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The influence of probiotics for preterm neonates on the incidence of atopic dermatitis-results from a historically controlled cohort study.

https://arctichealth.org/en/permalink/ahliterature282042
Source
Arch Dermatol Res. 2017 May;309(4):259-264
Publication Type
Article
Date
May-2017
Author
Julie A Damm
Birgitte Smith
Gorm Greisen
Karen A Krogfelt
Maja-Lisa Clausen
Tove Agner
Source
Arch Dermatol Res. 2017 May;309(4):259-264
Date
May-2017
Language
English
Publication Type
Article
Keywords
Child
Child, Preschool
Cohort Studies
Denmark - epidemiology
Dermatitis, Atopic - diet therapy - epidemiology
Dietary Supplements
Female
Humans
Incidence
Infant
Infant, Premature
Male
Premature Birth - diet therapy - epidemiology
Prevalence
Probiotics - therapeutic use
Abstract
Probiotic supplementation is a promising preventive strategy for atopic dermatitis (AD). To help clarifying the significance of timing with respect to prevention of AD, we here evaluate the benefit of prophylactic use of probiotic supplementation in neonates younger than 30 weeks of gestation. Preterm children from the Department of Neonatology, Rigshospitalet, Denmark from two different admission periods were included in a historically controlled cohort study. Neonates from January 2007 to February 2010, not treated with and neonates from March 2010 to February 2013 treated with probiotic were enrolled. Main outcome was prevalence of AD, and secondary outcomes were use of topical corticosteroids, and number of skin-related visits to GPs and dermatologists. 527 preterm neonates were included in the study, 249 treated and 278 not treated with probiotics. Response rate for the two cohorts was 76.7 and 77.7% respectively. The prevalence of AD was similar in the two groups (20.9% in the probiotic treated group versus 17.1% in the not treated group, p?=?0.33). No significant differences were found between the groups with respect to treatment with topical corticosteroids, or visits at GPs or dermatologist. We found no indication that probiotics may prevent AD when administered to neonates?
PubMed ID
28271213 View in PubMed
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