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450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.

https://arctichealth.org/en/permalink/ahliterature122072
Source
Environ Health Perspect. 2012 Oct;120(10):1425-31
Publication Type
Article
Date
Oct-2012
Author
Bonnie R Joubert
Siri E Håberg
Roy M Nilsen
Xuting Wang
Stein E Vollset
Susan K Murphy
Zhiqing Huang
Cathrine Hoyo
Øivind Midttun
Lea A Cupul-Uicab
Per M Ueland
Michael C Wu
Wenche Nystad
Douglas A Bell
Shyamal D Peddada
Stephanie J London
Author Affiliation
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Source
Environ Health Perspect. 2012 Oct;120(10):1425-31
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Adult
Basic Helix-Loop-Helix Transcription Factors - genetics - metabolism
Biological Markers - blood
Chromatography, Liquid
Cohort Studies
Cotinine - blood
Cytochrome P-450 CYP1A1 - genetics - metabolism
DNA Methylation
DNA-Binding Proteins - genetics - metabolism
Epigenesis, Genetic
Female
Fetal Blood
Genome-Wide Association Study
Humans
Infant, Newborn
Male
Maternal Exposure
Norway - epidemiology
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - epidemiology - genetics
Repressor Proteins - genetics - metabolism
Tandem Mass Spectrometry
Tobacco Smoke Pollution - adverse effects
Transcription Factors - genetics - metabolism
United States - epidemiology
Abstract
Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple adverse health outcomes in children, but the underlying mechanisms are unclear.
We investigated epigenome-wide methylation in cord blood of newborns in relation to maternal smoking during pregnancy.
We examined maternal plasma cotinine (an objective biomarker of smoking) measured during pregnancy in relation to DNA methylation at 473,844 CpG sites (CpGs) in 1,062 newborn cord blood samples from the Norwegian Mother and Child Cohort Study (MoBa) using the Infinium HumanMethylation450 BeadChip (450K).
We found differential DNA methylation at epigenome-wide statistical significance (p-value
Notes
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Comment In: Environ Health Perspect. 2012 Oct;120(10):a40223026408
Erratum In: Environ Health Perspect. 2012 Dec;120(12):A455
PubMed ID
22851337 View in PubMed
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Exposure to tobacco smoke in utero and subsequent plasma lipids, ApoB, and CRP among adult women in the MoBa cohort.

https://arctichealth.org/en/permalink/ahliterature122454
Source
Environ Health Perspect. 2012 Nov;120(11):1532-7
Publication Type
Article
Date
Nov-2012
Author
Lea A Cupul-Uicab
Rolv Skjaerven
Kjell Haug
Gregory S Travlos
Ralph E Wilson
Merete Eggesbø
Jane A Hoppin
Kristina W Whitworth
Matthew P Longnecker
Author Affiliation
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. cupuluicabl@niehs.nih.gov
Source
Environ Health Perspect. 2012 Nov;120(11):1532-7
Date
Nov-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Biological Markers - blood
C-Reactive Protein - metabolism
Cohort Studies
Female
Humans
Lipids - blood
Metabolic Syndrome X - blood - chemically induced - epidemiology
Norway - epidemiology
Pregnancy
Prenatal Exposure Delayed Effects - blood - chemically induced - epidemiology
Risk factors
Smoking - adverse effects - epidemiology
Tobacco Smoke Pollution - adverse effects
Young Adult
Abstract
Recent findings suggest that maternal smoking during pregnancy may play a role in the development of metabolic alterations in offspring during childhood. However, whether such exposure increases the risk of developing similar metabolic alterations during adulthood is uncertain.
We evaluated the association of in utero exposure to maternal tobacco smoke with plasma lipids, apolipoprotein B (apoB), and C-reactive protein (CRP) in adulthood.
The study was based on a subsample of the Norwegian Mother and Child Cohort Study (MoBa) and included 479 pregnant women with plasma lipids, apoB, and CRP measurements. Information on in utero exposure to tobacco smoke, personal smoking, and other factors were obtained from the women by a self-completed questionnaire at enrollment, at approximately 17 weeks of gestation.
Women exposed to tobacco smoke in utero had higher triglycerides [10.7% higher; 95% confidence interval (CI): 3.9, 17.9] and lower high-density lipoprotein cholesterol (HDL) (-1.9 mg/dL; 95% CI: -4.3, 0.5) compared with unexposed women, after adjusting for age, physical activity, education, personal smoking, and current body mass index (BMI). Exposed women were also more likely to have triglycerides = 200 mg/dL [adjusted odds ratio (aOR) = 2.5; 95% CI: 1.3, 5.1] and HDL
Notes
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PubMed ID
22814200 View in PubMed
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In utero exposure to maternal tobacco smoke and subsequent obesity, hypertension, and gestational diabetes among women in the MoBa cohort.

https://arctichealth.org/en/permalink/ahliterature129229
Source
Environ Health Perspect. 2012 Mar;120(3):355-60
Publication Type
Article
Date
Mar-2012
Author
Lea A Cupul-Uicab
Rolv Skjaerven
Kjell Haug
Kari K Melve
Stephanie M Engel
Matthew P Longnecker
Author Affiliation
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. cupuluicabl@niehs.nih.gov
Source
Environ Health Perspect. 2012 Mar;120(3):355-60
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Adult
Body mass index
Cohort Studies
Diabetes Mellitus, Type 2 - chemically induced - epidemiology
Diabetes, Gestational - chemically induced - epidemiology
Female
Humans
Hypertension - chemically induced - epidemiology
Hypertension, Pregnancy-Induced - chemically induced - epidemiology
Middle Aged
Norway - epidemiology
Obesity - chemically induced - epidemiology
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - epidemiology
Prevalence
Self Report
Tobacco Smoke Pollution
Young Adult
Abstract
Environmental factors influencing the developmental origins of health and disease need to be identified and investigated. In utero exposure to tobacco smoke has been associated with obesity and a small increase in blood pressure in children; however, whether there is a corresponding increased risk of conditions such as diabetes and hypertension during adulthood remains unclear.
Our goal was to assess the association of self-reported in utero exposure to tobacco smoke with the prevalence of obesity, hypertension, type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) in women 14-47 years of age.
We conducted a cross-sectional analysis of the Norwegian Mother and Child Cohort Study, which enrolled pregnant women in Norway from 1999 thorough 2008. Exposure to tobacco smoke in utero (yes vs. no) was ascertained on the baseline questionnaire (obtained at ~ 17 weeks' gestation); the outcomes were ascertained from the Medical Birth Registry of Norway and the questionnaire. Our analysis included 74,023 women.
Women exposed to tobacco smoke in utero had 1.53 times the odds of obesity [95% confidence interval (CI): 1.45, 1.61] relative to those unexposed, after adjusting for age, education, and personal smoking. After further adjustment for body mass index, the odds ratio for hypertension was 1.68 (95% CI: 1.19, 2.39); for T2DM 1.14 (95% CI: 0.79, 1.65); and for GDM 1.32 (95% CI: 1.10, 1.58) among exposed compared with unexposed.
Exposure to tobacco smoke in utero was associated with obesity, hypertension, and GDM in adult women. The possibility that the associations were attributable to unmeasured confounding cannot be excluded.
Notes
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PubMed ID
22128036 View in PubMed
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Perfluorinated compounds in relation to birth weight in the Norwegian Mother and Child Cohort Study.

https://arctichealth.org/en/permalink/ahliterature125081
Source
Am J Epidemiol. 2012 Jun 15;175(12):1209-16
Publication Type
Article
Date
Jun-15-2012
Author
Kristina W Whitworth
Line S Haug
Donna D Baird
Georg Becher
Jane A Hoppin
Rolv Skjaerven
Cathrine Thomsen
Merete Eggesbo
Gregory Travlos
Ralph Wilson
Lea A Cupul-Uicab
Anne Lise Brantsaeter
Matthew P Longnecker
Author Affiliation
National Institute for Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA. whitworthkw@niehs.nih.gov
Source
Am J Epidemiol. 2012 Jun 15;175(12):1209-16
Date
Jun-15-2012
Language
English
Publication Type
Article
Keywords
Adult
Alkanesulfonic Acids - blood - toxicity
Birth Weight - drug effects
Caprylates - blood - toxicity
Diet Surveys
Environmental Pollutants - blood - toxicity
Female
Fetal Macrosomia - chemically induced
Fluorocarbons - blood - toxicity
Food Contamination
Humans
Infant, Newborn
Infant, Small for Gestational Age
Maternal Exposure - adverse effects
Norway
Odds Ratio
Pregnancy
Premature Birth - chemically induced
Prospective Studies
Seafood
Single-Blind Method
Abstract
Perfluorooctane sulfonate and perfluorooctanoic acid are perfluorinated compounds (PFCs) widely distributed in the environment. Previous studies of PFCs and birth weight are equivocal. The authors examined this association in the Norwegian Mother and Child Cohort Study (MoBa), using data from 901 women enrolled from 2003 to 2004 and selected for a prior case-based study of PFCs and subfecundity. Maternal plasma samples were obtained around 17 weeks of gestation. Outcomes included birth weight z scores, preterm birth, small for gestational age, and large for gestational age. The adjusted birth weight z scores were slightly lower among infants born to mothers in the highest quartiles of PFCs compared with infants born to mothers in the lowest quartiles: for perfluorooctane sulfonate, ß = -0.18 (95% confidence interval: -0.41, 0.05) and, for perfluorooctanoic acid, ß = -0.21 (95% confidence interval: -0.45, 0.04). No clear evidence of an association with small for gestational age or large for gestational age was observed. Perfluorooctane sulfonate and perfluorooctanoic acid were each associated with decreased adjusted odds of preterm birth, although the cell counts were small. Whether some of the associations suggested by these findings may be due to a noncausal pharmacokinetic mechanism remains unclear.
Notes
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PubMed ID
22517810 View in PubMed
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Reproducibility of reported in utero exposure to tobacco smoke.

https://arctichealth.org/en/permalink/ahliterature138867
Source
Ann Epidemiol. 2011 Jan;21(1):48-52
Publication Type
Article
Date
Jan-2011
Author
Lea A Cupul-Uicab
Xibiao Ye
Rolv Skjaerven
Kjell Haug
Matthew P Longnecker
Author Affiliation
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Human and Health Services, Durham, NC 27709, USA. cupuluicabl@niehs.nih.gov
Source
Ann Epidemiol. 2011 Jan;21(1):48-52
Date
Jan-2011
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
Data Collection - standards
Female
Fetus
Humans
Norway
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Reproducibility of Results
Smoking - epidemiology
Tobacco Smoke Pollution
Abstract
In studies of the fetal origins of disease and life course epidemiology, measures of fetal exposure may be based on information reported by the adults who were exposed in utero. In particular, the full spectrum of consequences of in utero exposure to maternal tobacco smoking is now an area of active investigation, and the ability to report such exposure reproducibly is of interest. We evaluated the reproducibility of in utero exposure to tobacco smoke, reported by the adult daughter during consecutive pregnancies.
This study was based on 11,257 women who enrolled for more than one pregnancy in the Norwegian Mother and Child Cohort Study (MoBa). Participants completed a questionnaire around 17 weeks of gestation, which asked about their in utero exposure to tobacco smoke. Kappa statistics were calculated. Determinants of agreement were evaluated using logistic regression.
Weighted Kappa for in utero exposure for the first and second reports was 0.80. Determinants of agreement were higher education (better) and longer time between reports (worse).
Information on in utero exposure to maternal tobacco smoking provided by adult women was highly reproducible in this population.
Notes
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PubMed ID
21130369 View in PubMed
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