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Source
Epidemiol Rev. 2007;29:77-87
Publication Type
Article
Date
2007
Author
M U Jakobsen
T. Berentzen
T I A Sørensen
K. Overvad
Author Affiliation
Institute of Preventive Medicine, Centre for Health And Society, Copenhagen University Hospital, Copenhagen, Denmark. muj@dce.au.dk
Source
Epidemiol Rev. 2007;29:77-87
Date
2007
Language
English
Publication Type
Article
Keywords
Abdominal Fat - metabolism
Denmark
Fatty Liver - metabolism
Humans
Obesity - metabolism
Abstract
It has been hypothesized that visceral fat releases free fatty acids and adipokines and thereby exposes the liver to fat accumulation. The authors aimed to evaluate current epidemiologic evidence for an association between abdominal fat and liver fat content. Clinical and epidemiologic studies with data on abdominal fat and liver fat content were reviewed. Studies using waist circumference to estimate abdominal fat mass suggested a direct association between abdominal fat and liver fat content. Studies using imaging methods suggested a direct association between intraabdominal fat and liver fat content, but not between subcutaneous abdominal fat and liver fat content. In conclusion, clinical and epidemiologic studies of abdominal fat and liver fat content suggest a direct association between abdominal fat and liver fat content which is probably accounted for by visceral fat. However, results from the included studies do not allow strong conclusions regarding the temporal sequence of events. Future longitudinal studies are recommended to obtain additional information on associations and mechanisms. Both abdominal fat depots and other body compartments of interest should be included to further investigate the association between specific fat depots and liver fat content. Biomarkers may provide insight into underlying mechanisms.
PubMed ID
17478441 View in PubMed
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[Attitude of general practitioners to the importance of gender and diet in disease prevention]

https://arctichealth.org/en/permalink/ahliterature10741
Source
Ugeskr Laeger. 1999 Jan 4;161(1):40-3
Publication Type
Article
Date
Jan-4-1999
Author
U. Hølund
G. Boysen
P. Charles
E F Eriksen
O K Overvad
B H Petersson
B. Sandström
A R Thomassen
M A Vittrup
Author Affiliation
Mejeriernes Ernaeringscenter, Arhus.
Source
Ugeskr Laeger. 1999 Jan 4;161(1):40-3
Date
Jan-4-1999
Language
Danish
Publication Type
Article
Keywords
Attitude of Health Personnel
Denmark
Dietary Services
English Abstract
Female
Food Habits
Health Behavior
Humans
Life Style
Male
Physicians, Family - psychology
Preventive Health Services - economics - organization & administration - standards
Primary Prevention
Questionnaires
Sex Factors
Abstract
Three hundred and seventy-four general practitioners (GPs) in Denmark filled in a questionnaire on attitudes to include information on gender and diet in the strategy for prevention of coronary heart disease, cancer, osteoporosis, and overweight/underweight. Risk factors for disease in general were ranked as follows: smoking, alcohol, stress, diet, physical exercise, heredity and hygiene. The patients' lack of motivation, insufficient time for each patient, and inadequate knowledge about nutrition were stated as barriers to dietary counselling. The GPs stated that the gender of the patient was important only to the counselling on osteoporosis. Lack of time and insufficient knowledge were perceived as barriers for including gender specific issues in prevention. It is concluded that GPs consider dietary counselling important but lack time and knowledge. The results point at a need for better pre- and postgraduate training in nutrition, and for a better reimbursement system for time spent on prevention.
PubMed ID
9922687 View in PubMed
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A cross-sectional study of dietary habits and urinary glucose excretion - a predictor of non-insulin-dependent diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature20439
Source
Eur J Clin Nutr. 2000 May;54(5):434-9
Publication Type
Article
Date
May-2000
Author
A. Ekblond
L. Mellemkjaer
A. Tjonneland
M. Suntum
C. Stripp
K. Overvad
C. Johansen
J H Olsen
Author Affiliation
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
Source
Eur J Clin Nutr. 2000 May;54(5):434-9
Date
May-2000
Language
English
Publication Type
Article
Keywords
Animals
Cereals
Cross-Sectional Studies
Denmark
Diabetes Mellitus, Type 2 - etiology - prevention & control - urine
Diet
Dietary Fiber - administration & dosage
Female
Fishes
Fruit
Glycosuria
Humans
Male
Middle Aged
Milk
Poultry
Research Support, Non-U.S. Gov't
Sex Characteristics
Abstract
OBJECTIVE: To investigate the association between consumption of certain foods and macronutrients and urinary glucose excretion, which is a predictor of non-insulin-dependent diabetes mellitus. DESIGN: A cross-sectional study, Denmark, 1993-97. SUBJECTS: Participants in the Danish study 'Diet, Cancer and Health'. After exclusion of persons with postprandial urine samples and persons with diabetes or other diseases potentially resulting in glycosuria, the study population included 14 743 men and 18 064 women aged 50-64 y. We identified 183 men and 43 women with glucose in their urine. RESULTS: Consumption of poultry was negatively associated with glycosuria in both men (odds ratio, OR=0.87; 95% confidence interval, 95% CI=0.77-0.98) and women (OR=0.69; 0.48-1.00). Fiber from fruit showed a weak negative association with glycosuria in both men (0. 95; 0.90-1.01) and women (0.89; 0.78-1.02), whereas a significant negative association with total fiber (0.68; 0.51-0.91) and fiber from vegetables (0.94; 0.88-0.99) was seen in men. Intake of fish tended to reduce the risk of glycosuria in women only (0.80; 0.63-1. 02), whereas ingestion of milk products increased their risk significantly (1.15; 1.06-1.24). CONCLUSION: Although statistical significance and consistency in the two sexes were not achieved for all end-points, the study indicates a protective effect of dietary products like poultry, fruit and cereals against glycosuria and suggests a promoting effect of milk. SPONSORSHIP: The Danish National Board of Health and the Danish Cancer Society.
PubMed ID
10822293 View in PubMed
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Determinants of plasma alkylresorcinol concentration in Danish post-menopausal women.

https://arctichealth.org/en/permalink/ahliterature140604
Source
Eur J Clin Nutr. 2011 Jan;65(1):94-101
Publication Type
Article
Date
Jan-2011
Author
R. Landberg
A. Kamal-Eldin
P. Aman
J. Christensen
K. Overvad
A. Tjønneland
A. Olsen
Author Affiliation
Department of Food Science, Swedish University of Agriculture Science, SLU, Uppsala, Sweden. rikard.landberg@lmv.slu.se
Source
Eur J Clin Nutr. 2011 Jan;65(1):94-101
Date
Jan-2011
Language
English
Publication Type
Article
Keywords
Biological Markers - blood
Bread
Denmark
Diet
Dietary Fiber - analysis
Female
Humans
Middle Aged
Multivariate Analysis
Postmenopause
Questionnaires
Regression Analysis
Resorcinols - blood
Secale cereale - chemistry
Abstract
Alkylresorcinols (AR), a group of phenolic lipids present in the outer parts of wheat and rye grain kernels, have been suggested as biomarkers of whole-grain wheat and rye intake. In this study, we investigated potential determinants of plasma AR concentration in a free-living population.
Non-fasting samples from post-menopausal women enrolled in the Danish Diet, Cancer and Health study (n = 360) were selected. Diet was assessed using a semi-quantitative food frequency questionnaires (FFQ) and the association between food items likely to contain AR and relevant non-dietary factors were studied by analysis of covariance models.
The median AR concentration was 78 nmol/l (interquartile range = 106.9 nmol/l). Intake of rye bread, identified as the main determinant, was associated with 87% higher plasma total AR concentration per 100 g of bread (95% confidence interval = 46-139%). About 8-12% of the total variation (depending on the AR homologue) in plasma AR concentration was explained by the selected dietary variables. At a nutrient level, total dietary fiber and cereal fiber were significantly associated with plasma total AR concentration (P = 0.05), but only ˜2% of the total plasma AR concentration was explained by the dietary fiber or cereal fiber intake.
In the studied population, AR plasma concentration was mainly affected by rye bread intake among investigated determinants.
PubMed ID
20859297 View in PubMed
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Development of a semiquantitative food frequency questionnaire to assess food, energy and nutrient intake in Denmark.

https://arctichealth.org/en/permalink/ahliterature24666
Source
Int J Epidemiol. 1991 Dec;20(4):900-5
Publication Type
Article
Date
Dec-1991
Author
K. Overvad
A. Tjønneland
J. Haraldsdóttir
M. Ewertz
O M Jensen
Author Affiliation
Institute of Social Medicine, University of Arhus, Denmark.
Source
Int J Epidemiol. 1991 Dec;20(4):900-5
Date
Dec-1991
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Denmark
Diet Records
Diet Surveys
Energy intake
Female
Food - statistics & numerical data
Humans
Male
Middle Aged
Nutrition Surveys
Questionnaires
Regression Analysis
Research Support, Non-U.S. Gov't
Abstract
Foods to be included in a Danish self-administered semiquantitative food frequency questionnaire were identified from food tables developed, together with data collected, for the survey 'Dietary habits in Denmark, 1985'. The questionnaire was to be used in a prospective study on diet, cancer and health, and the aim was to rank individuals with regard to intake of 19 different nutrients considered of prime importance in human carcinogenesis. The questionnaire for the dietary survey included 247 foods and recipes. From stepwise multiple regression analyses with the intake of each of the 19 nutrients as the dependent variable and the intake of the 247 foods and recipes as independent variables, the foods in the models explaining 90% of the between-person variability were considered for the final questionnaire. All relevant analyses were performed for the study group as a whole, for men and women separately, and in each gender for subgroups of energy intake. Taken together, the models explaining 90% of the between-person variability identified a total of 74 foods or recipes, which were important predictors of the intake of one or more of the nutrients considered. A few foods were excluded and a few foods were added to the final questionnaire based on common biological background information, and on information on foods providing important amounts of given nutrients, but which failed to contribute to regression analyses. The 92 foods and recipes, which were included in the final questionnaire provided altogether 81% of the average total supply of the nutrients.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
1800428 View in PubMed
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Dietary risk factors for renal cell carcinoma in Denmark.

https://arctichealth.org/en/permalink/ahliterature22695
Source
Eur J Cancer. 1996 Apr;32A(4):673-82
Publication Type
Article
Date
Apr-1996
Author
A. Mellemgaard
J K McLaughlin
K. Overvad
J H Olsen
Author Affiliation
Danish Cancer Society, Division of Cancer Epidemiology, Copenhagen, Denmark.
Source
Eur J Cancer. 1996 Apr;32A(4):673-82
Date
Apr-1996
Language
English
Publication Type
Article
Keywords
Adult
Aged
Carcinoma, Renal Cell - etiology
Case-Control Studies
Denmark
Diet - adverse effects
Dietary Carbohydrates
Dietary Fats
Dietary Proteins
Energy intake
Female
Humans
Kidney Neoplasms - etiology
Logistic Models
Male
Middle Aged
Minerals
Sex Factors
Vitamins
Abstract
The role of diet in the aetiology of renal cell carcinoma was investigated in a population-based case-control study in Denmark. Cases were 20-79 years old, with a histologically verified diagnosis of renal cell carcinoma. Controls were sampled from the general population and were frequency-matched on age and sex. A total of 351 cases (73% of the eligible) and 340 controls (68% of the eligible) were included in the study. Dietary information was obtained in a self-administered food frequency questionnaire and the information was confirmed in a subsequent interview performed by trained interviewers who also elicited information on other suspected risk factors such as smoking, occupation, medical history, education and reproductive history. Logistic regression models were used to calculate the odds ratios, and, both frequency of consumption of various food stuffs and computed nutrients were examined. A positive association was observed between risk of renal cell carcinoma and total energy intake (odds ratio, OR, for highest quartile compared to lowest: 1.7 (95% confidence interval, CI, 1.0-3.0) for men, and 3.5 (95% CI 1.6-6.5) for women), fat intake (OR for highest quartile compared to lowest: 1.9 (95% CI 1.1-3.5) for men, and 3.3 (95% CI 1.6-6.9) for women). For women, an effect was also seen for intake of carbohydrates (OR for highest quartile compared to lowest: 3.2 (95% CI 1.5-6.8), while no protective effect was seen for vegetables or fruit. Dairy products may be associated with risk of renal cell cancer (OR for women using thickly spread butter compared to thinly spread: 11.4 (95% CI 2.8-45), OR for women who drank more than one glass of milk with 3.5% fat content compared to never drink milk: 3.7 (95% CI 1.2-11). As expected, total energy intake, intake of fat, protein and carbohydrates were closely correlated making it difficult to identify one of the energy sources as more closely associated with risk of renal cell cancer than the other. Several energy sources have been identified as possible risk factors for renal cell carcinoma. It is possible that a high energy intake as such rather than the individual sources are responsible for the increased risk. Furthermore, dairy fats may be associated with renal cell carcinoma risk. The observed associations appeared stronger in women, and did not explain the association with obesity and low socio-economic status previously found in Denmark.
PubMed ID
8695272 View in PubMed
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Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome -- a randomized study (SYSDIET).

https://arctichealth.org/en/permalink/ahliterature116441
Source
J Intern Med. 2013 Jul;274(1):52-66
Publication Type
Article
Date
Jul-2013
Author
M. Uusitupa
K. Hermansen
M J Savolainen
U. Schwab
M. Kolehmainen
L. Brader
L S Mortensen
L. Cloetens
A. Johansson-Persson
G. Onning
M. Landin-Olsson
K-H Herzig
J. Hukkanen
F. Rosqvist
D. Iggman
J. Paananen
K J Pulkki
M. Siloaho
L. Dragsted
T. Barri
K. Overvad
K E Bach Knudsen
M S Hedemann
P. Arner
I. Dahlman
G I A Borge
P. Baardseth
S M Ulven
I. Gunnarsdottir
S. Jónsdóttir
I. Thorsdottir
M. Orešic
K S Poutanen
U. Risérus
B. Akesson
Author Affiliation
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. matti.uusitupa@uef.fi
Source
J Intern Med. 2013 Jul;274(1):52-66
Date
Jul-2013
Language
English
Publication Type
Article
Keywords
Apolipoproteins A - blood
Apolipoproteins B - blood
Biological Markers - blood
Blood Glucose - metabolism
Blood pressure
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Denmark
Diet - methods
Energy intake
Fatty Acids - analysis
Finland
Glucose Tolerance Test
Humans
Iceland
Inflammation - blood
Insulin Resistance
Interleukin 1 Receptor Antagonist Protein - blood
Lipids - blood
Male
Metabolic Syndrome X - blood - metabolism - physiopathology
Middle Aged
Sweden
Treatment Outcome
Abstract
Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome.
We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m(-2) , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids.
Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L(-1) 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L(-1) , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra.
Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.
Notes
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PubMed ID
23398528 View in PubMed
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Source
Ugeskr Laeger. 1998 Dec 21;160(52):7601-5
Publication Type
Article
Date
Dec-21-1998
Author
B L Heitmann
M. Osler
O K Overvad
Author Affiliation
H:S Kommunehospitalet, Institut for Sygdomsforebyggelse, Epidemiologisk Grundforsknings center.
Source
Ugeskr Laeger. 1998 Dec 21;160(52):7601-5
Date
Dec-21-1998
Language
Danish
Publication Type
Article
Keywords
Denmark
Dietary Fats - administration & dosage
Energy intake
Food Habits
Heart Diseases - etiology
Humans
Life Style
Neoplasms - etiology
Obesity - complications - etiology - prevention & control
Obesity, Morbid - prevention & control
Risk factors
PubMed ID
9889680 View in PubMed
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Importance of diet and sex in prevention of coronary artery disease, cancer, osteoporosis, and overweight or underweight: a study of attitudes and practices of Danish primary care physicians.

https://arctichealth.org/en/permalink/ahliterature11048
Source
Am J Clin Nutr. 1997 Jun;65(6 Suppl):2004S-2006S
Publication Type
Article
Date
Jun-1997
Author
U. Hølund
A. Thomassen
G. Boysen
P. Charles
E F Eriksen
K. Overvad
B. Petersson
B. Sandström
M. Vittrup
Author Affiliation
Nutrition Department, Danish Dairy Board, Aarhus, Denmark.
Source
Am J Clin Nutr. 1997 Jun;65(6 Suppl):2004S-2006S
Date
Jun-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Attitude of Health Personnel
Child
Child, Preschool
Comparative Study
Coronary Disease - prevention & control
Denmark
Diet
Family Practice
Female
Humans
Infant
Male
Middle Aged
Neoplasms - prevention & control
Obesity - prevention & control
Osteoporosis - prevention & control
Physician's Practice Patterns
Primary Health Care
Questionnaires
Risk factors
Sex Factors
Abstract
General practitioners (GPs) in Denmark (n = 374) answered a questionnaire on attitudes toward including information on diet and sex in the prevention of coronary artery disease, cancers, osteoporosis, and weight problems. Risk factors for disease were ranked as follows: smoking, alcohol, stress, diet, physical exercise, heredity, and hygiene. Patients' lack of motivation, insufficient time for each patient, and inadequate knowledge about nutrition were listed by GPs as barriers to dietary counseling. GPs stated that the sex of the patient was important only for counseling on osteoporosis. Lack of time and insufficient knowledge were perceived as barriers to including sex-specific issues in prevention. One-half of the GPs were questioned about the issue of prevention on the basis of female case stories and the other half on the basis of male case stories with identical wording. Responses to the case stories indicated that GPs would give dietary guidance and recommend loss of weight to slightly overweight male patients to a much greater degree than to overweight female patients for prevention of coronary artery disease, give dietary counseling and recommend loss of weight and exercise to female patients more than to male patients for prevention of cancers, recommend a supplement of calcium and vitamin D for prevention of osteoporosis to female patients, and recommend weight gain and discuss psychosocial issues more with underweight female patients than with underweight male patients. Female GPs included measures of prevention such as dietary counseling, exercise prescription, dietary supplement prescription, and discussion of psychosocial issues to a greater extent than did male GPs.
PubMed ID
9174510 View in PubMed
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Intake of ruminant trans fatty acids and changes in body weight and waist circumference.

https://arctichealth.org/en/permalink/ahliterature122532
Source
Eur J Clin Nutr. 2012 Oct;66(10):1104-9
Publication Type
Article
Date
Oct-2012
Author
C P Hansen
T L Berentzen
J. Halkjær
A. Tjønneland
T I A Sørensen
K. Overvad
M U Jakobsen
Author Affiliation
Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. cph@soci.au.dk
Source
Eur J Clin Nutr. 2012 Oct;66(10):1104-9
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Animals
Body mass index
Body Weight
Cohort Studies
Dairy Products - adverse effects - analysis
Denmark
Diet - adverse effects
Female
Follow-Up Studies
Humans
Male
Meat - adverse effects - analysis
Middle Aged
Models, Biological
Obesity - etiology
Overweight - etiology
Questionnaires
Ruminants - metabolism
Trans Fatty Acids - administration & dosage - adverse effects - metabolism
Waist Circumference
Abstract
Follow-up studies have suggested that total intake of trans fatty acids (TFA) is a risk factor for gain in body weight and waist circumference (WC). However, in a cross-sectional study individual TFA isomers in adipose tissue had divergent associations with anthropometry. Our objective was to investigate the association between intake of TFA from ruminant dairy and meat products and subsequent changes in weight and WC. Furthermore, potential effect modification by sex, age, body mass index and WC at baseline was investigated.
Data on weight, WC, habitual diet and lifestyle were collected at baseline in a Danish cohort of 30,851 men and women aged 50-64 years. Follow-up information on weight and WC was collected 5 years after enrolment. The associations between intake of ruminant TFA (R-TFA) and changes in weight and WC were analysed using multiple linear regression with cubic spline modelling.
Intake of R-TFA, both absolute and energy-adjusted intake, was significantly associated with weight change. Inverse associations were observed at lower intakes with a levelling-off at intakes >1.2?g/day and 0.4 energy percentage (E %). Absolute, but not energy-adjusted, intake of R-TFA was significantly associated with WC change. An inverse association was observed at lower intakes with a plateau above an intake of 1.2?g/day.
The present study suggests that intake of R-TFA is weakly inversely associated with changes in weight, whereas no substantial association with changes in WC was found.
PubMed ID
22805493 View in PubMed
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20 records – page 1 of 2.