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An internet-based health survey on the co-morbidities of choroideremia patients.

https://arctichealth.org/en/permalink/ahliterature117429
Source
Ophthalmic Physiol Opt. 2013 Mar;33(2):157-63
Publication Type
Article
Date
Mar-2013
Author
Qi Zhou
Ekekiel Weis
Ming Ye
Shelly Benjaminy
Ian M MacDonald
Author Affiliation
Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Source
Ophthalmic Physiol Opt. 2013 Mar;33(2):157-63
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Canada - epidemiology
Child
Child, Preschool
Choroideremia - epidemiology - genetics
Comorbidity
Cross-Sectional Studies
Eye Diseases - epidemiology
Female
Health Surveys - methods
Heterozygote
Humans
Internet
Male
Middle Aged
Prevalence
Questionnaires
United States - epidemiology
Young Adult
Abstract
To examine the prevalence of systemic and ocular disease among choroideremia patients and carriers.
A cross-sectional analysis was performed on responses from affected males with choroideremia, female carriers, and unaffected brothers to an Internet-based survey made available from September 2009 to November 2010. Affected males were classified into two groups, those with or without functional vision. Carrier females were classified into those with and without symptoms. Comparisons were made between these groups.
There was a higher prevalence of dry eye in our respondents than the North American population. The prevalence of dry eye, cataract, hypertension, diabetes, psychological problems and hypercholesterolemia were higher in choroideremia males without functional vision compared to those with functional vision. Likewise, statin intake was more prevalent among the affected males without functional vision than those with functional vision. After age adjustment, any differences between the two subgroups of male patients (with and without functional vision) were not significant.
Age plays an important role in determining the onset of severe visual impairment with loss of functional vision in male subjects affected by choroideremia. Although Internet surveys have limitations such as the use of self-reported diagnoses and the possibility that the responses may not be representative of the population as a whole, this study shows that such surveys can provide data quickly and easily, and for rare diseases such as choroideremia, with relatively large numbers of responses.
PubMed ID
23297843 View in PubMed
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Association of breastfeeding with asthma in young Aboriginal children in Canada.

https://arctichealth.org/en/permalink/ahliterature117973
Source
Can Respir J. 2012 Nov-Dec;19(6):361-6
Publication Type
Article
Author
Ming Ye
Piushkumar J Mandhane
Ambikaipakan Senthilselvan
Author Affiliation
Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta.
Source
Can Respir J. 2012 Nov-Dec;19(6):361-6
Language
English
Publication Type
Article
Keywords
Age Factors
Asthma - ethnology
Breast Feeding - ethnology
Canada - epidemiology
Child
Child, Preschool
Female
Health Surveys
Humans
Indians, North American - statistics & numerical data
Infant
Infant, Newborn
Inuits - statistics & numerical data
Male
Prevalence
Abstract
Few studies have investigated the factors associated with asthma in young Aboriginal children.
To characterize the association of demographic, environmental and early life factors with asthma in young Aboriginal children in Canada.
The 2006 Aboriginal Children's Survey was conducted among off-reserve Aboriginal children zero to six years of age to obtain information on Aboriginal children's development and well-being. The prevalence of asthma in Aboriginal children was obtained from the parental report of asthma as diagnosed by a health care professional.
The prevalence of reported asthma among off-reserve Aboriginal children zero to six years of age (n=14,170) was 9.4%. Asthma prevalence in both exclusively breastfed children (6.8%) and ever but not exclusively breastfed children (9.0%) was significantly lower than that in nonbreastfed children (11.0%). In the multiple logistic regression analysis, exclusive breastfeeding was protective of asthma compared with nonbreastfeeding (OR 0.59 [95% CI 0.44 to 0.78]). Older age groups, male sex, having two or more older siblings, low birth weight, day care attendance and ear infection were significant risk factors for asthma.
The prevalence of asthma among young Aboriginal children zero to six years of age living off reserve was slightly lower than that reported for all other Canadian children. Breastfeeding, especially exclusively breastfeeding, was protective of asthma in Aboriginal children, which is consistent with what has been observed in non-Aboriginal children in Canada. Public health interventions intended for reducing asthma incidence in young Aboriginal children should include breastfeeding promotion programs.
Notes
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PubMed ID
23248799 View in PubMed
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Disparities in healthcare utilisation rates for Aboriginal and non-Aboriginal Albertan residents, 1997-2006: a population database study.

https://arctichealth.org/en/permalink/ahliterature118966
Source
PLoS One. 2012;7(11):e48355
Publication Type
Article
Date
2012
Author
Helen Chung
Ming Ye
Chris Hanson
Oluwaseun Oladokun
Michael J Campbell
Gordon Kramer
Ordan J Lehmann
Author Affiliation
Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada.
Source
PLoS One. 2012;7(11):e48355
Date
2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Alberta - ethnology
Child
Child, Preschool
Databases, Factual
Healthcare Disparities - ethnology - history
History, 20th Century
History, 21st Century
Humans
Infant
Infant, Newborn
Life expectancy
Middle Aged
Young Adult
Abstract
It is widely recognised that significant discrepancies exist between the health of indigenous and non-indigenous populations. Whilst the reasons are incompletely defined, one potential cause is that indigenous communities do not access healthcare to the same extent. We investigated healthcare utilisation rates in the Canadian Aboriginal population to elucidate the contribution of this fundamental social determinant for health to such disparities.
Healthcare utilisation data over a nine-year period were analysed for a cohort of nearly two million individuals to determine the rates at which Aboriginal and non-Aboriginal populations utilised two specialties (Cardiology and Ophthalmology) in Alberta, Canada. Unadjusted and adjusted healthcare utilisation rates obtained by mixed linear and Poisson regressions, respectively, were compared amongst three population groups - federally registered Aboriginals, individuals receiving welfare, and other Albertans.
Healthcare utilisation rates for Aboriginals were substantially lower than those of non-Aboriginals and welfare recipients at each time point and subspecialty studied [e.g. During 2005/06, unadjusted Cardiology utilisation rates were 0.28% (Aboriginal, n?=?97,080), 0.93% (non-Aboriginal, n?=?1,720,041) and 1.37% (Welfare, n?=?52,514), p?=?
Notes
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PubMed ID
23152770 View in PubMed
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Evidence of genetic heterogeneity in Alberta Hutterites with Usher syndrome type I.

https://arctichealth.org/en/permalink/ahliterature123521
Source
Mol Vis. 2012;18:1379-83
Publication Type
Article
Date
2012
Author
Qi Zhou
Chaeli Lenger
Richard Smith
William J Kimberling
Ming Ye
Ordan Lehmann
Ian MacDonald
Author Affiliation
Department of Ophthalmology, Peking Union Medical College, Beijing, China.
Source
Mol Vis. 2012;18:1379-83
Date
2012
Language
English
Publication Type
Article
Keywords
Adolescent
Alberta
Cadherins - genetics
Child
Ethnic Groups - genetics
Exons
Female
Genetic Heterogeneity
Genetic Linkage
Genotype
Homozygote
Humans
Male
Myosins - genetics
Pedigree
Phenotype
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Siblings
Usher Syndromes - genetics - pathology
Abstract
To identify the genetic defect in a Hutterite population from northern Alberta with Usher syndrome type I.
Complete ophthalmic examinations were conducted on two boys and two girls from two related Hutterite families diagnosed with Usher syndrome type I. DNA from patients and their parents was first evaluated for a mutation in exon 10 of the protocadherin-related 15 (PCDH15) gene (c.1471delG), previously reported in southern Alberta Hutterite patients with Usher syndrome (USH1F). Single nucleotide polymorphic linkage analysis was then used to confirm another locus, and DNA was analyzed with the Usher Chip v4.0 platform.
Severe hearing impairment, unintelligible speech, and retinitis pigmentosa with varying degrees of visual acuity and visual field loss established a clinical diagnosis of Usher syndrome type I. The patients did not carry the exon 10 mutation in the PCDH15 gene; however, with microarray analysis, a previously reported mutation (c.52C>T; p.Q18X) in the myosin VIIA (MYO7A) gene was found in the homozygous state in the affected siblings.
The finding of a MYO7A mutation in two related Hutterite families from northern Alberta provides evidence of genetic heterogeneity in Hutterites affected by Usher syndrome type I.
Notes
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PubMed ID
22690115 View in PubMed
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