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[Pathology of anthrax sepsis according to materials of the infectious outbreak in 1979 in Sverdlovsk (various aspects of morpho-, patho- and thanatogenesis)].

https://arctichealth.org/en/permalink/ahliterature222476
Source
Arkh Patol. 1993 Jan-Feb;55(1):23-6
Publication Type
Article
Author
L M Grinberg
A A Abramova
Source
Arkh Patol. 1993 Jan-Feb;55(1):23-6
Language
Russian
Publication Type
Article
Keywords
Anthrax - complications - epidemiology - pathology
Central Nervous System - pathology
Digestive System - pathology
Disease Outbreaks
Hemorrhage - etiology - pathology
Humans
Lung - pathology
Lymphadenitis - etiology - pathology
Russia - epidemiology
Sepsis - epidemiology - pathology
Thanatology
Abstract
Hemorrhagic lymphadenitis of the intrathoracic lymph nodes and mediastinitis are shown to be the primary septical focus, this indicating an inhalation route of the contamination with development of pulmonary anthrax. The alterations in the gastrointestinal tract and central nervous system are considered to be secondary resulting from lymphohematogenic generalization of the anthraxic sepsis. The attention is drawn to the morphological signs of the immunodepression and the inhibition of granulocytic reaction. It is noted that the epidemic outburst of the pulmonary anthrax is without analogs and its development may be the result only of a massive penetration of bacteria into the atmosphere.
PubMed ID
7980034 View in PubMed
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[Pathology of anthrax sepsis according to materials of the infectious outbreak in 1979 in Sverdlovsk (microscopic changes)].

https://arctichealth.org/en/permalink/ahliterature222477
Source
Arkh Patol. 1993 Jan-Feb;55(1):18-23
Publication Type
Article
Author
A A Abramova
L M Grinberg
Source
Arkh Patol. 1993 Jan-Feb;55(1):18-23
Language
Russian
Publication Type
Article
Keywords
Anthrax - complications - epidemiology - pathology
Central Nervous System - pathology
Digestive System - pathology
Disease Outbreaks
Humans
Inflammation - etiology - pathology
Lymph Nodes - pathology
Necrosis
Respiratory System - pathology
Russia - epidemiology
Sepsis - epidemiology - etiology - pathology
Viscera - pathology
Abstract
Histologic studies of 42 cases of anthrax revealed that serous-hemorrhagic, hemorrhagic and hemorrhagic-necrotic inflammation was a substrate of macroscopic changes. Morphological characteristics of alterations in the respiratory organs, lymph nodes and mediastinum, digestive tract and liver, spleen, kidneys, brain and meninges are presented.
PubMed ID
7980033 View in PubMed
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[Pathology of anthrax sepsis according to materials of the infectious outbreak in 1979 in Sverdlovsk (macroscopic changes)].

https://arctichealth.org/en/permalink/ahliterature222478
Source
Arkh Patol. 1993 Jan-Feb;55(1):12-7
Publication Type
Article
Author
A A Abramova
L M Grinberg
Source
Arkh Patol. 1993 Jan-Feb;55(1):12-7
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Anthrax - complications - epidemiology - pathology
Central Nervous System - pathology
Digestive System - pathology
Disease Outbreaks
Female
Humans
Male
Middle Aged
Respiratory System - pathology
Russia - epidemiology
Sepsis - epidemiology - etiology - pathology
Abstract
Obligatory findings in 42 postmortem observation of anthrax were hemorrhagic alterations of the intrathoracic lymph nodes and mediastinum. Hemorrhagic alterations in the respiratory organs, digestive tract, brain and meninges were also found macroscopically.
PubMed ID
7980032 View in PubMed
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Death at Sverdlovsk: what have we learned?

https://arctichealth.org/en/permalink/ahliterature218012
Source
Am J Pathol. 1994 Jun;144(6):1135-41
Publication Type
Article
Date
Jun-1994
Author
D H Walker
O. Yampolska
L M Grinberg
Author Affiliation
Department of Pathology, University of Texas Medical Branch, Galveston 77555-0609.
Source
Am J Pathol. 1994 Jun;144(6):1135-41
Date
Jun-1994
Language
English
Publication Type
Article
Keywords
Anthrax - epidemiology - etiology
Biological Warfare
Disease Outbreaks
Humans
Incidence
Russia - epidemiology
Notes
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PubMed ID
8203454 View in PubMed
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[Causes of death among tuberculosis patients (according to the findings of a unified phthisiatric prosectorium from 1981 to 1983)]

https://arctichealth.org/en/permalink/ahliterature39733
Source
Probl Tuberk. 1984 Nov;(11):58-61
Publication Type
Article
Date
Nov-1984

[Roentgeno-morphologic forms of bronchioloalveolar cancer].

https://arctichealth.org/en/permalink/ahliterature228805
Source
Vestn Rentgenol Radiol. 1990 Jul-Aug;(4):42-8
Publication Type
Article
Author
M L Shulutko
M G Vinner
L M Grinberg
G I Mazur
Source
Vestn Rentgenol Radiol. 1990 Jul-Aug;(4):42-8
Language
Russian
Publication Type
Article
Keywords
Adenocarcinoma, Bronchiolo-Alveolar - epidemiology - pathology - radiography
Humans
Lung Neoplasms - epidemiology - pathology - radiography
Retrospective Studies
Russia - epidemiology
Abstract
The paper is concerned with the description of clinical, x-ray and morphological investigation of 123 bronchoalveolar cancer patients. Three types of this disease were defined: nodular (homogeneous and nonhomogeneous), pneumonia-like (infiltrative and infiltrative-nodular) and mixed (focal-disseminated, focal-nodular and focal-infiltrative). These types of bronchoalveolar cancer are most probably stages of the same tumor process. Clinical and x-ray signs of each type showed correlation with a morphological picture of a tumor. Shadow nonhomogeneity as one of the main x-ray signs of bronchoalveolar cancer was shown to be determined by the "alveolar" structure of a tumor, a tendency to the formation of small cavities, filled with viscous mucosa and air. Correct clinical and x-ray diagnosis in all types of bronchoalveolar cancer (before the use of the morphological methods) was established in 45.5% of the patients.
PubMed ID
2176754 View in PubMed
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Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979.

https://arctichealth.org/en/permalink/ahliterature221444
Source
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2291-4
Publication Type
Article
Date
Mar-15-1993
Author
F A Abramova
L M Grinberg
O V Yampolskaya
D H Walker
Author Affiliation
Department of Pathology, Hospital 40, Ekaterinburg, Russia.
Source
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2291-4
Date
Mar-15-1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Anthrax - epidemiology - pathology - transmission
Bacillus anthracis - isolation & purification
Brain - pathology
Female
Hemorrhage
Humans
Intestinal Mucosa - pathology
Intestine, Small - pathology
Lung - pathology
Lymph Nodes - pathology
Male
Meninges - pathology
Middle Aged
Muscle, Smooth - pathology
Necrosis
Russia - epidemiology
Abstract
A large epidemic of anthrax that occurred in Sverdlovsk (now Ekaterinburg), Russia, in 1979 resulted in the deaths of many persons. A series of 42 necropsies, representing a majority of the fatalities from this outbreak, consistently revealed pathologic lesions diagnostic of inhalational anthrax, namely hemorrhagic necrosis of the thoracic lymph nodes in the lymphatic drainage of the lungs and hemorrhagic mediastinitis. Bacillus anthracis was recovered in bacterial cultures of 20 cases, and organisms were detected microscopically in the infected tissues of nearly all of the cases. A novel observation was primary focal hemorrhagic necrotizing pneumonia at the apparent portal of entry in 11 cases. Mesenteric lymphadenitis occurred in only 9 cases. This remarkably large series demonstrated the full range of effects of anthrax bacteremia and toxemia (edema especially adjacent to sites of extensive infection and pleural effusions) and hematogenously disseminated infection [hemorrhagic meningitis (21 cases) and multiple gastrointestinal submucosal hemorrhagic lesions (39 cases)].
Notes
Cites: Arch Environ Health. 1969 May;18(5):798-8054976545
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Cites: Pathol Annu. 1971;6:209-485005212
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Cites: Br Med J. 1976 Mar 27;1(6012):7481260311
Cites: Am J Med. 1977 Jan;62(1):130-2835581
Cites: Hum Pathol. 1978 Sep;9(5):594-7101438
Cites: Zh Mikrobiol Epidemiol Immunobiol. 1980 May;(5):111-37415678
Cites: Cent Afr J Med. 1980 Dec;26(12):253-47214503
Cites: Proc Natl Acad Sci U S A. 1982 May;79(10):3162-66285339
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Cites: Gut. 1970 Apr;11(4):352-45428857
PubMed ID
8460135 View in PubMed
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Quantitative pathology of inhalational anthrax I: quantitative microscopic findings.

https://arctichealth.org/en/permalink/ahliterature194677
Source
Mod Pathol. 2001 May;14(5):482-95
Publication Type
Article
Date
May-2001
Author
L M Grinberg
F A Abramova
O V Yampolskaya
D H Walker
J H Smith
Author Affiliation
Department of Pathology, Tuberculosis and Pulmonary Diseases Unit, Hospital 40, Ekaterinburg, Russia.
Source
Mod Pathol. 2001 May;14(5):482-95
Date
May-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Anthrax - epidemiology - microbiology - pathology
Bacillus anthracis - growth & development - isolation & purification - pathogenicity
Biological Warfare
Disease Outbreaks
Edema - microbiology - pathology
Female
Heart - microbiology
Humans
Inhalation Exposure
Lymph Nodes - microbiology - pathology
Male
Mediastinum - microbiology - pathology
Middle Aged
Myocardium - pathology
Occupational Diseases - epidemiology - microbiology - pathology
Respiratory Insufficiency - microbiology - pathology
Russia - epidemiology
Vasculitis - microbiology - pathology
Abstract
Forty-one cases of documented inhalational anthrax from the Sverdlovsk epidemic of 1979 traced to release of aerosols of Bacillus anthracis at a secret biologic-agent production facility were evaluated by semiquantitative histopathologic analysis of tissue concentrations of organisms, inflammation, hemorrhage, and other lesions in the mediastinum, mediastinal lymph nodes, bronchi, lungs, heart, spleen, liver, intestines, kidneys, adrenal glands, and central nervous system. These data were correlated with clinical, epidemiologic, and demographic data. The patients' courses, with a variable incubation period and short nonspecific course (4 days before hospitalization) with rapid demise (1 day of hospitalization before death), correlated with systemic bacterial infection and lesions. Bacillus anthracis were identified in all cases in which there was no antibiotic treatment or there was treatment for fewer than 21 hours. The lesions that were the most severe and apparently of longest duration were in the mediastinal lymph nodes and mediastinum. There and elsewhere, peripheral transudate surrounded fibrin-rich edema; necrosis of arteries and veins was the most likely source of large hemorrhages displacing tissue or infiltrating tissue, respectively; and apoptosis of lymphocytes was observed. Respiratory function was compromised by mediastinal expansion, large pleural effusions, and hematogenous and retrograde lymphatic vessel spread of B. anthracis to the lung with consequent pneumonia. The central nervous system and intestines manifested similar hematogenous spread, vasculitis, hemorrhages, and edema. These pathologic findings are consistent with previous experimental studies showing transport of inhaled spores to mediastinal lymph nodes, where germination and growth lead to local lesions and systemic spread, with resulting edema and cell death, owing to the effects of edema toxin and lethal toxin. The identification of the vascular lesions as a basis for the prominent hemorrhages is a novel observation for human inhalational anthrax.
PubMed ID
11353060 View in PubMed
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PCR analysis of tissue samples from the 1979 Sverdlovsk anthrax victims: the presence of multiple Bacillus anthracis strains in different victims.

https://arctichealth.org/en/permalink/ahliterature206325
Source
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1224-9
Publication Type
Article
Date
Feb-3-1998
Author
P J Jackson
M E Hugh-Jones
D M Adair
G. Green
K K Hill
C R Kuske
L M Grinberg
F A Abramova
P. Keim
Author Affiliation
Environmental Molecular Biology Group, Los Alamos National Laboratory, Los Alamos, NM, USA.
Source
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1224-9
Date
Feb-3-1998
Language
English
Publication Type
Article
Keywords
Animals
Anthrax - epidemiology - microbiology
Bacillus anthracis - genetics - isolation & purification
Biological Warfare
Cattle
Chromosomes, Bacterial - genetics
DNA, Bacterial - chemistry
Disease Outbreaks
Electrophoresis, Agar Gel
Humans
Meat - microbiology
Minisatellite Repeats
Polymerase Chain Reaction
Russia - epidemiology
Abstract
An outbreak of human anthrax occurred in Sverdlovsk, Union of Soviet Socialists Republic (now Ekaterinburg, Russia) in April 1979. Officials attributed this to consumption of contaminated meat, but Western governments believed it resulted from inhalation of spores accidentally released from a nearby military research facility. Tissue samples from 11 victims were obtained and methods of efficiently extracting high-quality total DNA from these samples were developed. Extracted DNA was analyzed by using PCR to determine whether it contained Bacillus anthracis-specific sequences. Double PCR using "nested primers" increased sensitivity of the assay significantly. Tissue samples from 11 persons who died during the epidemic were examined. Results demonstrated that the entire complement of B. anthracis toxin and capsular antigen genes required for pathogenicity were present in tissues from each of these victims. Tissue from a vaccination site contained primarily nucleic acids from a live vaccine, although traces of genes from the infecting organisms were also present. PCR analysis using primers that detect the vrrA gene variable region on the B. anthracis chromosome demonstrated that at least four of the five known strain categories defined by this region were present in the tissue samples. Only one category is found in a single B. anthracis strain.
Notes
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PubMed ID
9448313 View in PubMed
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9 records – page 1 of 1.