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13 records – page 1 of 2.

Adenocarcinoma of the fallopian tube. Experience with 41 patients.

https://arctichealth.org/en/permalink/ahliterature249383
Source
Obstet Gynecol. 1977 Dec;50(6):654-7
Publication Type
Article
Date
Dec-1977
Author
J L Benedet
G W White
R N Fairey
D A Boyes
Source
Obstet Gynecol. 1977 Dec;50(6):654-7
Date
Dec-1977
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - diagnosis - drug therapy - mortality - pathology - radiotherapy
Adult
Aged
Antineoplastic Agents - therapeutic use
British Columbia
Dilatation and Curettage
Fallopian Tube Neoplasms - diagnosis - drug therapy - mortality - pathology - radiotherapy
Female
Humans
Middle Aged
Neoplasm Staging
Phosphorus Radioisotopes - therapeutic use
Radiotherapy, High-Energy
Abstract
Forty-one cases of primary fallopian tube carcinoma treated at our institution over the years 1946 to 1976 are described. The overall 5-year survival rate was 34.4%, although patients with early tumors had a 72.7% survival rate. The single most important factor affecting survival appeared to be the extent of disease at the time of diagnosis. Past and present treatment modalities are discussed, and proposals for management of this disease are outlined.
PubMed ID
412144 View in PubMed
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An analysis of 84244 patients from the British Columbia cytology-colposcopy program.

https://arctichealth.org/en/permalink/ahliterature181762
Source
Gynecol Oncol. 2004 Jan;92(1):127-34
Publication Type
Article
Date
Jan-2004
Author
J L Benedet
J P Matisic
M A Bertrand
Author Affiliation
Divisions of Gynaecologic Oncology and Pathology, BC Cancer Agency and The University of British Columbia, Vancouver, BC, Canada V5Z 4E6. lbenedet@bccancer.bc.ca
Source
Gynecol Oncol. 2004 Jan;92(1):127-34
Date
Jan-2004
Language
English
Publication Type
Article
Keywords
Adult
British Columbia
Cervical Intraepithelial Neoplasia - diagnosis - pathology
Colposcopy
Female
Humans
Mass Screening - methods - standards
Retrospective Studies
Sensitivity and specificity
Uterine Cervical Neoplasms - diagnosis - pathology
Abstract
To determine the diagnostic correlation between referral cytology, initial biopsies and colposcopic impression in patients assessed in a provincial cytology screening program.
A retrospective review of the computerized cytology screening database for British Columbia (BC), to identify all patients having their first colposcopy between 1986 and 2000 in 24 participating clinics constituted the study population. 84244 patient records were identified for analysis. Colposcopies were performed mainly by 37 general gynecologists as part of a province-wide colposcopy program. Correlation of cytology, colposcopic impression and directed biopsies was performed.
The colposcopic impression correlated with the referral cytology within one degree in over 90% of cases. Colposcopists felt cytology underestimated disease in 1.5% and overestimated disease in 8.3%. Cytology-histology correlation within one degree occurred in 82%. Cytology underestimated the result of the biopsies in 2.3% and appeared to overestimate disease in 16.1% of patients. Patients with HSIL cytology had corresponding lesions in 77%, with a further 4.9% having LSIL disease. The predictive accuracy of colposcopy increased with advancing severity of disease expected. As the degree of cytological abnormality worsened, the predictive accuracy of colposcopic diagnosis increased.
Both cytology and colposcopy have high sensitivity but low to moderate specificity. Colposcopy is most accurate in identifying high-grade diseases. Colposcopic impression correlates closely with the cytology diagnosis and combining the two produces optimum results.
PubMed ID
14751148 View in PubMed
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An analysis of maternal deaths in British Columbia: 1963 to 1970.

https://arctichealth.org/en/permalink/ahliterature253563
Source
Can Med Assoc J. 1974 Apr 6;110(7):783-4 passim
Publication Type
Article
Date
Apr-6-1974
Author
J L Benedet
W D Thomas
B H Yuen
Source
Can Med Assoc J. 1974 Apr 6;110(7):783-4 passim
Date
Apr-6-1974
Language
English
Publication Type
Article
Keywords
Abortion, Criminal
Anesthesia, Obstetrical - adverse effects
Bacterial Infections - mortality
British Columbia
Embolism, Air - mortality
Embolism, Amniotic Fluid - mortality
Female
Humans
Maternal mortality
Obstetric Labor Complications - mortality
Postpartum Hemorrhage - mortality
Pre-Eclampsia - mortality
Pregnancy
Pregnancy Complications, Cardiovascular
Pregnancy Complications, Infectious
Pregnancy, Ectopic - mortality
Uterine Hemorrhage - mortality
Vascular Diseases - mortality
Abstract
There were 132 maternal deaths in British Columbia in the years 1963 to 1970. The mean maternal mortality rate for these eight years was 0.317. Sixty of these deaths (45.5%) were due to direct obstetrical causes. Indirect and nonrelated deaths accounted for 21.2 and 33.3% of the total, respectively. The most common causes of direct obstetrical deaths were hemorrhage, infection and vascular accidents, in that order; pre-eclampsia ranked a distant fourth. Ninety-five percent of direct obstetrical deaths were probably avoidable. Approximately 27% of all direct obstetrical deaths were abortion-related. Hemorrhage continues to be a major problem, in particular among the native Indian women of the province.If further reduction in maternal mortality is to be achieved, obstetrical hemorrhage must be better managed and deaths due to abortions reduced. Future studies should reveal if the liberalized abortion laws will assist in the realization of the latter goal.
Notes
Cites: Can Med Assoc J. 1965 Jan 23;92:160-7014232190
PubMed ID
4545159 View in PubMed
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Basal cell carcinoma of the vulva: clinical features and treatment results in 28 patients.

https://arctichealth.org/en/permalink/ahliterature207404
Source
Obstet Gynecol. 1997 Nov;90(5):765-8
Publication Type
Article
Date
Nov-1997
Author
J L Benedet
D M Miller
T G Ehlen
M A Bertrand
Author Affiliation
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada. lbenedet@bccancer.bc.ca
Source
Obstet Gynecol. 1997 Nov;90(5):765-8
Date
Nov-1997
Language
English
Publication Type
Article
Keywords
Aged
British Columbia - epidemiology
Carcinoma, Basal Cell - epidemiology - surgery
Female
Follow-Up Studies
Humans
Neoplasm Recurrence, Local - epidemiology - surgery
Retrospective Studies
Time Factors
Vulva - surgery
Vulvar Neoplasms - epidemiology - surgery
Abstract
To review our experience and that in the recent literature regarding basal cell carcinoma of the vulva to see whether current management guidelines are appropriate.
Twenty-eight women with basal cell carcinoma of the vulva were seen over 25 years at the BC Cancer Agency. The clinical-pathologic features were tabulated and the outcome was analyzed.
The mean age was 74 years, and almost two-thirds were over the age of 70 at diagnosis. Patients typically presented with an irritation or soreness, with a symptom duration ranging from a few months to several years. Most lesions were confined to the anterior half of the vulva, and 23 of the 28 patients had T1 lesions. Wide local excision was the treatment method used most commonly. Only one patient was known to have died from disease metastasis. Ten women had other basal cell carcinomas, either before or after the diagnosis of their vulvar lesions, and in ten patients 11 other malignancies were diagnosed.
Basal cell carcinoma of the vulva is an extremely uncommon tumor that rarely metastasizes or spreads. Primary treatment should consist of wide local excision and continued follow-up.
PubMed ID
9351761 View in PubMed
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Cervical intraepithelial neoplasia in British Columbia: a comprehensive program for detection, diagnosis, and treatment.

https://arctichealth.org/en/permalink/ahliterature244141
Source
Gynecol Oncol. 1981 Oct;12(2 Pt 2):S280-91
Publication Type
Article
Date
Oct-1981

Cervical intraepithelial neoplasia in female prisoners in British Columbia.

https://arctichealth.org/en/permalink/ahliterature232329
Source
CMAJ. 1988 Oct 15;139(8):733-6
Publication Type
Article
Date
Oct-15-1988
Author
H. Karsai
A J Coldman
D. Gavin
S. Brumelle
D A Boyes
G H Anderson
J L Benedet
Author Affiliation
Cancer Control Agency of British Columbia, Vancouver.
Source
CMAJ. 1988 Oct 15;139(8):733-6
Date
Oct-15-1988
Language
English
Publication Type
Article
Keywords
Adult
Aged
British Columbia
Female
Humans
Mass Screening
Middle Aged
Papanicolaou test
Precancerous Conditions - epidemiology - prevention & control
Prisoners
Risk factors
Uterine Cervical Neoplasms - epidemiology
Vaginal Smears
Abstract
The annual incidence rates of cervical intraepithelial neoplasia (CIN), grades I to III, from 1975 to 1983 among 2440 prisoners in British Columbia for whom a history of screening by means of the Papanicolaou test was available were two to three times higher than the expected rates in the general female population of British Columbia. The rates among the prisoners from 1970 to 1984, although small, increased with a trend similar to that in the general population. Despite increases in the general population we conclude that prisoners are still at high risk for CIN.
Notes
Cites: Am J Obstet Gynecol. 1968 Mar 1;100(5):607-145638481
Cites: Br J Vener Dis. 1968 Sep;44(3):254-55687050
Cites: Clin Invest Med. 1982;5(1):1-297116711
Cites: Acta Obstet Gynecol Scand. 1982;61(3):199-2037124352
Cites: Int J Epidemiol. 1985 Dec;14(4):521-74086138
PubMed ID
3167733 View in PubMed
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Colposcopy, conization, and hysterectomy practices: a current perspective.

https://arctichealth.org/en/permalink/ahliterature242770
Source
Obstet Gynecol. 1982 Nov;60(5):539-45
Publication Type
Article
Date
Nov-1982
Author
J L Benedet
G H Anderson
M L Simpson
D. Shaw
Source
Obstet Gynecol. 1982 Nov;60(5):539-45
Date
Nov-1982
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Biopsy
British Columbia
Carcinoma in Situ - epidemiology - pathology - surgery
Cervix Uteri - cytology - pathology - surgery
Colposcopy
Cryosurgery
Female
Humans
Hysterectomy
Laser Therapy
Middle Aged
Uterine Cervical Neoplasms - epidemiology - pathology - surgery
Abstract
Data from the provincial cytology program has shown a progressive increase in the number of cases of cervical carcinoma in situ detected in the general population and a doubling of disease rate in third decade women, with most of the cases now in the 25- to 29-year-old age group. The introduction of a colposcopy service has led to a significant decrease in the number of diagnostic conizations performed over a 5-year period. Conization was still used for therapy in a substantial number of women despite the availability of cryotherapy and laser surgery. Eighty-five percent of all patients undergoing cone biopsy had sever dysplasia or carcinoma in situ (CIN III) on pathological examination. In 25% of patients, the conization specimen revealed either dysplasia or carcinoma in situ extending to resection margins. During review of 2249 patients, 1174 were spared a conization and were treated by either hysterectomy, cryotherapy, or laser surgery. It would appear that, although colposcopy can reduce dramatically the number of diagnostic cone biopsies, conization will still be required for therapy in a substantial number of patients.
PubMed ID
7145247 View in PubMed
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A comprehensive program for cervical cancer detection and management.

https://arctichealth.org/en/permalink/ahliterature224052
Source
Am J Obstet Gynecol. 1992 Apr;166(4):1254-9
Publication Type
Article
Date
Apr-1992
Author
J L Benedet
G H Anderson
J P Matisic
Author Affiliation
British Columbia Cancer Agency, Division of Gynecologic Oncology, Vancouver, Canada.
Source
Am J Obstet Gynecol. 1992 Apr;166(4):1254-9
Date
Apr-1992
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
British Columbia
Carcinoma in Situ - epidemiology
Carcinoma, Squamous Cell - epidemiology
Cervix Uteri - pathology
Colposcopy
Female
Humans
Incidence
Mass Screening
Middle Aged
Mortality
National Health Programs
Uterine Cervical Neoplasms - pathology - prevention & control - therapy
Vaginal Smears
Abstract
The purpose of this study was to document some of the results of a comprehensive provincial cytology and colposcopy program for the year 1988 and also to review the impact on the incidence and mortality rates for a clinical carcinoma of the cervix.
This study is a retrospective analysis of the cytologic results of all patients examined provincially in 1988 and a review of the clinical records of patients diagnosed with invasive cancer and those who died of disease.
In 1988 490,985 women (40% of all women over the age of 15 in the population) were screened, with 9.2% showing abnormal cells. A total of 79% of women screened were less than 50 years old and accounted for 86.3% of all abnormal smears. Women less than 35 years old were more likely than older women to have moderate dyskaryosis or worse.
Intensive comprehensive cytology and colposcopy programs reduce not only the incidence and mortality of clinical carcinoma of the cervix but also rates of in situ disease and other precursors.
PubMed ID
1566781 View in PubMed
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Invasive cancer of the cervix in British Columbia: a review of the demography and screening histories of 437 cases seen from 1985-1988.

https://arctichealth.org/en/permalink/ahliterature223460
Source
Obstet Gynecol. 1992 Jul;80(1):1-4
Publication Type
Article
Date
Jul-1992
Author
G H Anderson
J L Benedet
J C Le Riche
J P Matisic
J E Thompson
Author Affiliation
Division of Cytology, British Columbia Cancer Agency, Vancouver, Canada.
Source
Obstet Gynecol. 1992 Jul;80(1):1-4
Date
Jul-1992
Language
English
Publication Type
Article
Keywords
British Columbia - epidemiology
Female
Humans
Mass Screening
Neoplasm Invasiveness
Neoplasm Staging
Uterine Cervical Neoplasms - epidemiology - pathology
Abstract
The charts of 437 patients with newly diagnosed invasive cervical cancer seen in British Columbia during 1985-1988 were reviewed to determine the age at diagnosis, stage of disease, and histology of the lesions. The patient's immigration status and country of birth were also examined. Two hundred forty-two patients (55%) were age 50 or over and 149 (34%) had preclinical stage IB disease. One hundred seventy of these patients (39%) had never had a cytologic examination before presenting with clinical symptoms, and 45 additional patients had not had cytology for 5 or more years before presenting with invasive disease; thus, a total of 215 cases (49%) fell into the category of "no cytology or cytology longer than 5 years ago." All negative smears were reviewed and in 39 patients (15%) having previous cytology, abnormal cells had been missed or undercalled. Native Indian women made up 10% of the cases of invasive carcinoma, a disproportionately large number as they represent only 2% of the British Columbian population. Of the 27 Native Indian patients in this series, 16 (59%) had never had a cytologic examination. Eighty-five (30%) of 276 women born in Canada had never had a cytologic examination, compared with 34 (71%) of 48 immigrants resident in the country for fewer than 10 years. Twenty-four patients were over the age of 60 with a history of negative Papanicolaou smears. We conclude that, if further gains are to be made in the reduction of death rates from invasive cervical carcinoma, new means must be found to encourage women to participate in Papanicolaou smear screening programs. In particular, special efforts must be made to attract specific groups, such as the Native Indian population and older recent immigrants.
PubMed ID
1603476 View in PubMed
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Organisation and results of the cervical cytology screening programme in British Columbia, 1955-85.

https://arctichealth.org/en/permalink/ahliterature233215
Source
Br Med J (Clin Res Ed). 1988 Apr 2;296(6627):975-8
Publication Type
Article
Date
Apr-2-1988
Author
G H Anderson
D A Boyes
J L Benedet
J C Le Riche
J P Matisic
K C Suen
A J Worth
A. Millner
O M Bennett
Author Affiliation
Division of Cytology, Cancer Control Agency of BC, Vancouver, Canada.
Source
Br Med J (Clin Res Ed). 1988 Apr 2;296(6627):975-8
Date
Apr-2-1988
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
British Columbia
Carcinoma in Situ - prevention & control
Carcinoma, Squamous Cell - prevention & control
Colposcopy
Female
Follow-Up Studies
Humans
Mass Screening - organization & administration
Medical Records
Middle Aged
Uterine Cervical Neoplasms - prevention & control
Vaginal Smears
Abstract
A screening programme to detect preinvasive carcinoma of the cervix was started in British Columbia in 1949. Since 1970 the number of women who have been screened at least once has been maintained at about 85% of the population at risk. More than 500,000 cervical smears are being examined each year in the central laboratory. There has been an appreciable increase in the number of cases and rates of carcinoma in situ seen since 1970, particularly in women between 20 and 30 years of age. Since the programme started over 26,000 cases of squamous carcinoma in situ have been detected and treated. The incidence of clinically invasive squamous carcinoma of the cervix has fallen by 78% during the period under review, and mortality from squamous carcinoma of the cervix has fallen by 72%. A colposcopy programme, introduced throughout British Columbia over the past 12 years, has been important in reducing the problems of managing preinvasive lesions, particularly in younger women. It is concluded that the reduction in morbidity and mortality from invasive squamous cancer of the cervix in British Columbia over the past 30 years is directly attributable to the province wide screening programme and that a large potential increase in invasive cervical cancer rates among younger women is being prevented.
Notes
Cites: Obstet Gynecol. 1981 Feb;57(2):145-97465117
Cites: Cancer. 1981 Mar 1;47(5 Suppl):1176-817237375
Cites: Gynecol Oncol. 1981 Oct;12(2 Pt 2):S259-647308858
Cites: Gynecol Oncol. 1981 Oct;12(2 Pt 2):S280-917308860
Cites: Acta Cytol. 1987 Nov-Dec;31(6):895-93425151
Cites: Br Med J (Clin Res Ed). 1983 Aug 20;287(6391):526-86411205
Cites: Obstet Gynecol. 1985 Apr;65(4):557-623982729
Cites: Lancet. 1987 May 30;1(8544):1247-92884378
Cites: Fam Plann Perspect. 1987 Mar-Apr;19(2):46-533595817
Cites: Br Med J (Clin Res Ed). 1983 Aug 20;287(6391):510-26411197
PubMed ID
3129115 View in PubMed
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13 records – page 1 of 2.