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Adjustable maintenance dosing with budesonide/formoterol reduces asthma exacerbations compared with traditional fixed dosing: a five-month multicentre Canadian study.

https://arctichealth.org/en/permalink/ahliterature9564
Source
Can Respir J. 2003 Nov-Dec;10(8):427-34
Publication Type
Article
Author
J Mark FitzGerald
Malcolm R Sears
Louis-Philippe Boulet
Allan B Becker
Andrew R McIvor
Pierre Ernst
Natasha M Smiljanic-Georgijev
Joanna S M Lee
Author Affiliation
The University of British Columbia, Vancouver, Canada. markj@interchange.ubc.ca
Source
Can Respir J. 2003 Nov-Dec;10(8):427-34
Language
English
Publication Type
Article
Keywords
Administration, Inhalation
Adrenal Cortex Hormones - administration & dosage - therapeutic use
Adult
Asthma - drug therapy
Bronchodilator Agents - administration & dosage - therapeutic use
Budesonide - administration & dosage - therapeutic use
Canada
Child
Costs and Cost Analysis
Drug Administration Schedule
Drug Combinations
Ethanolamines - administration & dosage - therapeutic use
Female
Humans
Male
Research Support, Non-U.S. Gov't
Time Factors
Abstract
BACKGROUND: Adjustable maintenance dosing with budesonide/formoterol in a single inhaler (Symbicort, AstraZeneca, Lund, Sweden) may provide a convenient means of maintaining asthma control with the minimum effective medication level. OBJECTIVES: To compare adjustable and fixed maintenance dosing regimens of budesonide/formoterol in asthma. METHODS: This was an open-label, randomized, parallel-group, multicentre, Canadian study of asthma patients (aged 12 years or older, postbronchodilator forced expiratory volume in 1 s 70% or greater of predicted normal). Following a one-month run-in on budesonide/formoterol (100/6 mg or 200/6 mg metered doses, two inhalations twice daily), 995 patients were randomly assigned either to continue on this fixed dosing regimen or to receive budesonide/formoterol adjustable dosing (step down to one inhalation twice daily if symptoms were controlled or temporarily step up to four inhalations twice daily for seven or 14 days if asthma worsened). The primary efficacy variable was the occurrence of exacerbations (requiring oral or inhaled corticosteroids, emergency department treatment, serious adverse events or added maintenance therapy because of asthma). RESULTS: With adjustable dosing, significantly fewer patients experienced exacerbations compared with fixed dosing (4.0% versus 8.9%, P=0.002; number needed to treat=21 [95% CI 13 to 59]). Patients required 36% fewer overall doses of budesonide/formoterol (2.5 versus 3.9 inhalations/day, P
PubMed ID
14679407 View in PubMed
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Source
Can Psychiatr Assoc J. 1977 Aug;22(5):243-51
Publication Type
Article
Date
Aug-1977
Author
N. el-Guebaly
M. Lee
Source
Can Psychiatr Assoc J. 1977 Aug;22(5):243-51
Date
Aug-1977
Language
English
Publication Type
Article
Keywords
Adult
Alcoholism - complications - rehabilitation
Antisocial Personality Disorder - diagnosis
Canada
Female
Homicide
Humans
Legislation as Topic
Male
Motivation
Psychological Tests
Social Control, Formal
Substance-Related Disorders - complications
Suicide
Violence
Wounds, Gunshot - etiology
Abstract
The recurring dilemma of having to deal with an intoxicated person in possession of a gun uttering homicidal or suicidal threats along with the current debate on gun control prompted this controlled survey of the characteristics of individuals with problems arising from the joint abuse of alcohol and possession of a gun. A comparison of the data point to violence as being the most significant differentiating variable involved. This violent potential was reflected by the presence among the alcoholics involved of more past and present antisocial traits, a higher rating on the Nicol's scale of violence, more offences committed against the person and homicidal behaviour. The availability of a gun was a significant factor. No correlation was found between the severity of the drinking problem and the risk of dangerous handling of a gun. The need for more stringent gun controls is supported but their implications to the physician and especially the psychiatrist as a potential guarantor for a licence application ought to be further explored by the professional bodies involved.
PubMed ID
890644 View in PubMed
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An eye screening program in a Chinese-Canadian community.

https://arctichealth.org/en/permalink/ahliterature250004
Source
Can J Ophthalmol. 1977 Apr;12(2):121-3
Publication Type
Article
Date
Apr-1977
Author
F. Feldman
M. Lee
Source
Can J Ophthalmol. 1977 Apr;12(2):121-3
Date
Apr-1977
Language
English
Publication Type
Article
Keywords
China - ethnology
Community Health Services
Eye Diseases - epidemiology
Hospitals, General
Humans
Mass Screening
Ontario
Public Relations
Transients and Migrants
Abstract
A screening program staffed by ophthalmologists, ophthalmology residents, ophthalmic assistants, social workers and Chinese-speaking volunteers and directed at a Chinese immigrant community, was conducted at the Mount Sinai Hospital, Toronto. The Chinese population had been hesitant to use our hospital facilities and we hoped to overcome their fears, as well as to detect previously undiagnosed ocular problems. The program succeeded in finding many eye problems, some serious, and in encouraging this immigrant group to come for proper medical care. We describe the method of setting up and conducting such an undertaking, which involved the Departments of Ophthalmology and Social work, hospital administrators and volunteers from the community.
PubMed ID
880511 View in PubMed
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Anthropometric measurements and physical examinations of Indian populations from British Columbia and the Yukon Territories, Canada.

https://arctichealth.org/en/permalink/ahliterature41834
Source
Hum Biol. 1977 Dec;49(4):581-91
Publication Type
Article
Date
Dec-1977

Association of blood lead levels with onset of puberty in Russian boys.

https://arctichealth.org/en/permalink/ahliterature156140
Source
Environ Health Perspect. 2008 Jul;116(7):976-80
Publication Type
Article
Date
Jul-2008
Author
Russ Hauser
Oleg Sergeyev
Susan Korrick
Mary M Lee
Boris Revich
Elena Gitin
Jane S Burns
Paige L Williams
Author Affiliation
Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. rhauser@hohp.harvard.edu
Source
Environ Health Perspect. 2008 Jul;116(7):976-80
Date
Jul-2008
Language
English
Publication Type
Article
Keywords
Body Weights and Measures
Child
Cross-Sectional Studies
Humans
Lead - blood - toxicity
Logistic Models
Male
Puberty - drug effects
Russia - epidemiology
Socioeconomic Factors
Abstract
Epidemiologic studies suggest a temporal trend of earlier onset and longer duration of puberty, raising concerns regarding the potential impact of environmental factors on pubertal development. Lead exposure has been associated with delayed pubertal onset in girls; however, epidemiologic data in boys are limited.
We used multivariable logistic regression models to explore the cross-sectional association of blood lead levels with growth and pubertal onset based on physician-assessed testicular volume (TV) and pubertal staging in 489 boys 8-9 years of age from Chapaevsk, Russia. We used multivariable linear regression models to assess associations of blood lead levels with somatic growth at the study entry visit.
The median (25th-75th percentile) blood lead level was 3 microg/dL (2-5 microg/dL). Height, weight, body mass index, birth weight, and gestational age were predictive of the onset of puberty as assessed either by TV (> 3 mL), genitalia stage (G2), or both. Blood lead level was inversely associated with height (p or = 5 microg/dL had 43% reduced odds of having entered G2 compared with those with lower levels (odds ratio = 0.57; 95% confidence interval, 0.34-0.95, p = 0.03).
Relatively low environmental blood lead levels were associated with decreased growth and differences in pubertal onset in periadolescent Russian boys. Future analyses of this prospective cohort will address pubertal onset and progression in relation to lead and other environmental chemicals.
Notes
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PubMed ID
18629324 View in PubMed
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The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children's Study.

https://arctichealth.org/en/permalink/ahliterature283496
Source
Rev Environ Health. 2017 Mar 01;32(1-2):83-92
Publication Type
Article
Date
Mar-01-2017
Author
Oleg Sergeyev
Jane S Burns
Paige L Williams
Susan A Korrick
Mary M Lee
Boris Revich
Russ Hauser
Source
Rev Environ Health. 2017 Mar 01;32(1-2):83-92
Date
Mar-01-2017
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Dioxins and Dioxin-like Compounds - blood
Endocrine Disruptors - blood
Environmental Exposure
Environmental pollutants - blood
Furans - blood
Humans
Hydrocarbons, Chlorinated - blood
Lead - blood
Longitudinal Studies
Male
Prospective Studies
Russia
Sexual Maturation - drug effects
Young Adult
Abstract
Organochlorine chemicals and lead are environmental exposures that have endocrine disrupting properties (EDCs) which interfere with many aspects of hormone action. Childhood and adolescence are windows of susceptibility for adverse health effects of EDCs. Our ongoing study, the Russian Children's Study (RCS), is one of the few longitudinal studies investigating the impact of EDCs on growth and puberty in boys. It is conducted in the historically contaminated city of Chapaevsk, in the Samara region. The study focuses on evaluating the associations of persistent organochlorine chemicals and lead with growth and pubertal timing. At enrollment in 2003-2005, we collected blood from 516 boys at ages 8-9 years to measure dioxins, furans, polychlorinated biphenyls (PCBs), chlorinated pesticides and lead. At enrollment and at annual visits through the ages of 18-19 years, a physician performed physical examinations that included pubertal staging and testicular volume measurements. We review the history of Chapaevsk as a research site and summarize published RCS data on the association of peripubertal serum concentrations of organochlorines and blood lead levels with growth, pubertal onset and sexual maturity. Overall, we found that persistent organochlorines and lead negatively affected growth during puberty. Our results also suggest that total toxic equivalents (TEQs), dioxin-like compounds, organochlorine pesticides and lead may delay, while nondioxin-like-PCBs may advance, the timing of male puberty. These findings promoted remediation programs in Chapaevsk, with improvement in health indicators, resulting in Chapaevsk being designated a member of the World Health Organization (WHO) network "Healthy Cities" in 2015.
PubMed ID
28231067 View in PubMed
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Association of Phosphodiesterase 4D Polymorphisms With Ischemic Stroke in a US Population Stratified by Hypertension Status.

https://arctichealth.org/en/permalink/ahliterature76235
Source
Stroke. 2006 May 4;
Publication Type
Article
Date
May-4-2006
Author
Victoria H Brophy
Sunhee K Ro
Brian K Rhees
Li-Yung Lui
Jocelyn M Lee
Nanette Umblas
L Gordon Bentley
Jia Li
Suzanne Cheng
Warren S Browner
Henry A Erlich
Author Affiliation
From Roche Molecular Systems, Alameda, Calif; and California Pacific Medical Center Research Institute, San Francisco, Calif.
Source
Stroke. 2006 May 4;
Date
May-4-2006
Language
English
Publication Type
Article
Abstract
BACKGROUND AND PURPOSE: Phosphodiesterase 4D (PDE4D) underlies the STRK1 linkage peak for stroke on chromosome 5q12 identified in Iceland. We tested association of 13 single-nucleotide polymorphisms (SNPs) and 1 microsatellite in a nested case-control sample of elderly white women (>65 years of age) from the Study of Osteoporotic Fractures (SOF) in the United States. METHODS: The genotypes of 248 women who experienced an incident ischemic stroke during an average of 5.4 years of follow-up were compared with 560 controls. RESULTS: Marginal associations with stroke (P
PubMed ID
16675738 View in PubMed
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Associations of Peripubertal Serum Dioxin and Polychlorinated Biphenyl Concentrations with Pubertal Timing among Russian Boys.

https://arctichealth.org/en/permalink/ahliterature282988
Source
Environ Health Perspect. 2016 Nov;124(11):1801-1807
Publication Type
Article
Date
Nov-2016
Author
Jane S Burns
Mary M Lee
Paige L Williams
Susan A Korrick
Oleg Sergeyev
Thuy Lam
Boris Revich
Russ Hauser
Source
Environ Health Perspect. 2016 Nov;124(11):1801-1807
Date
Nov-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Dioxins - blood - toxicity
Environmental Exposure - analysis
Humans
Longitudinal Studies
Male
Polychlorinated Biphenyls - blood - toxicity
Russia
Sexual Maturation - drug effects
Time Factors
Abstract
Dioxins, furans, and polychlorinated biphenyls (PCBs), dioxin-like and non-dioxin-like, have been linked to alterations in puberty.
We examined the association of peripubertal serum levels of these compounds [and their toxic equivalents (TEQs)] with pubertal onset and maturity among Russian boys enrolled at ages 8-9 years and followed prospectively through ages 17-18 years.
At enrollment, 473 boys had serum dioxin-like compounds and PCBs measured. At the baseline visit and annually until age 17-18 years, a physician performed pubertal staging [genitalia (G), pubarche (P), and testicular volume (TV)]. Three hundred fifteen subjects completed the follow-up visit at 17-18 years of age. Pubertal onset was defined as TV > 3 mL, G2, or P2. Sexual maturity was defined as TV = 20 mL, G5, or P5. Multivariable interval-censored models were used to evaluate associations of lipid-standardized concentrations with pubertal timing.
Medians (interquartile ranges) of the sum of dioxin-like compounds, TEQs, and non-dioxin-like PCBs were 362 pg/g lipid (279-495), 21.1 pg TEQ/g lipid (14.4-33.2), and 250 ng/g lipid (164-395), respectively. In adjusted models, the highest compared to lowest TEQ quartile was associated with later pubertal onset [TV = 11.6 months (95% CI: 3.8, 19.4); G2 = 10.1 months (95% CI: 1.4, 18.8)] and sexual maturity [TV = 11.6 months (95% CI: 5.7, 17.6); G5 = 9.7 months (95% CI: 3.1, 16.2)]. However, the highest compared to the lowest quartile of non-dioxin-like PCBs, when co-adjusted by TEQs, was associated with earlier pubertal onset [TV = -8.3 months (95% CI:-16.2, -0.3)] and sexual maturity [TV = -6.3 months (95% CI:-12.2, -0.3); G5 = -7.2 months (95% CI:-13.8, -0.6)]; the non-dioxin-like PCB associations were only significant when adjusted for TEQs. TEQs and PCBs were not significantly associated with pubic hair development.
Our results suggest that TEQs may delay, while non-dioxin-like PCBs advance, the timing of male puberty. Citation: Burns JS, Lee MM, Williams PL, Korrick SA, Sergeyev O, Lam T, Revich B, Hauser R. 2016. Associations of peripubertal serum dioxin and polychlorinated biphenyl concentrations with pubertal timing among Russian boys. Environ Health Perspect 124:1801-1807; http://dx.doi.org/10.1289/EHP154.
Notes
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PubMed ID
27187981 View in PubMed
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Aureimonas glaciistagni sp. nov., isolated from a melt pond on Arctic sea ice.

https://arctichealth.org/en/permalink/ahliterature265671
Source
Int J Syst Evol Microbiol. 2015 Jul 14;
Publication Type
Article
Date
Jul-14-2015
Author
Yirang Cho
Inae Lee
Yoon Y Yang
Kiwoon Baek
Soo J Yoon
Yung M Lee
Sung-Ho Kang
Hong K Lee
Chung Y Hwang
Source
Int J Syst Evol Microbiol. 2015 Jul 14;
Date
Jul-14-2015
Language
English
Publication Type
Article
Abstract
A Gram-negative, motile, aerobic and rod-shaped bacterial strain, PAMC 27157T, was isolated from a melt pond on sea ice in the Chukchi Sea. Phylogenetic analysis of the 16S rRNA gene sequence of strain PAMC 27157T, revealed an affiliation to the genus Aureimonas with the closest sequence similarity (96.2%) to that of Aureimonas phyllosphaerae. Strain PAMC 27157T, grew optimally at 30 °C and pH 7.0 in the presence of 3.5% (w/v) of NaCl. The major polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, phosphatidylmonomethylethanolamine, sulfoquinovosyldiacylglycerol and an unidentified aminolipid. The major cellular fatty acid was summed feature 8 (C18 : 1 ?7c and/or ?6c, 83.1%) and the major respiratory quinone was Q-10. The genomic DNA G+C content was 69.1 mol%. The combined phylogenetic, phenotypic, and chemotaxonomic data showed that strain PAMC 27157T, could be clearly distinguished from validly published species of the genus Aureimonas. Thus, strain PAMC 27157T, should be classified as representing a novel species in the genus Aureimonas, for which the name Aureimonas glaciistagni sp. nov. is proposed. The type strain is PAMC 27157T (= KCCM 43049T = JCM 30183T).
PubMed ID
26296341 View in PubMed
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72 records – page 1 of 8.