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[Population analysis and determination of the ethnic background are necessary in the study of multifactorial diseases: a study using the Dagestan population as a model].

https://arctichealth.org/en/permalink/ahliterature167149
Source
Genetika. 2006 Aug;42(8):1137-42
Publication Type
Article
Date
Aug-2006
Author
I V Goldenkova-Pavlova
An L Piruzian
R M Abdeev
L V Khripach
M O Radzhabov
L A Piruzian
Source
Genetika. 2006 Aug;42(8):1137-42
Date
Aug-2006
Language
Russian
Publication Type
Article
Keywords
Dagestan
Ethnic Groups - genetics
Genetic Predisposition to Disease
Genetics, Population - methods
Humans
Models, Genetic
Multifactorial Inheritance - genetics
Psoriasis - ethnology - genetics
Abstract
Psoriasis, a multifactorial disease with genetic predisposition, has been used as an example to study the role of the ethnic background in multifactorial diseases in the Dagestan population. The individual information card (IIC) is proposed as the main tool for correct collection and processing of information. The results of the study demonstrate that the Dagestan population is a convenient and adequate model population for studying multifactorial diseases, such as psoriasis, and may serve as an object for studying the role of heredity in the etiologies and pathogeneses of this and other multifactorial diseases.
PubMed ID
17025165 View in PubMed
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[Prevalence of gene polymorphisms associated with immune-dependent diseases in the populations of North Eurasia].

https://arctichealth.org/en/permalink/ahliterature270416
Source
Mol Biol (Mosk). 2015 Nov-Dec;49(6):984-92
Publication Type
Article
Author
A A Cherednichenko
E A Trifonova
K V Vagaitseva
A V Bocharova
A M Varzari
M O Radzhabov
V A Stepanov
Source
Mol Biol (Mosk). 2015 Nov-Dec;49(6):984-92
Language
Russian
Publication Type
Article
Keywords
Cytokines - genetics
Ecosystem
Gene Frequency
Humans
Immune System Diseases - epidemiology - ethnology - genetics
Immunoglobulin E - genetics
Polymorphism, Genetic
Population - genetics
Siberia
Abstract
The data on distribution of genetic diversity in gene polymorphisms associated with autoimmune and allergic diseases and with regulation of immunoglobulin E and cytokines levels in 26 populations of the Northern Eurasia is presented. Substantial correlation between the values of average expected heterozygosity by 44 gene polymorphisms with climatic and geographical factors has not been revealed. Clustering of population groups in correspondence with their geographic locations is observed. The degree of gene differentiation among populations and the selective neutrality of gene polymorphisms have been assessed. The results of our work evidence the substantial genetic diversity and differentiation of human populations by studied genes.
PubMed ID
26710779 View in PubMed
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