To estimate incidence rates for cerebrovascular diseases (CVD) in a cohort of workers occupationally exposed to radiation over prolonged time periods.
CVD incidence was estimated in a cohort of 22.377 workers of the nuclear facility "Mayak" Production Association over the follow-up period 1948-2008. Non standardized and standardized incidence rates were estimated. An indirect method of standardization was used for the estimates.
As of 31/12/2008, 8.717 CVD cases (5.802 men and 2.915 women) were registered in the study cohort of workers. CVD incidence in the cohort was significantly associated with sex, age, smoking, alcohol consumption (in men) and arterial hypertension. CVD incidence was increased in workers exposed to external gamma-rays at total dose above 0.5 Gy and/or to internal alpha-radiation due to incorporated plutonium at total absorbed liver dose above 0.025 Gy.
CVD incidence in the cohort of workers occupationally exposed to radiation over prolonged time periods was associated both with non-radiation and radiation factors.
Analysis of chronic morbidity parameters in workers engaged into processing and utilization of arms and military equipment did not reveal any case of occupational radiation disease over 30 years of medical observation. Standardized parameters in general and in separate diseases classes did not differ with general data collected in Russia. Occurrence of separate entities did not depend on influence of radiation factors.
The authors evaluated prevalence of aortal atherosclerosis in dependence on radiation and non-radiation factors in workers underwent occupational prolonged irradiation.The study included 22,377 workers of nuclear industry enterprise "Mayak", with verified diagnosis of aortal atherosclerosis. Up to 31th December 2008, a total of 1,840 aortal atherosclerosis cases were registered in the examinees group. Aortal atherosclerosis prevalence appeared to depend reliably on sex, age, smoking habit (in males), alcohol consumption (in males) and arterial hypertension. Findings are that aortal atherosclerosis prevalence was higher in males and females underwent external gamma-irradiation of total dose over 0.5 Gy, in males and females underwent internal alpha-irradiation from incorporated plutonium of total absorbed radiation dose in liver over 0.025 Gy. Thus, aortal atherosclerosis prevalence in workers underwent occupational irradiation de- pended both on radiational and non-radiational factors.