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Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults--the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature140840
Source
Ann Med. 2010 Dec;42(8):603-11
Publication Type
Article
Date
Dec-2010
Author
Liisa A Saarikoski
Risto K Huupponen
Jorma S A Viikari
Jukka Marniemi
Markus Juonala
Mika Kähönen
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Source
Ann Med. 2010 Dec;42(8):603-11
Date
Dec-2010
Language
English
Publication Type
Article
Keywords
Adiponectin - blood
Adult
Atherosclerosis - epidemiology - pathology - physiopathology
Biological Markers - blood
Brachial Artery - physiopathology - ultrasonography
Carotid Arteries - pathology - physiopathology - ultrasonography
Elasticity Imaging Techniques
Female
Finland - epidemiology
Follow-Up Studies
Humans
Male
Regional Blood Flow
Regression Analysis
Risk factors
Tunica Intima - pathology - ultrasonography
Young Adult
Abstract
Adiponectin may be involved in the pathogenesis of atherosclerosis. We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women.
We measured serum adiponectin using radioimmunoassay in 2,147 young adults (ages 24-39 years) participating in the Cardiovascular Risk in Young Finns Study. The subjects had ultrasound data on carotid intima-media thickness (IMT), carotid artery elasticity (n = 2,139) and brachial flow-mediated dilatation (FMD) (n = 1,996). In univariate analysis, adiponectin was inversely associated with IMT (r = -0.16, P
PubMed ID
20839916 View in PubMed
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Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature159355
Source
Clin Sci (Lond). 2008 Nov;115(9):265-71
Publication Type
Article
Date
Nov-2008
Author
Terho Lehtimäki
Nina Hutri-Kähönen
Mika Kähönen
Jukka Hemminki
Vera Mikkilä
Marika Laaksonen
Leena Räsänen
Nina Mononen
Markus Juonala
Jukka Marniemi
Jorma Viikari
Olli Raitakari
Author Affiliation
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, 33014 Tampere, Finland. terho.lehtimaki@uta.fi
Source
Clin Sci (Lond). 2008 Nov;115(9):265-71
Date
Nov-2008
Language
English
Publication Type
Article
Keywords
Adult
Atherosclerosis - epidemiology - etiology - genetics - physiopathology
Brachial Artery - physiopathology - ultrasonography
Carotid Arteries - pathology - ultrasonography
Dairy Products - statistics & numerical data
Diet - statistics & numerical data
Epidemiologic Methods
Female
Finland - epidemiology
Genetic Predisposition to Disease
Genotype
Humans
Lactase - deficiency
Lactase-Phlorizin Hydrolase - genetics
Lactose Intolerance - complications - epidemiology - genetics - pathology
Male
Polymorphism, Genetic
Tunica Intima - pathology - ultrasonography
Tunica Media - pathology - ultrasonography
Vasodilation
Abstract
Individuals suffering from ATH (adult-type hypolactasia), defined by the LCT (gene encoding lactase-phlorizin hydrolase) C/C(-13910) genotype (rs4988235), use less milk and dairy products and may have higher plasma HDL (high-density lipoprotein) and lower triacylglycerol (triglyceride) concentrations than their counterparts without ATH. To investigate the effects of ATH status on the early markers of atherosclerosis, we examined its association with CIMT (carotid intima-media thickness), CAC (carotid artery compliance) and brachial artery FMD (flow-mediated dilation) in a young population-based cohort of otherwise healthy individuals. As part of the Cardiovascular Risk in Young Finns Study, we performed CIMT, CAC and FMD analyses, LCT C/T(-13910) genotyping and risk factor determination in 2109 young subjects 24-39 years of age (45% males) at the time of the examination. The consumption of both milk and dairy products was lowest and the consumption of alcohol highest in subjects with the C/C(-13910) genotype (P
PubMed ID
18194137 View in PubMed
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Alcohol consumption is directly associated with carotid intima-media thickness in Finnish young adults: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature153337
Source
Atherosclerosis. 2009 Jun;204(2):e93-8
Publication Type
Article
Date
Jun-2009
Author
Markus Juonala
Jorma S A Viikari
Mika Kähönen
Tomi Laitinen
Leena Taittonen
Britt-Marie Loo
Antti Jula
Jukka Marniemi
Leena Räsänen
Tapani Rönnemaa
Olli T Raitakari
Author Affiliation
University of Turku, Department of Medicine, Finland. markus.juonala@utu.fi
Source
Atherosclerosis. 2009 Jun;204(2):e93-8
Date
Jun-2009
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - adverse effects - epidemiology
Cardiovascular Diseases - epidemiology - etiology
Carotid Arteries - ultrasonography
Carotid Artery Diseases - epidemiology - etiology - ultrasonography
Cross-Sectional Studies
Female
Finland - epidemiology
Humans
Linear Models
Male
Risk assessment
Risk factors
Tunica Intima - ultrasonography
Tunica Media - ultrasonography
Young Adult
Abstract
There is substantial epidemiological data suggesting a J- or U-shaped association between alcohol consumption and coronary events. However, some studies in experimental animals suggest that alcohol may increase atherosclerosis. Therefore, our aim was to study whether alcohol consumption is associated with carotid intima-media thickness (IMT), marker of subclinical atherosclerosis, in young, healthy adults.
Alcohol consumption, carotid IMT and conventional cardiovascular risk factors were investigated in 2074 subjects, aged 24-39 years.
In subjects consuming none, >0 to or=4 units of alcohol per day, the respective carotid IMT values were 0.57+/-0.004, 0.59+/-0.003, 0.59+/-0.006, and 0.60+/-0.012 mm (mean+/-S.E.M., P
PubMed ID
19124122 View in PubMed
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Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms and their association with carotid artery intima-media thickness in the Finnish population. The Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature175324
Source
Atherosclerosis. 2005 May;180(1):79-86
Publication Type
Article
Date
May-2005
Author
Md Shaheenul Islam
Olli T Raitakari
Markus Juonala
Mika Kähönen
Nina Hutri-Kähönen
Auni Collings
Katriina Aalto-Setälä
Kimmo Kontula
Jukka Marniemi
Jorma S A Viikari
Terho Lehtimäki
Author Affiliation
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Medical School, Tampere University Hospital, The University of Tampere, Tampere, Finland.
Source
Atherosclerosis. 2005 May;180(1):79-86
Date
May-2005
Language
English
Publication Type
Article
Keywords
Adult
Apolipoprotein A-I - genetics
Apolipoprotein C-III
Apolipoproteins A - genetics
Apolipoproteins B - genetics
Apolipoproteins C - genetics
C-Reactive Protein - metabolism
Carotid Arteries - pathology
Carotid Artery Diseases - epidemiology - genetics - pathology
Deoxyribonucleases, Type II Site-Specific
Finland - epidemiology
Gene Frequency
Genetic Predisposition to Disease - epidemiology
Genotype
Humans
Lipoproteins - blood
Polymorphism, Genetic
Risk factors
Tunica Intima - pathology
Tunica Media - pathology
Abstract
Apolipoprotein A-I/C-III/A-IV (apoA-I/C-III/A-IV) SstI and apolipoprotein B (apoB) XbaI polymorphisms have been shown to affect serum low-density lipoprotein (LDL) cholesterol concentrations in a sample of Finnish children. We studied whether these polymorphism are associated with carotid artery intima-media thickness (IMT), a marker of pre-clinical atherosclerosis, measured in the same subjects during their adulthood. A random sub-sample of 214 individuals from the "Cardiovascular Risk in Young Finns" study, for whom genotypes, cardiovascular risk factor data and carotid artery IMT measured in 2001 were available, were studied. Mean carotid IMT values increased according to the apoA-I/C-III/A-IV SstI genotype groups in the order of S1S1 (0.58+/-0.08 mm), S1S2 (0.61+/-0.08 mm), and S2S2 (0.70+/-0.16 mm, p=0.02, ANOVA). In multiple linear regression analysis after adjusting for age, sex and body mass index the mean IMT thickness among the S2 allele carriers was higher (p=0.02) compared to non-carriers. In logistic regression analysis the frequency of S2 allele carriers was higher among the high IMT group compared to the low IMT group (OR=4.02, CI: 1.68-9.61, p=0.002). No significant association between apoB XbaI polymorphism and carotid IMT was found. However, serum total and LDL cholesterol and apoB concentrations were significantly different among apoB genotype groups (p
PubMed ID
15823278 View in PubMed
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Arterial intima-media thickness in 13-year-old adolescents and previous antichlamydial antimicrobial use: a retrospective follow-up study.

https://arctichealth.org/en/permalink/ahliterature155386
Source
Pediatrics. 2008 Sep;122(3):e675-81
Publication Type
Article
Date
Sep-2008
Author
Iina Volanen
Katariina Kallio
Maiju Saarinen
Mikko J Järvisalo
Raija Vainionpää
Tapani Rönnemaa
Jorma Viikari
Jukka Marniemi
Olli Simell
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland. iina.volanen@utu.fi
Source
Pediatrics. 2008 Sep;122(3):e675-81
Date
Sep-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Anti-Bacterial Agents - therapeutic use
Antibodies, Bacterial - analysis
Aorta, Abdominal - ultrasonography
Atherosclerosis - epidemiology - etiology - prevention & control
Carotid Artery, Common - ultrasonography
Child
Child, Preschool
Chlamydophila Infections - complications - drug therapy - microbiology
Chlamydophila pneumoniae - immunology - isolation & purification
Female
Finland - epidemiology
Follow-Up Studies
Humans
Infant
Male
Prevalence
Prognosis
Retrospective Studies
Risk factors
Tunica Intima - ultrasonography
Abstract
Children with persistent Chlamydia pneumoniae infection may be at increased risk for atherosclerosis. The impact of antimicrobial therapy for primary prevention of atherosclerotic cardiovascular disease is unsolved.
The purpose of this study was to determine whether treatment with antimicrobial agents effective against C pneumoniae during childhood, regardless of indication, has a favorable influence on the arterial wall-thickness in children by the time they reach adolescence.
The association of macrolide, tetracycline, quinolone, and rifamycin use (number of exposure events) between ages 5 and 13 years with carotid and aortic intima-media thickness at age 13 years was investigated among 508 healthy children. Information about the use of medications was obtained from the Finnish prescription register. Arterial intima-media thickness was measured with a high-resolution ultrasound.
Mean aortic intima-media thickness showed a significant direct association with the number of antichlamydial antimicrobial exposure events also after controlling for established atherosclerotic risk factors. Elevated C-reactive protein level had an additional effect on aortic intima-media thickness in a multivariable model. Carotid intima-media thickness was not associated with the number of preceding antichlamydial treatments.
Recurrent antichlamydial treatments in childhood have no favorable influence on early vascular changes but are associated with increased intima-media thickness in the abdominal aorta. These findings suggest that the use of antimicrobial agents does not offer protection against the potential atherogenicity of repeated infectious insults.
PubMed ID
18762502 View in PubMed
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Assessment of alcohol consumption by mailed questionnaire in epidemiological studies: evaluation of misclassification using a dietary history interview and biochemical markers.

https://arctichealth.org/en/permalink/ahliterature184136
Source
Eur J Epidemiol. 2003;18(6):493-501
Publication Type
Article
Date
2003
Author
Sofia Carlsson
Niklas Hammar
Paula Hakala
Jaakko Kaprio
Jukka Marniemi
Tapani Rönnemaa
Author Affiliation
Division of Epidemiology, Stockholm Centre of Public Health, Stockholm, Sweden. sofia.carlsson@imm.ki.se
Source
Eur J Epidemiol. 2003;18(6):493-501
Date
2003
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcohol drinking - epidemiology
Biological Markers
Diseases in Twins - epidemiology
Finland - epidemiology
Food Habits
Humans
Male
Middle Aged
Questionnaires
Self Disclosure
Sensitivity and specificity
Transferrin - analogs & derivatives - metabolism
gamma-Glutamyltransferase - blood
Abstract
Self-reported information on alcohol from questionnaires is generally assumed to introduce misclassification of consumption, mainly in the direction of underestimation. The aim of this study was to evaluate self-reported information on alcohol consumption from a mailed questionnaire by comparing to a dietary history interview and biochemical markers of alcohol intake.
For 76 male twin pairs of the Finnish Twin Cohort Study aged 40-70 years information on self-reported alcohol consumption was collected through mailed questionnaire and dietary history interview. Carbohydrate-deficient transferrin (CDT), Gamma-glutamyltransferase (Gamma-GT) and mean corpuscular volume (MCV) were determined from blood samples.
Mean levels of CDT, gamma-GT and MCV showed a rise with increased self-reported alcohol consumption already at low levels of reported consumption ( or = 30 g/day) there was no such correlation. The questionnaire had sensitivity of 28-43% and specificity of 89% for identification of high consumers of alcohol using the biochemical markers as reference and sensitivity 41% and specificity 94% using the dietary history interview as reference. Sensitivity was improved when information on binge drinking (82%) or possible drinking problems (73%) was considered.
Comparison to dietary history interview as well as to biochemical markers indicate that self-reported information on alcohol consumption from a mailed questionnaire may be used to distinguish between groups with different levels of alcohol consumption. The suggested misclassification of high consumers implies that only strong associations between high alcohol intake and disease are likely to be detected in studies based on questionnaire data.
PubMed ID
12908714 View in PubMed
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Association of high sensitive C-reactive protein with apolipoprotein E polymorphism in children and young adults: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature158429
Source
Clin Chem Lab Med. 2008;46(2):179-86
Publication Type
Article
Date
2008
Author
Paula Grönroos
Olli T Raitakari
Mika Kähönen
Nina Hutri-Kähönen
Jukka Marniemi
Jorma Viikari
Terho Lehtimäki
Author Affiliation
Department of Clinical Chemistry, University of Turku, Turku, Finland. paula.gronroos@tyks.fi
Source
Clin Chem Lab Med. 2008;46(2):179-86
Date
2008
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Apolipoproteins E - genetics
C-Reactive Protein - analysis
Cardiovascular Diseases - genetics
Child
Female
Finland
Heterozygote Detection
Humans
Male
Polymorphism, Genetic
Sensitivity and specificity
Abstract
A relation between apolipoprotein E (APOE) genotypes and high sensitive C-reactive protein (hsCRP) has been observed in some studies with elderly subjects and different patient groups. We studied whether serum hsCRP levels are linked with common APOE (epsilon 2, epsilon 3, epsilon 4) polymorphism already in children and young adults.
The study cohort included 1221 subjects participating in the Cardiovascular Risk in Young Finns Study at age 3-18 years at baseline in 1980. These subjects were reexamined at the 21-year follow-up at age 24-39 years in 2001. APOE phenotypes were examined in 1986, serum hsCRP was measured from fresh samples in 2001 and baseline hsCRP (in 1980) was measured from frozen samples in 2005.
Serum hsCRP was significantly associated with APOE phenotypes in children and young adults using multivariate analysis adjusted for age, body mass index, smoking, total cholesterol and low-density lipoprotein cholesterol. Male epsilon 4 carriers had significantly lower hsCRP levels both in childhood (p=0.003) and in adulthood (p=0.013). hsCRP increased in both phenotype classes (epsilon 4+ and epsilon 4-) during the 21-year follow-up. Female epsilon 4 carriers had lower hsCRP levels in childhood (p=0.032) but not in adulthood (p=0.995). An interaction effect between time and APOE phenotype (p=0.045) in relation to hsCRP was observed in females during the 21-year follow-up.
Common APOE polymorphism affects the level of circulating hsCRP already in children and young adults. Male APOE epsilon 4 carriers have consistently lower hsCRP levels. In females, APOE epsilon 4 carriers had lower hsCRP levels in childhood but not in adulthood.
PubMed ID
18324906 View in PubMed
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Association of liver enzymes with metabolic syndrome and carotid atherosclerosis in young adults. The Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature137714
Source
Ann Med. 2012 Mar;44(2):187-95
Publication Type
Article
Date
Mar-2012
Author
Juha Koskinen
Costan G Magnussen
Mika Kähönen
Britt-Marie Loo
Jukka Marniemi
Antti Jula
Liisa A Saarikoski
Risto Huupponen
Jorma S A Viikari
Olli T Raitakari
Markus Juonala
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, Turku, Finland. jkkosk@utu.fi
Source
Ann Med. 2012 Mar;44(2):187-95
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Adult
Alanine Transaminase - metabolism
Atherosclerosis - etiology
Biological Markers - metabolism
Carotid Arteries - ultrasonography
Carotid Artery Diseases - etiology
Carotid Intima-Media Thickness
Fatty Liver - etiology
Female
Finland
Humans
Liver - enzymology
Male
Metabolic Syndrome X - complications - enzymology
Risk
Risk factors
Tunica Intima - ultrasonography
gamma-Glutamyltransferase - metabolism
Abstract
We examined whether metabolic syndrome (MetS) predicts increased alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) levels in young adults, whether spontaneous recovery from MetS has a favorable effect on liver enzyme activities, and whether these enzymes contribute to the atherogenicity of MetS (assessed by carotid intima-media thickness (IMT)).
The study included 1,553 subjects (base-line age 31.5 ± 5.0 years). ALT and GGT were measured in 2007. MetS was diagnosed by the new Joint Interim Societies definition.
ALT and GGT levels were higher in subjects with MetS compared to those without in 2007. The association was independent of alcohol intake and BMI. In multivariable models adjusted for base-line age, LDL cholesterol, CRP, alcohol intake, and adiponectin, MetS in 2001 predicted increased ALT (ß ± SEM = 0.320 ± 0.062, P
PubMed ID
21254896 View in PubMed
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Associations between connexin37 gene polymorphism and markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns study.

https://arctichealth.org/en/permalink/ahliterature165855
Source
Atherosclerosis. 2007 Dec;195(2):379-84
Publication Type
Article
Date
Dec-2007
Author
Auni Collings
Md Shaheenul Islam
Markus Juonala
Riikka Rontu
Mika Kähönen
Nina Hutri-Kähönen
Tomi Laitinen
Jukka Marniemi
Jorma S A Viikari
Olli T Raitakari
Terho J Lehtimäki
Author Affiliation
Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Tampere University Medical School, Finland. Auni.Collings@psghp.fi
Source
Atherosclerosis. 2007 Dec;195(2):379-84
Date
Dec-2007
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Brachial Artery - physiology
Carotid Artery Diseases - genetics - ultrasonography
Cohort Studies
Connexins - genetics
Female
Finland
Genetic Predisposition to Disease
Genotype
Humans
Male
Polymorphism, Single Nucleotide - genetics
Tunica Intima - ultrasonography
Tunica Media - ultrasonography
Vasodilation - genetics - physiology
Abstract
Connexin37 (cx37) C1019T polymorphism has been shown to associate with coronary artery disease in different populations. We investigated whether this polymorphism associates with carotid artery intima-media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow mediated dilatation (FMD) - i.e., early ultrasound markers of subclinical atherosclerosis - in a clinically healthy population of young Finnish adults.
1440 individuals from the Cardiovascular Risk in Young Finns study were genotyped and studied using cardiovascular risk factor and ultrasound data obtained in 2001. In linear regression models, no significant association between the cx37 polymorphism and carotid IMT, CAC or brachial artery FMD (ANOVA, p=0.159, 0.151 and 0.547), respectively, was found in the whole population or in women and men separately.
The connexin37 C1019T polymorphism is not related with markers of subclinical atherosclerosis in young adults.
PubMed ID
17196598 View in PubMed
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Associations between serum 25-hydroxyvitamin d and periodontal pocketing and gingival bleeding: results of a study in a non-smoking population in Finland.

https://arctichealth.org/en/permalink/ahliterature277832
Source
J Periodontol. 2015 Jun;86(6):755-65
Publication Type
Article
Date
Jun-2015
Author
Georgios N Antonoglou
Anna Liisa Suominen
Matti Knuuttila
Pekka Ylöstalo
Meeri Ojala
Satu Männistö
Jukka Marniemi
Annamari Lundqvist
Tellervo Tervonen
Source
J Periodontol. 2015 Jun;86(6):755-65
Date
Jun-2015
Language
English
Publication Type
Article
Keywords
Adult
Cross-Sectional Studies
DMF Index
Dental Plaque Index
Dietary Supplements
Educational Status
Energy intake
Female
Finland
Food Habits
Gingival Hemorrhage - blood
Humans
Male
Middle Aged
Oral Hygiene
Periodontal Pocket - blood
Toothbrushing - statistics & numerical data
Vitamin D - administration & dosage - analogs & derivatives - blood
Vitamins - administration & dosage - blood
Abstract
Apart from the effects of vitamin D on bone metabolism, it is also known for its immunomodulatory properties. However, so far, it is not clear whether serum 25-hydroxyvitamin D [25(OH)D] exerts any beneficial effect on the periodontium. The aim of the present study is to investigate whether the serum level of 25(OH)D is related to periodontal condition, measured by means of pocketing and gingival bleeding.
This cross-sectional study is based on a non-smoking subpopulation without diabetes of the Finnish Health 2000 Survey (N = 1,262). Periodontal condition was measured as the number of teeth with deep (=4 mm) periodontal pockets and the number of bleeding sextants per individual. Serum 25(OH)D level was determined by means of a standard laboratory measurement. Prevalence rate ratios and 95% confidence intervals were estimated using Poisson regression models.
There were practically no associations between serum 25(OH)D level and teeth with deep (=4 mm) periodontal pockets or bleeding sextants. A somewhat lower proportion of teeth with deep periodontal pockets was found in higher serum 25(OH)D quintiles among individuals with a good oral hygiene level.
Serum 25(OH)D did not seem to be related to periodontal condition, measured as periodontal pocketing and gingival bleeding in this low-risk, low-25(OH)D status population.
PubMed ID
25762358 View in PubMed
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43 records – page 1 of 5.