Skip header and navigation

2 records – page 1 of 1.

Implantable cardioverter-defibrillator implantation as a bridge to cardiac transplantation.

https://arctichealth.org/en/permalink/ahliterature159702
Source
J Heart Lung Transplant. 2007 Dec;26(12):1336-9
Publication Type
Article
Date
Dec-2007
Author
Michael R Da Rosa
John L Sapp
Jonathan G Howlett
Alec Falkenham
Jean-Francois Légaré
Author Affiliation
Division of Cardiac Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
Source
J Heart Lung Transplant. 2007 Dec;26(12):1336-9
Date
Dec-2007
Language
English
Publication Type
Article
Keywords
Adult
Aged
Death, Sudden, Cardiac - prevention & control
Defibrillators, Implantable
Female
Follow-Up Studies
Heart Failure - therapy
Heart Transplantation
Humans
Male
Middle Aged
Nova Scotia
Survival Analysis
Treatment Outcome
Waiting Lists
Abstract
Implantable cardioverter-defibrillators (ICDs) have been shown to reduce sudden cardiac death in select patients with impaired left ventricular function. However, consensus guidelines on ICD use have not historically addressed patients waiting for heart transplantation, and further evidence is needed to broaden and strengthen current recommendations. The objective of the present study was to review all patients listed for heart transplantation at a single institution and evaluate the impact of ICD implantation while waiting. All consecutive patients listed for heart transplantation at the Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, from 1995 to July 2006, were included in the study (n = 124). We observed 12 deaths while waiting among patients listed for transplantation (10%), with all deaths occurring in the non-ICD patients. In patients who did have an ICD prior to transplantation, 17% received appropriate defibrillation therapy while awaiting transplantation, and 3 of 12 patients in the non-ICD population who died while waiting died suddenly, suggesting that ICDs could be used as a "bridge to transplantation" in patients with refractory heart failure who are to be listed for heart transplantation.
PubMed ID
18096488 View in PubMed
Less detail

Use of primary prevention implantable cardioverter-defibrillators in a population-based cohort is associated with a significant survival benefit.

https://arctichealth.org/en/permalink/ahliterature123590
Source
Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):706-13
Publication Type
Article
Date
Aug-1-2012
Author
Ratika Parkash
John L Sapp
Magdy Basta
Steve Doucette
Kara Thompson
Martin Gardner
Chris Gray
Brenda Brownell
Hena Kidwai
Jafna Cox
Author Affiliation
Department of Medicine, Queen Elizabeth II Health Sciences Center and the Department of Community Health and Epidemiology, Research Methods Unit, Dalhousie University, Halifax, Nova Scotia, Canada. parkashr@cdha.nshealth.ca
Source
Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):706-13
Date
Aug-1-2012
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Chi-Square Distribution
Death, Sudden, Cardiac - etiology - prevention & control
Defibrillators, Implantable
Electric Countershock - adverse effects - instrumentation - mortality
Female
Humans
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Multivariate Analysis
Nova Scotia
Patient Selection
Primary prevention - methods
Propensity Score
Referral and Consultation
Registries
Retrospective Studies
Risk assessment
Risk factors
Time Factors
Treatment Outcome
Abstract
Underuse of implantable defibrillators has been previously noted in patients at risk for sudden cardiac death, as well as for survivors of sudden cardiac death. We sought to determine the utilization rates in a primary prevention implantable cardioverter-defibrillator (ICD)-eligible population and mortality in this group compared with a group that had undergone implantation of this therapy.
A retrospective cohort of patients from April 1, 2006, to December 31, 2009, was used to define a primary prevention ICD-eligible population. Two groups were compared on the basis of ICD implantation (no-ICD versus ICD). The primary outcome measure was mortality. Of the 717 patients found to be potentially eligible for a primary prevention ICD, 116 (16%) were referred. The remaining cohort of 601 patients were compared with an existing cohort of primary prevention ICD patients (n=290). A significant survival benefit was associated with primary prevention ICD implantation (hazard ratio, 0.46; 95% CI [0.33-0.64]; P
Notes
Comment In: Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):624-522895600
PubMed ID
22685111 View in PubMed
Less detail