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Relation of PvuII site polymorphism in the COL1A2 gene to the risk of fractures in prepubertal Finnish girls.

https://arctichealth.org/en/permalink/ahliterature184882
Source
Physiol Genomics. 2003 Aug 15;14(3):217-24
Publication Type
Article
Date
Aug-15-2003
Author
Miia Suuriniemi
Anitta Mahonen
Vuokko Kovanen
Markku Alén
Sulin Cheng
Author Affiliation
Department of Cell Biology, University of Jyväskylä, Finland.
Source
Physiol Genomics. 2003 Aug 15;14(3):217-24
Date
Aug-15-2003
Language
English
Publication Type
Article
Keywords
Binding Sites - genetics
Bone Density - genetics
Bone Remodeling - genetics
Child
Collagen - genetics
Collagen Type I
Deoxyribonucleases, Type II Site-Specific - genetics
Female
Finland - epidemiology
Fractures, Bone - epidemiology - genetics
Genetic Predisposition to Disease - genetics
Humans
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide
Puberty - genetics
Retrospective Studies
Risk factors
Abstract
Genetic susceptibility to fractures may be detectable in early childhood. We evaluated the associations between the polymorphic PvuII site of the COL1A2 gene and bone properties assessed by different modalities (dual-energy X-ray absorptiometry; peripheral quantitative computed tomography; gel coupling scanning quantitative ultrasonometry; ultrasound bone sonometry), bone turnover markers, and the occurrence of fractures in 244 prepubertal Finnish girls. Tanner stage and physical characteristics did not differ significantly among girls with different COL1A2 genotypes. The polymorphism was not significantly associated with different bone properties or any of the bone turnover markers when girls at Tanner stage I (prepuberty) and stage II (early puberty) were considered together, but there was a significant association with spine bone mineral content (BMC) and bone mineral density (BMD), as well as with speed of sound (SOS) (P
PubMed ID
12813128 View in PubMed
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