Skip header and navigation

2 records – page 1 of 1.

Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates.

https://arctichealth.org/en/permalink/ahliterature287249
Source
Int Arch Occup Environ Health. 2017 Jul;90(5):451-463
Publication Type
Article
Date
Jul-2017
Author
Katrin Dierschke
Christina Isaxon
Ulla B K Andersson
Eva Assarsson
Anna Axmon
Leo Stockfelt
Anders Gudmundsson
Bo A G Jönsson
Monica Kåredal
Jakob Löndahl
Joakim Pagels
Aneta Wierzbicka
Mats Bohgard
Jörn Nielsen
Source
Int Arch Occup Environ Health. 2017 Jul;90(5):451-463
Date
Jul-2017
Language
English
Publication Type
Article
Keywords
Adult
Aged
Biomarkers
Double-Blind Method
Dust
Humans
Interleukin-6 - analysis
Leukotriene B4 - adverse effects
Logistic Models
Male
Middle Aged
Nanoparticles - adverse effects
Nasal Lavage
Neutrophils
Occupational Exposure - adverse effects
Respiratory Function Tests
Surveys and Questionnaires
Sweden
Welding
Abstract
Welders are exposed to airborne particles from the welding environment and often develop symptoms work-related from the airways. A large fraction of the particles from welding are in the nano-size range. In this study we investigate if the welders' airways are affected by exposure to particles derived from gas metal arc welding in mild steel in levels corresponding to a normal welding day.
In an exposure chamber, 11 welders with and 10 welders without work-related symptoms from the lower airways and 11 non-welders without symptoms, were exposed to welding fumes (1 mg/m3) and to filtered air, respectively, in a double-blind manner. Symptoms from eyes and upper and lower airways and lung function were registered. Blood and nasal lavage (NL) were sampled before, immediately after and the morning after exposure for analysis of markers of oxidative stress. Exhaled breath condensate (EBC) for analysis of leukotriene B4 (LT-B4) was sampled before, during and immediately after exposure.
No adverse effects of welding exposure were found regarding symptoms and lung function. However, EBC LT-B4 decreased significantly in all participants after welding exposure compared to filtered air. NL IL-6 increased immediately after exposure in the two non-symptomatic groups and blood neutrophils tended to increase in the symptomatic welder group. The morning after, neutrophils and serum IL-8 had decreased in all three groups after welding exposure. Remarkably, the symptomatic welder group had a tenfold higher level of EBC LT-B4 compared to the two groups without symptoms.
Despite no clinical adverse effects at welding, changes in inflammatory markers may indicate subclinical effects even at exposure below the present Swedish threshold limit (8 h TWA respirable dust).
Notes
Cites: Int Arch Allergy Appl Immunol. 1973;45(1):57-604580380
Cites: J Allergy Clin Immunol. 2003 Oct;112(4):695-70114564346
Cites: Environ Health Perspect. 2005 Jul;113(7):823-3916002369
Cites: J Clin Invest. 1994 Nov;94(5):2028-357962549
Cites: J Toxicol Environ Health A. 2012;75(8-10):533-4322686313
Cites: Clin Exp Allergy. 1999 Oct;29(10):1395-40110520061
Cites: Palliat Med. 2007 Apr;21(3):177-9117363394
Cites: Am J Ind Med. 2012 Jan;55(1):54-6221959832
Cites: Int Arch Occup Environ Health. 2007 Jul;80(7):627-3317308916
Cites: J Adv Nurs. 1995 Nov;22(5):948-568568070
Cites: Clin Exp Allergy. 2014 Sep;44(9):1100-1825040251
Cites: Occup Environ Med. 1999 Mar;56(3):202-510448330
Cites: Eur Respir J. 2005 Jul;26(1):1-215994380
Cites: Occup Environ Med. 2015 Jan;72(1):49-5625104428
Cites: Exp Lung Res. 2007 Apr-May;33(3-4):115-3317558675
Cites: Am J Respir Crit Care Med. 2005 Dec 15;172(12):1541-816166614
Cites: J Occup Environ Med. 2015 Aug;57(8):845-5026247637
Cites: Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120742764
Cites: J Clin Invest. 1998 Jan 15;101(2):311-209435302
Cites: Int Arch Occup Environ Health. 2014 Aug;87(6):623-3423979145
Cites: Inhal Toxicol. 2000 Dec;12(12):1113-2611114784
Cites: Int Arch Occup Environ Health. 2011 Jan;84(1):105-1320862590
Cites: Respir Med. 2014 Jan;108(1):162-7024290899
Cites: J Breath Res. 2012 Jun;6(2):02710522622358
Cites: Part Fibre Toxicol. 2013 Dec 09;10:6024321138
Cites: J Immunotoxicol. 2012 Oct-Dec;9(4):411-2522734811
Cites: Eur Respir J. 2005 Aug;26(2):319-3816055882
Cites: Am J Respir Cell Mol Biol. 1992 May;6(5):535-421581076
Cites: Occup Environ Med. 2004 May;61(5):442-715090666
Cites: Scand J Clin Lab Invest. 2011 Nov;71(7):532-4121988588
Cites: Eur Respir J Suppl. 1993 Mar;16:5-408499054
Cites: Int Arch Occup Environ Health. 2015 Nov;88(8):1131-4025744592
Cites: Eur Respir J. 2004 Jan;23(1):82-614738236
Cites: Crit Rev Toxicol. 2003;33(1):61-10312585507
Cites: Ann Occup Hyg. 2008 Mar;52(2):107-1518216372
Cites: Acta Med Scand. 1963 Feb;173:185-9213970718
Cites: Ann Occup Hyg. 2002 Nov;46(8):663-7212406860
Cites: Nature. 1994 Mar 24;368(6469):339-428127368
Cites: J Aerosol Med. 2002 Summer;15(2):213-2012184871
Cites: Ann Occup Hyg. 2013 Jan;57(1):6-2522997412
Cites: Allergy. 2002;57 Suppl 70:5-3911990714
Cites: Int J Occup Med Environ Health. 2005;18(3):265-7416411566
Cites: Lancet. 1965 Apr 10;1(7389):775-94165081
Cites: Free Radic Biol Med. 2010 May 1;48(9):1211-720153423
Cites: Acta Otolaryngol. 1983 Jul-Aug;96(1-2):157-616613544
Cites: J Immunol. 2000 Oct 1;165(7):4051-6111034416
Cites: PLoS One. 2014 Apr 15;9(4):e9418824736635
Cites: Rapid Commun Mass Spectrom. 2009 Jan;23(2):258-6619072863
PubMed ID
28258373 View in PubMed
Less detail

Air contaminants in a submarine equipped with air independent propulsion.

https://arctichealth.org/en/permalink/ahliterature166824
Source
J Environ Monit. 2006 Nov;8(11):1111-21
Publication Type
Article
Date
Nov-2006
Author
Ola Persson
Christina Ostberg
Joakim Pagels
Aleksandra Sebastian
Author Affiliation
Division of Heat Transfer, Department of Heat and Power Engineering, Lund Institute of Technology, Box 118, 221 00, Lund, Sweden.
Source
J Environ Monit. 2006 Nov;8(11):1111-21
Date
Nov-2006
Language
English
Publication Type
Article
Keywords
Air Pollutants, Occupational - analysis - standards
Carbon Dioxide - analysis - standards
Ecological Systems, Closed
Environmental Monitoring - standards
Gram-Negative Bacteria - isolation & purification
Humans
Hydrogen - analysis - standards
Life Support Systems
Organic Chemicals - analysis - standards
Oxygen - analysis - standards
Ozone - analysis - standards
Pressure
Submarine Medicine
Sweden
Temperature
Volatilization
Abstract
The Swedish Navy has operated submarines equipped with air independent propulsion for two decades. This type of submarine can stay submerged for periods far longer than other non-nuclear submarines are capable of. The air quality during longer periods of submersion has so far not been thoroughly investigated. This study presents results for a number of air quality parameters obtained during more than one week of continuous submerged operation. The measured parameters are pressure, temperature, relative humidity, oxygen, carbon dioxide, hydrogen, formaldehyde and other volatile organic compounds, ozone, nitrogen dioxide, particulate matter and microbiological contaminants. The measurements of airborne particles demonstrate that air pollutants typically occur at a low baseline level due to high air exchange rates and efficient air-cleaning devices. However, short-lived peaks with comparatively high concentrations occur, several of the sources for these have been identified. The concentrations of the pollutants measured in this study do not indicate a build-up of hazardous compounds during eight days of submersion. It is reasonable to assume that a substantial build-up of the investigated contaminants is not likely if the submersion period is prolonged several times, which is the case for modern submarines equipped with air independent propulsion.
PubMed ID
17075617 View in PubMed
Less detail