Skip header and navigation

Refine By

27 records – page 1 of 3.

The aetiology of paediatric bloodstream infections changes after pneumococcal vaccination and group B streptococcus prophylaxis.

https://arctichealth.org/en/permalink/ahliterature273598
Source
Acta Paediatr. 2015 Sep;104(9):933-9
Publication Type
Article
Date
Sep-2015
Author
Joachim Luthander
Rutger Bennet
Christian G Giske
Anna Nilsson
Margareta Eriksson
Source
Acta Paediatr. 2015 Sep;104(9):933-9
Date
Sep-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Antibiotic Prophylaxis
Bacteremia - microbiology - prevention & control
Child
Child, Preschool
Female
Gram-Positive Bacterial Infections - microbiology - prevention & control
Humans
Infant
Infant, Newborn
Male
Pneumococcal Vaccines
Retrospective Studies
Staphylococcus aureus
Streptococcus agalactiae
Streptococcus pneumoniae
Sweden
Abstract
This study explored the incidence and aetiology of bloodstream infections after patients received the pneumococcal conjugate vaccination and a risk-based intrapartum antibiotic prophylaxis against early onset sepsis caused by group B streptococcus. We also monitored clinically relevant antimicrobial resistance.
We studied 3986 positive blood cultures from children up to 17?years of age at a paediatric hospital in Stockholm, Sweden, using data from medical records before and after the initiatives, to reduce early onset sepsis, were introduced in 2007 and 2008.
Bloodstream infections caused by Streptococcus pneumoniae declined by 42% overall (5.6 to 3.2/100?000) and by 62% in previously healthy children under 36?months of age (24.2 to 9.2/100?000). Early onset sepsis caused by group B streptococcus declined by 60% (0.5 to 0.2/1000 live born children). Bacterial meningitis caused by these bacteria decreased by 70%. Staphylococcus aureus and various Gram-negative bacteria became the dominant pathogens, in both previously healthy children and those with underlying disease. Overall, antimicrobial resistance remained low between the two 5-year study periods.
Pneumococcal conjugate vaccination and risk-based intrapartum antibiotic prophylaxis against group B streptococcus effectively decreased the incidence of bloodstream infections. Empirical antibiotic therapy should target Staphylococcus aureus in?both community and hospital-acquired invasive bacterial infections.
PubMed ID
26060088 View in PubMed
Less detail

Age and risk factors influence the microbial aetiology of bloodstream infection in children.

https://arctichealth.org/en/permalink/ahliterature119258
Source
Acta Paediatr. 2013 Feb;102(2):182-6
Publication Type
Article
Date
Feb-2013
Author
Joachim Luthander
Rutger Bennet
Christian G Giske
Anna Nilsson
Margareta Eriksson
Author Affiliation
Pediatric Infectious Diseases Unit at the Pediatric Emergency Department, Astrid Lindgren's Children Hospital, Stockholm, Sweden. joachim.luthander@karolinska.se
Source
Acta Paediatr. 2013 Feb;102(2):182-6
Date
Feb-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Age Factors
Anti-Bacterial Agents - therapeutic use
Bacteremia - drug therapy - epidemiology - etiology - microbiology
Candidemia - drug therapy - epidemiology - etiology - microbiology
Child
Child, Preschool
Comorbidity
Drug Resistance, Bacterial
Humans
Incidence
Infant
Infant, Newborn
Pneumococcal Infections - drug therapy - epidemiology - etiology - microbiology
Retrospective Studies
Risk factors
Staphylococcal Infections - drug therapy - epidemiology - etiology - microbiology
Sweden - epidemiology
Treatment Outcome
Abstract
To study the aetiology of bloodstream infections (BSI) in children 0-17 years, the influence of age and underlying co-morbidity on BSI rate, distribution of pathogens and outcome; and to provide data on antimicrobial susceptibility patterns.
A retrospective population-based study. Data on blood cultures were collected at yearly intervals during 1998-2008. Information about risk factors, focal infection and outcome was retrieved from the patient charts.
We identified 1097 BSI. The incidence of BSI was 0.4/1000. The age-specific incidence was 2.3/1000 in neonates (0-28 days old) and 0.2/1000 in the age group 6-17 years. Staphylococcus aureus was the most common pathogen. The number of species causing BSI in previously healthy children was lower compared with children with co-morbidity. Most children requiring intensive care had a serious underlying illness. Antimicrobial resistance was rare and did not influence outcome. The case-fatality rate was 14.4% in neonates, 5.4% in children with co-morbidity and 1.7% in previously healthy children.
Mortality from BSI is low, and a limited spectrum of pathogens is isolated from previously healthy children compared with children with co-morbidity. When choosing empirical therapy for suspected BSI, age and presence of risk factors should be taken into account.
PubMed ID
23121094 View in PubMed
Less detail

Burden of severe rotavirus disease leading to hospitalization assessed in a prospective cohort study in Sweden.

https://arctichealth.org/en/permalink/ahliterature259023
Source
Scand J Infect Dis. 2014 Apr;46(4):294-302
Publication Type
Article
Date
Apr-2014
Author
Malin Rinder
Anh Nhi Tran
Rutger Bennet
Maria Brytting
Tobias Cassel
Margareta Eriksson
Deborah Frithiof
Leif Gothefors
Jann Storsaeter
Birger Trollfors
Sindri Valdimarsson
Martin Wennerström
Kari Johansen
Source
Scand J Infect Dis. 2014 Apr;46(4):294-302
Date
Apr-2014
Language
English
Publication Type
Article
Keywords
Child, Preschool
Community-Acquired Infections - epidemiology - virology
Cross Infection - epidemiology - virology
Female
Gastroenteritis - epidemiology - virology
Hospitalization - statistics & numerical data
Humans
Incidence
Infant
Infant, Newborn
Male
Prospective Studies
Rotavirus - genetics - isolation & purification
Rotavirus Infections - epidemiology - virology
Sweden - epidemiology
Abstract
The aim of this prospective cohort study was to estimate the burden of severe disease caused by rotavirus-induced gastroenteritis in Swedish children aged 38.5°C upon admission. Complications occurred in > 10% of the children, with hypertonic dehydration (32/604) and seizures (10/604) occurring most frequently.
Rotaviruses may cause severe febrile acute gastroenteritis leading to dehydration requiring acute rehydration in hospital. In addition, further complications occurred in > 10% of hospitalized children.
PubMed ID
24484415 View in PubMed
Less detail

Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types.

https://arctichealth.org/en/permalink/ahliterature264841
Source
Eur Respir J. 2014 Dec;44(6):1646-57
Publication Type
Article
Date
Dec-2014
Author
Sarah Browall
Erik Backhaus
Pontus Naucler
Ilias Galanis
Karin Sjöström
Diana Karlsson
Stefan Berg
Joachim Luthander
Margareta Eriksson
Carl Spindler
Mikael Ejdebäck
Birger Trollfors
Jessica Darenberg
Mats Kalin
Ake Örtqvist
Rune Andersson
Birgitta Henriques-Normark
Source
Eur Respir J. 2014 Dec;44(6):1646-57
Date
Dec-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Carrier state
Child
Child, Preschool
Cohort Studies
Comorbidity
DNA, Bacterial - analysis
Diabetes Mellitus - epidemiology
Female
Hematologic Neoplasms - epidemiology
Humans
Infant
Infant, Newborn
Logistic Models
Lung Diseases - epidemiology
Male
Meningitis, Pneumococcal - epidemiology - microbiology - prevention & control
Middle Aged
Molecular Epidemiology
Odds Ratio
Pneumococcal Infections - epidemiology - microbiology - prevention & control
Pneumococcal Vaccines - immunology - therapeutic use
Pneumonia, Pneumococcal - epidemiology - microbiology - prevention & control
Serogroup
Serotyping
Streptococcus pneumoniae - genetics - immunology - isolation & purification
Sweden - epidemiology
Young Adult
Abstract
Pneumococcal conjugated vaccines (PCVs) have shown protection against invasive pneumococcal disease by vaccine serotypes, but an increase in non-vaccine serotype disease has been observed. Type-specific effects on clinical manifestation need to be explored. Clinical data from 2096 adults and 192 children with invasive pneumococcal disease were correlated to pneumococcal molecular serotypes. Invasive disease potential for pneumococcal serotypes were calculated using 165 invasive and 550 carriage isolates from children. The invasive disease potential was lower for non-PCV13 compared to vaccine-type strains. Patients infected with non-PCV13 strains had more underlying diseases, were less likely to have pneumonia and, in adults, tended to have a higher mortality. Furthermore, patients infected with pneumococci belonging to clonal serotypes only expressing non-PCV13 capsules had a higher risk for septicaemia and mortality. PCV vaccination will probably lead to a decrease in invasive pneumococcal disease but an alteration in the clinical manifestation of invasive pneumococcal disease. Genetic lineages causing invasive pneumococcal disease in adults often express non-vaccine serotypes, which can expand after vaccination with an increased risk of infection in patients with underlying diseases.
PubMed ID
25323223 View in PubMed
Less detail

Coexistence of two clades of enterovirus D68 in pediatric Swedish patients in the summer and fall of 2014.

https://arctichealth.org/en/permalink/ahliterature272581
Source
Infect Dis (Lond). 2015;47(10):734-8
Publication Type
Article
Date
2015
Author
Robert Dyrdak
Maria Rotzén-Östlund
Agneta Samuelson
Margareta Eriksson
Jan Albert
Source
Infect Dis (Lond). 2015;47(10):734-8
Date
2015
Language
English
Publication Type
Article
Keywords
Capsid Proteins - genetics
Child
Child, Preschool
Disease Outbreaks
Enterovirus - genetics - isolation & purification - physiology
Enterovirus D, Human - classification - genetics - physiology
Enterovirus Infections - diagnosis - epidemiology - virology
Female
Genotype
Humans
Infant
Infant, Newborn
Male
Phylogeny
Respiratory Tract Infections - epidemiology - virology
Rhinovirus - genetics - isolation & purification - physiology
Seasons
Sequence Analysis, DNA
Sweden - epidemiology
Abstract
In 2014, an outbreak of enterovirus D68 (EV-D68) was observed in North America, with cases of severe respiratory illness and a possible etiological link to cases of acute flaccid paralysis. EV-D68 has also been reported from European countries, but no data from Sweden are available. This study investigated respiratory specimens collected during July-October 2014 from 30 Swedish children aged 0-9 years who were positive for enterovirus and/or rhinovirus in routine clinical PCR. Seven samples were typed as EV-D68 by VP4/VP2 sequencing. Two genetically distinct EV-D68 variants coexisted. Six viruses belonged to clade B, the variant involved in the North American outbreak, and one virus belonged to clade A. Respiratory illness was the major symptom among EV-D68 infected patients and all fully recovered. This is the first report of EV-D68 in Sweden. Considering the current epidemiological situation, genotyping and specific EV-D68 testing should be considered in patients with severe respiratory illness who test positive for enterovirus or rhinovirus in routine diagnostics.
PubMed ID
25972105 View in PubMed
Less detail

Effectiveness of the monovalent AS03-adjuvanted influenza A(H1N1)pdm09 vaccine against hospitalization in children because of influenza.

https://arctichealth.org/en/permalink/ahliterature122416
Source
Vaccine. 2012 Aug 24;30(39):5699-702
Publication Type
Article
Date
Aug-24-2012
Author
Ake Ortqvist
Rutger Bennet
Malin Ryd Rinder
Hans Lindblad
Margareta Eriksson
Author Affiliation
Karolinska Institutet, Department of Medicine, Unit of Infectious Diseases, Karolinska Solna, Sweden. ake.ortqvist@sll.se
Source
Vaccine. 2012 Aug 24;30(39):5699-702
Date
Aug-24-2012
Language
English
Publication Type
Article
Keywords
Adjuvants, Immunologic - administration & dosage
Adolescent
Case-Control Studies
Child
Child, Preschool
Hospitalization - statistics & numerical data
Humans
Infant
Influenza A Virus, H1N1 Subtype
Influenza Vaccines
Influenza, Human - epidemiology - prevention & control
Retrospective Studies
Sweden - epidemiology
Vaccination - statistics & numerical data
Abstract
We studied the effectiveness of the AS03-adjuvanted monovalent vaccine (Pandemrix(®)) for the prevention of severe pandemic influenza A(H1N1)pdm09 in children, in 2009. All children hospitalized for influenza-like illness in Stockholm County during the peak of the pandemic were included. We compared the frequency of vaccinated children between influenza A(H1N1)pdm09 PCR positive cases and PCR negative controls in a retrospective case-control study. 95 cases and 177 controls were identified. About half of the children in both groups were between 6 months and 2 years of age. Only 1/95 (1%) cases had been vaccinated more than 14 days prior to admission, compared to 23/177 controls (13%), corresponding to a vaccine effectiveness, adjusted for co-morbid conditions, of 91% (95% confidence interval [CI] 30-99). In contrast, the risk for being a case was significantly higher among children vaccinated between 1 and 14 days prior to hospitalization, than among those who were non-vaccinated 13/95 vs. 7/177 (OR 3.6, 95% CI 1.4-9.5). We conclude that a single dose of adjuvanted vaccine was highly protective against hospitalization for influenza A(H1N1)pdm09 in children 6 month to 17 years. The reason for the increased rate of hospitalizations with confirmed influenza in children just following immunization is unclear and should be studied further.
PubMed ID
22819987 View in PubMed
Less detail

The impact of pneumococcal conjugate vaccine on community-acquired pneumonia hospitalizations in children with comorbidity.

https://arctichealth.org/en/permalink/ahliterature284739
Source
Eur J Pediatr. 2017 Mar;176(3):337-342
Publication Type
Article
Date
Mar-2017
Author
Ellinor Sterky
Rutger Bennet
Ann Lindstrand
Margareta Eriksson
Anna Nilsson
Source
Eur J Pediatr. 2017 Mar;176(3):337-342
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Chi-Square Distribution
Child, Preschool
Community-Acquired Infections - epidemiology
Comorbidity
Female
Hospitalization - statistics & numerical data
Humans
Infant
Infant, Newborn
Male
Pneumococcal Vaccines - administration & dosage
Pneumonia, Viral - epidemiology
Retrospective Studies
Severity of Illness Index
Sweden - epidemiology
Vaccines, Conjugate - administration & dosage
Abstract
The burden of community-acquired pneumonia (CAP) in high-income countries is still significant. The introduction of pneumococcal conjugate vaccines (PCV) has reduced the overall need for hospitalization for CAP. However, it is not clear whether children with underlying disease also have benefitted from the PCV immunization programme. Children 0 to
Notes
Cites: Pediatrics. 2014 Dec;134(6):e1528-3625384486
Cites: Pediatrics. 2010 Aug;126(2):204-1320643717
Cites: Lancet. 2009 Sep 12;374(9693):903-1119748399
Cites: Lancet. 2013 Apr 20;381(9875):1417-2923582723
Cites: Pediatr Infect Dis J. 2005 Jan;24(1):17-2315665705
Cites: Pediatr Infect Dis J. 2013 Mar;32(3):e119-2723099423
Cites: PLoS One. 2014 Nov 07;9(11):e11221125379659
Cites: Pediatrics. 2010 Jul;126(1):e9-1720547641
Cites: Pediatrics. 2014 Mar;133(3):e538-4524567027
Cites: J Med Virol. 2009 Jan;81(1):167-7519031448
Cites: Lancet. 2013 Apr 20;381(9875):1380-9023369797
Cites: PLoS Med. 2013;10(5):e100144423690754
Cites: N Engl J Med. 2015 Jul 30;373(5):415-2726172429
Cites: Curr Opin Pediatr. 2016 Dec;28(6):786-79327755118
Cites: Pediatr Infect Dis J. 2012 May;31(5):501-822327872
Cites: Cochrane Database Syst Rev. 2009 Oct 07;(4):CD00497719821336
Cites: Clin Infect Dis. 2011 Oct;53(7):e25-7621880587
Cites: Thorax. 2015 Sep;70(9):847-5326077969
Cites: Vaccine. 2006 Apr 12;24 Suppl 2:S2-79-8016823937
Cites: Clin Infect Dis. 2010 Mar 15;50(6):805-1320166818
Cites: Lancet. 2009 Sep 12;374(9693):893-90219748398
PubMed ID
28070670 View in PubMed
Less detail

Impact on affected families and society of severe rotavirus infections in Swedish children assessed in a prospective cohort study.

https://arctichealth.org/en/permalink/ahliterature296021
Source
Infect Dis (Lond). 2018 05; 50(5):361-371
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
05-2018

Influenza epidemiology among hospitalized children in Stockholm, Sweden 1998-2014.

https://arctichealth.org/en/permalink/ahliterature286770
Source
Vaccine. 2016 Jun 14;34(28):3298-302
Publication Type
Article
Date
Jun-14-2016
Author
Rutger Bennet
Johan Hamrin
Benita Zweygberg Wirgart
Maria Rotzén Östlund
Åke Örtqvist
Margareta Eriksson
Source
Vaccine. 2016 Jun 14;34(28):3298-302
Date
Jun-14-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Age Distribution
Child
Child, Hospitalized
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza, Human - epidemiology
Intensive Care Units, Pediatric
Male
Retrospective Studies
Sweden - epidemiology
Abstract
Influenza remains a common reason for the hospitalization of children. There is a need for long term studies that are also population based. We describe the epidemiology of severe influenza in a defined population 1998-2014.
Retrospective study of annually collected data of virologically confirmed influenza in hospitalized children 0-17 years living in the catchment area (230,000 children). We gathered information about comorbidity and complications from case records, and compared Influenza A, B and A(H1N1)pdm09 with respect to these factors.
A total of 922 children with influenza were hospitalized. The mean rate remained unchanged at 22.5-24.2 per 100,000 children per year. There were two major outbreaks: influenza A(H3N2) in 2003-2004 and the A(H1N1) pandemic in 2009-2010. The proportion of children with influenza B increased from 8% during the first half of the study period to 28% during the second half. The highest admission rate was found in children
PubMed ID
27155498 View in PubMed
Less detail

27 records – page 1 of 3.