Skip header and navigation

1 records – page 1 of 1.

Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.

https://arctichealth.org/en/permalink/ahliterature139234
Source
PLoS One. 2010;5(11):e15402
Publication Type
Article
Date
2010
Author
Russell Lewis McLaughlin
Julie Phukan
William McCormack
David S Lynch
Matthew Greenway
Simon Cronin
Jean Saunders
Agnieska Slowik
Barbara Tomik
Peter M Andersen
Daniel G Bradley
Phil Jakeman
Orla Hardiman
Author Affiliation
Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. mclaugr@tcd.ie
Source
PLoS One. 2010;5(11):e15402
Date
2010
Language
English
Publication Type
Article
Keywords
Alleles
Amyotrophic Lateral Sclerosis - genetics
Gene Frequency
Genetic Predisposition to Disease - genetics
Genotype
Haplotypes
Humans
Ireland
Linkage Disequilibrium
Poland
Polymorphism, Single Nucleotide
Ribonuclease, Pancreatic - blood - cerebrospinal fluid - genetics
Sweden
Abstract
To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF.
Allelic association statistics were calculated for polymorphisms in the ANG gene in 859 patients and 1047 controls from Sweden, Ireland and Poland. Plasma, serum and CSF angiogenin levels were quantified and stratified according to genotypes across the ANG gene. The contribution of SNP genotypes to variance in circulating angiogenin levels was estimated in patients and controls.
All SNPs showed association with ALS in the Irish group. The SNP rs17114699 replicated in the Swedish cohort. No SNP associated in the Polish cohort. Age- and sex-corrected circulating angiogenin levels were significantly lower in patients than in controls (p
Notes
Cites: Nat Genet. 2001 Jun;28(2):131-811381259
Cites: Eur J Hum Genet. 2009 Feb;17(2):213-818987618
Cites: Neuroreport. 2002 Dec 3;13(17):2199-20112488796
Cites: Nat Genet. 2003 Aug;34(4):383-9412847526
Cites: Exp Neurol. 2004 Jun;187(2):246-5315144851
Cites: Neurology. 2004 Jun 8;62(11):2127-915184633
Cites: Clin Neurol Neurosurg. 2004 Sep;106(4):289-9315297002
Cites: J Neurol Sci. 1994 Jul;124 Suppl:96-1077807156
Cites: Bioinformatics. 2005 Jan 15;21(2):263-515297300
Cites: Clin Endocrinol (Oxf). 2006 Mar;64(3):271-916487436
Cites: Nat Genet. 2006 Apr;38(4):411-316501576
Cites: Methods Mol Biol. 2006;342:129-3816957372
Cites: Neurology. 2006 Nov 28;67(10):1833-617130418
Cites: Cell. 2007 Jun 29;129(7):1401-1417604727
Cites: Am J Hum Genet. 2007 Sep;81(3):559-7517701901
Cites: Nature. 2007 Oct 18;449(7164):851-6117943122
Cites: Hum Mol Genet. 2008 Jan 1;17(1):130-4917916583
Cites: Ann Neurol. 2007 Dec;62(6):609-1717886298
Cites: Neurogenetics. 2008 Feb;9(1):33-4018087731
Cites: Hum Mol Genet. 2008 Mar 1;17(5):768-7418057069
Cites: Amyotroph Lateral Scler. 2008 Dec;9(6):323-3818752088
Cites: Nature. 2008 Nov 6;456(7218):98-10118758442
Cites: Hum Mol Genet. 2008 Dec 1;17(23):3631-4218723524
Cites: Science. 2002 Jun 21;296(5576):2225-912029063
PubMed ID
21085671 View in PubMed
Less detail