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Expression and developmental profile of antioxidant enzymes in human lung and liver.

https://arctichealth.org/en/permalink/ahliterature58929
Source
Am J Respir Cell Mol Biol. 1998 Dec;19(6):942-9
Publication Type
Article
Date
Dec-1998
Author
T M Asikainen
K O Raivio
M. Saksela
V L Kinnula
Author Affiliation
Hospital for Children and Adolescents, University of Helsinki, Helsinki; and Department of Internal Medicine, University of Oulu, Oulu, Finland. tmasikai@cc.helsinki.fi
Source
Am J Respir Cell Mol Biol. 1998 Dec;19(6):942-9
Date
Dec-1998
Language
English
Publication Type
Article
Keywords
Adult
Antioxidants
Catalase - genetics - metabolism
Gene Expression
Glutathione Peroxidase - genetics - metabolism
Humans
Infant, Newborn
Liver - embryology - enzymology - growth & development
Lung - embryology - enzymology - growth & development
Lung Transplantation
RNA, Messenger - metabolism
Research Support, Non-U.S. Gov't
Smoking
Superoxide Dismutase - genetics - metabolism
Abstract
Air breathing, especially oxygen therapy, exposes the lung to reactive oxygen species (ROS). Antioxidant enzymes (AOEs) may protect the lung from ROS-mediated injury. Because expression of the key AOEs increases in several animal species during gestation, we investigated (1) the messenger RNA (mRNA) and activity levels of the key AOEs manganese and copper-zinc superoxide dismutases (MnSOD and CuZnSOD, respectively), catalase (CAT), and glutathione peroxidase (GPx) in adult lung samples and during ontogenesis; and (2) the difference in AOE expression between lung and liver. In the lung, the mRNA expression of MnSOD, CuZnSOD, and CAT increased toward adulthood, and GPx was unchanged. Pulmonary activities of MnSOD and CuZnSOD were unchanged, whereas CAT increased 3-fold from fetuses to adults. In the liver, the mRNA expression of MnSOD, CuZnSOD, and GPx increased, whereas that of CAT decreased toward adulthood. Hepatic activities of MnSOD and CuZnSOD increased 2-fold and 4-fold, respectively, whereas CAT was similar in fetuses and adults. Neonatal GPx activity was 2-fold higher in the lung and 6-fold higher in the liver compared with adults. The mRNA levels of MnSOD correlated positively with those of CuZnSOD and CAT in the lung, and GPx with those of MnSOD and CuZnSOD in the liver. Activities of MnSOD and CuZnSOD correlated positively in the liver. We conclude that the regulation of AOEs differs between human lung and liver, and is not tightly coordinated in either tissue.
PubMed ID
9843929 View in PubMed
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Internal Radiation Doses from radioactivity of drinking water in Finland.

https://arctichealth.org/en/permalink/ahliterature245625
Source
Health Phys. 1980 Jul;39(1):108-11
Publication Type
Article
Date
Jul-1980

Natural radioactivity of drinking water in Finland.

https://arctichealth.org/en/permalink/ahliterature245624
Source
Health Phys. 1980 Jul;39(1):77-83
Publication Type
Article
Date
Jul-1980