Skip header and navigation

Refine By

15 records – page 1 of 2.

Adipose tissue fatty acids as biomarkers of dietary exposure in Danish men and women.

https://arctichealth.org/en/permalink/ahliterature24046
Source
Am J Clin Nutr. 1993 May;57(5):629-33
Publication Type
Article
Date
May-1993
Author
A. Tjønneland
K. Overvad
E. Thorling
M. Ewertz
Author Affiliation
Danish Cancer Registry, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Source
Am J Clin Nutr. 1993 May;57(5):629-33
Date
May-1993
Language
English
Publication Type
Article
Keywords
Adipose Tissue - metabolism
Adult
Biological Markers - analysis
Denmark - epidemiology
Diet - statistics & numerical data
Dietary Fats - administration & dosage
Fatty Acids - analysis
Female
Humans
Male
Middle Aged
Nutrition Surveys
Research Support, Non-U.S. Gov't
Abstract
Adipose tissue fatty acids, it has been proposed, reflect dietary intake. Using data from a validation study preceding a prospective study on diet, cancer, and health in Denmark, we were able to compare fatty acid profiles in adipose tissue biopsies from 86 individuals (23 men and 63 women) aged 40-64 y and dietary intake of fatty acids (as percentage of total fat) assessed by two 7-d weighed-diet records or by a semi-quantitative food frequency questionnaire. Correlation coefficients (Pearson r) between fatty acid concentrations in adipose tissue biopsies (as percentage of total peak area) and dietary intake of fatty acid (percentage of total fat), determined from the diet records for men and women, respectively, were as follows: polyunsaturated fatty acids r = 0.74 and r = 0.46; n - 3 fatty acids of marine origin: eicosapentaenoic acid r = 0.15 and r = 0.61, and docosahexaenoic acid r = 0.47 and r = 0.57. Correlation coefficients obtained by using the food frequency questionnaire were slightly lower for most fatty acids.
PubMed ID
8480677 View in PubMed
Less detail

[A quantitative assessment of the impact of diet on the mortality of heart disease in Denmark. Estimation of etiologic fraction]

https://arctichealth.org/en/permalink/ahliterature10365
Source
Ugeskr Laeger. 2000 Sep 11;162(37):4921-5
Publication Type
Article
Date
Sep-11-2000
Author
M. Osler
J. Godtfredsen
M N Grønbaek
P. Marckmann
O K Overvad
Author Affiliation
Københavns Universitet, Panum Instituttet, afdeling for social medicin og psykosocial sundhed (Institut for Folkesundhedsvidenskab).
Source
Ugeskr Laeger. 2000 Sep 11;162(37):4921-5
Date
Sep-11-2000
Language
Danish
Publication Type
Article
Keywords
Alcohol Drinking
Coronary Disease - etiology - mortality
Denmark - epidemiology
Dietary Fats - administration & dosage
English Abstract
Food Habits
Fruit
Guidelines
Humans
Myocardial Ischemia - etiology - mortality
Risk assessment
Risk factors
Vegetables
Abstract
INTRODUCTION: The aim of the present study was to quantify the impact of different dietary factors on the mortality from ischaemic heart disease in Denmark. METHODS: Relative risks and knowledge on the distribution of different dietary factors were used to estimate etiological fractions. RESULTS: It is estimated that an intake of fruit and vegetables and saturated fat as recommended would prevent 12 and 22%, respectively, of deaths from ischaemic heart disease in Denmark. An intake of fish among those at high risk for ischaemic heart disease, would lead to a 26% lower mortality, while alcohol intake among abstainers would have no significant quantitative effect. DISCUSSION: These results suggest that changes in dietary habits according to current recommendations would have an impact on public health in Denmark.
PubMed ID
11002740 View in PubMed
Less detail

Baseline patterns of adipose tissue fatty acids and long-term risk of breast cancer: a case-cohort study in the Danish cohort Diet, Cancer and Health.

https://arctichealth.org/en/permalink/ahliterature264936
Source
Eur J Clin Nutr. 2014 Oct;68(10):1088-94
Publication Type
Article
Date
Oct-2014
Author
J A Schmidt
A. Gorst-Rasmussen
P W Nyström
J H Christensen
E B Schmidt
C. Dethlefsen
A. Tjønneland
K. Overvad
C C Dahm
Source
Eur J Clin Nutr. 2014 Oct;68(10):1088-94
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - epidemiology - pathology
Cohort Studies
Denmark - epidemiology
Fatty Acids - analysis
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk
Risk factors
Subcutaneous Fat - chemistry
Abstract
The evidence regarding fatty acids and breast cancer risk is inconclusive. Adipose tissue fatty acids can be used as biomarkers of fatty acid intake and of endogenous fatty acid exposure. Fatty acids in adipose tissue are correlated owing to common dietary sources and shared metabolic pathways, which group fatty acids into naturally occurring patterns. We aimed to prospectively investigate associations between adipose tissue fatty acid patterns and long-term risk of total breast cancer and breast cancer subtypes characterised by oestrogen and progesterone receptor status (ER and PR).
This case-cohort study was based on data from the Danish cohort Diet, Cancer and Health. At baseline, a fat biopsy and information on lifestyle and reproductive factors were collected. From the 31 original fatty acids measured, patterns of fatty acids were identified using the treelet transform. During a median follow-up of 5.3 years, 474 breast cancer cases were identified. Hazard ratios and 95% confidence intervals of risk of total breast cancer and of subtypes according to quintiles of factor score were determined by weighted Cox proportional hazards regression.
After adjustment for potential confounders, factor scores for the seven patterns identified by the treelet transform were not associated with risk of total breast cancer, nor with risk of ER+, ER-, PR+ or PR- tumours.
No clear associations between the patterns of fatty acids at baseline and long-term risk of total breast cancer or ER+, ER-, PR+ or PR- tumours were observed.
PubMed ID
24642780 View in PubMed
Less detail

Body composition and body fat distribution in relation to later risk of acute myocardial infarction: a Danish follow-up study.

https://arctichealth.org/en/permalink/ahliterature137399
Source
Int J Obes (Lond). 2011 Nov;35(11):1433-41
Publication Type
Article
Date
Nov-2011
Author
J G Stegger
E B Schmidt
T. Obel
T L Berentzen
A. Tjønneland
T I A Sørensen
K. Overvad
Author Affiliation
Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. Jakob.Stegger@rn.dk
Source
Int J Obes (Lond). 2011 Nov;35(11):1433-41
Date
Nov-2011
Language
English
Publication Type
Article
Keywords
Body Composition
Body Fat Distribution
Body mass index
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction - epidemiology - etiology - physiopathology
Obesity - complications - epidemiology - physiopathology
Predictive value of tests
Proportional Hazards Models
Prospective Studies
Questionnaires
Risk factors
Abstract
Obesity is a modifiable risk factor for acute myocardial infarction (MI), but lean body mass (LBM) may also be an important factor. Low LBM may increase the risk of MI and LBM may modify the effect of obesity on MI. Thus, the inability of the classical anthropometric measures to evaluate LBM may lead to misclassification of MI risk in both lean and obese persons. We investigated the associations between incident MI and bioelectrical impedance analyses (BIA) derived measures of body composition in combination with body mass index (BMI) and anthropometric measures of body fat distribution.
From 1993 to 1997, 27?148 men and 29?863 women, aged 50 to 64 year, were recruited into the Danish prospective study Diet, Cancer and Health. During 11.9 years of follow-up we identified 2028 cases of incident MI (1487 men and 541 women). BMI, waist circumference (WC), hip circumference and BIA of body composition including body fat mass (BFM), body fat percentage and LBM were measured at baseline. We used Cox proportional hazard models with age as time axis and performed extensive control for confounding. Weight, BMI, classical estimates of abdominal obesity and BIA estimates of obesity showed significant positive associations with incident MI. However, BFM adjusted for WC showed no association. Low LBM was associated with a higher risk of incident MI in both genders, and high LBM was associated with a higher risk in men.
Obesity was positively associated with MI. Estimates of obesity achieved by BIA seemed not to add additional information to classical anthropometric measures regarding MI risk. Both high and low LBM may be positively associated with MI.
PubMed ID
21285940 View in PubMed
Less detail

[Diet, cancer and health--a population study and establishment of a biological bank in Denmark]

https://arctichealth.org/en/permalink/ahliterature20597
Source
Ugeskr Laeger. 2000 Jan 17;162(3):350-4
Publication Type
Article
Date
Jan-17-2000
Author
A M Tjønneland
O K Overvad
Author Affiliation
Aarhus Universitet, Institut for Epidemiologi og Socialmedicin.
Source
Ugeskr Laeger. 2000 Jan 17;162(3):350-4
Date
Jan-17-2000
Language
Danish
Publication Type
Article
Keywords
Aged
Cohort Studies
Databases, Factual
Denmark - epidemiology
English Abstract
Follow-Up Studies
Food Habits
Humans
Life Style
Middle Aged
Neoplasms - epidemiology - etiology - mortality
Prospective Studies
Questionnaires
Registries
Risk factors
Specimen Handling
Tissue Banks
Abstract
In order to test hypotheses on diet and the risk of cancer, a prospective cohort study was established. A total of 57,055 persons living in Copenhagen and Aarhus, between 50 and 65 years of age, visited a study clinic between December 1993 and May 1997. The participants provided questionnaire data on diet and lifestyle. Furthermore, anthropometric measurements, blood pressure and biological material were collected. All participants will be followed by linkage to health registries including the Cancer Registry and by self-administered follow-up questionnaires. The purpose of this publication is to describe the data-base, which will be available for research in the years to come including the results of the first two years of follow-up.
PubMed ID
10680472 View in PubMed
Less detail

Does the association between smoking status and selected healthy foods depend on gender? A population-based study of 54 417 middle-aged Danes.

https://arctichealth.org/en/permalink/ahliterature19306
Source
Eur J Clin Nutr. 2002 Jan;56(1):57-63
Publication Type
Article
Date
Jan-2002
Author
M. Osler
A. Tjønneland
M. Suntum
B L Thomsen
C. Stripp
M. Grønbaek
K. Overvad
Author Affiliation
Institute of Public Health, University of Copenhagen, Copenhagen, Denmark.
Source
Eur J Clin Nutr. 2002 Jan;56(1):57-63
Date
Jan-2002
Language
English
Publication Type
Article
Keywords
Body mass index
Denmark - epidemiology
Diet Surveys
Dietary Fats, Unsaturated - analysis
Educational Status
Female
Food Habits - drug effects
Humans
Life Style
Male
Middle Aged
Questionnaires
Research Support, Non-U.S. Gov't
Sex Factors
Smoking - adverse effects - epidemiology
Abstract
OBJECTIVE: Smoking serves different functions for men and women. Thus, we wanted to investigate the association between smoking behaviour and intakes of selected healthy foods in men and women with special focus on differences and similarities between the two genders. DESIGN: In 1993-1997, a random sample of 80 996 men and 79 729 women aged 50-64 y was invited to participate in the study 'Diet, Cancer and Health'. In all, 27 179 men and 29 876 women attended a health examination and completed a 192-item food-frequency questionnaire (FFQ). The association between smoking status and low, median and high intakes of selected foods was examined among 25 821 men and 28 596 women. SETTING: The greater Copenhagen and Aarhus area, Denmark. RESULTS: For both men and women, smoking status group was associated with diet, such that increasing level of smoking status ranging from never smokers over ex-smokers to currently heavy smokers was associated with a lower intake of the healthy foods: fresh fruit, cooked vegetables, raw vegetables/salad, and olive oil. For wine, increasing level of smoking status category was associated with a higher fraction of abstainers and heavy drinkers. The difference between the extreme smoking status categories was larger than the difference between men and women within smoking status categories such that never smoking men in general had a higher intake of healthy foods than heavy smoking women. Correction for age, educational level, and body mass index (BMI) did not affect the results. CONCLUSION: In this middle-aged population, intake of healthy foods were associated with smoking behaviour with a dose-response type of relationship. The overall pattern was similar for men and women.
PubMed ID
11840181 View in PubMed
Less detail

Interaction between blood type, smoking and factor V Leiden mutation and risk of venous thromboembolism: a Danish case-cohort study.

https://arctichealth.org/en/permalink/ahliterature124479
Source
J Thromb Haemost. 2012 Oct;10(10):2191-3
Publication Type
Article
Date
Oct-2012

Iodine. Do we need an enrichment program in Denmark?

https://arctichealth.org/en/permalink/ahliterature61975
Source
Int J Food Sci Nutr. 1996 Sep;47(5):377-81
Publication Type
Article
Date
Sep-1996
Author
L B Rasmussen
G. Andersson
J. Haraldsdóttir
E. Kristiansen
K. Molsted
P. Laurberg
K. Overvad
H. Perrild
L. Ovesen
Author Affiliation
National Food Agency, Royal Veterinary and Agricultural University, Søborg, Denmark.
Source
Int J Food Sci Nutr. 1996 Sep;47(5):377-81
Date
Sep-1996
Language
English
Publication Type
Article
Keywords
Animals
Beverages
Cattle
Denmark - epidemiology
Diet
Eggs
Female
Fishes
Food, Fortified
Goiter - classification - epidemiology - prevention & control
Humans
Incidence
Iodine - administration & dosage - urine
Meat
Middle Aged
Milk
Nutritional Requirements
Abstract
A working group was established to evaluate the need for iodine enrichment in Denmark. Judged from studies of urinary iodine excretion and one dietary survey the intake of iodine in Denmark is low compared with recommended intakes. The occurrence of non-toxic goitre is relatively high; between 9 and 13% in elderly women. Furthermore, a high occurrence of toxic goitre has been seen in the western part of Denmark. On the other hand, an increased or a high intake of iodine may lead to hyperthyroidism and thyroiditis. The working group concluded that an increase in iodine intake in the Danish population is needed and the best way to achieve this is to iodize all salt. To avoid side effects of a sudden large increase in iodine intake the initial amount of iodine in salt will only be 2 ppm.
PubMed ID
8889622 View in PubMed
Less detail

Long-term exposure to traffic-related air pollution and diabetes-associated mortality: a cohort study.

https://arctichealth.org/en/permalink/ahliterature121320
Source
Diabetologia. 2013 Jan;56(1):36-46
Publication Type
Article
Date
Jan-2013
Author
O. Raaschou-Nielsen
M. Sørensen
M. Ketzel
O. Hertel
S. Loft
A. Tjønneland
K. Overvad
Z J Andersen
Author Affiliation
Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark. ole@cancer.dk
Source
Diabetologia. 2013 Jan;56(1):36-46
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Air Pollutants - toxicity
Cohort Studies
Confounding Factors (Epidemiology)
Denmark - epidemiology
Diabetes Mellitus - epidemiology - mortality
Environmental Exposure - adverse effects
Female
Follow-Up Studies
Humans
Male
Middle Aged
Nitrogen Dioxide - toxicity
Proportional Hazards Models
Prospective Studies
Questionnaires
Registries
Residence Characteristics
Time Factors
Urban health
Vehicle Emissions - toxicity
Abstract
The aim of this study was to investigate whether air pollution from traffic at a residence is associated with mortality related to type 1 or type 2 diabetes.
We followed up 52,061 participants in the Danish Diet, Cancer and Health cohort for diabetes-related mortality in the nationwide Register of Causes of Death, from baseline in 1993-1997 up to the end of 2009, and traced their residential addresses since 1971 in the Central Population Registry. We used dispersion-modelled concentration of nitrogen dioxide (NO2) since 1971 and amount of traffic at the baseline residence as indicators of traffic-related air pollution and used Cox regression models to estimate mortality-rate ratios (MRRs) with adjustment for potential confounders.
Mean levels of NO2 at the residence since 1971 were significantly associated with mortality from diabetes. Exposure above 19.4 µg/m³ (upper quartile) was associated with a MRR of 2.15 (95% CI 1.21, 3.83) when compared with below 13.6 µg/m³ (lower quartile), corresponding to an MRR of 1.31 (95% CI 0.98, 1.76) per 10 µg/m³ NO2 after adjustment for potential confounders.
This study suggests that traffic-related air pollution is associated with mortality from diabetes. If confirmed, reduction in population exposure to traffic-related air pollution could be an additional strategy against the global public health burden of diabetes.
PubMed ID
22918192 View in PubMed
Less detail

Obesity and risk of subsequent hospitalisation with pneumonia.

https://arctichealth.org/en/permalink/ahliterature144594
Source
Eur Respir J. 2010 Dec;36(6):1330-6
Publication Type
Article
Date
Dec-2010
Author
J B Kornum
M. Nørgaard
C. Dethlefsen
K M Due
R W Thomsen
A. Tjønneland
H T Sørensen
K. Overvad
Author Affiliation
Dept of Clinical Epidemiology, Aarhus University Hospital, Denmark. j.kornum@rn.dk
Source
Eur Respir J. 2010 Dec;36(6):1330-6
Date
Dec-2010
Language
English
Publication Type
Article
Keywords
Alcohol drinking - epidemiology
Body mass index
Chronic Disease
Cohort Studies
Comorbidity
Denmark - epidemiology
Female
Hospitalization
Humans
Life Style
Male
Middle Aged
Obesity - epidemiology
Pneumonia - epidemiology
Prospective Studies
Risk factors
Smoking - epidemiology
Abstract
Obesity may be associated with increased risk of pneumonia, but available data on this relationship are sparse and inconsistent. We followed a prospective cohort of 22,578 males and 25,973 females from the Danish Diet, Cancer and Health Study, aged 50-64 yrs and free from major chronic diseases at baseline (1993-1997), for first-time hospitalisation with pneumonia (median follow-up 12 yrs). Compared with males of normal weight, adjusted hazard ratios (HRs) for pneumonia were 1.4 (95% CI 1.2-1.7) for males with moderate obesity (body mass index (BMI) 30.0-34.9 kg·m?²), and 2.0 (95% CI 1.4-2.8) for males with severe obesity (BMI = 35.0 kg·m?²), controlling for lifestyle and educational variables. Among females the associations were weaker, with adjusted HRs of 0.8 (95% CI 0.6-1.0) for moderate obesity, and 1.2 (95% CI 0.8-1.6) for severe obesity. Adjustment for major chronic diseases diagnosed during follow-up eliminated the associations between obesity and pneumonia risk. Obesity is associated with higher risk of hospitalisation with pneumonia among males but not among females, which is apparently explained by occurrence of other chronic diseases.
Notes
Comment In: Eur Respir J. 2011 May;37(5):1298; author reply 1299-130021532024
Comment In: Eur Respir J. 2011 May;37(5):1299; author reply 1299-130021532025
PubMed ID
20351023 View in PubMed
Less detail

15 records – page 1 of 2.