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5HTR2A gene polymorphism and personality traits in patients with major psychoses.

https://arctichealth.org/en/permalink/ahliterature190821
Source
Eur Psychiatry. 2002 Mar;17(1):24-8
Publication Type
Article
Date
Mar-2002
Author
V E Golimbet
M V Alfimova
K K Manandyan
N G Mitushina
L I Abramova
V G Kaleda
I V Oleichik
YuB Yurov
V I Trubnikov
Author Affiliation
Laboratory of Preventive Genetics, Research Mental Health Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, Moscow, Russia 113152. golimbet@mail.ru
Source
Eur Psychiatry. 2002 Mar;17(1):24-8
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Adult
Analysis of Variance
Female
Humans
Male
Moscow
Personality - genetics
Personality Inventory
Polymorphism, Genetic - genetics
Psychiatric Status Rating Scales
Psychotic Disorders - genetics
Receptors, Serotonin - genetics
Abstract
Serotonin receptor (5HTR2A) gene polymorphism has been reported to be associated with clinical phenotypes in schizophrenia. The current study attempted to investigate a relationship between 5HTR2A 102T/C polymorphism and personality traits as well as clinical symptoms in patients with ICD-10 diagnoses of schizophrenia and affective disorders. 5HTR2A genotyping, clinical and psychological assessment were administered to 375 patients, 104 first-degree healthy relatives of the patients and 157 controls. In the patients an association was observed between the 2/2 5HTR2A genotype and scores on the Hypochondriasis scale (MMPI) (ANOVA, F = 4.56; P = 0.011) and trait anxiety (F = 4.21; P = 0.002). A significant difference between 1/1 and 2/2 genotypes has been also found for Neuroticism scores (EPI) (t = 2.18; P = 0.0031). No significant differences by 5HTR2A genotype were observed in either the control or first-degree relatives group for all scales studied. Positive, negative and psychopathological symptoms emerged higher in the 2/2 genotype patients compared to other genotype carriers. Therefore, the 2/2 genotype may contribute to produce the phenotype, with specific clinical and pathological features in common, regardless of nosologic heterogeneity of psychoses.
PubMed ID
11918989 View in PubMed
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