Skip header and navigation

2 records – page 1 of 1.

Effect of expanded US recommendations for seasonal influenza vaccination: comparison of two pediatric emergency departments in the United States and Canada.
CMAJ. 2011 Sep 20;183(13):E1025-32
Publication Type
Anne Gatewood Hoen
David L Buckeridge
Katia M L Charland
Kenneth D Mandl
Caroline Quach
John S Brownstein
Author Affiliation
Computational Epidemiology Group, Children's Hospital Informatics Program, Children's Hospital Boston, Boston, MA, USA.
CMAJ. 2011 Sep 20;183(13):E1025-32
Publication Type
Age Distribution
Child, Preschool
Emergency Service, Hospital
Influenza Vaccines
Influenza, Human - epidemiology - prevention & control
Practice Guidelines as Topic
Retrospective Studies
United States
Starting in the 2006/2007 influenza season, the US Advisory Committee on Immunization Practices expanded its recommendations for seasonal influenza vaccination to include healthy children aged 24-59 months. The parallel Canadian organization, the National Advisory Committee on Immunization, did not at that time issue a similar recommendation, thereby creating a natural experiment to evaluate the effect of the policy in the United States.
We examined data for 2000/2001 through 2008/2009 and estimated relative changes in visits to the emergency department for influenza-like illness at two pediatric hospitals, one in Boston, Massachusetts, and the other in Montréal, Quebec, following the US policy change. Models were adjusted for virologic factors, seasonal trends and all-cause utilization of the emergency department.
Of 1 043 989 visits to the emergency departments of the two hospitals for any reason during the study period, 114 657 visits were related to influenza-like illness. Adjusted models estimated a 34% decline in rates of influenza-like illness among children two to four years old in the US hospital relative to the Canadian hospital (rate ratio 0.66, 95% confidence interval 0.58-0.75) following the 2006 policy change of the Advisory Committee on Immunization Practices. This was accompanied by more modest declines of 11% to 18% for the other age groups studied.
The divergence in influenza rates among children in the US and Canadian sample populations after institution of the US policy to vaccinate children two to four years of age is evidence that the recommendation of the US Advisory Committee on Immunization Practices resulted in a reduction in influenza-related morbidity in the target group and may have indirectly affected other pediatric age groups. Provincial adoption of the 2010 recommendation of the National Advisory Committee on Immunization in Canada to vaccinate children two to four years of age might positively affect influenza morbidity in Canada.
Cites: N Engl J Med. 2001 Mar 22;344(12):889-9611259722
Cites: Influenza Other Respir Viruses. 2010 Sep;4(5):295-30620716158
Cites: Am J Prev Med. 2001 May;20(4 Suppl):17-2411331127
Cites: Health Rep. 2002;13(3):9-1412743956
Cites: MMWR Recomm Rep. 2003 Apr 25;52(RR-8):1-34; quiz CE1-412755288
Cites: Clin Infect Dis. 2004 Mar 1;38(5):678-8814986252
Cites: MMWR Recomm Rep. 2004 May 28;53(RR-6):1-4015163927
Cites: Bull World Health Organ. 1969;41(3):537-425309469
Cites: Am J Epidemiol. 1982 May;115(5):736-517081204
Cites: Epidemiol Infect. 1993 Feb;110(1):145-608432318
Cites: J Infect Dis. 1993 Oct;168(4):881-78376833
Cites: MMWR CDC Surveill Summ. 1997 Aug 1;46(3):1-319259213
Cites: Am J Public Health. 1997 Dec;87(12):1944-509431281
Cites: Lancet. 1999 Oct 9;354(9186):1277-8210520648
Cites: Am J Epidemiol. 2005 Feb 15;161(4):303-615692073
Cites: Vaccine. 2005 Feb 18;23(13):1540-815694506
Cites: Science. 2006 Feb 3;311(5761):615-616456066
Cites: Ann Emerg Med. 2006 Mar;47(3):265.e116492494
Cites: Pediatrics. 2006 Jul;118(1):e1-816818524
Cites: N Engl J Med. 2006 Jul 6;355(1):31-4016822994
Cites: MMWR Recomm Rep. 2006 Jul 28;55(RR-10):1-4216874296
Cites: J Infect Dis. 2006 Nov 1;194 Suppl 2:S111-817163383
Cites: J Am Med Inform Assoc. 2007 Sep-Oct;14(5):581-817600100
Cites: MMWR Recomm Rep. 2008 Aug 8;57(RR-7):1-6018685555
Cites: PLoS Med. 2008 Oct 28;5(10):e21118959473
Cites: MMWR Recomm Rep. 2009 Jul 31;58(RR-8):1-5219644442
Cites: JAMA. 2010 Mar 10;303(10):943-5020215608
Cites: MMWR Recomm Rep. 2010 Aug 6;59(RR-8):1-6220689501
Comment In: CMAJ. 2011 Sep 20;183(13):1464-521930746
PubMed ID
21930745 View in PubMed
Less detail

Pediatric versus adult drug trials for conditions with high pediatric disease burden.
Pediatrics. 2012 Aug;130(2):285-92
Publication Type
Florence T Bourgeois
Srinivas Murthy
Catia Pinto
Karen L Olson
John P A Ioannidis
Kenneth D Mandl
Author Affiliation
Division of Emergency Medicine, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA.
Pediatrics. 2012 Aug;130(2):285-92
Publication Type
Age Factors
Cost of Illness
Drug Industry - statistics & numerical data
Drugs, Investigational - adverse effects - therapeutic use
Evidence-Based Medicine - statistics & numerical data
Quality Indicators, Health Care - standards - statistics & numerical data
Randomized Controlled Trials as Topic - standards - statistics & numerical data
Research Support as Topic
Treatment Outcome
Optimal treatment decisions in children require sufficient evidence on the safety and efficacy of pharmaceuticals in pediatric patients. However, there is concern that not enough trials are conducted in children and that pediatric trials differ from those performed in adults. Our objective was to measure the prevalence of pediatric studies among clinical drug trials and compare trial characteristics and quality indicators between pediatric and adult drug trials.
For conditions representing a high burden of pediatric disease, we identified all drug trials registered in with start dates between 2006 and 2011 and tracked the resulting publications. We measured the proportion of pediatric trials and subjects for each condition and compared pediatric and adult trial characteristics and quality indicators.
For the conditions selected, 59.9% of the disease burden was attributable to children, but only 12.0% (292/2440) of trials were pediatric (P
Cites: Arch Pediatr Adolesc Med. 2010 Mar;164(3):283-820194264
Cites: PLoS Med. 2008 Nov 25;5(11):e23019067481
Cites: Arch Dis Child. 2010 Jun;95(6):469-7320501540
Cites: J Pediatr. 2010 Aug;157(2):322-330.e1720434730
Cites: Ann Intern Med. 2010 Aug 3;153(3):158-6620679560
Cites: Arch Dis Child. 2010 Sep;95(9):731-820522477
Cites: PLoS One. 2010;5(9). pii: e13106. doi: 10.1371/journal.pone.001310620927344
Cites: BMC Pediatr. 2010;10:9621176224
Cites: N Engl J Med. 2011 Mar 3;364(9):852-6021366476
Cites: PLoS One. 2011;6(2):e1470121383991
Cites: Br J Clin Pharmacol. 2011 Jun;71(6):929-3521564161
Cites: Arch Intern Med. 2012 Feb 13;172(3):237-4422332155
Cites: N Engl J Med. 2003 Sep 18;349(12):1157-6713679531
Cites: BMJ. 2002 Mar 23;324(7339):70211909786
Cites: N Engl J Med. 2002 Oct 31;347(18):1462-7012409558
Cites: Lancet. 2002 Nov 23;360(9346):1620-212457782
Cites: JAMA. 2003 Aug 20;290(7):905-1112928467
Cites: CMAJ. 2004 Feb 17;170(4):477-8014970094
Cites: Lancet. 2004 Aug 28-Sep 3;364(9436):803-1115337409
Cites: Rev Infect Dis. 1981 May-Jun;3(3):479-916792681
Cites: Pediatrics. 1996 Jul;98(1):118-238668382
Cites: JAMA. 1998 Jan 28;279(4):281-69450711
Cites: Lancet. 1998 May 30;351(9116):1652-49620734
Cites: Lancet. 1999 Apr 3;353(9159):1117-810209973
Cites: N Engl J Med. 1999 Jun 17;340(24):1881-710369852
Cites: Lancet. 1999 Jul 10;354(9173):16410408518
Cites: Lancet. 1999 Sep;354 Suppl 2:SII21-410507255
Cites: Eur J Clin Pharmacol. 2005 Apr;61(2):165-715761753
Cites: Eur J Pediatr. 2005 Sep;164(9):552-815912383
Cites: J Clin Epidemiol. 2007 Feb;60(2):118-2317208117
Cites: Arch Pediatr Adolesc Med. 2007 Mar;161(3):282-9017339510
Cites: Br J Clin Pharmacol. 2007 Jul;64(1):1-217577389
Cites: BMJ. 2007 Dec 15;335(7632):1221-218079516
Cites: BMJ. 2007 Dec 15;335(7632):122718079526
Cites: Pediatrics. 2008 Jul;122(1):52-718595986
Cites: Ann Emerg Med. 2008 Aug;52(2):137-918672488
Cites: PLoS Med. 2008 Sep 23;5(9):e19118816163
Cites: Paediatr Drugs. 2010 Apr 1;12(2):99-10320218746
PubMed ID
22826574 View in PubMed
Less detail