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Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts.

https://arctichealth.org/en/permalink/ahliterature108601
Source
BMJ. 2013;347:f4262
Publication Type
Article
Date
2013
Author
Tom M Palmer
Børge G Nordestgaard
Marianne Benn
Anne Tybjærg-Hansen
George Davey Smith
Debbie A Lawlor
Nicholas J Timpson
Author Affiliation
Division of Health Sciences, Warwick Medical School, University of Warwick, Warwick, UK.
Source
BMJ. 2013;347:f4262
Date
2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Blood Pressure - genetics
Body mass index
Denmark
Female
Humans
Hyperuricemia - etiology - genetics
Male
Mendelian Randomization Analysis
Middle Aged
Myocardial Ischemia - blood - genetics
Prospective Studies
Regression Analysis
Uric Acid - blood
Abstract
To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index.
Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as an instrument for uric acid; and FTO (rs9939609), MC4R (rs17782313), and TMEM18 (rs6548238) for body mass index).
Two large, prospective cohort studies in Denmark.
We measured levels of uric acid and related covariables in 58,072 participants from the Copenhagen General Population Study and 10,602 from the Copenhagen City Heart Study, comprising 4890 and 2282 cases of ischaemic heart disease, respectively.
Blood pressure and prospectively assessed ischaemic heart disease.
Estimates confirmed known observational associations between plasma uric acid and hyperuricaemia with risk of ischaemic heart disease and diastolic and systolic blood pressure. However, when using genotypic instruments for uric acid and hyperuricaemia, we saw no evidence for causal associations between uric acid, ischaemic heart disease, and blood pressure. We used genetic instruments to investigate body mass index as a potentially confounding factor in observational associations, and saw a causal effect on uric acid levels. Every four unit increase of body mass index saw a rise in uric acid of 0.03 mmol/L (95% confidence interval 0.02 to 0.04), and an increase in risk of hyperuricaemia of 7.5% (3.9% to 11.1%).
By contrast with observational findings, there is no strong evidence for causal associations between uric acid and ischaemic heart disease or blood pressure. However, evidence supports a causal effect between body mass index and uric acid level and hyperuricaemia. This finding strongly suggests body mass index as a confounder in observational associations, and suggests a role for elevated body mass index or obesity in the development of uric acid related conditions.
Notes
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Comment In: Rev Clin Esp. 2014 Jan-Feb;214(1):48
PubMed ID
23869090 View in PubMed
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Does gallium uptake in the pulmonary hila predict involvement by non-Hodgkin's lymphoma?

https://arctichealth.org/en/permalink/ahliterature222935
Source
Nucl Med Commun. 1992 Oct;13(10):730-7
Publication Type
Article
Date
Oct-1992
Author
P E Champion
D. Groshar
H R Hooper
M. Palmer
Z. Catz
A. Belch
A. McEwan
Author Affiliation
Department of Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada.
Source
Nucl Med Commun. 1992 Oct;13(10):730-7
Date
Oct-1992
Language
English
Publication Type
Article
Keywords
Alberta - epidemiology
Gallium Radioisotopes - diagnostic use - pharmacokinetics
Humans
Lung - metabolism
Lung Neoplasms - epidemiology - radionuclide imaging
Lymphoma, Non-Hodgkin - epidemiology - radionuclide imaging
Prognosis
Retrospective Studies
Tomography, Emission-Computed, Single-Photon
Abstract
67Ga imaging of non-Hodgkin's lymphoma is useful for evaluating the presence of viable tumour in a residual mass after treatment. However, we have frequently seen gallium uptake in the pulmonary hila without other evidence of lymphoma. To study the significance of this finding, 79 patients with intermediate grade non-Hodgkin's lymphoma were reviewed. Thirty-seven (47%) had abnormal hilar gallium uptake. Twenty-three of these could be fully evaluated, and only five (22%) had hilar lymphoma. A pattern of bilateral, symmetric hilar uptake was seen in 19 patients, but only one had evidence of lymphoma. In 15 cases, this pattern was seen only on single photon emission computed tomography (SPECT). The aetiology of this uptake remains unknown. It is not treatment related, as 12 patients had hilar gallium uptake prior to chemotherapy. Unless confirmed by other methods, hilar gallium uptake should not be attributed to lymphoma, and should not influence patient management.
PubMed ID
1491837 View in PubMed
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Evaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma.

https://arctichealth.org/en/permalink/ahliterature309225
Source
Melanoma Res. 2019 10; 29(5):483-490
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
10-2019
Author
Peter A Johansson
Vaishnavi Nathan
Lauren M Bourke
Jane M Palmer
Tongwu Zhang
Judith Symmons
Madeleine Howlie
Ann-Marie Patch
Jazlyn Read
Elizabeth A Holland
Helen Schmid
Sunil Warrier
William Glasson
Veronica Höiom
Karin Wadt
Göran Jönsson
Håkan Olsson
Christian Ingvar
Graham Mann
Kevin M Brown
Nicholas K Hayward
Antonia L Pritchard
Author Affiliation
Oncogenomics Group.
Source
Melanoma Res. 2019 10; 29(5):483-490
Date
10-2019
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Alleles
Australia
BRCA1 Protein - genetics
BRCA2 Protein - genetics
Computational Biology
Denmark
Exome
Female
Frameshift Mutation
Gene Deletion
Gene Frequency
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Male
Melanoma - genetics
Netherlands
Skin Neoplasms - genetics
Sweden
Uveal Neoplasms - genetics
Whole Genome Sequencing
Abstract
Germline mutations of BRCA1 and BRCA2 predispose individuals to a high risk of breast and ovarian cancer, and elevated risk of other cancers, including those of the pancreas and prostate. BRCA2 mutation carriers may have increased risk of uveal melanoma (UM) and cutaneous melanoma (CM), but associations with these cancers in BRCA1 mutation carriers have been mixed. Here, we further assessed whether UM and CM are associated with BRCA1 or BRCA2 by assessing the presence, segregation and reported/predicted pathogenicity of rare germline mutations (variant allele frequency
PubMed ID
31464824 View in PubMed
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Fatigue in patients with cancer: results with National Cancer Institute of Canada Clinical Trials Group studies employing the EORTC QLQ-C30.

https://arctichealth.org/en/permalink/ahliterature207540
Source
Support Care Cancer. 1997 Sep;5(5):410-3
Publication Type
Article
Date
Sep-1997
Author
J L Pater
B. Zee
M. Palmer
D. Johnston
D. Osoba
Author Affiliation
NCIC Clinical Trials Group, Queen's University, Kingston, Ontario, Canada.
Source
Support Care Cancer. 1997 Sep;5(5):410-3
Date
Sep-1997
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Aged, 80 and over
Analysis of Variance
Canada - epidemiology
Clinical Trials as Topic - statistics & numerical data
Fatigue - epidemiology - etiology - physiopathology
Female
Guidelines as Topic
Humans
Incidence
Linear Models
Longitudinal Studies
Male
Middle Aged
Multivariate Analysis
Neoplasms - complications - diagnosis - therapy
Quality of Life
Questionnaires
Sex Distribution
Societies, Medical
Abstract
The purpose of this study was to examine the factors which affect the level of fatigue among patients participating in clinical trials in which this symptom had been assessed with the EORTC QLQ-C30. Data were assembled from 2390 patients in ten clinical trials in which the QLQ-C30 had been used to assess baseline and on-study quality of life. The relationship between the level of fatigue reported by the patients on the fatigue scale of this questionnaire and patient and disease characteristics was assessed in univariate and multivariate cross-sectional analyses. In addition, changes in fatigue scores were compared in a longitudinal analysis among patients on two arms of an anti-emetic trial whose emesis control was markedly different. Baseline fatigue levels differed substantially among patients taking part in the different trials. Factors associated with greater fatigue severity on univariate analysis included: female gender, presence of metastatic disease, and poorer performance status. In addition, on multivariate analyses the oldest patients were found to have less fatigue, as were patients with breast cancer, while patients with ovarian and lung cancer experienced greater fatigue. Patients on the arm of the anti-emetic trial in which emesis was better controlled showed significantly less increase in fatigue after receiving chemotherapy. The fatigue scale of the QLQ-C30 appears to provide a useful approach to assessing this important symptom. The relationships found between fatigue and patient and disease characteristics need further exploration as does the degree to which the QLQ-C30 fully captures this dimension of quality of life.
PubMed ID
9322354 View in PubMed
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Increased risk of malignant diseases after surgery for primary hyperparathyroidism. A nationwide cohort study.

https://arctichealth.org/en/permalink/ahliterature25863
Source
Am J Epidemiol. 1988 May;127(5):1031-40
Publication Type
Article
Date
May-1988
Author
M. Palmér
H O Adami
U B Krusemo
S. Ljunghall
Author Affiliation
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Source
Am J Epidemiol. 1988 May;127(5):1031-40
Date
May-1988
Language
English
Publication Type
Article
Keywords
Adult
Aged
Epidemiologic Methods
Female
Humans
Hyperparathyroidism - complications - surgery
Male
Middle Aged
Neoplasms - epidemiology - etiology
Postoperative Complications
Registries
Research Support, Non-U.S. Gov't
Risk factors
Sweden
Abstract
A cohort of 4,163 persons reported to the nationwide Swedish Cancer Registry by reason of hyperparathyroidism was followed for up to 22 completed years (24,593 person-years of observation). The occurrence of malignant disease manifested after parathyroid surgery was investigated through computerized linkage to the entire Cancer Registry. During the entire period, the hyperparathyroidism patients suffered malignant diseases significantly more often than the background population (relative risk (RR) = 1.6, 95% confidence interval (CI) 1.5-1.8). Even if all cases with malignant diseases detected at the same time as hyperparathyroidism or during the first year after parathyroid surgery were eliminated, a significantly increased risk remained for the following years (RR = 1.4, 95% CI 1.2-1.6). A significantly increased relative risk of developing gastrointestinal cancers, endocrine tumors, kidney carcinomas, and mammary carcinomas was found. During the first postoperative year, an increased surveillance of the cohort is likely to have contributed to the increased risk, but detection bias is considered unlikely to be the only explanation for the higher risk during all subsequent years. The findings indicate that hyperparathyroidism either promotes later development of malignant tumors or that this condition and certain malignant diseases have etiologic factors in common.
PubMed ID
3358404 View in PubMed
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Influence of age and run training on cardiac Na+/Ca2+ exchange.

https://arctichealth.org/en/permalink/ahliterature49737
Source
J Appl Physiol. 2003 Nov;95(5):1994-2003
Publication Type
Article
Date
Nov-2003
Author
Lisa C Mace
Bradley M Palmer
David A Brown
Korinne N Jew
Joshua M Lynch
Jason M Glunt
Todd A Parsons
Joseph Y Cheung
Russell L Moore
Author Affiliation
Department of Integrative Physiology, University of Colorado at Boulder, Boulder, Colorado 80309-0354, USA.
Source
J Appl Physiol. 2003 Nov;95(5):1994-2003
Date
Nov-2003
Language
English
Publication Type
Article
Keywords
Action Potentials - physiology
Aging - physiology
Animals
Blotting, Western
Caffeine - pharmacology
Calcium - metabolism
Exercise Test
Male
Myocardial Contraction - drug effects - physiology
Myocytes, Cardiac - physiology
Pacemaker, Artificial
Patch-Clamp Techniques
Phosphodiesterase Inhibitors - pharmacology
Physical Conditioning, Animal - physiology
Rats
Rats, Inbred BN
Rats, Inbred F344
Research Support, U.S. Gov't, P.H.S.
Running - physiology
Sodium - metabolism
Sodium-Calcium Exchanger - physiology
Ventricular Function, Left - physiology
Abstract
Effects of age and training on myocardial Na+/Ca2+ exchange were examined in young sedentary (YS; 14-15 mo), aged sedentary (AS; 27-31 mo), and aged trained (AT; 8- to 11-wk treadmill run training) male Fischer Brown Norway rats. Whole heart performance and isolated cardiocyte Na+/Ca2+ exchange characteristics were measured. At the whole heart level, a small but significant slowing of late isovolumic left ventricular (LV) relaxation, which may be indicative of altered Na+/Ca2+ exchange activity, was seen in hearts from AS rats. This subtle impairment in relaxation was not observed in hearts from AT rats. At the single-cardiocyte level, late action potential duration was prolonged, resting membrane potential was more positive, and overshoot potential was greater in cardiocytes from AS rats than from YS rats (P
PubMed ID
12882992 View in PubMed
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Longitudinal studies of mild primary hyperparathyroidism.

https://arctichealth.org/en/permalink/ahliterature73577
Source
J Bone Miner Res. 1991 Oct;6 Suppl 2:S111-6; discussion S121-4
Publication Type
Article
Date
Oct-1991
Author
S. Ljunghall
S. Jakobsson
C. Joborn
M. Palmér
J. Rastad
G. Akerström
Author Affiliation
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Source
J Bone Miner Res. 1991 Oct;6 Suppl 2:S111-6; discussion S121-4
Date
Oct-1991
Language
English
Publication Type
Article
Keywords
Adult
Aged
Calcium - blood
Comparative Study
Female
Follow-Up Studies
Health Surveys
Humans
Hypercalcemia - complications - mortality - physiopathology
Hyperparathyroidism - complications - mortality - physiopathology
Longitudinal Studies
Male
Mental Disorders - etiology
Middle Aged
Parathyroidectomy
Sweden
Abstract
In 1969, a health survey was offered to all inhabitants of a town district in Sweden. A clinical examination was carried out, and among other variables, a measurement was made of serum calcium. The same procedure was repeated in 1971. From these two investigations a cohort of 176 individuals (1.1%) with sustained hypercalcemia was identified who could be followed during the subsequent 15 years. Comparisons were made with an age- and sex-matched control group from the same health survey. Survival was significantly lower in the hypercalcemic cohort than in the control group. This reduction was related to the degree of hypercalcemia and apparently mainly due to diseases of the circulatory organs. There was no marked deterioration of renal function, and although there was in some patients a moderate progression of the hypercalcemia, none developed a hypercalcemic crisis during 15 years of follow-up. In consecutively referred patients with primary hyperparathyroidism, psychiatric disturbances of mainly a depressive character were found upon detailed analysis within a majority of the patients, and parathyroid surgery resulted in a clear improvement in mental health.
PubMed ID
1763661 View in PubMed
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[Morbus Whipple--occurrence, symptoms, diagnosis and treatment of 4 cases].

https://arctichealth.org/en/permalink/ahliterature230979
Source
Lakartidningen. 1989 Apr 5;86(14):1275-7
Publication Type
Article
Date
Apr-5-1989

Phenotypic and genotypic characterization of prolyliminopeptidase-negative Neisseria gonorrhoeae isolates in Denmark.

https://arctichealth.org/en/permalink/ahliterature174740
Source
Eur J Clin Microbiol Infect Dis. 2005 Apr;24(4):280-3
Publication Type
Article
Date
Apr-2005
Author
H. Fjeldsøe-Nielsen
M. Unemo
H. Fredlund
S V Hjorth
L M Berthelsen
H M Palmer
A. Friis-Møller
Author Affiliation
Department of Clinical Microbiology, H:S Hvidovre Hospital, Kettegaard allé 30, 2650 Hvidovre, Denmark,
Source
Eur J Clin Microbiol Infect Dis. 2005 Apr;24(4):280-3
Date
Apr-2005
Language
English
Publication Type
Article
Keywords
Adult
Aminopeptidases
Denmark - epidemiology
Female
Genotype
Gonorrhea - epidemiology - microbiology
Humans
Male
Neisseria gonorrhoeae - classification - enzymology - genetics
Phenotype
Phylogeny
Porins - genetics
Abstract
In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (PIP)-negative Neisseria gonorrhoeae were phenotypically and genotypically characterized to investigate whether one or more PIP-negative strains are circulating in the Danish community. The profiles of these isolates were compared with those of three isolates from a recent outbreak of PIP-negative N. gonorrhoeae infection in the UK. Twenty-five of the Danish isolates and all three UK isolates had similar antibiograms and were designated serovar IB-4. Genotypic characterization by pulsed-field gel electrophoresis, porB1b gene sequencing, and opa-typing revealed that these isolates were indistinguishable or closely related. The results indicate that at least one PIP-negative N. gonorrhoeae strain is currently circulating in the Danish community, and this strain is indistinguishable from the one that caused an outbreak in the UK.
Notes
Erratum In: Eur J Clin Microbiol Infect Dis. 2005 Jul;24(7):503
PubMed ID
15902536 View in PubMed
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Prevalence of urinary tract symptoms in long-standing type 1 diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature48048
Source
Diabetes Metab. 1998 Sep;24(4):351-4
Publication Type
Article
Date
Sep-1998
Author
C M Ingberg
M. Palmer
E. Schvarcz
J. Aman
Author Affiliation
Dept. of Internal Medicine, Orebro Medical Centre Hospital, Sweden.
Source
Diabetes Metab. 1998 Sep;24(4):351-4
Date
Sep-1998
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Adult
Age of Onset
Anti-Bacterial Agents - therapeutic use
Cohort Studies
Diabetes Mellitus, Type 1 - complications
Female
Hemoglobin A, Glycosylated - analysis
Humans
Male
Middle Aged
Prevalence
Questionnaires
Reference Values
Sex Characteristics
Social Behavior
Sweden - epidemiology
Urinary Tract Infections - drug therapy - epidemiology - psychology
Abstract
The purpose of this study was to evaluate the prevalence of urinary tract symptoms in a population-based cohort of 109 young adult patients with Type 1 diabetes mellitus with onset at 9.0% did not have significantly more treated UTIs than those with HbA1c
PubMed ID
9805646 View in PubMed
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17 records – page 1 of 2.