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Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome -- a randomized study (SYSDIET).
J Intern Med. 2013 Jul;274(1):52-66
Publication Type
M. Uusitupa
K. Hermansen
M J Savolainen
U. Schwab
M. Kolehmainen
L. Brader
L S Mortensen
L. Cloetens
A. Johansson-Persson
G. Onning
M. Landin-Olsson
K-H Herzig
J. Hukkanen
F. Rosqvist
D. Iggman
J. Paananen
K J Pulkki
M. Siloaho
L. Dragsted
T. Barri
K. Overvad
K E Bach Knudsen
M S Hedemann
P. Arner
I. Dahlman
G I A Borge
P. Baardseth
S M Ulven
I. Gunnarsdottir
S. Jónsdóttir
I. Thorsdottir
M. OreŇ°ic
K S Poutanen
U. Risérus
B. Akesson
Author Affiliation
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
J Intern Med. 2013 Jul;274(1):52-66
Publication Type
Apolipoproteins A - blood
Apolipoproteins B - blood
Biological Markers - blood
Blood Glucose - metabolism
Blood pressure
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diet - methods
Energy intake
Fatty Acids - analysis
Glucose Tolerance Test
Inflammation - blood
Insulin Resistance
Interleukin 1 Receptor Antagonist Protein - blood
Lipids - blood
Metabolic Syndrome X - blood - metabolism - physiopathology
Middle Aged
Treatment Outcome
Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome.
We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m(-2) , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids.
Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L(-1) 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L(-1) , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra.
Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.
Cites: Diabetes Care. 2009 Mar;32(3):421-319073760
Cites: Circulation. 2009 Mar 3;119(8):1093-10019221219
Cites: Am J Cardiol. 2012 Nov 15;110(10):1468-7622906895
Cites: Diabetes. 2009 May;58(5):1212-2119223598
Cites: Circulation. 2009 Oct 20;120(16):1640-519805654
Cites: Am J Clin Nutr. 2001 Jul;74(1):80-911451721
Cites: Appetite. 2001 Aug;37(1):33-4511562156
Cites: Eur J Clin Nutr. 2002 May;56(5):455-6112001018
Cites: Circulation. 2003 Oct 14;108(15):1822-3014517163
Cites: JAMA. 2004 Sep 22;292(12):1440-615383514
Cites: Am J Clin Nutr. 2004 Oct;80(4):1029-3515447916
Cites: Clin Sci (Lond). 1985 May;68(5):581-73919990
Cites: J Intern Med Suppl. 1989;731:105-102650688
Cites: Am J Physiol. 1992 Sep;263(3 Pt 2):R734-71384353
Cites: Int J Eat Disord. 1993 Mar;13(2):137-538477283
Cites: Am J Clin Nutr. 1994 Dec;60(6 Suppl):1017S-1022S7977143
Cites: Am J Clin Nutr. 1995 Jun;61(6 Suppl):1402S-1406S7754995
Cites: N Engl J Med. 1997 Apr 17;336(16):1117-249099655
Cites: Eur J Immunol. 1998 Aug;28(8):2598-6029710237
Cites: Lancet. 1999 Mar 27;353(9158):1045-810199351
Cites: Circulation. 2004 Dec 21;110(25):3842-815596567
Cites: Eur J Clin Nutr. 2006 Apr;60(4):478-8516306923
Cites: Arterioscler Thromb Vasc Biol. 2006 May;26(5):995-100116484595
Cites: Am J Clin Nutr. 2007 Apr;85(4):1068-7417413107
Cites: Am J Clin Nutr. 2008 Feb;87(2):323-3118258621
Cites: Eur J Clin Nutr. 2008 May;62(5):651-917440519
Cites: BMJ. 2008;337:a134418786971
Cites: JAMA. 2008 Dec 17;300(23):2742-5319088352
Cites: Public Health Nutr. 2009 Jan;12(1):91-618339225
Cites: Clin Chem. 2009 Mar;55(3):407-1919168552
Cites: PLoS Med. 2010 Mar;7(3):e100025220351774
Cites: Nutr Rev. 2010 Mar;68(3):168-7720384847
Cites: Diabetes. 2010 May;59(5):1222-720185814
Cites: Nat Rev Endocrinol. 2010 Jun;6(6):335-4620421882
Cites: Diabetes Care. 2011 Jan;34(1):14-920929998
Cites: J Intern Med. 2011 Feb;269(2):150-920964740
Cites: N Engl J Med. 2011 Jan 13;364(2):127-3521226578
Cites: Nat Rev Immunol. 2011 Feb;11(2):98-10721233852
Cites: Nat Immunol. 2011 Mar;12(3):204-1221321594
Cites: J Intern Med. 2011 Mar;269(3):322-3221205020
Cites: J Nutr. 2011 Apr 1;141(4):639-4421346102
Cites: Circulation. 2011 Jun 21;123(24):2870-9121690503
Cites: J Am Coll Cardiol. 2011 Jul 26;58(5):457-6321777740
Cites: J Intern Med. 2011 Oct;270(4):356-6421466598
Cites: Diabetologia. 2011 Nov;54(11):2755-6721870174
Cites: J Hepatol. 2012 Mar;56(3):663-7022027586
Cites: JAMA. 2012 Mar 28;307(12):1302-922453571
Cites: Am J Clin Nutr. 2012 May;95(5):1003-1222492369
PubMed ID
23398528 View in PubMed
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