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The association between circulating endostatin levels and incident myocardial infarction.

https://arctichealth.org/en/permalink/ahliterature299297
Source
Scand Cardiovasc J. 2018 Dec; 52(6):315-319
Publication Type
Journal Article
Multicenter Study
Date
Dec-2018
Author
Toralph Ruge
Axel C Carlsson
Jan-Håkan Jansson
Stefan Söderberg
Anders Larsson
Johan Ärnlöv
Author Affiliation
a Department of Emergency Medicine , Karolinska University Hospital , Stockholm , Sweden.
Source
Scand Cardiovasc J. 2018 Dec; 52(6):315-319
Date
Dec-2018
Language
English
Publication Type
Journal Article
Multicenter Study
Keywords
Adult
Aged
Biomarkers - blood
C-Reactive Protein - analysis
Case-Control Studies
Endostatins - blood
Female
Humans
Incidence
Male
Middle Aged
Myocardial Infarction - blood - diagnosis - epidemiology
Prognosis
Prospective Studies
Registries
Risk assessment
Risk factors
Sex Factors
Sweden - epidemiology
Time Factors
Up-Regulation
Abstract
Increased levels of circulating endostatin have been observed in patients with prevalent ischemic heart disease. However, the association between circulating endostatin, and incident myocardial infarction (MI) is less studied. Our main aim was to study the association between circulating endostatin and incident MI in the community adjusted for established cardiovascular risk factors in men and women.
Circulating endostatin was measured in a nested case control study based on three large community-based Swedish cohorts, including 533?MI cases, and 1003 age-, sex- and cohort-matched controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with adjustments for established cardiovascular risk factors.
Higher endostatin was associated with a higher incidence of MI independently of established cardiovascular risk factors (OR 1.19, 95% CI 1.03-1.37, p?=?.02), but this association was abolished after additional adjustment for C-reactive protein. Sex-stratified analyses suggest that the association was substantially stronger in women as compared to men.
In our community based sample, higher endostatin predicted incident myocardial infarction predominantly in women but not independently of CRP. Thus, our findings do not support a broad utility of endostatin measurements for the prediction of incident myocardial infarction in clinical practice.
PubMed ID
30474426 View in PubMed
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Association of Pregnancy Complications and Characteristics With Future Risk of Elevated Blood Pressure: The VĂ€sterbotten Intervention Program.

https://arctichealth.org/en/permalink/ahliterature284906
Source
Hypertension. 2017 Mar;69(3):475-483
Publication Type
Article
Date
Mar-2017
Author
Nisha I Parikh
Margareta Norberg
Erik Ingelsson
Sven Cnattingius
Ramachandran S Vasan
Magnus Domellöf
Jan Håkan Jansson
Anna-Karin Edstedt Bonamy
Source
Hypertension. 2017 Mar;69(3):475-483
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Adult
Blood Pressure - physiology
Female
Humans
Hypertension - epidemiology - etiology - physiopathology
Pre-Eclampsia - epidemiology
Pregnancy
Pregnancy Complications, Cardiovascular
Pregnancy outcome
Prevalence
Risk factors
Sweden - epidemiology
Abstract
Pregnancy characteristics are associated with risk of cardiovascular diseases, but their independent associations with hypertension or blood pressure (BP) levels remain uncertain. We linked the Swedish Medical Birth Register with Västerbotten Intervention Program data (Northern Sweden). Using linear and logistic regression, we related pregnancy factors in any prior pregnancy with BP and hypertension at 40 years of age in 15?896 parous women free of prepregnancy hypertension. Pregnancy factors included parity, age at first delivery, preeclampsia, gestational diabetes mellitus, placental abruption, shortest gestational age small for gestational age baby (
Notes
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PubMed ID
28137991 View in PubMed
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Better long-term survival in young and middle-aged women than in men after a first myocardial infarction between 1985 and 2006. An analysis of 8630 patients in the Northern Sweden MONICA Study.

https://arctichealth.org/en/permalink/ahliterature99717
Source
BMC Cardiovasc Disord. 2011 Jan 5;11(1):1
Publication Type
Article
Date
Jan-5-2011
Author
Rose-Marie Isaksson
Jan-Hakan Jansson
Dan Lundblad
Ulf Naslund
Karin Zingmark
Mats Eliasson
Source
BMC Cardiovasc Disord. 2011 Jan 5;11(1):1
Date
Jan-5-2011
Language
English
Publication Type
Article
Abstract
ABSTRACT: BACKGROUND: There is conflicting and only scant evidence on the effect of gender on long-term survival after a myocardial infarction (MI). Our aim was to analyse sex-specific survival of patients for up to 23 years after a first MI in northern Sweden and to describe time trends. METHODS: The Northern Sweden MONICA Myocardial Infarction Registry was linked to The Swedish National Cause of Death Registry for a total of 8630 patients, 25 to 64 years of age, 6762 men and 1868 women, with a first MI during 1985-2006. Also deaths before admission to hospital were included. Follow-up ended on August 30, 2008. RESULTS: Median follow-up was 7.1 years, maximum 23 years and the study included 70 072 patient-years. During the follow-up 45.3% of the men and 43.7% of the women had died. Median survival for men was 187 months (95% confidence interval (CI) 179-194) and for women 200 months (95% CI 186-214). The hazard ratio (HR) for all cause mortality after adjustment for age group was 1.092 (1.010-1.18, P = 0.025) for males compared to females, i.e. 9 percent higher survival in women. After excluding subjects who died before reaching hospital HR declined to 1.017 (95%CI 0.93-1.11, P = 0.7). For any duration of follow-up a higher proportion of women were alive, irrespective of age group. The 5-year survivals were 75.3% and 77.5%, in younger (
PubMed ID
21208409 View in PubMed
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Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study.

https://arctichealth.org/en/permalink/ahliterature96924
Source
Am J Clin Nutr. 2010 Jul;92(1):194-202
Publication Type
Article
Date
Jul-2010
Author
Eva Warensjö
Jan-Håkan Jansson
Tommy Cederholm
Kurt Boman
Mats Eliasson
Göran Hallmans
Ingegerd Johansson
Per Sjögren
Author Affiliation
Department of Public Health, Uppsala University, Uppsala, Sweden. eva.warensjo@pubcare.uu.se
Source
Am J Clin Nutr. 2010 Jul;92(1):194-202
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Animals
Blood pressure
Cohort Studies
Dietary Fats - adverse effects
Educational Status
Female
Humans
Male
Middle Aged
Milk - adverse effects
Models, Statistical
Myocardial Infarction - epidemiology - physiopathology
Odds Ratio
Patient Selection
Phospholipids - blood - pharmacology
Questionnaires
Reference Values
Risk assessment
Risk factors
Sex Characteristics
Smoking - epidemiology
Sweden - epidemiology
Abstract
BACKGROUND: High intakes of saturated fat have been associated with cardiovascular disease, and milk fat is rich in saturated fat. OBJECTIVE: The objective of this study was to investigate the association between the serum milk fat biomarkers pentadecanoic acid (15:0), heptadecanoic acid (17:0), and their sum (15:0+17:0) and a first myocardial infarction (MI). DESIGN: The study design was a prospective case-control study nested within a large population-based cohort in Sweden. Included in the study were 444 cases (307 men) and 556 controls (308 men) matched on sex, age, date of examination, and geographic region. Clinical, anthropometric, biomarker fatty acid, physical activity, and dietary data were collected. The odds of a first MI were investigated by using conditional logistic regression. RESULTS: In women, proportions of milk fat biomarkers in plasma phospholipids were significantly higher (P
PubMed ID
20484449 View in PubMed
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CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.

https://arctichealth.org/en/permalink/ahliterature114521
Source
Clin Sci (Lond). 2013 Oct;125(8):401-7
Publication Type
Article
Date
Oct-2013
Author
Geena Varghese Paramel
Lasse Folkersen
Rona J Strawbridge
Ali Ateia Elmabsout
Eva Särndahl
Pia Lundman
Jan-Håkan Jansson
Göran K Hansson
Allan Sirsjö
Karin Fransén
Author Affiliation
Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Source
Clin Sci (Lond). 2013 Oct;125(8):401-7
Date
Oct-2013
Language
English
Publication Type
Article
Keywords
Atherosclerosis - blood - genetics
Biological Markers - blood
C-Reactive Protein - metabolism
CARD Signaling Adaptor Proteins - genetics
Chemokine CCL2 - blood
Cohort Studies
Cytokines - blood
Gene Expression Profiling
Gene Frequency
Genotype
Humans
Immunity, Innate - genetics
Inflammation - blood - genetics
Inflammation Mediators - blood
Myocardial Infarction - blood - genetics
Neoplasm Proteins - genetics
Oligonucleotide Array Sequence Analysis
Plaque, Atherosclerotic - blood - genetics
Polymorphism, Single Nucleotide
Risk factors
Sweden
Abstract
Inflammation is a key factor in the development of atherosclerotic coronary artery disease. It is promoted through the inflammasome, a molecular machine that produces IL (interleukin)-1? in response to cholesterol crystal accumulation in macrophages. The CARD8 (caspase recruitment domain 8) protein modulates this process by suppressing caspase 1 and the transcription factor NF-?B (nuclear factor ?B). The expression of CARD8 mRNA was examined in atherosclerotic vascular tissue and the impact on MI (myocardial infarction) of a polymorphism in the CARD8 gene determined. CARD8 mRNA was analysed by microarray of human atherosclerotic tissue and compared with transplant donor arterial tissue. Microarray analysis was performed for proximal genes associated with the rs2043211 locus in plaque. The CARD8 rs2043211 polymorphism was analysed by genotyping of two Swedish MI cohorts, FIA (First Myocardial Infarction in Northern Sweden) and SCARF (Stockholm Coronary Atherosclerosis Risk Factor). The CRP (C-reactive protein) level was measured in both cohorts, but the levels of the pro-inflammatory cytokines IL-1?, IL-18, TNF (tumour necrosis factor) and MCP-1 (monocyte chemoattractant protein) were measured in sera available from the SCARF cohort. CARD8 mRNA was highly expressed in atherosclerotic plaques compared with the expression in transplant donor vessel (P
PubMed ID
23611467 View in PubMed
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Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort - evaluation of risk factors and their interactions.

https://arctichealth.org/en/permalink/ahliterature47322
Source
Scand J Public Health Suppl. 2003;61:18-24
Publication Type
Article
Date
2003
Author
Göran Hallmans
Asa Agren
Gerd Johansson
Anders Johansson
Birgitta Stegmayr
Jan-Håkan Jansson
Bernt Lindahl
Olle Rolandsson
Stefan Söderberg
Mats Nilsson
Ingegerd Johansson
Lars Weinehall
Author Affiliation
Nutritional Research, Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden. goran.hallmans@nutrires.umu.se
Source
Scand J Public Health Suppl. 2003;61:18-24
Date
2003
Language
English
Publication Type
Article
Keywords
Cardiovascular Diseases - epidemiology
Cohort Studies
Diabetes Mellitus - epidemiology
Humans
Risk factors
Sweden - epidemiology
Abstract
The purpose of this paper is, first, to describe the organization, sampling procedures, availability of samples/database, ethical considerations, and quality control program of the Northern Sweden Health and Disease Study Cohort. Secondly, some examples are given of studies on cardiovascular disease and diabetes with a focus on the biomarker programme. The cohort has been positioned as a national and international resource for scientific research.
PubMed ID
14660243 View in PubMed
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Characterization of patients with atrial fibrillation not treated with oral anticoagulants.

https://arctichealth.org/en/permalink/ahliterature263161
Source
Scand J Prim Health Care. 2014 Dec;32(4):226-31
Publication Type
Article
Date
Dec-2014
Author
Cecilia Johansson
Lovisa Hägg
Lars Johansson
Jan-Håkan Jansson
Source
Scand J Prim Health Care. 2014 Dec;32(4):226-31
Date
Dec-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Anticoagulants - administration & dosage - adverse effects - therapeutic use
Atrial Fibrillation - drug therapy - epidemiology
Cardiovascular Diseases - drug therapy
Child
Child, Preschool
Cross-Sectional Studies
Female
Guideline Adherence
Humans
Infant
Infant, Newborn
Male
Middle Aged
Retrospective Studies
Risk factors
Sweden - epidemiology
Young Adult
Abstract
An underuse of oral anticoagulants (OAC) in patients with atrial fibrillation (AF) has been suggested, as only 50% of all patients with AF receive OAC treatment. Whether this is due to contraindications, lack of an indication to treat, or an expression of underuse is sparsely investigated. This study therefore aimed to characterize individuals without OAC treatment in a real-life population of patients with AF.
Retrospective cross-sectional study. The medical records were scrutinized in order to identify the type of AF, risk factors for embolism and bleeding, and other factors of importance for OAC treatment.
The municipalities of Skellefteå and Norsjö, northern Sweden.
A total of 2274 living residents with at least one verified episode of AF on or before December 31, 2010.
Prevalence of treatment with OAC and documented reasons to withhold OAC treatment.
Among all 2274 patients with AF, 1187 (52%) were not treated with OAC. Of the untreated patients, 19% had no indication or had declined or had experienced adverse effects other than bleeding on warfarin treatment. The most common reason to withhold OAC was presence of risk factors for bleeding, found in 38% of all untreated patients. Furthermore, a documented reason could be identified to withhold OAC in 75%.
Among patients with AF without OAC treatment a reason could be identified to withhold OAC in 75%. The underuse of OAC is estimated to be 25%.
Notes
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PubMed ID
25464863 View in PubMed
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Comparison of blood pressure measurements between an automated oscillometric device and a Hawksley random-zero sphygmomanometer in the northern Sweden MONICA study.

https://arctichealth.org/en/permalink/ahliterature122732
Source
Blood Press Monit. 2012 Aug;17(4):164-70
Publication Type
Article
Date
Aug-2012
Author
Marie Eriksson
Bo Carlberg
Jan-Håkan Jansson
Author Affiliation
Department of Statistics, Umeå School of Business and Economics Umeå University, Umeå, Sweden. marie.eriksson@stat.umu.se
Source
Blood Press Monit. 2012 Aug;17(4):164-70
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Blood pressure
Blood Pressure Determination - instrumentation
Female
Humans
Hypertension - diagnosis
Linear Models
Male
Middle Aged
Oscillometry - instrumentation
Sphygmomanometers
Sweden
Abstract
The Hawksley random-zero sphygmomanometer (random-zero) has been used widely in epidemiological observation studies. This study compares blood pressure measurements using the random-zero with measurements using an automated oscillometric device and suggests a correction of the automated oscillometric measurements to enable comparisons of blood pressure levels over time.
The northern Sweden MONICA population survey 2009 included 1729 participants, 853 men and 876 women, 25-74 years old. Blood pressure was measured using both random-zero and an automated oscillometric device in all participants. The Omron M7 digital blood pressure monitor was used for automated oscillometric measurements. A linear mixed model was used to derive a formula to adjust the automated oscillometric readings.
Automated oscillometric measurements of systolic blood pressure were generally lower than random-zero measurements in women [oscillometric mean 122.1 mmHg (95% confidence interval: 121.0-123.2) versus random-zero mean 124.4 mmHg (123.5-125.5)], whereas automated oscillometric measurements of systolic blood pressure were generally higher than random-zero measurements in men [oscillometric 131.1 mmHg (130.0-132.2) versus random-zero 129.0 mmHg (127.9-130.1)]. For diastolic blood pressure, automated oscillometric measurements were higher in both women [oscillometric 79.9 mmHg (79.2-80.5) versus random-zero 76.7 mmHg (76.0-77.4)] and men [oscillometric 83.1 mmHg (82.4-83.8) vs. random-zero 81.2 mmHg (80.6-81.9)]. The difference also varied with age and order of measurement. Adjustment of the automated oscillometric measurements using mixed model regression coefficients produced estimates of blood pressure that were close to the random-zero measurements.
Blood pressure measurements using an automated oscillometric device differ from those with random-zero, but the oscillometric measurements can be adjusted, on the basis of sex, age and measurement order, to be similar to the random-zero measurements.
PubMed ID
22781634 View in PubMed
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[Comparison Riks-HIA--medical records gave no basis for care improvement. Difficult to explain the lower number of reperfusion in ST elevation infarction in the Norrland's counties].

https://arctichealth.org/en/permalink/ahliterature125429
Source
Lakartidningen. 2012 Jan 25-31;109(4):158-60
Publication Type
Article

Cystatin C and creatinine as markers of bleeding complications, cardiovascular events and mortality during oral anticoagulant treatment.

https://arctichealth.org/en/permalink/ahliterature112423
Source
Thromb Res. 2013 Aug;132(2):e77-82
Publication Type
Article
Date
Aug-2013
Author
Marcus Lind
Jan-Håkan Jansson
Torbjörn K Nilsson
Lisbeth Slunga Järvholm
Lars Johansson
Author Affiliation
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Electronic address: Marcus.lind@vll.se.
Source
Thromb Res. 2013 Aug;132(2):e77-82
Date
Aug-2013
Language
English
Publication Type
Article
Keywords
Administration, Oral
Aged
Anticoagulants - administration & dosage - adverse effects
Biological Markers - blood
Cardiovascular Diseases - blood - mortality
Cohort Studies
Creatinine - blood - metabolism
Cystatin C - blood - metabolism
Female
Hemorrhage - blood - mortality
Humans
Longitudinal Studies
Male
Prognosis
Risk factors
Sweden - epidemiology
Abstract
Impaired kidney function has been linked to both ischemic events as well as bleeding complications in several clinical conditions. Our aim was to investigate if cystatin C, creatinine and calculated glomerular filtration rate (eGFR) were related to future risk of bleeding complications, cardiovascular events or all-cause mortality during oral anticoagulant treatment.
In a cohort study, 719 patients on long-term vitamin K antagonist (VKA) treatment were followed for a mean of 4.2 years. Blood sampling was taken at inclusion and patients were followed prospectively. Cystatin C and creatinine were analysed and eGFR was calculated. All medical records were reviewed. Major bleeding events, myocardial infarctions, strokes, arterial emboli, and deaths were recorded and classified.
After adjustment for age, no association between cystatin C, creatinine or eGFR and major bleeding was found. Cystatin C was independently associated with cardiovascular events (hazard ratio 1.50 (95% CI: 1.27-1.77)) and all-cause mortality (hazard ratio 1.62 (95% CI: 1.38-1.90)).Creatinine was only associated with all-cause mortality, while eGFR was not associated with any of the outcomes.
Our findings underscore the superiority of cystatin C as a marker of cardiovascular risk compared to creatinine or eGFR. VKA-treated patients with increased cystatin C levels should be considered to be at an increased risk of cardiovascular events, and not bleeding complications.
PubMed ID
23834818 View in PubMed
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45 records – page 1 of 5.