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Baseline patterns of adipose tissue fatty acids and long-term risk of breast cancer: a case-cohort study in the Danish cohort Diet, Cancer and Health.

https://arctichealth.org/en/permalink/ahliterature264936
Source
Eur J Clin Nutr. 2014 Oct;68(10):1088-94
Publication Type
Article
Date
Oct-2014
Author
J A Schmidt
A. Gorst-Rasmussen
P W Nyström
J H Christensen
E B Schmidt
C. Dethlefsen
A. Tjønneland
K. Overvad
C C Dahm
Source
Eur J Clin Nutr. 2014 Oct;68(10):1088-94
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - epidemiology - pathology
Cohort Studies
Denmark - epidemiology
Fatty Acids - analysis
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk
Risk factors
Subcutaneous Fat - chemistry
Abstract
The evidence regarding fatty acids and breast cancer risk is inconclusive. Adipose tissue fatty acids can be used as biomarkers of fatty acid intake and of endogenous fatty acid exposure. Fatty acids in adipose tissue are correlated owing to common dietary sources and shared metabolic pathways, which group fatty acids into naturally occurring patterns. We aimed to prospectively investigate associations between adipose tissue fatty acid patterns and long-term risk of total breast cancer and breast cancer subtypes characterised by oestrogen and progesterone receptor status (ER and PR).
This case-cohort study was based on data from the Danish cohort Diet, Cancer and Health. At baseline, a fat biopsy and information on lifestyle and reproductive factors were collected. From the 31 original fatty acids measured, patterns of fatty acids were identified using the treelet transform. During a median follow-up of 5.3 years, 474 breast cancer cases were identified. Hazard ratios and 95% confidence intervals of risk of total breast cancer and of subtypes according to quintiles of factor score were determined by weighted Cox proportional hazards regression.
After adjustment for potential confounders, factor scores for the seven patterns identified by the treelet transform were not associated with risk of total breast cancer, nor with risk of ER+, ER-, PR+ or PR- tumours.
No clear associations between the patterns of fatty acids at baseline and long-term risk of total breast cancer or ER+, ER-, PR+ or PR- tumours were observed.
PubMed ID
24642780 View in PubMed
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Consumption of added fats and oils in the European Prospective Investigation into Cancer and Nutrition (EPIC) centres across 10 European countries as assessed by 24-hour dietary recalls.

https://arctichealth.org/en/permalink/ahliterature18552
Source
Public Health Nutr. 2002 Dec;5(6B):1227-42
Publication Type
Article
Date
Dec-2002
Author
J. Linseisen
E. Bergström
L. Gafá
C A González
A. Thiébaut
A. Trichopoulou
R. Tumino
C. Navarro Sánchez
C. Martínez Garcia
I. Mattisson
S. Nilsson
A. Welch
E A Spencer
K. Overvad
A. Tjønneland
F. Clavel-Chapelon
E. Kesse
A B Miller
M. Schulz
K. Botsi
A. Naska
S. Sieri
C. Sacerdote
M C Ocké
P H M Peeters
G. Skeie
D. Engeset
U R Charrondière
N. Slimani
Author Affiliation
Unit of Human Nutrition and Cancer Prevention, Technical University of Munich, Alte Akademie 16, D-85350 Freising-Weihenstephan, Germany. j.linseisen@wzw.tum.de
Source
Public Health Nutr. 2002 Dec;5(6B):1227-42
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adult
Aged
Diet Surveys
Dietary Fats - administration & dosage - adverse effects
Educational Status
Energy intake
Europe
Female
Humans
Male
Mental Recall
Middle Aged
Neoplasms - etiology
Population Surveillance - methods
Prospective Studies
Research Support, Non-U.S. Gov't
Abstract
OBJECTIVE: To evaluate the consumption of added fats and oils across the European centres and countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). DESIGN AND SETTING: 24-Hour dietary recalls were collected by means of standardised computer-guided interviews in 27 redefined EPIC centres across 10 European countries. SUBJECTS: From an initial number of 36 900 subjects, single dietary recalls from 22 924 women and 13 031 men in the age range of 35-74 years were included. RESULTS: Mean daily intake of added fats and oils varied between 16.2 g (Varese, Italy) and 41.1 g (Malmö, Sweden) in women and between 24.7 g (Ragusa, Italy) and 66.0 g (Potsdam, Germany) in men. Total mean lipid intake by consumption of added fats and oils, including those used for sauce preparation, ranged between 18.3 (Norway) and 37.2 g day-1 (Greece) in women and 28.4 (Heidelberg, Germany) and 51.2 g day-1 (Greece) in men. The Mediterranean EPIC centres with high olive oil consumption combined with low animal fat intake contrasted with the central and northern European centres where fewer vegetable oils, more animal fats and a high proportion of margarine were consumed. The consumption of added fats and oils of animal origin was highest in the German EPIC centres, followed by the French. The contribution of added fats and oils to total energy intake ranged from 8% in Norway to 22% in Greece. CONCLUSIONS: The results demonstrate a high variation in dietary intake of added fats and oils in EPIC, providing a good opportunity to elucidate the role of dietary fats in cancer aetiology.
PubMed ID
12639229 View in PubMed
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Consumption of dairy products in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: data from 35 955 24-hour dietary recalls in 10 European countries.

https://arctichealth.org/en/permalink/ahliterature18551
Source
Public Health Nutr. 2002 Dec;5(6B):1259-71
Publication Type
Article
Date
Dec-2002
Author
A. Hjartåker
A. Lagiou
N. Slimani
E. Lund
M D Chirlaque
E. Vasilopoulou
X. Zavitsanos
F. Berrino
C. Sacerdote
M C Ocké
P H M Peeters
D. Engeset
G. Skeie
A. Aller
P. Amiano
G. Berglund
S. Nilsson
A. McTaggart
E A Spencer
K. Overvad
A. Tjønneland
F. Clavel-Chapelon
J. Linseisen
M. Schulz
B. Hemon
E. Riboli
Author Affiliation
Section of Medical Statistics, University of Oslo, PO Box 1122, Blindern, N-0317 Norway. anette.hjartaker@basalmed.uio.no
Source
Public Health Nutr. 2002 Dec;5(6B):1259-71
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adult
Aged
Dairy Products
Diet
Diet Surveys
Europe
Female
Humans
Male
Mental Recall
Middle Aged
Population Surveillance - methods
Prospective Studies
Research Support, Non-U.S. Gov't
Abstract
OBJECTIVES: To describe and compare the consumption of dairy products in cohorts included in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: Data from single 24-hour dietary recall interviews collected through a highly standardised computer-based program (EPIC-SOFT) in 27 redefined centres in 10 European countries between 1995 and 2000. From a total random sample of 36 900, 22 924 women and 13 031 men were selected after exclusion of subjects under 35 and over 74 years of age. RESULTS: A high total consumption of dairy products was reported in most of the centres in Spain and in the UK cohort sampled from the general population, as well as in the Dutch, Swedish and Danish centres. A somewhat low consumption was reported in the Greek centre and in some of the Italian centres (Ragusa and Turin). In all centres and for both sexes, milk constituted the dairy sub-group with the largest proportion (in grams) of total dairy consumption, followed by yoghurt and other fermented milk products, and cheese. Still, there was a wide range in the contributions of the different dairy sub-groups between centres. The Spanish and Nordic centres generally reported a high consumption of milk, the Swedish and Dutch centres reported a high consumption of yoghurt and other fermented milk products, whereas the highest consumption of cheese was reported in the French centres. CONCLUSION: The results demonstrate both quantitative and qualitative disparities in dairy product consumption among the EPIC centres. This offers a sound starting point for analyses of associations between dairy intake and chronic diseases such as cancer.
PubMed ID
12639231 View in PubMed
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Development of a semiquantitative food frequency questionnaire to assess food, energy and nutrient intake in Denmark.

https://arctichealth.org/en/permalink/ahliterature24666
Source
Int J Epidemiol. 1991 Dec;20(4):900-5
Publication Type
Article
Date
Dec-1991
Author
K. Overvad
A. Tjønneland
J. Haraldsdóttir
M. Ewertz
O M Jensen
Author Affiliation
Institute of Social Medicine, University of Arhus, Denmark.
Source
Int J Epidemiol. 1991 Dec;20(4):900-5
Date
Dec-1991
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Denmark
Diet Records
Diet Surveys
Energy intake
Female
Food - statistics & numerical data
Humans
Male
Middle Aged
Nutrition Surveys
Questionnaires
Regression Analysis
Research Support, Non-U.S. Gov't
Abstract
Foods to be included in a Danish self-administered semiquantitative food frequency questionnaire were identified from food tables developed, together with data collected, for the survey 'Dietary habits in Denmark, 1985'. The questionnaire was to be used in a prospective study on diet, cancer and health, and the aim was to rank individuals with regard to intake of 19 different nutrients considered of prime importance in human carcinogenesis. The questionnaire for the dietary survey included 247 foods and recipes. From stepwise multiple regression analyses with the intake of each of the 19 nutrients as the dependent variable and the intake of the 247 foods and recipes as independent variables, the foods in the models explaining 90% of the between-person variability were considered for the final questionnaire. All relevant analyses were performed for the study group as a whole, for men and women separately, and in each gender for subgroups of energy intake. Taken together, the models explaining 90% of the between-person variability identified a total of 74 foods or recipes, which were important predictors of the intake of one or more of the nutrients considered. A few foods were excluded and a few foods were added to the final questionnaire based on common biological background information, and on information on foods providing important amounts of given nutrients, but which failed to contribute to regression analyses. The 92 foods and recipes, which were included in the final questionnaire provided altogether 81% of the average total supply of the nutrients.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
1800428 View in PubMed
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Dietary risk factors for renal cell carcinoma in Denmark.

https://arctichealth.org/en/permalink/ahliterature22695
Source
Eur J Cancer. 1996 Apr;32A(4):673-82
Publication Type
Article
Date
Apr-1996
Author
A. Mellemgaard
J K McLaughlin
K. Overvad
J H Olsen
Author Affiliation
Danish Cancer Society, Division of Cancer Epidemiology, Copenhagen, Denmark.
Source
Eur J Cancer. 1996 Apr;32A(4):673-82
Date
Apr-1996
Language
English
Publication Type
Article
Keywords
Adult
Aged
Carcinoma, Renal Cell - etiology
Case-Control Studies
Denmark
Diet - adverse effects
Dietary Carbohydrates
Dietary Fats
Dietary Proteins
Energy intake
Female
Humans
Kidney Neoplasms - etiology
Logistic Models
Male
Middle Aged
Minerals
Sex Factors
Vitamins
Abstract
The role of diet in the aetiology of renal cell carcinoma was investigated in a population-based case-control study in Denmark. Cases were 20-79 years old, with a histologically verified diagnosis of renal cell carcinoma. Controls were sampled from the general population and were frequency-matched on age and sex. A total of 351 cases (73% of the eligible) and 340 controls (68% of the eligible) were included in the study. Dietary information was obtained in a self-administered food frequency questionnaire and the information was confirmed in a subsequent interview performed by trained interviewers who also elicited information on other suspected risk factors such as smoking, occupation, medical history, education and reproductive history. Logistic regression models were used to calculate the odds ratios, and, both frequency of consumption of various food stuffs and computed nutrients were examined. A positive association was observed between risk of renal cell carcinoma and total energy intake (odds ratio, OR, for highest quartile compared to lowest: 1.7 (95% confidence interval, CI, 1.0-3.0) for men, and 3.5 (95% CI 1.6-6.5) for women), fat intake (OR for highest quartile compared to lowest: 1.9 (95% CI 1.1-3.5) for men, and 3.3 (95% CI 1.6-6.9) for women). For women, an effect was also seen for intake of carbohydrates (OR for highest quartile compared to lowest: 3.2 (95% CI 1.5-6.8), while no protective effect was seen for vegetables or fruit. Dairy products may be associated with risk of renal cell cancer (OR for women using thickly spread butter compared to thinly spread: 11.4 (95% CI 2.8-45), OR for women who drank more than one glass of milk with 3.5% fat content compared to never drink milk: 3.7 (95% CI 1.2-11). As expected, total energy intake, intake of fat, protein and carbohydrates were closely correlated making it difficult to identify one of the energy sources as more closely associated with risk of renal cell cancer than the other. Several energy sources have been identified as possible risk factors for renal cell carcinoma. It is possible that a high energy intake as such rather than the individual sources are responsible for the increased risk. Furthermore, dairy fats may be associated with renal cell carcinoma risk. The observed associations appeared stronger in women, and did not explain the association with obesity and low socio-economic status previously found in Denmark.
PubMed ID
8695272 View in PubMed
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[Diet, cancer and health--a population study and establishment of a biological bank in Denmark]

https://arctichealth.org/en/permalink/ahliterature20597
Source
Ugeskr Laeger. 2000 Jan 17;162(3):350-4
Publication Type
Article
Date
Jan-17-2000
Author
A M Tjønneland
O K Overvad
Author Affiliation
Aarhus Universitet, Institut for Epidemiologi og Socialmedicin.
Source
Ugeskr Laeger. 2000 Jan 17;162(3):350-4
Date
Jan-17-2000
Language
Danish
Publication Type
Article
Keywords
Aged
Cohort Studies
Databases, Factual
Denmark - epidemiology
English Abstract
Follow-Up Studies
Food Habits
Humans
Life Style
Middle Aged
Neoplasms - epidemiology - etiology - mortality
Prospective Studies
Questionnaires
Registries
Risk factors
Specimen Handling
Tissue Banks
Abstract
In order to test hypotheses on diet and the risk of cancer, a prospective cohort study was established. A total of 57,055 persons living in Copenhagen and Aarhus, between 50 and 65 years of age, visited a study clinic between December 1993 and May 1997. The participants provided questionnaire data on diet and lifestyle. Furthermore, anthropometric measurements, blood pressure and biological material were collected. All participants will be followed by linkage to health registries including the Cancer Registry and by self-administered follow-up questionnaires. The purpose of this publication is to describe the data-base, which will be available for research in the years to come including the results of the first two years of follow-up.
PubMed ID
10680472 View in PubMed
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Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (EPIC) project.

https://arctichealth.org/en/permalink/ahliterature18549
Source
Public Health Nutr. 2002 Dec;5(6B):1311-28
Publication Type
Article
Date
Dec-2002
Author
N. Slimani
M. Fahey
A A Welch
E. Wirfält
C. Stripp
E. Bergström
J. Linseisen
M B Schulze
C. Bamia
Y. Chloptsios
F. Veglia
S. Panico
H B Bueno-de-Mesquita
M C Ocké
M. Brustad
E. Lund
C A González
A. Barcos
G. Berglund
A. Winkvist
A. Mulligan
P. Appleby
K. Overvad
A. Tjønneland
F. Clavel-Chapelon
E. Kesse
P. Ferrari
W A Van Staveren
E. Riboli
Author Affiliation
Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France. Slimani@iarc.fr
Source
Public Health Nutr. 2002 Dec;5(6B):1311-28
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cultural Diversity
Diet
Diet Surveys
Europe
Female
Food Habits
Humans
Male
Mental Recall
Middle Aged
Population Surveillance - methods
Research Support, Non-U.S. Gov't
Abstract
OBJECTIVE: To describe the diversity in dietary patterns existing across centres/regions participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). DESIGN AND SETTING: Single 24-hour dietary recall measurements were obtained by means of standardised face-to-face interviews using the EPIC-SOFT software. These have been used to present a graphic multi-dimensional comparison of the adjusted mean consumption of 22 food groups. SUBJECTS: In total, 35 955 men and women, aged 35-74 years, participating in the EPIC nested calibration study. RESULTS: Although wide differences were observed across centres, the countries participating in EPIC are characterised by specific dietary patterns. Overall, Italy and Greece have a dietary pattern characterised by plant foods (except potatoes) and a lower consumption of animal and processed foods, compared with the other EPIC countries. France and particularly Spain have more heterogeneous dietary patterns, with a relatively high consumption of both plant foods and animal products. Apart from characteristics specific to vegetarian groups, the UK 'health-conscious' group shares with the UK general population a relatively high consumption of tea, sauces, cakes, soft drinks (women), margarine and butter. In contrast, the diet in the Nordic countries, The Netherlands, Germany and the UK general population is relatively high in potatoes and animal, processed and sweetened/refined foods, with proportions varying across countries/centres. In these countries, consumption of vegetables and fruit is similar to, or below, the overall EPIC means, and is low for legumes and vegetable oils. Overall, dietary patterns were similar for men and women, although there were large gender differences for certain food groups. CONCLUSIONS: There are considerable differences in food group consumption and dietary patterns among the EPIC study populations. This large heterogeneity should be an advantage when investigating the relationship between diet and cancer and formulating new aetiological hypotheses related to dietary patterns and disease.
PubMed ID
12639235 View in PubMed
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Food sources of carbohydrates in a European cohort of adults.

https://arctichealth.org/en/permalink/ahliterature18553
Source
Public Health Nutr. 2002 Dec;5(6B):1197-215
Publication Type
Article
Date
Dec-2002
Author
E. Wirfält
A. McTaggart
V. Pala
B. Gullberg
G. Frasca
S. Panico
H B Bueno-de-Mesquita
P H M Peeters
D. Engeset
G. Skeie
M D Chirlaque
P. Amiano
E. Lundin
A. Mulligan
E A Spencer
K. Overvad
A. Tjønneland
F. Clavel-Chapelon
J. Linseisen
U. Nöthlings
E. Polychronopoulos
K. Georga
U R Charrondière
N. Slimani
Author Affiliation
Department of Medicine, Lund University, Malmö, SE-20502 Sweden. elisabet.wirfalt@smi.mas.lu.se
Source
Public Health Nutr. 2002 Dec;5(6B):1197-215
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adult
Aged
Diet Surveys
Dietary Carbohydrates - administration & dosage
Europe
Female
Food Habits
Humans
Male
Mental Recall
Middle Aged
Population Surveillance - methods
Prospective Studies
Research Support, Non-U.S. Gov't
Abstract
OBJECTIVE: To describe the average consumption of carbohydrate-providing food groups among study centres of the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: Of the 27 redefined EPIC study centres, 19 contributed subjects of both genders and eight centres female participants only (men, women, after exclusion of subjects under 35 and over 74 years of age from the original 36 900 total). Dietary data were obtained using the 24-hour recall methodology using the EPIC-SOFT software. The major sources of dietary carbohydrate were identified, and 16 food groups were examined. RESULTS: The 10 food groups contributing most carbohydrate were bread; fruit; milk and milk products; sweet buns, cakes and pies; potato; sugar and jam; pasta and rice; vegetables and legumes; crispbread; and fruit and vegetable juices. Consumption of fruits as well as vegetables and legumes was higher in southern compared with northern centres, while soft drinks consumption was higher in the north. Italian centres had high pasta and rice consumption, but breakfast cereal, potato, and sweet buns, cakes and pies were higher in northern centres. In Sweden, lower bread consumption was balanced with a higher consumption of crispbread, and with sweet buns, cakes and pies. Overall, men consumed higher amounts of vegetables and legumes, bread, soft drinks, potatoes, pasta and rice, breakfast cereal and sugar and jam than women, but fruit consumption appeared more frequent in women. CONCLUSION: The study supports the established idea that carbohydrate-rich foods chosen in northern Europe are different from those in the Mediterranean region. When comparing and interpreting diet-disease relationships across populations, researchers need to consider all types of foods.
PubMed ID
12639227 View in PubMed
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Importance of diet and sex in prevention of coronary artery disease, cancer, osteoporosis, and overweight or underweight: a study of attitudes and practices of Danish primary care physicians.

https://arctichealth.org/en/permalink/ahliterature11048
Source
Am J Clin Nutr. 1997 Jun;65(6 Suppl):2004S-2006S
Publication Type
Article
Date
Jun-1997
Author
U. Hølund
A. Thomassen
G. Boysen
P. Charles
E F Eriksen
K. Overvad
B. Petersson
B. Sandström
M. Vittrup
Author Affiliation
Nutrition Department, Danish Dairy Board, Aarhus, Denmark.
Source
Am J Clin Nutr. 1997 Jun;65(6 Suppl):2004S-2006S
Date
Jun-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Attitude of Health Personnel
Child
Child, Preschool
Comparative Study
Coronary Disease - prevention & control
Denmark
Diet
Family Practice
Female
Humans
Infant
Male
Middle Aged
Neoplasms - prevention & control
Obesity - prevention & control
Osteoporosis - prevention & control
Physician's Practice Patterns
Primary Health Care
Questionnaires
Risk factors
Sex Factors
Abstract
General practitioners (GPs) in Denmark (n = 374) answered a questionnaire on attitudes toward including information on diet and sex in the prevention of coronary artery disease, cancers, osteoporosis, and weight problems. Risk factors for disease were ranked as follows: smoking, alcohol, stress, diet, physical exercise, heredity, and hygiene. Patients' lack of motivation, insufficient time for each patient, and inadequate knowledge about nutrition were listed by GPs as barriers to dietary counseling. GPs stated that the sex of the patient was important only for counseling on osteoporosis. Lack of time and insufficient knowledge were perceived as barriers to including sex-specific issues in prevention. One-half of the GPs were questioned about the issue of prevention on the basis of female case stories and the other half on the basis of male case stories with identical wording. Responses to the case stories indicated that GPs would give dietary guidance and recommend loss of weight to slightly overweight male patients to a much greater degree than to overweight female patients for prevention of coronary artery disease, give dietary counseling and recommend loss of weight and exercise to female patients more than to male patients for prevention of cancers, recommend a supplement of calcium and vitamin D for prevention of osteoporosis to female patients, and recommend weight gain and discuss psychosocial issues more with underweight female patients than with underweight male patients. Female GPs included measures of prevention such as dietary counseling, exercise prescription, dietary supplement prescription, and discussion of psychosocial issues to a greater extent than did male GPs.
PubMed ID
9174510 View in PubMed
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Is the effect of alcohol on risk of stroke confined to highly stressed persons?

https://arctichealth.org/en/permalink/ahliterature9192
Source
Neuroepidemiology. 2005;25(3):105-13
Publication Type
Article
Date
2005
Author
N R Nielsen
T. Truelsen
J C Barefoot
S P Johnsen
K. Overvad
G. Boysen
P. Schnohr
M. Grønbaek
Author Affiliation
Centre for Alcohol Research, National Institute of Public Health, Copenhagen, Denmark. nrn@niph.dk
Source
Neuroepidemiology. 2005;25(3):105-13
Date
2005
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Alcohol Drinking - psychology
Alcoholic Beverages - adverse effects
Cerebrovascular Accident - etiology
Denmark
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Risk factors
Self Assessment (Psychology)
Stress, Psychological - psychology
Abstract
BACKGROUND: Psychological stress and alcohol are both suggested as risk factors for stroke. Further, there appears to be a close relation between stress and alcohol consumption. Several experimental studies have found alcohol consumption to reduce the immediate effects of stress in a laboratory setting. We aimed to examine whether the association between alcohol and stroke depends on level of self-reported stress in a large prospective cohort. METHODS: The 5,373 men and 6,723 women participating in the second examination of the Copenhagen City Heart Study in 1981-1983 were asked at baseline about their self-reported level of stress and their weekly alcohol consumption. The participants were followed-up until 31st of December 1997 during which 880 first ever stroke events occurred. Data were analysed by means of Cox regression modelling. RESULTS: At a high stress level, weekly total consumption of 1-14 units of alcohol compared with no consumption seemed associated with a lower risk of stroke (adjusted RR: 0.57, 95% CI: 0.31-1.07). At lower stress levels, no clear associations were observed. Regarding subtypes, self-reported stress appeared only to modify the association between alcohol intake and ischaemic stroke events. Regarding specific types of alcoholic beverages, self-reported stress only modified the associations for intake of beer and wine. CONCLUSIONS: This study indicates that the apparent lower risk of stroke associated with moderate alcohol consumption is confined to a group of highly stressed persons. It is suggested that alcohol consumption may play a role in reducing the risk of stroke by modifying the physiological or psychological stress response.
PubMed ID
15956807 View in PubMed
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18 records – page 1 of 2.