Skip header and navigation

1 records – page 1 of 1.

[Further evidence that the serotonin transporter gene is associated with schizotypal traits in a healthy Russian population].

https://arctichealth.org/en/permalink/ahliterature150588
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(5):43-7
Publication Type
Article
Date
2009
Author
V E Golimbet
M V Alfimova
G I Korovaitseva
O M Lavrushina
T V Lezheiko
L G Uvarova
Liashenko
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(5):43-7
Date
2009
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Data Interpretation, Statistical
Female
Genotype
Humans
MMPI
Male
Middle Aged
Polymorphism, Genetic
Questionnaires
Risk factors
Russia
Schizotypal Personality Disorder - genetics
Serotonin Plasma Membrane Transport Proteins - genetics
Abstract
Genetic factors are thought to contribute to schizotypal dimensions. Recently, a number of genetic variants associated with schizotypal traits in psychiatrically healthy people have been found. Authors reported earlier the association between the SERT 5-HTTLPR polymorphism and schizotypal traits measured with MMPI. The present study aimed at the replication of association on a larger sample using other questionnaires and methods of data analysis. The sample comprised 657 people from the Russian population. MMPI, SPQ-74 and TCI-125 were used to measure personality traits. Based on the results of psychological testing, the sample was divided into high risk and control groups. For MMPI, the high risk group included people with the elevation on scale Schizophrenia, for SPQ-74 - people with a total score more than 25 and for TCI-125 - people with lower scores on scale Cooperation and higher scores on Self-Transcendence. In all high-risk groups assessed by different psychological instruments, the frequency of the SS 5-HTTLPR genotype was significantly lower as compared to the corresponding control groups. MANCOVA also showed that individuals with the SS genotype had lower scores on scales related to schizotypal traits. Thus, we have confirmed our previous results on the association between the 5-HTTLPR polymorphism and schizotypal traits in psychiatrically healthy subjects.
PubMed ID
19491818 View in PubMed
Less detail