral cancer solution: together we can make a difference.

https://arctichealth.org/en/permalink/ahliterature157902
Source
J Can Dent Assoc. 2008 Apr;74(3):261-6
Publication Type
Article
Date
Apr-2008
Author
Miriam P Rosin
Catherine F Poh
J Mark Elwood
P Michele Williams
Richard Gallagher
Calum MacAulay
Wan W Lam
Ajit Auluck
Lewei Zhang
T Gregory Hislop
Author Affiliation
Simon Fraser University, and BC Oral Cancer Prevention Program, BC Cancer Agency/Cancer Research Centre, Vancouver, British Columbia.
Source
J Can Dent Assoc. 2008 Apr;74(3):261-6
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
British Columbia
Canada
Coloring Agents - diagnostic use
Community-Institutional Relations
Fluorescence
Gene Expression Profiling
Humans
Imaging, Three-Dimensional
Mass Screening - methods
Microsatellite Repeats
Mouth Neoplasms - diagnosis - prevention & control
Preventive Health Services - organization & administration
Regional Health Planning
Saliva - chemistry
Tolonium Chloride - diagnostic use
Tumor Markers, Biological - analysis
Abstract
Oral cancer is associated with high mortality and morbidity rates, largely as a result of late diagnosis. Although dental practitioners are trained to identify premalignant and malignant lesions, an organized system is needed to offer guidance and to improve access to experts in diagnosis and management of these lesions. In this article, we describe the many ways in which the British Columbia Oral Cancer Prevention Program (BC OCPP) is addressing this challenge: by linking community dental practices and referral centres, by creating partnerships between scientists and clinicians that already have resulted in new technologies to enhance early diagnosis, by involving a broad range of stakeholders to ensure population-based screening and by engaging in provincial, national and international outreach.
Notes
Cites: Ann N Y Acad Sci. 2007 Mar;1098:184-9117435127
Cites: J Can Dent Assoc. 2008 Apr;74(3):239-4118387264
Cites: J Health Care Poor Underserved. 2007 Nov;18(4):767-7817982206
Cites: J Indian Med Assoc. 1999 Sep;97(9):370-310638084
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Comment In: J Can Dent Assoc. 2008 Apr;74(3):20718401900
PubMed ID
18387266 View in PubMed
Less detail
Source
J Can Dent Assoc. 2008 Apr;74(3):269-72
Publication Type
Article
Date
Apr-2008
Author
Denise M Laronde
T Greg Hislop
J Mark Elwood
Miriam P Rosin
Author Affiliation
Simon Fraser University and BC Oral Cancer Prevention Program, BC Cancer Agency/Cancer Research Centre, Vancouver, British Columbia.
Source
J Can Dent Assoc. 2008 Apr;74(3):269-72
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
Age Factors
Alcohol Drinking - adverse effects
Alphapapillomavirus - pathogenicity
Canada - epidemiology
Early Diagnosis
Humans
Incidence
Mass Screening
Mouth Neoplasms - diagnosis - epidemiology - etiology
Prevalence
Risk factors
Sex Factors
Smoking - adverse effects
Abstract
Oral cancer screening should be an integral part of a clinician's routine. This article reviews facts about oral cancer that are relevant to screening. The relevance of some issues in a particular dental practice will vary with the patient composition of the practice.
PubMed ID
18387267 View in PubMed
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Voices from the community--experiences from the dental office: initiating oral cancer screening.

https://arctichealth.org/en/permalink/ahliterature157904
Source
J Can Dent Assoc. 2008 Apr;74(3):239-41
Publication Type
Article
Date
Apr-2008
Author
Denise M Laronde
Joan L Bottorff
T Greg Hislop
Catherine Y Poh
Brenda Currie
P Michele Williams
Miriam P Rosin
Author Affiliation
Simon Fraser University and BC Oral Cancer Prevention Program, BC Cancer Agency/Cancer Research Centre, Vancouver, British Columbia. dlaronde@bccancer.bc.ca
Source
J Can Dent Assoc. 2008 Apr;74(3):239-41
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
British Columbia
Dentist's Practice Patterns
Dentist-Patient Relations
Education, Dental, Continuing
Humans
Mass Screening
Mouth Neoplasms - diagnosis
Patient Acceptance of Health Care
Professional Role
Time Management
PubMed ID
18387264 View in PubMed
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Why should dentists screen for oral cancer?

https://arctichealth.org/en/permalink/ahliterature157903
Source
J Can Dent Assoc. 2008 Apr;74(3):243-4
Publication Type
Article
Date
Apr-2008
Author
Zahra Musa
Karissa Johnston
Stuart Peacock
Miriam P Rosin
J Mark Elwood
Author Affiliation
University of British Columbia and Centre for Health Economics in Cancer, BC Cancer Agency/Cancer Research Centre, Vancouver, British Columbia. zmusa@bccrc.ca
Source
J Can Dent Assoc. 2008 Apr;74(3):243-4
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
Age Factors
Alcohol Drinking
British Columbia
Dentist's Practice Patterns
Early Diagnosis
Humans
Mass Screening
Mouth Neoplasms - diagnosis
Risk factors
Smoking
PubMed ID
18387265 View in PubMed
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10 records – page 1 of 1.