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Folic acid fortification prevents neural tube defects and may also reduce cancer risks.

https://arctichealth.org/en/permalink/ahliterature122710
Source
Acta Paediatr. 2012 Oct;101(10):1007-12
Publication Type
Article
Date
Oct-2012
Author
Margaretha Jägerstad
Author Affiliation
Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden. Margaretha.Jagerstad@slu.se
Source
Acta Paediatr. 2012 Oct;101(10):1007-12
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Dietary Supplements - adverse effects - standards - statistics & numerical data
Dose-Response Relationship, Drug
Europe - epidemiology
Female
Flour
Folic Acid - administration & dosage - adverse effects
Food, Fortified - adverse effects - standards - statistics & numerical data
Guidelines as Topic
Humans
Mandatory Programs
Neoplasms - chemically induced
Neural Tube Defects - epidemiology - prevention & control
Nutritional Requirements
Pregnancy
Pregnancy Complications - prevention & control
Prevalence
Program Evaluation
Risk assessment
United States - epidemiology
World Health
Abstract
The prevalence of neural tube defect (NTD)-affected pregnancies ranges between 0.4 and 2/1000 pregnancies in EU. NTDs result in severe malformations and sometimes miscarriages. Children born with NTD suffer for the rest of their life of disability and chronic healthcare issues, and many women therefore choose termination of pregnancy if NTD is diagnosed prenatally. Women planning for pregnancy are recommended to eat 400 µg folic acid/d, whereas average figures across Europe indicate intakes of ~250 µg/d for women of fertile age, a gap that could be bridged by implementation of folic acid fortification. The results of mandatory folic acid fortifications introduced in USA and Canada are a decrease between 25 and 45% of NTD pregnancies.
Evidence-based NTD prophylaxis is now practised in more than 60 countries worldwide. EU countries worry over possible cancer risks, but ignore a wealth of studies reporting decreasing cancer risks with folate intakes at recommended levels. Currently, there are indications of a U-shaped relationship, that is, higher cancer risks at low folate intakes (1 mg/day), respectively. However neither the global World Cancer Research review nor EU's European Food Safety Authority report present data on increased cancer risk at physiological folate intake levels. Therefore, EU should act to implement folic acid fortification as NTD prophylaxis as soon as possible.
Notes
Comment In: Acta Paediatr. 2012 Oct;101(10):100622928788
PubMed ID
22783992 View in PubMed
Less detail

Study of wheat breakfast rolls fortified with folic acid. The effect on folate status in women during a 3-month intervention.

https://arctichealth.org/en/permalink/ahliterature61647
Source
Eur J Nutr. 2002 Dec;41(6):279-86
Publication Type
Article
Date
Dec-2002
Author
Madelene Johansson
Cornelia M Witthöft
Ake Bruce
Margaretha Jägerstad
Author Affiliation
Dept. of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden. madelene.johansson@lmv.slu.se
Source
Eur J Nutr. 2002 Dec;41(6):279-86
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adult
Biological Availability
Bread
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Erythrocytes - chemistry
Female
Folic Acid - administration & dosage - blood - pharmacokinetics
Food Handling - methods
Food, Fortified
Homocysteine - blood
Humans
Middle Aged
Neural Tube Defects - prevention & control
Nutritional Status
Research Support, Non-U.S. Gov't
Triticum
Abstract
BACKGROUND: Folate has come into focus due to its protective role against child birth defects such as neural tube defects (NTD). Swedish authorities recommend all fertile women to increase their folate intake to 400 microg/day by eating folate-rich foods. Because not all women follow these recommendations, there is a discussion today about whether Sweden should introduce folic acid fortification in wheat flour and sifted rye flour. This decision needs knowledge about the bioavailability of folic acid from fortified foods. AIM OF THE STUDY: To investigate effects of two folic acid fortification levels on folate status in healthy female volunteers and to study the folic acid stability during the baking procedure and storage of the fortified breakfast rolls. METHOD: Twenty-nine healthy women were recruited. Folic acid-fortified wheat breakfast rolls were baked with the purpose to contain 200 microg folic acid/roll (roll L) and 400 microg folic acid/roll (roll H). Fourteen women were given one roll/day of roll L (group L) and 15 one roll/day of roll H (group H) during 12 weeks of intervention. Fasting venous blood samples were collected on days 0, 30, 60 and 90. Serum homocysteine concentrations were determined using an immunoassay. Serum and erythrocyte folate concentrations were analysed using a protein-binding assay with fluorescent quantification. The folic acid concentration in the breakfast rolls was analysed by HPLC on days 0, 30, 60 and 90. Total folate concentration was measured with microbiological assay on day 45. RESULTS: Group L Group L had initially an average erythrocyte folate concentration of 577 +/- 93 nmol/L. After 90 days of intervention, an increase of 20 % (p
PubMed ID
12474072 View in PubMed
Less detail

[Sweden should introduce mandatory folic acid fortification. Risk of cancer is not convincingly proved--neural tube defect prophylaxis is more important].

https://arctichealth.org/en/permalink/ahliterature125607
Source
Lakartidningen. 2011 Dec 7-13;108(49):2558-9
Publication Type
Article