Skip header and navigation

Refine By

91 records – page 1 of 10.

Adolescence physical activity is associated with higher tibial pQCT bone values in adulthood after 28-years of follow-up--the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature269110
Source
Bone. 2015 Jun;75:77-83
Publication Type
Article
Date
Jun-2015
Author
S. Tolonen
H. Sievänen
V. Mikkilä
R. Telama
M. Oikonen
M. Laaksonen
J. Viikari
M. Kähönen
O T Raitakari
Source
Bone. 2015 Jun;75:77-83
Date
Jun-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Bone Density - physiology
Child
Child, Preschool
Cohort Studies
Female
Finland
Follow-Up Studies
Fractures, Bone - epidemiology
Humans
Life Style
Male
Middle Aged
Motor Activity - physiology
Odds Ratio
Prevalence
Tibia - growth & development - radiography
Tomography, X-Ray Computed
Young Adult
Abstract
High peak bone mass and strong bone phenotype are known to be partly explained by physical activity during growth but there are few prospective studies on this topic. In this 28-year follow-up of Cardiovascular Risk in Young Finns Study cohort, we assessed whether habitual childhood and adolescence physical activity or inactivity at the age of 3-18 years were associated with adult phenotype of weight-bearing tibia and the risk of low-energy fractures. Baseline physical activity and data on clinical, nutritional and lifestyle factors were assessed separately for females and males aged 3-6-years (N=395-421) and 9-18-years (N=923-965). At the age of 31-46-years, the prevalence of low-energy fractures was assessed with a questionnaire and several tibial traits were measured with pQCT (bone mineral content (BMC; mg), total and cortical cross-sectional areas (mm(2)), trabecular (for the distal site only) and cortical (for the shaft only) bone densities (mg/cm(3)), stress-strain index (SSI; mm(3), for the shaft only), bone strength index (BSI; mg(2)/cm(4), for the distal site only) and the cortical strength index (CSI, for the shaft only)). For the statistical analysis, each bone trait was categorized as below the cohort median or the median and above and the adjusted odds ratios (OR) were determined. In females, frequent physical activity at the age of 9-18-years was associated with higher adulthood values of BSI, total and cortical areas, BMC, CSI and SSI at the tibia independently of many health and lifestyle factors (ORs 0.33-0.53, P=0.05; P-values for trend 0.002-0.05). Cortical density at the tibial shaft showed the opposite trend (P-value for trend 0.03). Similarly in males, frequent physical activity was associated with higher values of adult total and cortical areas and CSI at the tibia (ORs 0.48-0.53, P=0.05; P-values for trend 0.01-0.02). However, there was no evidence that childhood or adolescence physical activity was associated with lower risk of low energy fractures during the follow-up. In conclusion, frequent habitual physical activity in adolescence seems to confer benefits on tibial bone size and geometry in adulthood.
PubMed ID
25697084 View in PubMed
Less detail

Apolipoprotein B polymorphism and altered apolipoprotein B and low density lipoprotein cholesterol concentrations in Finnish children.

https://arctichealth.org/en/permalink/ahliterature233599
Source
Br Med J (Clin Res Ed). 1988 Jan 16;296(6616):169-70
Publication Type
Article
Date
Jan-16-1988
Author
M J Tikkanen
J. Viikari
H K Akerblom
E. Pesonen
Author Affiliation
Third Department of Medicine, Meilahti Hospital, University of Helsinki.
Source
Br Med J (Clin Res Ed). 1988 Jan 16;296(6616):169-70
Date
Jan-16-1988
Language
English
Publication Type
Article
Keywords
Alleles
Apolipoproteins B - blood - genetics
Child
Cholesterol, LDL - blood
Finland
Humans
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Notes
Cites: Acta Paediatr Scand Suppl. 1985;318:103-93879089
Cites: Atherosclerosis. 1987 Sep;67(1):81-92890359
Cites: Clin Genet. 1986 Dec;30(6):515-203502691
Cites: Arteriosclerosis. 1987 Jan-Feb;7(1):61-52434069
PubMed ID
2892566 View in PubMed
Less detail

Apolipoprotein E phenotypes and serum lipids in newborns and 3-year-old children: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature217182
Source
Pediatrics. 1994 Oct;94(4 Pt 1):489-93
Publication Type
Article
Date
Oct-1994
Author
T. Lehtimäki
K. Porkka
J. Viikari
C. Ehnholm
H K Akerblom
T. Nikkari
Author Affiliation
Department of Biomedical Sciences, University of Tampere, Finland.
Source
Pediatrics. 1994 Oct;94(4 Pt 1):489-93
Date
Oct-1994
Language
English
Publication Type
Article
Keywords
Adolescent
Age Factors
Alleles
Analysis of Variance
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E - genetics
Arteriosclerosis - epidemiology - etiology
Child
Child, Preschool
Cholesterol - blood
Cholesterol, LDL - blood
Enteral Nutrition
Female
Fetal Blood - chemistry
Finland - epidemiology
Follow-Up Studies
Humans
Infant, Newborn - blood
Male
Phenotype
Risk factors
Abstract
Apolipoprotein E (apoE) phenotype is a genetic determinant of plasma total cholesterol and low density lipoprotein (LDL) cholesterol concentrations, that are classical coronary heart disease risk factors. ApoE appears in three major isoforms E2, E3, and E4, coded by corresponding alleles epsilon 2, epsilon 3, and epsilon 4. These give rise to six different phenotypes.
To study the associations of apoE phenotype with cord serum lipids (during minimal enteral nutrition), and with serum lipids of 3-year-old children.
We determined serum lipid levels and apoE phenotypes in 206 newborns and 259 3-year-old children in connection with a larger follow-up study of atherosclerosis precursors in children and young adults. ApoE phenotyping was done directly from plasma by isoelectric focusing followed by immunoblotting.
The effect of apoE phenotype on serum total and LDL cholesterol was significantly different in newborns and 3-year-old children (two-way ANOVA, interaction between apoE phenotype and age group: P .05) either in males or in females. The mean serum levels of triglycerides and high density lipoprotein cholesterol did not differ between apoE phenotypes either in 3-year-old children or newborns.
The results show that the differences in serum total and LDL cholesterol levels between apoE phenotypes are formed after birth by the influence of environmental factors and suggest that both genetic and external factors influence the levels of serum cholesterol concentrations during the first years of life.
PubMed ID
7936857 View in PubMed
Less detail

Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study.

https://arctichealth.org/en/permalink/ahliterature229497
Source
J Lipid Res. 1990 Mar;31(3):487-95
Publication Type
Article
Date
Mar-1990
Author
T. Lehtimäki
T. Moilanen
J. Viikari
H K Akerblom
C. Ehnholm
T. Rönnemaa
J. Marniemi
G. Dahlen
T. Nikkari
Author Affiliation
Department of Biomedical Sciences, University of Tampere, Finland.
Source
J Lipid Res. 1990 Mar;31(3):487-95
Date
Mar-1990
Language
English
Publication Type
Article
Keywords
Adolescent
Alleles
Analysis of Variance
Apolipoproteins B - blood
Apolipoproteins E - blood - genetics
Child
Child, Preschool
Cholesterol - blood
Coronary Disease - epidemiology
Cross-Sectional Studies
Female
Finland - epidemiology
Follow-Up Studies
Gene Frequency
Humans
Immunoblotting
Isoelectric Focusing
Lipids - blood
Male
Phenotype
Random Allocation
Triglycerides - blood
Abstract
Apolipoprotein E (apoE) polymorphism is a genetic determinant of plasma lipid levels and of coronary heart disease (CHD) risk. We determined the apoE phenotypes and plasma lipid levels in 1577 youths aged 3 to 18 years in 1980. The subjects were randomly selected from five areas of Finland. ApoE phenotyping was performed directly from plasma by isoelectric focusing and immunoblotting. The apoE allele frequencies in the population sample were epsilon 2 = 0.039, epsilon 3 = 0.767, and epsilon 4 = 0.194. There were no differences in the apoE phenotype distribution between East and West Finland or between sexes. The concentrations of serum total cholesterol, low density lipoprotein cholesterol, and apolipoprotein B increased with apoE phenotype in the order of E2/2, E3/2, E4/2, E3/3, E4/3, and E4/4. This increase was already seen in 3-year-old children; it was observed in both sexes, but was clearer in males than in females. The mean levels of high density lipoprotein (HDL) cholesterol, apolipoprotein A-I, triglyceride, Lp[a] lipoprotein, and the activity of lecithin:cholesterol acyltransferase did not differ between the apoE phenotypes. The observed differences in serum cholesterol remained fairly stable during the 6-year follow-up from 1980 to 1986, while the mean serum cholesterol concentration in the whole study population decreased by 6.3%. This study confirms the reported higher frequency of the epsilon 4 allele in Finns as compared to most other populations; this may contribute to the high rates of CHD in Finland as compared to most other populations. The results do not, however, explain the higher rate of CHD in East Finland in comparison to the western part of the country.
PubMed ID
2341810 View in PubMed
Less detail

[Apolipoprotein E polymorphism and serum cholesterol levels in Finnish children and adolescents].

https://arctichealth.org/en/permalink/ahliterature219597
Source
Duodecim. 1994;110(14):1313-9
Publication Type
Article
Date
1994
Source
Acta Paediatr. 2004 Mar;93(3):306-7
Publication Type
Article
Date
Mar-2004
Author
J. Viikari
Author Affiliation
Department of Internal Medicine, University of Turku, Turku University Central Hospital, Turku, Finland. jorma.viikari@utu.fi
Source
Acta Paediatr. 2004 Mar;93(3):306-7
Date
Mar-2004
Language
English
Publication Type
Article
Keywords
Body mass index
Child
Humans
Obesity - epidemiology
Physical Fitness
Sweden - epidemiology
Walking
Abstract
Overweight and obesity are increasing in Swedish boys and girls aged 7-16 y. The fitness of 16-y-old Swedish boys in 2001 was approximately 10% worse than in 1987. CONCLUSION: It is important to start the prevention of atherosclerosis and type 2 diabetes early. The number of children with physical inactivity and obesity should be as low as possible.
Notes
Comment On: Acta Paediatr. 2004 Mar;93(3):400-415124847
Comment On: Acta Paediatr. 2004 May;93(5):681-615174795
PubMed ID
15124829 View in PubMed
Less detail

Association between serum lipids and apolipoprotein E phenotype is influenced by diet in a population-based sample of free-living children and young adults: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature215501
Source
J Lipid Res. 1995 Apr;36(4):653-61
Publication Type
Article
Date
Apr-1995
Author
T. Lehtimäki
T. Moilanen
K. Porkka
H K Akerblom
T. Rönnemaa
L. Räsänen
J. Viikari
C. Ehnholm
T. Nikkari
Author Affiliation
Department of Biomedical Sciences, University of Tampere, Finland.
Source
J Lipid Res. 1995 Apr;36(4):653-61
Date
Apr-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alleles
Apolipoproteins E - genetics
Cardiovascular Diseases - epidemiology - etiology - genetics
Child
Diet
Female
Finland - epidemiology
Humans
Male
Risk factors
Abstract
Apolipoprotein E (apoE) is a genetic determinant of coronary heart disease and lipid levels in several populations. We studied whether the association of apoE alleles with serum lipids varies with diet in a population of free-living young Finns. One thousand twelve subjects, aged 9-24 years, were studied as a part of the Cardiovascular Risk in Young Finns Study in 1986. Serum lipid concentrations and apoE phenotypes were determined, and the composition of the diet was assessed by the 48-h recall method. The subjects were divided into three groups according to the intake of dietary saturated fatty acids (SAFA, g/1000 kcal) and cholesterol (mg/1000 kcal). Group one (high SAFA-cholesterol group) was formed from subjects belonging to the highest tertiles of both cholesterol and SAFA intakes (n = 175); group two (middle SAFA-cholesterol group) consisted of subjects belonging to the middle respective tertiles (n = 119); and group three (low SAFA-cholesterol group) consisted of subjects belonging to the lowest respective tertiles (n = 192). The statistical significance of the association of serum total cholesterol and low density lipoprotein (LDL) concentration with apoE phenotype increased from the low SAFA-cholesterol group (P = 0.024 for total cholesterol and P = 0.015 for LDL-cholesterol, respectively) to the high SAFA-cholesterol group (P = 0.0022 and P = 0.00073, respectively). The middle SAFA-cholesterol group fell between these two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
7616113 View in PubMed
Less detail

Association of apolipoprotein E and B polymorphisms with serum lipids.

https://arctichealth.org/en/permalink/ahliterature225359
Source
Ann Med. 1991 Dec;23(6):657-62
Publication Type
Article
Date
Dec-1991
Author
T. Lehtimäki
T. Moilanen
K. Aalto-Setälä
K. Kontula
K. Porkka
H K Akerblom
C. Ehnholm
T. Rönnemaa
J. Viikari
Author Affiliation
Department of Biomedical Sciences, University of Tampere, Finland.
Source
Ann Med. 1991 Dec;23(6):657-62
Date
Dec-1991
Language
English
Publication Type
Article
Keywords
Adolescent
Analysis of Variance
Apolipoproteins B - genetics
Apolipoproteins E - genetics
Child
Cholesterol - blood
Coronary Disease - epidemiology
Female
Finland - epidemiology
Humans
Immunoblotting
Male
Phenotype
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Risk factors
Sex Characteristics
Abstract
Genetic polymorphism of apolipoprotein E (apoE) and the Xbal restriction-fragment-length polymorphisms (RFLP) of the gene for apolipoprotein B (apoB) have both been shown to be associated with plasma lipid concentration. We studied the combined effect of these gene polymorphisms on serum cholesterol concentrations in 300 subjects aged nine to 18 years. In three way ANOVA, there was a statistically significant interaction between the effects of apoE phenotype and gender on serum cholesterol (P = 0.009). Therefore, males and females were analysed separately by two way ANOVA: there was no interaction between the effects of apoE phenotype and apoB Xbal polymorphism in either gender. In females, there were independent effects of both the apoE phenotype (P = 0.020) and the apoB Xbal genotype (P = 0.037) on serum cholesterol, but in males these effects were not statistically significant. These data suggest that variations at the apolipoprotein B and E gene locus play a role in the determination of serum cholesterol concentration in young female Finns.
PubMed ID
1685655 View in PubMed
Less detail

Atherosclerosis precursors in Finnish children and adolescents. I. General description of the cross-sectional study of 1980, and an account of the children's and families' state of health.

https://arctichealth.org/en/permalink/ahliterature239557
Source
Acta Paediatr Scand Suppl. 1985;318:49-63
Publication Type
Article
Date
1985
Author
H K Akerblom
J. Viikari
M. Uhari
L. Räsänen
T. Byckling
K. Louhivuori
E. Pesonen
P. Suoninen
M. Pietikäinen
P L Lähde
Source
Acta Paediatr Scand Suppl. 1985;318:49-63
Date
1985
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Child
Child Development
Child, Preschool
Coronary Disease - etiology - genetics
Cross-Sectional Studies
Female
Finland
Humans
Life Style
Male
Middle Aged
Risk
Abstract
The paper describes the general outline of a multicentre study on the risk factors of coronary heart disease (CHD) and their determinants in children of various ages in different parts of Finland. The study was a cross-sectional one, and was carried out in 1980 in five university cities of Finland with medical schools and in 12 rural communities in their vicinity. The randomized sample included an equal number of boys and girls, aged 3, 6, 9, 12, 15, and 18 years, and an equal number of urban and rural population in each area. The total sample size was 4,320 subjects, and of these 3,596 participated (83.1%). The families received before the medical examination of the child, questionnaires on the socioeconomic background the child's general health and development, the parents' and grandparents' health status, and the child's food and exercise habits. At the physical examination also a fasting blood sample (lipids, insulin, trace elements) was taken, a bundle of hair was cut for trace element analysis, and a 48-hour recall on food intake was obtained from every second subject. 19.5% of the children had in their history some long-term disease, allergic diseases being the most common. CHD and other cardiovascular diseases were significantly more frequent among the grandparents and parents in eastern than in western Finland. The study is meant to be a basis for a longitudinal study.
PubMed ID
3879091 View in PubMed
Less detail

Atherosclerosis precursors in Finnish children and adolescents. II. Height, weight, body mass index, and skinfolds, and their correlation to metabolic variables.

https://arctichealth.org/en/permalink/ahliterature239555
Source
Acta Paediatr Scand Suppl. 1985;318:65-78
Publication Type
Article
Date
1985
Author
S. Dahlström
J. Viikari
H K Akerblom
T. Solakivi-Jaakkola
M. Uhari
M. Dahl
P L Lähde
E. Pesonen
M. Pietikäinen
P. Suoninen
Source
Acta Paediatr Scand Suppl. 1985;318:65-78
Date
1985
Language
English
Publication Type
Article
Keywords
Adolescent
Body Height
Body Weight
Child
Child Development
Child, Preschool
Coronary Disease - etiology
Cross-Sectional Studies
Female
Finland
Humans
Male
Puberty
Risk
Skinfold thickness
Abstract
In a Finnish Multicentre Study, height, weight and skinfold thicknesses were measured in 3-, 6-, 9-, 12-, 15-, and 18-year-old children (N = 3,596). Height and weight percentiles superimposed on the current Finnish growth charts were above the standards in 6-15-year-old boys and 3-12-year-old girls. Triceps skinfold thickness percentiles (10% and 90%) appeared to be closest to British values and below American values. Weight, body mass index (BMI) and skinfold thicknesses showed good intercorrelations (up to .90) except in young boys. Height had a low positive correlation with BMI (.28 to .36) and with skinfold thickness (.23 to .36) in the age groups 6-12 years. BMI and subscapular skinfold seem to be useful obesity indicators. No consistent correlations were seen between physical variables and serum LDL- or total cholesterol and apoprotein B concentrations. There was a slight negative correlation between the physical variables and serum HDL-cholesterol. Apoprotein A1 correlated negatively to all obesity indicators in 12-year-old girls. Serum triglycerides showed slight positive correlation to physical variables. BMI and skinfolds had a low to moderate correlation with insulin (.21-.51) mainly in the three oldest age groups. On the ground of BMI and skinfold measurements we have reason to believe that the prevalence of obesity at 3-18 years of age is similar in Finland as in other countries in Europe.
PubMed ID
3879093 View in PubMed
Less detail

91 records – page 1 of 10.